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Entry version 141 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

2-hydroxyacyl-CoA lyase 2

Gene

Ilvbl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei98Thiamine pyrophosphateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi521MagnesiumBy similarity1
Metal bindingi547MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processFatty acid metabolism, Lipid metabolism
LigandMagnesium, Metal-binding, Thiamine pyrophosphate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-hydroxyacyl-CoA lyase 2 (EC:4.1.2.-By similarity)
Alternative name(s):
Acetolactate synthase-like protein
IlvB-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ilvbl
Synonyms:Hacl2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351911, Ilvbl

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000032763

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148261 – 6322-hydroxyacyl-CoA lyase 2Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei369PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BU33

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BU33

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BU33

PeptideAtlas

More...
PeptideAtlasi
Q8BU33

PRoteomics IDEntifications database

More...
PRIDEi
Q8BU33

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
267127 [Q8BU33-1]
267128 [Q8BU33-2]
267129 [Q8BU33-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BU33

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BU33

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BU33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032763, Expressed in intestine and 268 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BU33, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229702, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8BU33

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101023

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BU33, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BU33

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni470 – 550Thiamine pyrophosphate bindingBy similarityAdd BLAST81

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPP enzyme family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1185, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013748_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BU33

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCVDELM

Database of Orthologous Groups

More...
OrthoDBi
1132247at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BU33

TreeFam database of animal gene trees

More...
TreeFami
TF354221

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR029061, THDP-binding
IPR012000, Thiamin_PyroP_enz_cen_dom
IPR012001, Thiamin_PyroP_enz_TPP-bd_dom
IPR000399, TPP-bd_CS
IPR011766, TPP_enzyme-bd_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02775, TPP_enzyme_C, 1 hit
PF00205, TPP_enzyme_M, 1 hit
PF02776, TPP_enzyme_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52467, SSF52467, 1 hit
SSF52518, SSF52518, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00187, TPP_ENZYMES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BU33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METSAAAASA GGFFPSFLLL AFGTLVAAVL GVAHRLGLFY QLMHKVDKTS
60 70 80 90 100
IRHGGESVAA VLRAHGVRFV FTLVGGHISP LLVACEKLGI RVVDTRHEVT
110 120 130 140 150
AVFAADAVAR LTGTVGVAAV TAGPGLTNTV TAVKNAQVAQ SPVLLLGGAA
160 170 180 190 200
STLLQKRGAL QAIDQMSLFR PLCKFCASVR RVRDIVPTLR TAIAAAQSGT
210 220 230 240 250
PGPVFVELPL DVLYPYFMVE KEMIPTKLPN SLMGRVVVWY LQNCLANLFV
260 270 280 290 300
GAWEPRPEGP LPLDIPQASP QQVQRCVEIL SRAKRPLLVL GSQALLPPTP
310 320 330 340 350
ANKLRAAVET LGVPCFLGGM SRGLLGRNHP LHIRQNRSAA LKKADVVVLA
360 370 380 390 400
GAVCDFRLSY GRVLNRKSSI IIVNRNRDDL LLNSDIFWKP QEAVQGDVGS
410 420 430 440 450
FMIKLVEGLQ GQMWSSDWAE ELRKADQQKE QTYRDKALMP VLQHLNPVWV
460 470 480 490 500
LQQVEETLPD NALLVVDGGD FVATAAYLVQ PRGPLRWLDP GAFGTLGVGA
510 520 530 540 550
GFALGAKLCQ PEAEVWCLFG DGAFGYSLIE FDTFVRHKVP VIALVGNDAG
560 570 580 590 600
WTQISREQVP RLGSDVACSL AYTDYHKAAM GLGAQGLILS RDNKDQVVKV
610 620 630
LREGQQLCQD GHAVVVNILI GRTDFRDGSI SV
Length:632
Mass (Da):68,156
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02B5C5ED36ECDE89
GO
Isoform 2 (identifier: Q8BU33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-416: DVGSFMIKLVEGLQGQMWSS → ECTPRDPTMCMVSSSCLCCI
     417-632: Missing.

Show »
Length:416
Mass (Da):44,550
Checksum:i2F6AF90E9154B5DC
GO
Isoform 3 (identifier: Q8BU33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-401: GDVGSF → AGPASP
     402-632: Missing.

Show »
Length:401
Mass (Da):42,812
Checksum:i66B7E30E903AE2B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P8E1A0A1W2P8E1_MOUSE
2-hydroxyacyl-CoA lyase 2
Ilvbl
596Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P727A0A1W2P727_MOUSE
2-hydroxyacyl-CoA lyase 2
Ilvbl
531Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6L8A0A1W2P6L8_MOUSE
2-hydroxyacyl-CoA lyase 2
Ilvbl
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6Y9A0A1W2P6Y9_MOUSE
2-hydroxyacyl-CoA lyase 2
Ilvbl
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6P8A0A1W2P6P8_MOUSE
2-hydroxyacyl-CoA lyase 2
Ilvbl
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P8D6A0A1W2P8D6_MOUSE
2-hydroxyacyl-CoA lyase 2
Ilvbl
328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030392396 – 401GDVGSF → AGPASP in isoform 3. 1 Publication6
Alternative sequenceiVSP_030393397 – 416DVGSF…QMWSS → ECTPRDPTMCMVSSSCLCCI in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_030394402 – 632Missing in isoform 3. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_030395417 – 632Missing in isoform 2. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK087956 mRNA Translation: BAC40057.1
AK133553 mRNA Translation: BAE21720.1
AK143918 mRNA Translation: BAE25603.1
AK146075 mRNA Translation: BAE26879.1
BC056459 mRNA Translation: AAH56459.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23966.1 [Q8BU33-1]
CCDS88046.1 [Q8BU33-3]

NCBI Reference Sequences

More...
RefSeqi
NP_776112.1, NM_173751.4 [Q8BU33-1]
XP_011241702.1, XM_011243400.2 [Q8BU33-1]
XP_011241703.1, XM_011243401.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105384; ENSMUSP00000101023; ENSMUSG00000032763 [Q8BU33-1]
ENSMUST00000218271; ENSMUSP00000151480; ENSMUSG00000032763 [Q8BU33-3]
ENSMUST00000218885; ENSMUSP00000151263; ENSMUSG00000032763 [Q8BU33-1]
ENSMUST00000220430; ENSMUSP00000151674; ENSMUSG00000032763 [Q8BU33-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
216136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:216136

UCSC genome browser

More...
UCSCi
uc007fxv.2, mouse [Q8BU33-1]
uc007fxw.1, mouse [Q8BU33-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087956 mRNA Translation: BAC40057.1
AK133553 mRNA Translation: BAE21720.1
AK143918 mRNA Translation: BAE25603.1
AK146075 mRNA Translation: BAE26879.1
BC056459 mRNA Translation: AAH56459.1
CCDSiCCDS23966.1 [Q8BU33-1]
CCDS88046.1 [Q8BU33-3]
RefSeqiNP_776112.1, NM_173751.4 [Q8BU33-1]
XP_011241702.1, XM_011243400.2 [Q8BU33-1]
XP_011241703.1, XM_011243401.1

3D structure databases

SMRiQ8BU33
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229702, 4 interactors
MINTiQ8BU33
STRINGi10090.ENSMUSP00000101023

PTM databases

iPTMnetiQ8BU33
PhosphoSitePlusiQ8BU33
SwissPalmiQ8BU33

Proteomic databases

EPDiQ8BU33
jPOSTiQ8BU33
PaxDbiQ8BU33
PeptideAtlasiQ8BU33
PRIDEiQ8BU33
ProteomicsDBi267127 [Q8BU33-1]
267128 [Q8BU33-2]
267129 [Q8BU33-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26957, 317 antibodies

The DNASU plasmid repository

More...
DNASUi
216136

Genome annotation databases

EnsembliENSMUST00000105384; ENSMUSP00000101023; ENSMUSG00000032763 [Q8BU33-1]
ENSMUST00000218271; ENSMUSP00000151480; ENSMUSG00000032763 [Q8BU33-3]
ENSMUST00000218885; ENSMUSP00000151263; ENSMUSG00000032763 [Q8BU33-1]
ENSMUST00000220430; ENSMUSP00000151674; ENSMUSG00000032763 [Q8BU33-2]
GeneIDi216136
KEGGimmu:216136
UCSCiuc007fxv.2, mouse [Q8BU33-1]
uc007fxw.1, mouse [Q8BU33-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10994
MGIiMGI:1351911, Ilvbl
VEuPathDBiHostDB:ENSMUSG00000032763

Phylogenomic databases

eggNOGiKOG1185, Eukaryota
GeneTreeiENSGT00940000158035
HOGENOMiCLU_013748_3_3_1
InParanoidiQ8BU33
OMAiHCVDELM
OrthoDBi1132247at2759
PhylomeDBiQ8BU33
TreeFamiTF354221

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
216136, 1 hit in 63 CRISPR screens

Protein Ontology

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PROi
PR:Q8BU33
RNActiQ8BU33, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032763, Expressed in intestine and 268 other tissues
GenevisibleiQ8BU33, MM

Family and domain databases

InterProiView protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR029061, THDP-binding
IPR012000, Thiamin_PyroP_enz_cen_dom
IPR012001, Thiamin_PyroP_enz_TPP-bd_dom
IPR000399, TPP-bd_CS
IPR011766, TPP_enzyme-bd_C
PfamiView protein in Pfam
PF02775, TPP_enzyme_C, 1 hit
PF00205, TPP_enzyme_M, 1 hit
PF02776, TPP_enzyme_N, 1 hit
SUPFAMiSSF52467, SSF52467, 1 hit
SSF52518, SSF52518, 2 hits
PROSITEiView protein in PROSITE
PS00187, TPP_ENZYMES, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHACL2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BU33
Secondary accession number(s): Q3UNZ4, Q3UZY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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