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Protein

COP9 signalosome complex subunit 7b

Gene

Cops7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7b
Short name:
SGN7b
Short name:
Signalosome subunit 7b
Alternative name(s):
JAB1-containing signalosome subunit 7b
Gene namesi
Name:Cops7b
Synonyms:Csn7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1349388 Cops7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210002 – 264COP9 signalosome complex subunit 7bAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BV13
MaxQBiQ8BV13
PaxDbiQ8BV13
PeptideAtlasiQ8BV13
PRIDEiQ8BV13

PTM databases

iPTMnetiQ8BV13
PhosphoSitePlusiQ8BV13

Expressioni

Gene expression databases

BgeeiENSMUSG00000026240 Expressed in 295 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiQ8BV13 baseline and differential
GenevisibleiQ8BV13 MM

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with EIF3S6 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi205046, 4 interactors
IntActiQ8BV13, 2 interactors
MINTiQ8BV13
STRINGi10090.ENSMUSP00000027446

Structurei

3D structure databases

ProteinModelPortaliQ8BV13
SMRiQ8BV13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 159PCIPROSITE-ProRule annotationAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili194 – 237Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00390000013069
HOGENOMiHOG000006003
HOVERGENiHBG051138
InParanoidiQ8BV13
KOiK12180
OMAiKENHHRT
OrthoDBiEOG091G0I8H
PhylomeDBiQ8BV13
TreeFamiTF101149

Family and domain databases

InterProiView protein in InterPro
IPR027530 Csn7b
IPR000717 PCI_dom
PANTHERiPTHR15350:SF8 PTHR15350:SF8, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BV13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTTL ISQVLEAPGV YVFGELLELA
60 70 80 90 100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELSV AQQNKLKHLT
110 120 130 140 150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ
160 170 180 190 200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE
210 220 230 240 250
NHHRTQQQVE AEVSNIKKTL KATASSSAQE MEQQLAEREC PPHTEQRQPT
260
KKMSKVKGLV SSRH
Length:264
Mass (Da):29,689
Last modified:March 1, 2003 - v1
Checksum:iBD6088424F5537EA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH36D6RH36_MOUSE
COP9 signalosome complex subunit 7b
Cops7b
62Annotation score:
D6RI85D6RI85_MOUSE
COP9 signalosome complex subunit 7b
Cops7b
103Annotation score:
D3Z6T8D3Z6T8_MOUSE
COP9 signalosome complex subunit 7b
Cops7b
199Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → A in AAH12659 (PubMed:15489334).Curated1
Sequence conflicti97K → N in AAC33904 (PubMed:9707402).Curated1
Sequence conflicti102V → L in AAC33904 (PubMed:9707402).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071317 mRNA Translation: AAC33904.1
AK081309 mRNA Translation: BAC38192.1
AK168740 mRNA Translation: BAE40581.1
BC012659 mRNA Translation: AAH12659.1
CCDSiCCDS15122.1
RefSeqiNP_766562.1, NM_172974.2
XP_006529686.1, XM_006529623.3
XP_006529687.1, XM_006529624.3
UniGeneiMm.12973

Genome annotation databases

EnsembliENSMUST00000027446; ENSMUSP00000027446; ENSMUSG00000026240
ENSMUST00000121534; ENSMUSP00000113587; ENSMUSG00000026240
GeneIDi26895
KEGGimmu:26895
UCSCiuc007bvr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071317 mRNA Translation: AAC33904.1
AK081309 mRNA Translation: BAC38192.1
AK168740 mRNA Translation: BAE40581.1
BC012659 mRNA Translation: AAH12659.1
CCDSiCCDS15122.1
RefSeqiNP_766562.1, NM_172974.2
XP_006529686.1, XM_006529623.3
XP_006529687.1, XM_006529624.3
UniGeneiMm.12973

3D structure databases

ProteinModelPortaliQ8BV13
SMRiQ8BV13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205046, 4 interactors
IntActiQ8BV13, 2 interactors
MINTiQ8BV13
STRINGi10090.ENSMUSP00000027446

PTM databases

iPTMnetiQ8BV13
PhosphoSitePlusiQ8BV13

Proteomic databases

EPDiQ8BV13
MaxQBiQ8BV13
PaxDbiQ8BV13
PeptideAtlasiQ8BV13
PRIDEiQ8BV13

Protocols and materials databases

DNASUi26895
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027446; ENSMUSP00000027446; ENSMUSG00000026240
ENSMUST00000121534; ENSMUSP00000113587; ENSMUSG00000026240
GeneIDi26895
KEGGimmu:26895
UCSCiuc007bvr.1 mouse

Organism-specific databases

CTDi64708
MGIiMGI:1349388 Cops7b

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00390000013069
HOGENOMiHOG000006003
HOVERGENiHBG051138
InParanoidiQ8BV13
KOiK12180
OMAiKENHHRT
OrthoDBiEOG091G0I8H
PhylomeDBiQ8BV13
TreeFamiTF101149

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCops7b mouse
PROiPR:Q8BV13
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026240 Expressed in 295 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiQ8BV13 baseline and differential
GenevisibleiQ8BV13 MM

Family and domain databases

InterProiView protein in InterPro
IPR027530 Csn7b
IPR000717 PCI_dom
PANTHERiPTHR15350:SF8 PTHR15350:SF8, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN7B_MOUSE
AccessioniPrimary (citable) accession number: Q8BV13
Secondary accession number(s): O88547, Q3TGG7, Q921G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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