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Protein

E3 ubiquitin-protein ligase RNF26

Gene

Rnf26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri371 – 413RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF26Curated (EC:2.3.2.27By similarity)
Alternative name(s):
RING finger protein 26Curated
Gene namesi
Name:Rnf26Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2388131 Rnf26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158161 – 424E3 ubiquitin-protein ligase RNF26Add BLAST424

Proteomic databases

PaxDbiQ8BUH7
PRIDEiQ8BUH7

PTM databases

iPTMnetiQ8BUH7
PhosphoSitePlusiQ8BUH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000053128 Expressed in 72 organ(s), highest expression level in colon
ExpressionAtlasiQ8BUH7 baseline and differential
GenevisibleiQ8BUH7 MM

Interactioni

Subunit structurei

Interacts with INCA1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BUH7
SMRiQ8BUH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri371 – 413RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ8 Eukaryota
ENOG410XVCP LUCA
GeneTreeiENSGT00390000016584
HOGENOMiHOG000136849
HOVERGENiHBG054207
InParanoidiQ8BUH7
KOiK15693
OMAiCRRGILQ
OrthoDBiEOG091G195F
PhylomeDBiQ8BUH7
TreeFamiTF331813

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BUH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVYLVVNG VGLVLDLLTL MLDLNFLLVS SLLATLAWLL AFIYNLPHTV
60 70 80 90 100
LTSLLHLGRG FLLSLLALVE AVVRFTFGGL QALGTLLYSC YSGLESLKLL
110 120 130 140 150
GHLASHGALR SREFLNRGIL NMVSNGHALL RQACDICAIA MSLVAYVINS
160 170 180 190 200
LVNICLISTQ NFFSLVLALW DAVTGPLWRM TDVVAAFLAH ISSSAVAMAI
210 220 230 240 250
LLWTPCQLAL ELLASAARLL ASCVVFHLTG LVLLACVLAV ILIVLHPEQT
260 270 280 290 300
LRLATQALSQ LHARPSYHRL WEDIVRLTRL PLGLEAWRRV WSRSLQLASW
310 320 330 340 350
PNRGGAPGAP QGGPRRVFSA RIQPQDTPPE AEEEVIRTAP ARGREQLNED
360 370 380 390 400
EPAAGQDPWK LLKEQEERKK CVICQDQSKT VLLLPCRHLC LCQACTEILM
410 420
RHPVYHRNCP LCRRSILQTL NVYL
Length:424
Mass (Da):46,914
Last modified:March 1, 2003 - v1
Checksum:i919A8F83E1B515B9
GO
Isoform 2 (identifier: Q8BUH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-181: VAYVINSLVN...AVTGPLWRMT → EPQPTTGQLA...SQDPATGHSS
     182-424: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):19,479
Checksum:iE6C25EB672C58E15
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQ68A0A1L1SQ68_MOUSE
E3 ubiquitin-protein ligase RNF26
Rnf26
303Annotation score:
A0A1L1SUH0A0A1L1SUH0_MOUSE
E3 ubiquitin-protein ligase RNF26
Rnf26
181Annotation score:
H9KV16H9KV16_MOUSE
E3 ubiquitin-protein ligase RNF26
Rnf26
64Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → V in AAH04739 (PubMed:15489334).Curated1
Sequence conflicti158S → G in AAH04739 (PubMed:15489334).Curated1
Sequence conflicti310P → H in BAC28179 (PubMed:16141072).Curated1
Sequence conflicti338T → A in AAH04739 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042390144 – 181VAYVI…LWRMT → EPQPTTGQLAKSGRSTRSPP RWPQEGVLSQDPATGHSS in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_042391182 – 424Missing in isoform 2. 1 PublicationAdd BLAST243

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033164 mRNA Translation: BAC28179.1
AK085078 mRNA Translation: BAC39357.1
AK157821 mRNA Translation: BAE34211.1
AK169538 mRNA Translation: BAE41218.1
AC148328 Genomic DNA No translation available.
BC004739 mRNA Translation: AAH04739.1
BC063251 mRNA Translation: AAH63251.1
BC086757 mRNA Translation: AAH86757.1
CCDSiCCDS23096.1 [Q8BUH7-1]
RefSeqiNP_717095.2, NM_153762.3 [Q8BUH7-1]
UniGeneiMm.392032

Genome annotation databases

EnsembliENSMUST00000056328; ENSMUSP00000110478; ENSMUSG00000053128 [Q8BUH7-1]
ENSMUST00000065379; ENSMUSP00000070060; ENSMUSG00000053128 [Q8BUH7-1]
ENSMUST00000162126; ENSMUSP00000123938; ENSMUSG00000111409 [Q8BUH7-1]
ENSMUST00000185479; ENSMUSP00000140405; ENSMUSG00000111409 [Q8BUH7-1]
GeneIDi213211
KEGGimmu:213211
UCSCiuc009pbu.2 mouse [Q8BUH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033164 mRNA Translation: BAC28179.1
AK085078 mRNA Translation: BAC39357.1
AK157821 mRNA Translation: BAE34211.1
AK169538 mRNA Translation: BAE41218.1
AC148328 Genomic DNA No translation available.
BC004739 mRNA Translation: AAH04739.1
BC063251 mRNA Translation: AAH63251.1
BC086757 mRNA Translation: AAH86757.1
CCDSiCCDS23096.1 [Q8BUH7-1]
RefSeqiNP_717095.2, NM_153762.3 [Q8BUH7-1]
UniGeneiMm.392032

3D structure databases

ProteinModelPortaliQ8BUH7
SMRiQ8BUH7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BUH7
PhosphoSitePlusiQ8BUH7

Proteomic databases

PaxDbiQ8BUH7
PRIDEiQ8BUH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056328; ENSMUSP00000110478; ENSMUSG00000053128 [Q8BUH7-1]
ENSMUST00000065379; ENSMUSP00000070060; ENSMUSG00000053128 [Q8BUH7-1]
ENSMUST00000162126; ENSMUSP00000123938; ENSMUSG00000111409 [Q8BUH7-1]
ENSMUST00000185479; ENSMUSP00000140405; ENSMUSG00000111409 [Q8BUH7-1]
GeneIDi213211
KEGGimmu:213211
UCSCiuc009pbu.2 mouse [Q8BUH7-1]

Organism-specific databases

CTDi79102
MGIiMGI:2388131 Rnf26

Phylogenomic databases

eggNOGiENOG410ITZ8 Eukaryota
ENOG410XVCP LUCA
GeneTreeiENSGT00390000016584
HOGENOMiHOG000136849
HOVERGENiHBG054207
InParanoidiQ8BUH7
KOiK15693
OMAiCRRGILQ
OrthoDBiEOG091G195F
PhylomeDBiQ8BUH7
TreeFamiTF331813

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiRnf26 mouse
PROiPR:Q8BUH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053128 Expressed in 72 organ(s), highest expression level in colon
ExpressionAtlasiQ8BUH7 baseline and differential
GenevisibleiQ8BUH7 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNF26_MOUSE
AccessioniPrimary (citable) accession number: Q8BUH7
Secondary accession number(s): F6SS41
, Q5PR90, Q8BZY8, Q99KC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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