UniProtKB - Q8BUH1 (TXN4B_MOUSE)
Protein
Thioredoxin-like protein 4B
Gene
Txnl4b
Organism
Mus musculus (Mouse)
Status
Functioni
Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition (By similarity).By similarity
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- mRNA splicing, via spliceosome Source: MGI
- positive regulation of cell population proliferation Source: MGI
Keywordsi
Biological process | Cell cycle, mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Recommended name: Thioredoxin-like protein 4B |
Gene namesi | Name:Txnl4b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443724, Txnl4b |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- U4/U6 x U5 tri-snRNP complex Source: GO_Central
- U5 snRNP Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218290 | 1 – 149 | Thioredoxin-like protein 4BAdd BLAST | 149 |
Proteomic databases
EPDi | Q8BUH1 |
MaxQBi | Q8BUH1 |
PaxDbi | Q8BUH1 |
PRIDEi | Q8BUH1 |
PTM databases
iPTMneti | Q8BUH1 |
PhosphoSitePlusi | Q8BUH1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031723, Expressed in granulocyte and 240 other tissues |
Genevisiblei | Q8BUH1, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with the U5-102 kDa protein subunit of the spliceosome (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034159 |
Miscellaneous databases
RNActi | Q8BUH1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DIM1 family.Curated
Phylogenomic databases
eggNOGi | KOG3414, Eukaryota |
GeneTreei | ENSGT00390000010779 |
HOGENOMi | CLU_117348_1_0_1 |
InParanoidi | Q8BUH1 |
OMAi | VPVYTQY |
OrthoDBi | 1320693at2759 |
TreeFami | TF332397 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR004123, Dim1 IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12052, PTHR12052, 1 hit |
Pfami | View protein in Pfam PF02966, DIM1, 1 hit |
PIRSFi | PIRSF017199, mRNA_splic_U5, 1 hit |
SMARTi | View protein in SMART SM01410, DIM1, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8BUH1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSA
60 70 80 90 100
DLSKMAAIYL VDVDHTPVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT
110 120 130 140
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNVP KYDLLYQDI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | V → G in BAC39394 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 61 | V → G in BAC39394 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 92 | V → G in BAC39394 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK085226 mRNA Translation: BAC39394.1 AC125162 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11422.1 BC094379 mRNA Translation: AAH94379.1 BC132373 mRNA Translation: AAI32374.1 BC138333 mRNA Translation: AAI38334.1 |
CCDSi | CCDS40469.1 |
RefSeqi | NP_783577.2, NM_175646.4 |
Genome annotation databases
Ensembli | ENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723 ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723 |
GeneIDi | 234723 |
KEGGi | mmu:234723 |
UCSCi | uc012gkh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK085226 mRNA Translation: BAC39394.1 AC125162 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11422.1 BC094379 mRNA Translation: AAH94379.1 BC132373 mRNA Translation: AAI32374.1 BC138333 mRNA Translation: AAI38334.1 |
CCDSi | CCDS40469.1 |
RefSeqi | NP_783577.2, NM_175646.4 |
3D structure databases
SMRi | Q8BUH1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034159 |
PTM databases
iPTMneti | Q8BUH1 |
PhosphoSitePlusi | Q8BUH1 |
Proteomic databases
EPDi | Q8BUH1 |
MaxQBi | Q8BUH1 |
PaxDbi | Q8BUH1 |
PRIDEi | Q8BUH1 |
Protocols and materials databases
Antibodypediai | 30184, 67 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723 ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723 |
GeneIDi | 234723 |
KEGGi | mmu:234723 |
UCSCi | uc012gkh.1, mouse |
Organism-specific databases
CTDi | 54957 |
MGIi | MGI:2443724, Txnl4b |
Phylogenomic databases
eggNOGi | KOG3414, Eukaryota |
GeneTreei | ENSGT00390000010779 |
HOGENOMi | CLU_117348_1_0_1 |
InParanoidi | Q8BUH1 |
OMAi | VPVYTQY |
OrthoDBi | 1320693at2759 |
TreeFami | TF332397 |
Miscellaneous databases
BioGRID-ORCSi | 234723, 6 hits in 17 CRISPR screens |
PROi | PR:Q8BUH1 |
RNActi | Q8BUH1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031723, Expressed in granulocyte and 240 other tissues |
Genevisiblei | Q8BUH1, MM |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR004123, Dim1 IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR12052, PTHR12052, 1 hit |
Pfami | View protein in Pfam PF02966, DIM1, 1 hit |
PIRSFi | PIRSF017199, mRNA_splic_U5, 1 hit |
SMARTi | View protein in SMART SM01410, DIM1, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TXN4B_MOUSE | |
Accessioni | Q8BUH1Primary (citable) accession number: Q8BUH1 Secondary accession number(s): Q52KF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | September 18, 2013 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families