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Protein

39S ribosomal protein L22, mitochondrial

Gene

Mrpl22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L22, mitochondrial
Short name:
L22mt
Short name:
MRP-L22
Gene namesi
Name:Mrpl22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333794 Mrpl22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionBy similarityAdd BLAST40
ChainiPRO_000026164541 – 20639S ribosomal protein L22, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ8BU88
MaxQBiQ8BU88
PaxDbiQ8BU88
PeptideAtlasiQ8BU88
PRIDEiQ8BU88

PTM databases

iPTMnetiQ8BU88
PhosphoSitePlusiQ8BU88

Expressioni

Gene expression databases

BgeeiENSMUSG00000020514 Expressed in 268 organ(s), highest expression level in vestibular organ
CleanExiMM_MRPL22
GenevisibleiQ8BU88 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

IntActiQ8BU88, 1 interactor
STRINGi10090.ENSMUSP00000020820

Structurei

3D structure databases

ProteinModelPortaliQ8BU88
SMRiQ8BU88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1711 Eukaryota
COG0091 LUCA
GeneTreeiENSGT00390000002110
HOGENOMiHOG000048027
HOVERGENiHBG093486
InParanoidiQ8BU88
KOiK02890
OMAiHKVIRQM
OrthoDBiEOG091G0FH3
PhylomeDBiQ8BU88
TreeFamiTF315111

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR036394 Ribosomal_L22/L17_sf
IPR005727 Ribosomal_L22_bac/chlpt-type
PANTHERiPTHR13501 PTHR13501, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BU88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAALLRELG ALRVPNLRIW ATQTLRVLPP SCIHTSASLD ISRKWEKKNK
60 70 80 90 100
IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKMIRG MSIDQALAQL
110 120 130 140 150
EFNDKKGAQI IKEVLLEAQD MAVRDHNVEF RSNLHIAEST SGRGQCLKRI
160 170 180 190 200
RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EVPKTAVDHA KDYIQQLRSR

TIIHTL
Length:206
Mass (Da):23,805
Last modified:March 1, 2003 - v1
Checksum:iB7326DC02BED3390
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198R → P in BAC36901 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077615 mRNA Translation: BAC36901.1
AK086913 mRNA Translation: BAC39761.1
AK164417 mRNA Translation: BAE37779.1
AL928857 Genomic DNA No translation available.
BC061191 mRNA Translation: AAH61191.1
CCDSiCCDS24724.1
RefSeqiNP_778166.2, NM_175001.3
UniGeneiMm.259907

Genome annotation databases

EnsembliENSMUST00000020820; ENSMUSP00000020820; ENSMUSG00000020514
GeneIDi216767
KEGGimmu:216767
UCSCiuc007jap.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077615 mRNA Translation: BAC36901.1
AK086913 mRNA Translation: BAC39761.1
AK164417 mRNA Translation: BAE37779.1
AL928857 Genomic DNA No translation available.
BC061191 mRNA Translation: AAH61191.1
CCDSiCCDS24724.1
RefSeqiNP_778166.2, NM_175001.3
UniGeneiMm.259907

3D structure databases

ProteinModelPortaliQ8BU88
SMRiQ8BU88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BU88, 1 interactor
STRINGi10090.ENSMUSP00000020820

PTM databases

iPTMnetiQ8BU88
PhosphoSitePlusiQ8BU88

Proteomic databases

EPDiQ8BU88
MaxQBiQ8BU88
PaxDbiQ8BU88
PeptideAtlasiQ8BU88
PRIDEiQ8BU88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020820; ENSMUSP00000020820; ENSMUSG00000020514
GeneIDi216767
KEGGimmu:216767
UCSCiuc007jap.3 mouse

Organism-specific databases

CTDi29093
MGIiMGI:1333794 Mrpl22

Phylogenomic databases

eggNOGiKOG1711 Eukaryota
COG0091 LUCA
GeneTreeiENSGT00390000002110
HOGENOMiHOG000048027
HOVERGENiHBG093486
InParanoidiQ8BU88
KOiK02890
OMAiHKVIRQM
OrthoDBiEOG091G0FH3
PhylomeDBiQ8BU88
TreeFamiTF315111

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q8BU88
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020514 Expressed in 268 organ(s), highest expression level in vestibular organ
CleanExiMM_MRPL22
GenevisibleiQ8BU88 MM

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR036394 Ribosomal_L22/L17_sf
IPR005727 Ribosomal_L22_bac/chlpt-type
PANTHERiPTHR13501 PTHR13501, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM22_MOUSE
AccessioniPrimary (citable) accession number: Q8BU88
Secondary accession number(s): Q8BK04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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