UniProtKB - Q8BTK5 (SMYD4_MOUSE)
Protein
SET and MYND domain-containing protein 4
Gene
Smyd4
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 569 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 | |
Binding sitei | 591 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 296 – 335 | MYND-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Smyd4 Synonyms:Kiaa1936 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442796 Smyd4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227785 | 1 – 799 | SET and MYND domain-containing protein 4Add BLAST | 799 |
Proteomic databases
EPDi | Q8BTK5 |
PaxDbi | Q8BTK5 |
PRIDEi | Q8BTK5 |
PTM databases
iPTMneti | Q8BTK5 |
PhosphoSitePlusi | Q8BTK5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018809 Expressed in 169 organ(s), highest expression level in ureter smooth muscle |
Genevisiblei | Q8BTK5 MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 233 – 570 | SETPROSITE-ProRule annotationAdd BLAST | 338 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 114 | S-adenosyl-L-methionine bindingBy similarity | 3 | |
Regioni | 535 – 536 | S-adenosyl-L-methionine bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 296 – 335 | MYND-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2084 Eukaryota COG2940 LUCA |
GeneTreei | ENSGT00730000111079 |
InParanoidi | Q8BTK5 |
OMAi | TPIPGCD |
OrthoDBi | 1278034at2759 |
TreeFami | TF106441 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR001214 SET_dom IPR011990 TPR-like_helical_dom_sf IPR002893 Znf_MYND |
Pfami | View protein in Pfam PF00856 SET, 1 hit PF01753 zf-MYND, 1 hit |
SUPFAMi | SSF48452 SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50280 SET, 1 hit PS01360 ZF_MYND_1, 1 hit PS50865 ZF_MYND_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8BTK5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLPVDEWKS YLLKKWASLP KSVQDTISTA ETLSDIFLPS SSLLQPEDEM
60 70 80 90 100
FLKELSSSYS VEKDNDAPLF YREEGNRKFQ EKEYTDAAVL YSKGVSHSRP
110 120 130 140 150
NTEDISLCYA NRSAALFHLG QYEACLKDIV EAGMHGYPER LQPKMMVRKT
160 170 180 190 200
ECLVNLGRLQ EARQTISDLE SSLTAKPTLV LSSYQILQRN VQHLKIKIQE
210 220 230 240 250
KETLPEPIPA ALTNAFEDIA LGEENTQISG ASLSVSLCTH PLKGRHLVAT
260 270 280 290 300
KDILPGELLV KEDAFVSVLI PGEMPRPHHC LENKWDTRVT SGDLYCHRCL
310 320 330 340 350
KHTLATVPCG SCSYAKYCSQ ECMQQAWDLY HSTECSLGGL LLTLGVFCHV
360 370 380 390 400
ALRMTLLARF EDVDRVVRML CDEVGSTDTC LPESKNLVKA FDYTSQGESE
410 420 430 440 450
EKSKIGEPPI PGCNVNGKYG SNYNAIFSLL PHTEKHSPEH RFICAISVSA
460 470 480 490 500
LCRQLKADSV QAQTLKSPKL KAVTPGLCAD LTVWGAAMLR HMLQLQCNAQ
510 520 530 540 550
AITSICHTGS NESIITNSRQ IRLATGIFPV VSLLNHSCRP NTSVSFTGTV
560 570 580 590 600
ATVRAAQRIA KGQEILHCYG PHESRMGVAE RQQRLSSQYF FDCRCGACHA
610 620 630 640 650
ETLRAAAAPR WEAFCCKTCR ALMQGNDVLS CSNESCTNSV SRDQLVSRLQ
660 670 680 690 700
DLQQQVCMAQ KLLRTGKPEQ AIQQLLRCRE AAESFLSAEH TVLGEIEDGL
710 720 730 740 750
AQAHATLGNW LKSAAHVQKS LQVVETRHGP SSVEIGHELF KLAQVLFNGL
760 770 780 790
