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Protein

Translocation protein SEC62

Gene

Sec62

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein SEC62
Alternative name(s):
Translocation protein 1
Short name:
TP-1
Gene namesi
Name:Sec62
Synonyms:Tloc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916526 Sec62

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 196CytoplasmicSequence analysisAdd BLAST196
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 234LumenalSequence analysisAdd BLAST17
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 398CytoplasmicSequence analysisAdd BLAST143

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066171 – 398Translocation protein SEC62Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei356PhosphoserineCombined sources1
Modified residuei375PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BU14
MaxQBiQ8BU14
PaxDbiQ8BU14
PeptideAtlasiQ8BU14
PRIDEiQ8BU14

PTM databases

iPTMnetiQ8BU14
PhosphoSitePlusiQ8BU14
SwissPalmiQ8BU14

Expressioni

Gene expression databases

BgeeiENSMUSG00000027706 Expressed in 297 organ(s), highest expression level in cochlea
GenevisibleiQ8BU14 MM

Interactioni

Subunit structurei

The ER translocon complex that consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. Interacts with SEC61B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029256

Structurei

3D structure databases

ProteinModelPortaliQ8BU14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC62 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2927 Eukaryota
COG5232 LUCA
GeneTreeiENSGT00390000002757
HOGENOMiHOG000016701
HOVERGENiHBG055550
InParanoidiQ8BU14
KOiK12275
OMAiFEMITRE
OrthoDBiEOG091G0KPB
PhylomeDBiQ8BU14
TreeFamiTF314944

Family and domain databases

InterProiView protein in InterPro
IPR004728 Sec62
PANTHERiPTHR12443 PTHR12443, 1 hit
PfamiView protein in Pfam
PF03839 Sec62, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BU14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS
60 70 80 90 100
KAVECLLDSK WAKAKKGEDA LFTTRESVVD YCNRLLKKQF FHRALKVMKM
110 120 130 140 150
KYDKDVKKEK DKGKSESGKE DDKKSKKESV KEEKTKKEKE KKKDGEKEDS
160 170 180 190 200
KKEETPGTPK KKETKKKFKL EPHDDQVFLD GNEVFVWIYD PVHIKTFVMG
210 220 230 240 250
LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL LAIARCILFL
260 270 280 290 300
IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE
310 320 330 340 350
TKKQQKSDSE EKSDSEKKED EEGKGAPADH GPEGSGGERH SDTDSDRRED
360 370 380 390
DRSQHSSGNG NDFEMITKEE LEQQTDGDCD EEDDDKDGEV PKSAHEKS
Length:398
Mass (Da):45,581
Last modified:March 1, 2003 - v1
Checksum:iF91B3E90336FFC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85L → F in AAH67202 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088093 mRNA Translation: BAC40140.1
BC067202 mRNA Translation: AAH67202.1
CCDSiCCDS17286.1
RefSeqiNP_081292.1, NM_027016.2
UniGeneiMm.26017

Genome annotation databases

EnsembliENSMUST00000029256; ENSMUSP00000029256; ENSMUSG00000027706
GeneIDi69276
KEGGimmu:69276
UCSCiuc008ovh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088093 mRNA Translation: BAC40140.1
BC067202 mRNA Translation: AAH67202.1
CCDSiCCDS17286.1
RefSeqiNP_081292.1, NM_027016.2
UniGeneiMm.26017

3D structure databases

ProteinModelPortaliQ8BU14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029256

PTM databases

iPTMnetiQ8BU14
PhosphoSitePlusiQ8BU14
SwissPalmiQ8BU14

Proteomic databases

EPDiQ8BU14
MaxQBiQ8BU14
PaxDbiQ8BU14
PeptideAtlasiQ8BU14
PRIDEiQ8BU14

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029256; ENSMUSP00000029256; ENSMUSG00000027706
GeneIDi69276
KEGGimmu:69276
UCSCiuc008ovh.1 mouse

Organism-specific databases

CTDi7095
MGIiMGI:1916526 Sec62

Phylogenomic databases

eggNOGiKOG2927 Eukaryota
COG5232 LUCA
GeneTreeiENSGT00390000002757
HOGENOMiHOG000016701
HOVERGENiHBG055550
InParanoidiQ8BU14
KOiK12275
OMAiFEMITRE
OrthoDBiEOG091G0KPB
PhylomeDBiQ8BU14
TreeFamiTF314944

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSec62 mouse
PROiPR:Q8BU14
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027706 Expressed in 297 organ(s), highest expression level in cochlea
GenevisibleiQ8BU14 MM

Family and domain databases

InterProiView protein in InterPro
IPR004728 Sec62
PANTHERiPTHR12443 PTHR12443, 1 hit
PfamiView protein in Pfam
PF03839 Sec62, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC62_MOUSE
AccessioniPrimary (citable) accession number: Q8BU14
Secondary accession number(s): Q6NX81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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