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Protein

RAS guanyl-releasing protein 4

Gene

Rasgrp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5673001 RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAS guanyl-releasing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rasgrp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2386851 Rasgrp4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003152141 – 673RAS guanyl-releasing protein 4Add BLAST673

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BTM9

PRoteomics IDEntifications database

More...
PRIDEi
Q8BTM9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BTM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8BTM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by mast cells and their progenitors (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at all stages in the development of mast cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030589 Expressed in 23 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
MM_RASGRP4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BTM9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BTM9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231357, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8BTM9, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000092200

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8BTM9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8BTM9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 175N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST127
Domaini201 – 432Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini466 – 501EF-handAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RASGRP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD3C Eukaryota
ENOG410XQ12 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159883

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007513

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8BTM9

KEGG Orthology (KO)

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KOi
K12363

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8BTM9

Family and domain databases

Conserved Domains Database

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CDDi
cd00029 C1, 1 hit
cd00155 RasGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020454 DAG/PE-bd
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23113 PTHR23113, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00008 DAGPEDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48366 SSF48366, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BTM9-1) [UniParc]FASTAAdd to basket
Also known as: RASGRP4alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRKDIKRKS HQECSGKAGG RGRSRQARRH KTCPTPREIS KVMASMNLGV
60 70 80 90 100
LSESSCSEDE LLEECIRCFD SAGSLRRGDH ILKMVLTMHS WVLPSSELAA
110 120 130 140 150
RLLTSYQKAA KDAQELRQLQ ICYLVRYWLT HHHEAVHQEP QLEAVISRFW
160 170 180 190 200
TTVAQEGNMA QRSLGDASSL LSPGGPGPPP PMSSPGLGKK RKVSLLFDHL
210 220 230 240 250
ETEELAQHLT YLEFRSFQAI TPQDLRGYVL QGSVRGCPAL EGSVGLSNSV
260 270 280 290 300
SRWVQVMVLS RPGPAQRAQV LDKFIRVAQR LHQLQNFNTL MAVTGGLCHS
310 320 330 340 350
AISRLKDSHV HLSPDSTKAL LELTELLSSH NNYAHYRRTW AGCTGFRLPV
360 370 380 390 400
LGVHLKDLVS LYEAHPDRLP DGRLHLPKLN SLYLRLQELM ALQGQHPPCS
410 420 430 440 450
ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPPS PFKAPVVVEW
460 470 480 490 500
AQGVTPKPDS VTLGQHVEQL VESVFKNYDP EGRGSISLED FERLSGNFPF
510 520 530 540 550
ACHGLHPPPR HGSGSFSREE LTKYLLHASA ICSKLGLAFL HAFQEVTFRK
560 570 580 590 600
PTFCHSCSGF LWGVTKQGYR CRDCGLCCHR HCRDQVRVEC KKRPETKGDP
610 620 630 640 650
GPPGAPVPAT SLPPANCGSE ESLSYTLSPD PESGCHLRHA WTQTESSHSS
660 670
WEPEVVPCPA RVLPSRASSK PSV
Length:673
Mass (Da):74,907
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i418DACEF8064AD18
GO
Isoform 2 (identifier: Q8BTM9-2) [UniParc]FASTAAdd to basket
Also known as: RASGRP4beta

The sequence of this isoform differs from the canonical sequence as follows:
     560-560: F → FVSTGP

Show »
Length:678
Mass (Da):75,349
Checksum:i3D24B36EB8FE2454
GO
Isoform 3 (identifier: Q8BTM9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-611: LWGVTKQGYR...PPGAPVPATS → VSTGPVSTLG...PHLRYSTEFI
     612-673: Missing.

Note: Due to an intron retention. No experimental confirmation available.
Show »
Length:611
Mass (Da):68,428
Checksum:i3693356ABF9B65E6
GO
Isoform 4 (identifier: Q8BTM9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-578: CGLCC → TAGIK
     579-673: Missing.