AVPEALSAIW KAERILLVHC GPESEEVREL REMRSCLLDS SFVPVGPLV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 363 | V → D in BAC26933 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 374 | V → I in BAC41013 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 751 | A → P in BAC26933 (PubMed:16141072).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 65 | N → Y in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 208 | I → V in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 226 | T → K in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 397 | G → E in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 458 | D → A in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 486 | A → T in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 527 | I → V in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 553 | V → I in strain: Czech II. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017580 | 1 – 133 | Missing in isoform 2. 2 PublicationsAdd BLAST | 133 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030380 mRNA Translation: BAC26933.1 AK089959 mRNA Translation: BAC41013.1 AK154507 mRNA Translation: BAE32637.1 AL591496 Genomic DNA No translation available. AL603834 Genomic DNA No translation available. BC095952 mRNA Translation: AAH95952.1 BC130220 mRNA Translation: AAI30221.1 AK173306 mRNA Translation: BAD32584.1 |
CCDSi | CCDS48848.1 [Q8BTK5-1] |
RefSeqi | NP_001096081.1, NM_001102611.1 [Q8BTK5-1] XP_006533600.1, XM_006533537.3 [Q8BTK5-2] |
Genome annotation databases
Ensembli | ENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809 [Q8BTK5-1] |
GeneIDi | 319822 |
KEGGi | mmu:319822 |
UCSCi | uc007kdm.1 mouse [Q8BTK5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030380 mRNA Translation: BAC26933.1 AK089959 mRNA Translation: BAC41013.1 AK154507 mRNA Translation: BAE32637.1 AL591496 Genomic DNA No translation available. AL603834 Genomic DNA No translation available. BC095952 mRNA Translation: AAH95952.1 BC130220 mRNA Translation: AAI30221.1 AK173306 mRNA Translation: BAD32584.1 |
CCDSi | CCDS48848.1 [Q8BTK5-1] |
RefSeqi | NP_001096081.1, NM_001102611.1 [Q8BTK5-1] XP_006533600.1, XM_006533537.3 [Q8BTK5-2] |
3D structure databases
SMRi | Q8BTK5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047505 |
PTM databases
iPTMneti | Q8BTK5 |
PhosphoSitePlusi | Q8BTK5 |
Proteomic databases
EPDi | Q8BTK5 |
PaxDbi | Q8BTK5 |
PRIDEi | Q8BTK5 |
Genome annotation databases
Ensembli | ENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809 [Q8BTK5-1] |
GeneIDi | 319822 |
KEGGi | mmu:319822 |
UCSCi | uc007kdm.1 mouse [Q8BTK5-1] |
Organism-specific databases
CTDi | 114826 |
MGIi | MGI:2442796 Smyd4 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2084 Eukaryota COG2940 LUCA |
GeneTreei | ENSGT00730000111079 |
InParanoidi | Q8BTK5 |
OMAi | TPIPGCD |
OrthoDBi | 1278034at2759 |
TreeFami | TF106441 |
Miscellaneous databases
ChiTaRSi | Smyd4 mouse |
PROi | PR:Q8BTK5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018809 Expressed in 169 organ(s), highest expression level in ureter smooth muscle |
Genevisiblei | Q8BTK5 MM |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR001214 SET_dom IPR011990 TPR-like_helical_dom_sf IPR002893 Znf_MYND |
Pfami | View protein in Pfam PF00856 SET, 1 hit PF01753 zf-MYND, 1 hit |
SUPFAMi | SSF48452 SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50280 SET, 1 hit PS01360 ZF_MYND_1, 1 hit PS50865 ZF_MYND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMYD4_MOUSE | |
Accessioni | Q8BTK5Primary (citable) accession number: Q8BTK5 Secondary accession number(s): A2BDD0 Q8BMP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 21, 2006 | |
Last modified: | October 16, 2019 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot