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Entry version 143 (12 Aug 2020)
Sequence version 2 (13 Apr 2004)
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Protein

Low-density lipoprotein receptor-related protein 12

Gene

Lrp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-975634, Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 12
Short name:
LRP-12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrp12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443132, Lrp12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 492ExtracellularSequence analysisAdd BLAST460
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 858CytoplasmicSequence analysisAdd BLAST345

Keywords - Cellular componenti

Coated pit, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001734033 – 858Low-density lipoprotein receptor-related protein 12Add BLAST826

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 76By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 122By similarity
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Disulfide bondi215 ↔ 232By similarity
Disulfide bondi222 ↔ 245By similarity
Disulfide bondi239 ↔ 254By similarity
Disulfide bondi259 ↔ 285By similarity
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi375 ↔ 388By similarity
Disulfide bondi382 ↔ 401By similarity
Disulfide bondi395 ↔ 410By similarity
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi420 ↔ 439By similarity
Disulfide bondi433 ↔ 448By similarity
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi451 ↔ 463By similarity
Disulfide bondi458 ↔ 476By similarity
Disulfide bondi470 ↔ 485By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BUJ9

PRoteomics IDEntifications database

More...
PRIDEi
Q8BUJ9

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8BUJ9, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BUJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BUJ9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BUJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022305, Expressed in pes and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BUJ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BUJ9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with RACK1, ZFYVE9 and NMRK2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
232078, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022916

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BUJ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BUJ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 159CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini165 – 201LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini214 – 255LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST42
Domaini259 – 372CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini374 – 411LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini412 – 449LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini450 – 486LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158307

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013747_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BUJ9

KEGG Orthology (KO)

More...
KOi
K20050

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYSATHH

Database of Orthologous Groups

More...
OrthoDBi
135036at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BUJ9

TreeFam database of animal gene trees

More...
TreeFami
TF332149

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 2 hits
cd00112, LDLa, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 2 hits
4.10.400.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BUJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARRWSTKES QRRGSAWLLL FLAGVYGNGA LAELSENVHI SGVSTACGES
60 70 80 90 100
PEQIRAPSGI ITSPGWPSDY PAQVNCSWLI RANPGEIITI SFQDFDIQGS
110 120 130 140 150
RRCTLDWLTI ETYKNIESYR ACGSTIPPPY ISSQDHVWIR FHSDDSVSRK
160 170 180 190 200
GFRLAYFSGK SEQPDCACDQ FRCGNGKCIP EAWKCNSMDE CGDSSDEEVC
210 220 230 240 250
ASDAHPPTTT AFQPCAYNQF QCLSRFTKVY TCLPESLKCD GNIDCLDLGD
260 270 280 290 300
EIDCDMPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR
310 320 330 340 350
FTDFKLDGTG YGDYVKIYDG LEENPRKLLR VLTAFDSHAP LTVVSSSGQI
360 370 380 390 400
RVHFCADKVN AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH
410 420 430 440 450
CPNGRDEINC TMCQKEEFPC SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF
460 470 480 490 500
CQPGNFHCKN NRCVFESWVC DSQDDCGDGS DEENCPVIVP TRVITAAVIG
510 520 530 540 550
SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL LRREAPPSYG
560 570 580 590 600
QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS IRLPMTGRSS
610 620 630 640 650
NIWNRIFNFA RSRHSGSLAL VSGDGDEVVP SQSSSRETER SRPHRSLFSV
660 670 680 690 700
ESDDTDTENE RRDTAGASGG VAAPLPQKVP PTTAVEATVG SGGNSSAQST
710 720 730 740 750
RGGHADGREV SSVEAPSVSP ARHQLTSALS RMTQGLRWVR FTLGRSSSTT
760 770 780 790 800
QNRSPLRQLD TAVSGREDDD DVEMLIPVSD GASDIDANDC SRPLLDLASD
810 820 830 840 850
QVQGFRQPHS AGNPGVRTSN RDGPCERCGI VHTAQIPDTC LEATVKTETS

DDEALLLC
Length:858
Mass (Da):94,551
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6E4AC8C2B69798C
GO
Isoform 2 (identifier: Q8BUJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-45: Missing.

Show »
Length:839
Mass (Da):92,714
Checksum:iDF761D18D823AF0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQR2A0A2I3BQR2_MOUSE
Low-density lipoprotein receptor-re...
Lrp12
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC39247 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00982127 – 45Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK050512 mRNA Translation: BAC34299.1
AK084675 mRNA Translation: BAC39247.1 Sequence problems.
BC058345 mRNA Translation: AAH58345.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27446.1 [Q8BUJ9-1]
CCDS84168.1 [Q8BUJ9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001333965.1, NM_001347036.1 [Q8BUJ9-2]
NP_766402.1, NM_172814.3 [Q8BUJ9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022916; ENSMUSP00000022916; ENSMUSG00000022305 [Q8BUJ9-1]
ENSMUST00000110305; ENSMUSP00000105934; ENSMUSG00000022305 [Q8BUJ9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
239393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:239393

UCSC genome browser

More...
UCSCi
uc007vom.1, mouse [Q8BUJ9-1]
uc007von.1, mouse [Q8BUJ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050512 mRNA Translation: BAC34299.1
AK084675 mRNA Translation: BAC39247.1 Sequence problems.
BC058345 mRNA Translation: AAH58345.1
CCDSiCCDS27446.1 [Q8BUJ9-1]
CCDS84168.1 [Q8BUJ9-2]
RefSeqiNP_001333965.1, NM_001347036.1 [Q8BUJ9-2]
NP_766402.1, NM_172814.3 [Q8BUJ9-1]

3D structure databases

SMRiQ8BUJ9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232078, 1 interactor
STRINGi10090.ENSMUSP00000022916

PTM databases

GlyGeniQ8BUJ9, 5 sites
iPTMnetiQ8BUJ9
PhosphoSitePlusiQ8BUJ9
SwissPalmiQ8BUJ9

Proteomic databases

PaxDbiQ8BUJ9
PRIDEiQ8BUJ9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2508, 184 antibodies

Genome annotation databases

EnsembliENSMUST00000022916; ENSMUSP00000022916; ENSMUSG00000022305 [Q8BUJ9-1]
ENSMUST00000110305; ENSMUSP00000105934; ENSMUSG00000022305 [Q8BUJ9-2]
GeneIDi239393
KEGGimmu:239393
UCSCiuc007vom.1, mouse [Q8BUJ9-1]
uc007von.1, mouse [Q8BUJ9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29967
MGIiMGI:2443132, Lrp12

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
GeneTreeiENSGT00940000158307
HOGENOMiCLU_013747_0_0_1
InParanoidiQ8BUJ9
KOiK20050
OMAiPYSATHH
OrthoDBi135036at2759
PhylomeDBiQ8BUJ9
TreeFamiTF332149

Enzyme and pathway databases

ReactomeiR-MMU-975634, Retinoid metabolism and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
239393, 0 hits in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8BUJ9
RNActiQ8BUJ9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000022305, Expressed in pes and 253 other tissues
ExpressionAtlasiQ8BUJ9, baseline and differential
GenevisibleiQ8BUJ9, MM

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00112, LDLa, 5 hits
Gene3Di2.60.120.290, 2 hits
4.10.400.10, 5 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 4 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 5 hits
SUPFAMiSSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 5 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP12_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BUJ9
Secondary accession number(s): Q8BWM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: August 12, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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