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Entry version 118 (26 Feb 2020)
Sequence version 2 (30 May 2006)
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Protein

G-protein coupled receptor-associated sorting protein 2

Gene

Gprasp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in regulation of a variety of G-protein coupled receptors.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name:
GASP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gprasp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442071 Gprasp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002390541 – 826G-protein coupled receptor-associated sorting protein 2Add BLAST826

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei275PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8BUY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BUY8

PeptideAtlas

More...
PeptideAtlasi
Q8BUY8

PRoteomics IDEntifications database

More...
PRIDEi
Q8BUY8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BUY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BUY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in the brain and the cochlea. Also in lung and muscle tissues. Localized in multiple structures of the cochlea, detected in the spiral ganglion, stria vascularis, spiral ligament, inner and outer hair cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000072966 Expressed in subparaventricular zone and 200 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BUY8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000134666

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BUY8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVHR Eukaryota
ENOG410XUVQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017437_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BUY8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWPREEA

Database of Orthologous Groups

More...
OrthoDBi
860703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BUY8

TreeFam database of animal gene trees

More...
TreeFami
TF335652

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04826 Arm_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BUY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGAEVETGS QAKPDKKPQE EVAGGAERES EAPLVVRPKV RPQAPATSGA
60 70 80 90 100
RPKTETKSSS RARPKTETQS VSGTRHRMSG ARPRSEAQLM SGARPKTDAR
110 120 130 140 150
AVGGARPKTE AKPIPGARPK GDAQAWAHSE FGAEAMPRAE RAHLSNSVTW
160 170 180 190 200
PPVNVGSATV TKSKSLSMNT ELASMGSEIF SGTQGQPGIE PWFGPREEAN
210 220 230 240 250
MGSWCYPRPR AREETSNESA DENSTMSSFW TREETSIRSW PREEVNTRSR
260 270 280 290 300
HRAKHQTNAR SKPRSKQDPY IDSLSGSEDE ASNPFCFWAG ENTNDMFRAR
310 320 330 340 350
GRDEANARPK IRTKREDYFE DEDEIYKESW LLPGEEGNRF RRRDKEEPNK
360 370 380 390 400
TLKNENEKDV KNDETVEQES RLEEEVIIGS WFWAEQETNV EAGASAICDA
410 420 430 440 450
EPGAEEGAIG GSLFWTEEKP SLGAVARDEV RPESEEEALF GSWFWDRDEA
460 470 480 490 500
CFDPNPTPVY TAKSRYRDPE EDLNLASRPK TWDEVTIEFK PPCHGLGFPS
510 520 530 540 550
PRPFIIPEGA SGNSEEKAKN AELGAEGEEQ DSVAQRDLPE PEFPFQYDPS
560 570 580 590 600
YRSVQEIREH LKARESAQPE NWSCTCIQCE LRISSAEFEE LLLLMDRIRD
610 620 630 640 650
PFIHEIAKIA MGMRTASQFT RDFIRDSGVV SLIEALMNYP SSRVRTNFLE
660 670 680 690 700
NMVHMAPPYP NLNMIETFIC QVCEETLSHS VNSPEQLTGM RMLRHLTITT
710 720 730 740 750
DYHVLIANYV SGFLALLTTG DARTKFHVLK MLLNLSDNPM VAKKLFSAKA
760 770 780 790 800
LSIFVGLFNI EETNDNIQIV IKMFQNISNI VKSGAMSLLD DDFSLEPLVS
810 820
AFHEFEELAK QLQIQIDNQN DPEEGQ
Length:826
Mass (Da):92,802
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01E28D8B629F36A6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL683822 Genomic DNA No translation available.
BC117923 mRNA Translation: AAI17924.1
BC117924 mRNA Translation: AAI17925.1
AK081764 mRNA Translation: BAC38324.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53191.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156487.1, NM_001163015.1
NP_001156488.1, NM_001163016.1
NP_001156489.1, NM_001163017.1
XP_017173986.1, XM_017318497.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
245607

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:245607

UCSC genome browser

More...
UCSCi
uc009uhs.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683822 Genomic DNA No translation available.
BC117923 mRNA Translation: AAI17924.1
BC117924 mRNA Translation: AAI17925.1
AK081764 mRNA Translation: BAC38324.1
CCDSiCCDS53191.1
RefSeqiNP_001156487.1, NM_001163015.1
NP_001156488.1, NM_001163016.1
NP_001156489.1, NM_001163017.1
XP_017173986.1, XM_017318497.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000134666

PTM databases

iPTMnetiQ8BUY8
PhosphoSitePlusiQ8BUY8

Proteomic databases

MaxQBiQ8BUY8
PaxDbiQ8BUY8
PeptideAtlasiQ8BUY8
PRIDEiQ8BUY8

Genome annotation databases

EnsembliENSMUST00000113136; ENSMUSP00000108761; ENSMUSG00000072966
ENSMUST00000173804; ENSMUSP00000134666; ENSMUSG00000072966
GeneIDi245607
KEGGimmu:245607
UCSCiuc009uhs.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114928
MGIiMGI:2442071 Gprasp2

Phylogenomic databases

eggNOGiENOG410IVHR Eukaryota
ENOG410XUVQ LUCA
GeneTreeiENSGT00940000162726
HOGENOMiCLU_017437_0_0_1
InParanoidiQ8BUY8
OMAiSWPREEA
OrthoDBi860703at2759
PhylomeDBiQ8BUY8
TreeFamiTF335652

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gprasp2 mouse

Protein Ontology

More...
PROi
PR:Q8BUY8
RNActiQ8BUY8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000072966 Expressed in subparaventricular zone and 200 other tissues
GenevisibleiQ8BUY8 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGASP2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BUY8
Secondary accession number(s): Q148X7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: February 26, 2020
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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