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Entry version 115 (13 Nov 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Pyrin and HIN domain-containing protein 1

Gene

Pyhin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyrin and HIN domain-containing protein 1
Alternative name(s):
Interferon-inducible protein 209
Short name:
Ifi-209
Interferon-inducible protein X
Interferon-inducible protein p209
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pyhin1
Synonyms:Ifi209, Ifix
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2138243 Pyhin1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003345251 – 420Pyrin and HIN domain-containing protein 1Add BLAST420

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BV49

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BV49

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BV49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BV49

PeptideAtlas

More...
PeptideAtlasi
Q8BV49

PRoteomics IDEntifications database

More...
PRIDEi
Q8BV49

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BV49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BV49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043263 Expressed in 87 organ(s), highest expression level in lymph node

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BV49 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BV49 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231754, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8BV49, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8BV49

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061900

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BV49

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 87PyrinPROSITE-ProRule annotationAdd BLAST87
Domaini219 – 416HIN-200PROSITE-ProRule annotationAdd BLAST198

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 200Ser-richAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HIN-200 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J5NP Eukaryota
ENOG410Y78B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013296

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033871

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BV49

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISHICLQ

Database of Orthologous Groups

More...
OrthoDBi
1304994at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BV49

TreeFam database of animal gene trees

More...
TreeFami
TF337385

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004020 DAPIN
IPR040205 HIN-200
IPR004021 HIN200/IF120x

The PANTHER Classification System

More...
PANTHERi
PTHR12200 PTHR12200, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01289 PYRIN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BV49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNEYKRIVL LTGLMGINDH DFRMVKSLLS KELKLNRMQD QYDRVKIADL
60 70 80 90 100
MEDKFPKDAG VDQLIKLYKQ IPGLGDIANK LKNEKAKAKR TRTGKRKTAA
110 120 130 140 150
KRQRQEEPST SQPMSTTNED AEPESGRSTP DTQVAQLSLP TASRRNQAIQ
160 170 180 190 200
ISPTIASSSG QTSSRSSETL QSIIQSPKTP KRPSSSILDP PVSSGTASSS
210 220 230 240 250
AQALGVPLAT IAKRQRLKNV PKEPSEENGH QQGSKKVMVL KVTEPFSYDV
260 270 280 290 300
TEEKMFHATV ATETEFFRVK VFDIVLKEKF IPNKVLTISN YVGCNGFINI
310 320 330 340 350
YSASSVSEVN DGEPMNIPLS LRKSANRTPK INYLCSKKRG IFVNGVFTVC
360 370 380 390 400
KKEEKWNYIC YEIGDDTGMM EVEVYGRLTN IACNPGDKLR LICFKLIPDE
410 420
EKAQLRSTTH SNMQVIKAKN
Length:420
Mass (Da):46,887
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1983C4F11956A8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXV9A0A0A6YXV9_MOUSE
Interferon-activated gene 209
Ifi209 Pyhin1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85K → M in AAI07379 (PubMed:15489334).Curated1
Sequence conflicti85K → M in AAI07380 (PubMed:15489334).Curated1
Sequence conflicti227E → V in AAI07380 (PubMed:15489334).Curated1
Sequence conflicti248Y → H in BAC30731 (PubMed:16141072).Curated1
Sequence conflicti291Y → C in BAC30731 (PubMed:16141072).Curated1
Sequence conflicti313E → D in AAI07380 (PubMed:15489334).Curated1
Sequence conflicti338K → R in AAI07380 (PubMed:15489334).Curated1
Sequence conflicti418A → T in AAI07380 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK040884 mRNA Translation: BAC30731.1
AK076726 mRNA Translation: BAC36457.1
AK080371 mRNA Translation: BAC37894.1
AK150817 mRNA Translation: BAE29880.1
BC096384 mRNA Translation: AAH96384.1
BC107378 mRNA Translation: AAI07379.1
BC107379 mRNA Translation: AAI07380.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35791.1

NCBI Reference Sequences

More...
RefSeqi
NP_778191.1, NM_175026.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000056071; ENSMUSP00000061900; ENSMUSG00000043263

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
236312

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:236312

UCSC genome browser

More...
UCSCi
uc007drr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040884 mRNA Translation: BAC30731.1
AK076726 mRNA Translation: BAC36457.1
AK080371 mRNA Translation: BAC37894.1
AK150817 mRNA Translation: BAE29880.1
BC096384 mRNA Translation: AAH96384.1
BC107378 mRNA Translation: AAI07379.1
BC107379 mRNA Translation: AAI07380.1
CCDSiCCDS35791.1
RefSeqiNP_778191.1, NM_175026.3

3D structure databases

SMRiQ8BV49
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231754, 1 interactor
IntActiQ8BV49, 1 interactor
MINTiQ8BV49
STRINGi10090.ENSMUSP00000061900

PTM databases

iPTMnetiQ8BV49
PhosphoSitePlusiQ8BV49

Proteomic databases

EPDiQ8BV49
jPOSTiQ8BV49
MaxQBiQ8BV49
PaxDbiQ8BV49
PeptideAtlasiQ8BV49
PRIDEiQ8BV49

Genome annotation databases

EnsembliENSMUST00000056071; ENSMUSP00000061900; ENSMUSG00000043263
GeneIDi236312
KEGGimmu:236312
UCSCiuc007drr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
236312
MGIiMGI:2138243 Pyhin1

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOGENOMiHOG000033871
InParanoidiQ8BV49
OMAiISHICLQ
OrthoDBi1304994at2759
PhylomeDBiQ8BV49
TreeFamiTF337385

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8BV49

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043263 Expressed in 87 organ(s), highest expression level in lymph node
ExpressionAtlasiQ8BV49 baseline and differential
GenevisibleiQ8BV49 MM

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR040205 HIN-200
IPR004021 HIN200/IF120x
PANTHERiPTHR12200 PTHR12200, 2 hits
PfamiView protein in Pfam
PF02760 HIN, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFIX_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BV49
Secondary accession number(s): Q3KNA6
, Q3KNA7, Q8BLY5, Q8BVS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: November 13, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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