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Protein

Complex I assembly factor TIMMDC1, mitochondrial

Gene

Timmdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity).By similarity

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Complex I assembly factor TIMMDC1, mitochondrial
Alternative name(s):
Translocase of inner mitochondrial membrane domain-containing protein 1
Short name:
TIMM domain containing-protein 1
Gene namesi
Name:Timmdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1922139 Timmdc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei137 – 159HelicalSequence analysisAdd BLAST23
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524791 – 285Complex I assembly factor TIMMDC1, mitochondrialAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei277PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BUY5
MaxQBiQ8BUY5
PaxDbiQ8BUY5
PeptideAtlasiQ8BUY5
PRIDEiQ8BUY5

PTM databases

iPTMnetiQ8BUY5
PhosphoSitePlusiQ8BUY5

Expressioni

Gene expression databases

BgeeiENSMUSG00000002846 Expressed in 208 organ(s), highest expression level in pineal body
CleanExiMM_4930455C21RIK
GenevisibleiQ8BUY5 MM

Interactioni

Subunit structurei

Associates with the intermediate 315 kDa subcomplex of incompletely assembled complex I.By similarity

Protein-protein interaction databases

BioGridi218392, 2 interactors
IntActiQ8BUY5, 1 interactor
STRINGi10090.ENSMUSP00000002925

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4608 Eukaryota
ENOG4111F79 LUCA
GeneTreeiENSGT00390000013817
HOVERGENiHBG081001
InParanoidiQ8BUY5
OMAiWRTAVFV
OrthoDBiEOG091G0PD2
PhylomeDBiQ8BUY5
TreeFamiTF324676

Sequencei

Sequence statusi: Complete.

Q8BUY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAPPPAPRS RLCGAWGPFP RVFAAGAVAA DSPGFVEDRE QRSGVSDPGS
60 70 80 90 100
LESGWDRLRQ LFAKDEQQRF SKEIDYIYRA AVSAGIIGWA YGGIPAFIYA
110 120 130 140 150
KKRYIEQSQA EIYHNRFDAV QSAHRAATRG FIRYGWRWSW RTAVFVTIFN
160 170 180 190 200
TVNTGLTVYR NKDAMSHFAI AGAVTGGLFR INLGVRGLVA GSIIGALLGA
210 220 230 240 250
PMGSLLMALE KYSGETVQER RQKEWKALHE QRLEEWRSSL QVTELLPMEI
260 270 280
ESGLEKIQPE GDAQRIEELL SLPRNPSSPH QQSKH
Length:285
Mass (Da):31,791
Last modified:March 1, 2003 - v1
Checksum:iF4E1FB023769B158
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26G → E in AAH02243 (PubMed:15489334).Curated1
Sequence conflicti261 – 262GD → EN in AAH02243 (PubMed:15489334).Curated2
Sequence conflicti280H → D in AAH02243 (PubMed:15489334).Curated1
Sequence conflicti285H → D in AAH02243 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012774 mRNA Translation: BAB28461.1
AK081781 mRNA Translation: BAC38330.1
BC002243 mRNA Translation: AAH02243.1
CCDSiCCDS28169.1
RefSeqiNP_077235.2, NM_024273.2
UniGeneiMm.132231

Genome annotation databases

EnsembliENSMUST00000002925; ENSMUSP00000002925; ENSMUSG00000002846
GeneIDi76916
KEGGimmu:76916
UCSCiuc012afp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012774 mRNA Translation: BAB28461.1
AK081781 mRNA Translation: BAC38330.1
BC002243 mRNA Translation: AAH02243.1
CCDSiCCDS28169.1
RefSeqiNP_077235.2, NM_024273.2
UniGeneiMm.132231

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218392, 2 interactors
IntActiQ8BUY5, 1 interactor
STRINGi10090.ENSMUSP00000002925

PTM databases

iPTMnetiQ8BUY5
PhosphoSitePlusiQ8BUY5

Proteomic databases

EPDiQ8BUY5
MaxQBiQ8BUY5
PaxDbiQ8BUY5
PeptideAtlasiQ8BUY5
PRIDEiQ8BUY5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002925; ENSMUSP00000002925; ENSMUSG00000002846
GeneIDi76916
KEGGimmu:76916
UCSCiuc012afp.1 mouse

Organism-specific databases

CTDi51300
MGIiMGI:1922139 Timmdc1

Phylogenomic databases

eggNOGiKOG4608 Eukaryota
ENOG4111F79 LUCA
GeneTreeiENSGT00390000013817
HOVERGENiHBG081001
InParanoidiQ8BUY5
OMAiWRTAVFV
OrthoDBiEOG091G0PD2
PhylomeDBiQ8BUY5
TreeFamiTF324676

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:Q8BUY5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002846 Expressed in 208 organ(s), highest expression level in pineal body
CleanExiMM_4930455C21RIK
GenevisibleiQ8BUY5 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTIDC1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUY5
Secondary accession number(s): Q99LS9, Q9CSI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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