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Protein

Thioredoxin-like protein 4B

Gene

Txnl4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4B
Gene namesi
Name:Txnl4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443724 Txnl4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182901 – 149Thioredoxin-like protein 4BAdd BLAST149

Proteomic databases

EPDiQ8BUH1
MaxQBiQ8BUH1
PaxDbiQ8BUH1
PRIDEiQ8BUH1

PTM databases

iPTMnetiQ8BUH1
PhosphoSitePlusiQ8BUH1

Expressioni

Gene expression databases

BgeeiENSMUSG00000031723 Expressed in 223 organ(s), highest expression level in oocyte
CleanExiMM_TXNL4B
GenevisibleiQ8BUH1 MM

Interactioni

Subunit structurei

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034159

Structurei

3D structure databases

ProteinModelPortaliQ8BUH1
SMRiQ8BUH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOGENOMiHOG000198385
HOVERGENiHBG053996
InParanoidiQ8BUH1
OMAiAMKGKMI
OrthoDBiEOG091G0QHA
TreeFamiTF332397

Family and domain databases

InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BUH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSA
60 70 80 90 100
DLSKMAAIYL VDVDHTPVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT
110 120 130 140
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNVP KYDLLYQDI
Length:149
Mass (Da):17,020
Last modified:September 18, 2013 - v2
Checksum:iA9DA3896F5F28758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → G in BAC39394 (PubMed:16141072).Curated1
Sequence conflicti61V → G in BAC39394 (PubMed:16141072).Curated1
Sequence conflicti92V → G in BAC39394 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085226 mRNA Translation: BAC39394.1
AC125162 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11422.1
BC094379 mRNA Translation: AAH94379.1
BC132373 mRNA Translation: AAI32374.1
BC138333 mRNA Translation: AAI38334.1
CCDSiCCDS40469.1
RefSeqiNP_783577.2, NM_175646.4
UniGeneiMm.37667

Genome annotation databases

EnsembliENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723
ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723
GeneIDi234723
KEGGimmu:234723
UCSCiuc012gkh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085226 mRNA Translation: BAC39394.1
AC125162 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11422.1
BC094379 mRNA Translation: AAH94379.1
BC132373 mRNA Translation: AAI32374.1
BC138333 mRNA Translation: AAI38334.1
CCDSiCCDS40469.1
RefSeqiNP_783577.2, NM_175646.4
UniGeneiMm.37667

3D structure databases

ProteinModelPortaliQ8BUH1
SMRiQ8BUH1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034159

PTM databases

iPTMnetiQ8BUH1
PhosphoSitePlusiQ8BUH1

Proteomic databases

EPDiQ8BUH1
MaxQBiQ8BUH1
PaxDbiQ8BUH1
PRIDEiQ8BUH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723
ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723
GeneIDi234723
KEGGimmu:234723
UCSCiuc012gkh.1 mouse

Organism-specific databases

CTDi54957
MGIiMGI:2443724 Txnl4b

Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOGENOMiHOG000198385
HOVERGENiHBG053996
InParanoidiQ8BUH1
OMAiAMKGKMI
OrthoDBiEOG091G0QHA
TreeFamiTF332397

Miscellaneous databases

PROiPR:Q8BUH1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031723 Expressed in 223 organ(s), highest expression level in oocyte
CleanExiMM_TXNL4B
GenevisibleiQ8BUH1 MM

Family and domain databases

InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXN4B_MOUSE
AccessioniPrimary (citable) accession number: Q8BUH1
Secondary accession number(s): Q52KF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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