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Protein

Pleckstrin homology domain-containing family A member 1

Gene

Plekha1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • androgen metabolic process Source: MGI
  • B cell receptor signaling pathway Source: MGI
  • cellular response to hydrogen peroxide Source: MGI
  • establishment of protein localization Source: MGI
  • estrogen metabolic process Source: MGI
  • face morphogenesis Source: MGI
  • female gonad development Source: MGI
  • Leydig cell differentiation Source: MGI
  • luteinization Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of protein kinase B signaling Source: MGI
  • phosphatidylinositol 3-kinase signaling Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • post-embryonic development Source: MGI
  • roof of mouth development Source: MGI
  • ruffle organization Source: MGI
  • skeletal system morphogenesis Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 1
Short name:
PH domain-containing family A member 1
Alternative name(s):
Tandem PH domain-containing protein 1
Short name:
TAPP-1
Gene namesi
Name:Plekha1
Synonyms:Tapp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442213 Plekha1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538741 – 383Pleckstrin homology domain-containing family A member 1Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q8BUL6-2)
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiQ8BUL6
PRIDEiQ8BUL6

PTM databases

iPTMnetiQ8BUL6
PhosphoSitePlusiQ8BUL6

Expressioni

Gene expression databases

BgeeiENSMUSG00000040268
ExpressionAtlasiQ8BUL6 baseline and differential
GenevisibleiQ8BUL6 MM

Interactioni

Subunit structurei

Interacts with MPDZ and PTPN13.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8BUL6
SMRiQ8BUL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 112PH 1PROSITE-ProRule annotationAdd BLAST106
Domaini191 – 289PH 2PROSITE-ProRule annotationAdd BLAST99

Domaini

Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain.

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00440000037398
HOGENOMiHOG000116175
HOVERGENiHBG053612
InParanoidiQ8BUL6
OMAiPCIQRSI
OrthoDBiEOG091G08U3
PhylomeDBiQ8BUL6
TreeFamiTF329516

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BUL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTREDSFV WYMDNPQNLP
60 70 80 90 100
SGSSRVGAIK LTYISKVSDA TKLRPKAEFC FVMNAGMRKY FLQANDQQDL
110 120 130 140 150
VEWVNVLNKA IKITVPKQSD SQPASDSLSR QGDCGKKQVS YRTDIVGGVP
160 170 180 190 200
IITPTQKEEV NECGESLDRN NLKRSQSHLP YFAPKPPSDS AVIKAGYCVK
210 220 230 240 250
QGAVMKNWKR RYFQLDENTI GYFKSELEKE PLRVIPLKEV HKVQECKQSD
260 270 280 290 300
IMMRDNLFEI VTTSRTFYVQ ADSPEEMHSW IKAVSGAIVA QRGPGRSSSS
310 320 330 340 350
MRQARRLSNP CIQRSIPAGL QNPNSLSVLP GPQPPPHIPQ PLAATLWSQA
360 370 380
VPWRSEEFTN LLPRSSQGTS RSRLSLQESQ LPK
Note: No experimental confirmation available.
Length:383
Mass (Da):43,371
Last modified:March 1, 2003 - v1
Checksum:i6020E5A2F3184C19
GO
Isoform 2 (identifier: Q8BUL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-115: Missing.
     301-383: MRQARRLSNP...LSLQESQLPK → EHSGWPSEPK...DDASLPVSDV

Note: No experimental confirmation available.Combined sources
Show »
Length:356
Mass (Da):39,575
Checksum:i057CFEA1551371E0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00976468 – 115Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_009767301 – 383MRQAR…SQLPK → EHSGWPSEPKFTVRPAGAAA TASHSPASRSHSLVSGCAME KRGVYQSLAKVKPGNFKVQT VSPREPASKVTEQALLRPQS KNGPQGEDGEPVDLDDASLP VSDV in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083340 mRNA Translation: BAC38874.1
BC020017 mRNA Translation: AAH20017.1
CCDSiCCDS21907.1 [Q8BUL6-2]
CCDS85434.1 [Q8BUL6-1]
RefSeqiNP_001333444.1, NM_001346515.1 [Q8BUL6-1]
NP_598703.1, NM_133942.2 [Q8BUL6-2]
XP_006507212.1, XM_006507149.3 [Q8BUL6-1]
UniGeneiMm.323554

Genome annotation databases

EnsembliENSMUST00000048180; ENSMUSP00000035375; ENSMUSG00000040268 [Q8BUL6-2]
ENSMUST00000075181; ENSMUSP00000074675; ENSMUSG00000040268 [Q8BUL6-1]
GeneIDi101476
KEGGimmu:101476
UCSCiuc009kar.1 mouse [Q8BUL6-1]
uc009kat.1 mouse [Q8BUL6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPKHA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUL6
Secondary accession number(s): Q8BK96, Q8BXU1, Q8VE13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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