Txnl4b

Functionⁱ

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G₂ transition (By similarity).By similarity

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
mRNA splicing, via spliceosome
Source: MGI
Inferred from sequence orthologyⁱ
- 15161931
positive regulation of cell proliferation
Source: MGI
Inferred from sequence orthologyⁱ
- 15161931

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, mRNA processing, mRNA splicing

Biological process

Cell cycle, mRNA processing, mRNA splicing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thioredoxin-like protein 4B
Gene namesⁱ	Name:Txnl4b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:2443724 Txnl4b

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218290	1 – 149	Thioredoxin-like protein 4BAdd BLAST		149

Proteomic databases

EPDⁱ	Q8BUH1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BUH1
PaxDbⁱ	Q8BUH1
PRIDEⁱ	Q8BUH1

PTM databases

iPTMnetⁱ	Q8BUH1
PhosphoSitePlusⁱ	Q8BUH1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031723 Expressed in 223 organ(s), highest expression level in oocyte
CleanExⁱ	MM_TXNL4B
Genevisibleⁱ	Q8BUH1 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000034159

STRINGⁱ

10090.ENSMUSP00000034159

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BUH1
SMRⁱ	Q8BUH1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3414 Eukaryota ENOG4111FE6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010779
HOGENOMⁱ	HOG000198385
HOVERGENⁱ	HBG053996
InParanoidⁱ	Q8BUH1
OMAⁱ	AMKGKMI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QHA
TreeFamⁱ	TF332397

Family and domain databases

InterProⁱ	View protein in InterPro IPR004123 Dim1 IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR12052 PTHR12052, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02966 DIM1, 1 hit
PIRSFⁱ	PIRSF017199 mRNA_splic_U5, 1 hit
SMARTⁱ	View protein in SMART SM01410 DIM1, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8BUH1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSA 
        60         70         80         90        100
DLSKMAAIYL VDVDHTPVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT 
       110        120        130        140 
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNVP KYDLLYQDI

Length:149

Mass (Da):17,020

Last modified:September 18, 2013 - v2

Checksum:ⁱA9DA3896F5F28758

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	V → G in BAC39394 (PubMed:16141072).Curated	1
Sequence conflictⁱ	61	V → G in BAC39394 (PubMed:16141072).Curated	1
Sequence conflictⁱ	92	V → G in BAC39394 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK085226 mRNA Translation: BAC39394.1 AC125162 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11422.1 BC094379 mRNA Translation: AAH94379.1 BC132373 mRNA Translation: AAI32374.1 BC138333 mRNA Translation: AAI38334.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40469.1
NCBI Reference Sequences More...RefSeqⁱ	NP_783577.2, NM_175646.4
UniGeneⁱ	Mm.37667

Genome annotation databases

Ensemblⁱ	ENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723 ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723
GeneIDⁱ	234723
KEGGⁱ	mmu:234723
UCSC genome browser More...UCSCⁱ	uc012gkh.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BUH1	Thioredoxin-like protein 4B	)	HUMAN		149	UniRef90_Q9NX01
TXNL4B isoform 1		PANTR		149
Uncharacterized protein		PANPA		149
Thioredoxin like 4B		GORGO		149
thioredoxin-like protein 4B isoform X2		Yangtze finless porpoise		176
+116

Protein	Similar proteins		Species	Score	Length	Source
Q8BUH1	Thioredoxin-like protein 4B	)	HUMAN		149	UniRef50_Q9NX01
TXNL4B isoform 1		PANTR		149
Uncharacterized protein		PANPA		149
Thioredoxin like 4B		GORGO		149
thioredoxin-like protein 4B isoform X2		Yangtze finless porpoise		176
+256

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK085226 mRNA Translation: BAC39394.1 AC125162 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL11422.1 BC094379 mRNA Translation: AAH94379.1 BC132373 mRNA Translation: AAI32374.1 BC138333 mRNA Translation: AAI38334.1
CCDSⁱ	CCDS40469.1
RefSeqⁱ	NP_783577.2, NM_175646.4
UniGeneⁱ	Mm.37667

3D structure databases

ProteinModelPortalⁱ	Q8BUH1
SMRⁱ	Q8BUH1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000034159

STRINGⁱ

10090.ENSMUSP00000034159

PTM databases

iPTMnetⁱ	Q8BUH1
PhosphoSitePlusⁱ	Q8BUH1

Proteomic databases

EPDⁱ	Q8BUH1
MaxQBⁱ	Q8BUH1
PaxDbⁱ	Q8BUH1
PRIDEⁱ	Q8BUH1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723 ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723
GeneIDⁱ	234723
KEGGⁱ	mmu:234723
UCSCⁱ	uc012gkh.1 mouse

Organism-specific databases

CTDⁱ	54957
MGIⁱ	MGI:2443724 Txnl4b

Phylogenomic databases

eggNOGⁱ	KOG3414 Eukaryota ENOG4111FE6 LUCA
GeneTreeⁱ	ENSGT00390000010779
HOGENOMⁱ	HOG000198385
HOVERGENⁱ	HBG053996
InParanoidⁱ	Q8BUH1
OMAⁱ	AMKGKMI
OrthoDBⁱ	EOG091G0QHA
TreeFamⁱ	TF332397

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BUH1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031723 Expressed in 223 organ(s), highest expression level in oocyte
CleanExⁱ	MM_TXNL4B
Genevisibleⁱ	Q8BUH1 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004123 Dim1 IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR12052 PTHR12052, 1 hit
Pfamⁱ	View protein in Pfam PF02966 DIM1, 1 hit
PIRSFⁱ	PIRSF017199 mRNA_splic_U5, 1 hit
SMARTⁱ	View protein in SMART SM01410 DIM1, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TXN4B_MOUSE
Accessionⁱ	Q8BUH1Primary (citable) accession number: Q8BUH1 Secondary accession number(s): Q52KF0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	September 18, 2013
	Last modified:	November 7, 2018
	This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BUH1 (TXN4B_MOUSE)

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Thioredoxin-like protein 4B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