Note: Minor isoform which is not activated by DAG and probably not functional. Preferentially expressed in the C3H/HeJ strain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:578
Mass (Da):64,654
Checksum:iEF858A9B62D5411F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QKB7E9QKB7_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
679Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZ06E0CZ06_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
659Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SW33A0A0N4SW33_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUN7A0A0N4SUN7_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVV6A0A0N4SVV6_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUQ3A0A0N4SUQ3_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
639Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVP1A0A0N4SVP1_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
484Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CX54E0CX54_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BK25F7BK25_MOUSE
RAS guanyl-releasing protein 4
Rasgrp4
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE32802 differs from that shown. Reason: Frameshift at position 672.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182M → I in AAK81694 (PubMed:11956218).Curated1
Sequence conflicti182M → I in AAK84299 (PubMed:11956218).Curated1
Sequence conflicti443K → R in AAK81694 (PubMed:11956218).Curated1
Sequence conflicti443K → R in AAK84299 (PubMed:11956218).Curated1
Sequence conflicti468E → G in AAK81694 (PubMed:11956218).Curated1
Sequence conflicti468E → G in AAK84299 (PubMed:11956218).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030483560F → FVSTGP in isoform 2. 1 Publication1
Alternative sequenceiVSP_030484561 – 611LWGVT…VPATS → VSTGPVSTLGSHLPWIVSAP HTLTWDSVGTGFWWWWGLQK CPHLRYSTEFI in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_030485574 – 578CGLCC → TAGIK in isoform 4. 1 Publication5
Alternative sequenceiVSP_030486579 – 673Missing in isoform 4. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_030487612 – 673Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF331457 mRNA Translation: AAK84299.1
AY040628 mRNA Translation: AAK81694.1
AY196476 mRNA Translation: AAO20841.1
AK049562 mRNA Translation: BAC33811.1
AK089282 mRNA Translation: BAC40827.1
AK154746 mRNA Translation: BAE32802.1 Frameshift.
AK162667 mRNA Translation: BAE37013.1
AK165106 mRNA Translation: BAE38037.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS85257.1 [Q8BTM9-1]
CCDS85258.1 [Q8BTM9-2]

NCBI Reference Sequences

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RefSeqi
NP_001167626.1, NM_001174155.1 [Q8BTM9-2]
NP_660131.2, NM_145149.4 [Q8BTM9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.465324

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000032811; ENSMUSP00000032811; ENSMUSG00000030589 [Q8BTM9-1]
ENSMUST00000159351; ENSMUSP00000124183; ENSMUSG00000030589 [Q8BTM9-4]
ENSMUST00000159975; ENSMUSP00000125137; ENSMUSG00000030589 [Q8BTM9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
233046

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:233046

UCSC genome browser

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UCSCi
uc009gas.2 mouse [Q8BTM9-1]
uc009gat.1 mouse [Q8BTM9-3]
uc012fha.1 mouse [Q8BTM9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331457 mRNA Translation: AAK84299.1
AY040628 mRNA Translation: AAK81694.1
AY196476 mRNA Translation: AAO20841.1
AK049562 mRNA Translation: BAC33811.1
AK089282 mRNA Translation: BAC40827.1
AK154746 mRNA Translation: BAE32802.1 Frameshift.
AK162667 mRNA Translation: BAE37013.1
AK165106 mRNA Translation: BAE38037.1
CCDSiCCDS85257.1 [Q8BTM9-1]
CCDS85258.1 [Q8BTM9-2]
RefSeqiNP_001167626.1, NM_001174155.1 [Q8BTM9-2]
NP_660131.2, NM_145149.4 [Q8BTM9-1]
UniGeneiMm.465324

3D structure databases

ProteinModelPortaliQ8BTM9
SMRiQ8BTM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231357, 1 interactor
IntActiQ8BTM9, 2 interactors
STRINGi10090.ENSMUSP00000092200

PTM databases

iPTMnetiQ8BTM9
PhosphoSitePlusiQ8BTM9

Proteomic databases

PaxDbiQ8BTM9
PRIDEiQ8BTM9

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
233046
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032811; ENSMUSP00000032811; ENSMUSG00000030589 [Q8BTM9-1]
ENSMUST00000159351; ENSMUSP00000124183; ENSMUSG00000030589 [Q8BTM9-4]
ENSMUST00000159975; ENSMUSP00000125137; ENSMUSG00000030589 [Q8BTM9-2]
GeneIDi233046
KEGGimmu:233046
UCSCiuc009gas.2 mouse [Q8BTM9-1]
uc009gat.1 mouse [Q8BTM9-3]
uc012fha.1 mouse [Q8BTM9-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115727
MGIiMGI:2386851 Rasgrp4

Phylogenomic databases

eggNOGiENOG410KD3C Eukaryota
ENOG410XQ12 LUCA
GeneTreeiENSGT00940000159883
HOVERGENiHBG007513
InParanoidiQ8BTM9
KOiK12363
PhylomeDBiQ8BTM9

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8BTM9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030589 Expressed in 23 organ(s), highest expression level in bone marrow
CleanExiMM_RASGRP4
ExpressionAtlasiQ8BTM9 baseline and differential
GenevisibleiQ8BTM9 MM

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRP4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BTM9
Secondary accession number(s): Q3TNQ1
, Q3TRL5, Q3U3I4, Q811P7, Q8BKV7, Q91ZC8, Q920A2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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