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Protein

CDK5 regulatory subunit-associated protein 1

Gene

Cdk5rap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi144Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi182Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi257Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi261Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi264Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 1
Alternative name(s):
CDK5 activator-binding protein C42
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914221 Cdk5rap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001417651 – 588CDK5 regulatory subunit-associated protein 1Add BLAST588

Proteomic databases

EPDiQ8BTW8
MaxQBiQ8BTW8
PaxDbiQ8BTW8
PeptideAtlasiQ8BTW8
PRIDEiQ8BTW8

PTM databases

PhosphoSitePlusiQ8BTW8

Expressioni

Gene expression databases

BgeeiENSMUSG00000027487 Expressed in 258 organ(s), highest expression level in heart
CleanExiMM_CDK5RAP1
ExpressionAtlasiQ8BTW8 baseline and differential
GenevisibleiQ8BTW8 MM

Interactioni

Subunit structurei

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028990

Structurei

3D structure databases

ProteinModelPortaliQ8BTW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 219MTTase N-terminalAdd BLAST121
Domaini500 – 575TRAMAdd BLAST76

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2492 Eukaryota
COG0621 LUCA
GeneTreeiENSGT00530000063447
HOGENOMiHOG000224767
HOVERGENiHBG050975
InParanoidiQ8BTW8
OMAiKVCEHFH
OrthoDBiEOG091G07M5
PhylomeDBiQ8BTW8
TreeFamiTF101033

Family and domain databases

Gene3Di3.40.50.12160, 1 hit
3.80.30.20, 1 hit
HAMAPiMF_01864 tRNA_metthiotr_MiaB, 1 hit
InterProiView protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006463 MiaB_methiolase
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF01938 TRAM, 1 hit
PF00919 UPF0004, 1 hit
SFLDiSFLDF00273 (dimethylallyl)adenosine_tRNA_, 1 hit
SFLDG01061 methylthiotransferase, 2 hits
SFLDS00029 Radical_SAM, 3 hits
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR00089 TIGR00089, 1 hit
PROSITEiView protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BTW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPLRCVLQV QRLSAPFTSM CWVLLRTCRA QSSVSSTPCP SPEAKSSEAQ
60 70 80 90 100
KDFSSRLATG PTFQHFLRSA SVPQEKPSSP EVEDPPPYLS GDELLGRQRK
110 120 130 140 150
VYLETYGCQM NVNDTEIAWS ILQKSGYLRT SNLQEADVIL LVTCSIREKA
160 170 180 190 200
EQTIWNRLHQ LKVLKTKRPR SRVPLRIGIL GCMAERLKGE ILNREKMVDL
210 220 230 240 250
LAGPDAYRDL PRLLAVVESG QQAANVLLSL DETYADIMPV QTSPSATSAF
260 270 280 290 300
VSIMRGCDNM CSYCIVPFTR GRERSRPVAS ILDEVRKLSE QGLKEVTLLG
310 320 330 340 350
QNVNSFRDNS EVQFNNAGSA NLSRGFTTNY KPKQGGLRFS HLLDQVSRID
360 370 380 390 400
PEMRIRFTSP HPKDFPDEVL QLIRERHNIC KQIHLPAQSG SSRVLDAMRR
410 420 430 440 450
GYSREAYVAL VHHVRETIPG VSLSSDFITG FCGETEDDHR QTVSLLREVQ
460 470 480 490 500
YNTGFLFAYS MRQKTRAYHR LKDDVPEEVK LRRLEELITV FREEASKANK
510 520 530 540 550
TSVGCSQLVL VEGFSKRSTT DLCGRNDANL KVIFPDAEVE DITNPGLKVR
560 570 580
AQPGDYVLVK ITSASSQTLK GHILCRTTMK DSLTYCTT
Length:588
Mass (Da):66,110
Last modified:June 16, 2003 - v2
Checksum:i4430C4F1A067093C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UW67Q3UW67_MOUSE
CDK5 regulatory subunit-associated ...
Cdk5rap1
190Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti505C → Y in BAC40398 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010097 mRNA Translation: BAB26700.1
AK088517 mRNA Translation: BAC40398.1
BC025132 mRNA Translation: AAH25132.1
CCDSiCCDS16931.1
RefSeqiNP_080152.1, NM_025876.2
UniGeneiMm.289427

Genome annotation databases

EnsembliENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487
ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487
GeneIDi66971
KEGGimmu:66971
UCSCiuc008njb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010097 mRNA Translation: BAB26700.1
AK088517 mRNA Translation: BAC40398.1
BC025132 mRNA Translation: AAH25132.1
CCDSiCCDS16931.1
RefSeqiNP_080152.1, NM_025876.2
UniGeneiMm.289427

3D structure databases

ProteinModelPortaliQ8BTW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028990

PTM databases

PhosphoSitePlusiQ8BTW8

Proteomic databases

EPDiQ8BTW8
MaxQBiQ8BTW8
PaxDbiQ8BTW8
PeptideAtlasiQ8BTW8
PRIDEiQ8BTW8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487
ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487
GeneIDi66971
KEGGimmu:66971
UCSCiuc008njb.1 mouse

Organism-specific databases

CTDi51654
MGIiMGI:1914221 Cdk5rap1

Phylogenomic databases

eggNOGiKOG2492 Eukaryota
COG0621 LUCA
GeneTreeiENSGT00530000063447
HOGENOMiHOG000224767
HOVERGENiHBG050975
InParanoidiQ8BTW8
OMAiKVCEHFH
OrthoDBiEOG091G07M5
PhylomeDBiQ8BTW8
TreeFamiTF101033

Miscellaneous databases

PROiPR:Q8BTW8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027487 Expressed in 258 organ(s), highest expression level in heart
CleanExiMM_CDK5RAP1
ExpressionAtlasiQ8BTW8 baseline and differential
GenevisibleiQ8BTW8 MM

Family and domain databases

Gene3Di3.40.50.12160, 1 hit
3.80.30.20, 1 hit
HAMAPiMF_01864 tRNA_metthiotr_MiaB, 1 hit
InterProiView protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006463 MiaB_methiolase
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF01938 TRAM, 1 hit
PF00919 UPF0004, 1 hit
SFLDiSFLDF00273 (dimethylallyl)adenosine_tRNA_, 1 hit
SFLDG01061 methylthiotransferase, 2 hits
SFLDS00029 Radical_SAM, 3 hits
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR00089 TIGR00089, 1 hit
PROSITEiView protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCK5P1_MOUSE
AccessioniPrimary (citable) accession number: Q8BTW8
Secondary accession number(s): Q9D6Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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