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Protein

SET and MYND domain-containing protein 4

Gene

Smyd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei569S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei591S-adenosyl-L-methioninePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 335MYND-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SET and MYND domain-containing protein 4 (EC:2.1.1.-)
Gene namesi
Name:Smyd4
Synonyms:Kiaa1936
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442796 Smyd4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277851 – 799SET and MYND domain-containing protein 4Add BLAST799

Proteomic databases

PaxDbiQ8BTK5
PRIDEiQ8BTK5

PTM databases

iPTMnetiQ8BTK5
PhosphoSitePlusiQ8BTK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000018809 Expressed in 169 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_SMYD4
GenevisibleiQ8BTK5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047505

Structurei

3D structure databases

ProteinModelPortaliQ8BTK5
SMRiQ8BTK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 570SETPROSITE-ProRule annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 114S-adenosyl-L-methionine bindingBy similarity3
Regioni535 – 536S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 335MYND-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00730000111079
HOVERGENiHBG082493
InParanoidiQ8BTK5
OMAiGQEILHC
OrthoDBiEOG091G0BCB
TreeFamiTF106441

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR001214 SET_dom
IPR011990 TPR-like_helical_dom_sf
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BTK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLPVDEWKS YLLKKWASLP KSVQDTISTA ETLSDIFLPS SSLLQPEDEM
60 70 80 90 100
FLKELSSSYS VEKDNDAPLF YREEGNRKFQ EKEYTDAAVL YSKGVSHSRP
110 120 130 140 150
NTEDISLCYA NRSAALFHLG QYEACLKDIV EAGMHGYPER LQPKMMVRKT
160 170 180 190 200
ECLVNLGRLQ EARQTISDLE SSLTAKPTLV LSSYQILQRN VQHLKIKIQE
210 220 230 240 250
KETLPEPIPA ALTNAFEDIA LGEENTQISG ASLSVSLCTH PLKGRHLVAT
260 270 280 290 300
KDILPGELLV KEDAFVSVLI PGEMPRPHHC LENKWDTRVT SGDLYCHRCL
310 320 330 340 350
KHTLATVPCG SCSYAKYCSQ ECMQQAWDLY HSTECSLGGL LLTLGVFCHV
360 370 380 390 400
ALRMTLLARF EDVDRVVRML CDEVGSTDTC LPESKNLVKA FDYTSQGESE
410 420 430 440 450
EKSKIGEPPI PGCNVNGKYG SNYNAIFSLL PHTEKHSPEH RFICAISVSA
460 470 480 490 500
LCRQLKADSV QAQTLKSPKL KAVTPGLCAD LTVWGAAMLR HMLQLQCNAQ
510 520 530 540 550
AITSICHTGS NESIITNSRQ IRLATGIFPV VSLLNHSCRP NTSVSFTGTV
560 570 580 590 600
ATVRAAQRIA KGQEILHCYG PHESRMGVAE RQQRLSSQYF FDCRCGACHA
610 620 630 640 650
ETLRAAAAPR WEAFCCKTCR ALMQGNDVLS CSNESCTNSV SRDQLVSRLQ
660 670 680 690 700
DLQQQVCMAQ KLLRTGKPEQ AIQQLLRCRE AAESFLSAEH TVLGEIEDGL
710 720 730 740 750
AQAHATLGNW LKSAAHVQKS LQVVETRHGP SSVEIGHELF KLAQVLFNGL
760 770 780 790
AVPEALSAIW KAERILLVHC GPESEEVREL REMRSCLLDS SFVPVGPLV
Length:799
Mass (Da):88,538
Last modified:March 21, 2006 - v2
Checksum:i6C4CAA5AC7B5874A
GO
Isoform 2 (identifier: Q8BTK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:666
Mass (Da):73,475
Checksum:iB0E543D471700937
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363V → D in BAC26933 (PubMed:16141072).Curated1
Sequence conflicti374V → I in BAC41013 (PubMed:16141072).Curated1
Sequence conflicti751A → P in BAC26933 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti65N → Y in strain: Czech II. 1 Publication1
Natural varianti208I → V in strain: Czech II. 1 Publication1
Natural varianti226T → K in strain: Czech II. 1 Publication1
Natural varianti397G → E in strain: Czech II. 1 Publication1
Natural varianti458D → A in strain: Czech II. 1 Publication1
Natural varianti486A → T in strain: Czech II. 1 Publication1
Natural varianti527I → V in strain: Czech II. 1 Publication1
Natural varianti553V → I in strain: Czech II. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175801 – 133Missing in isoform 2. 2 PublicationsAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030380 mRNA Translation: BAC26933.1
AK089959 mRNA Translation: BAC41013.1
AK154507 mRNA Translation: BAE32637.1
AL603834, AL591496 Genomic DNA Translation: CAI23978.1
AL591496, AL603834 Genomic DNA Translation: CAI35377.1
BC095952 mRNA Translation: AAH95952.1
BC130220 mRNA Translation: AAI30221.1
AK173306 mRNA Translation: BAD32584.1
CCDSiCCDS48848.1 [Q8BTK5-1]
RefSeqiNP_001096081.1, NM_001102611.1 [Q8BTK5-1]
XP_006533600.1, XM_006533537.3 [Q8BTK5-2]
UniGeneiMm.340377
Mm.445425

Genome annotation databases

EnsembliENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809 [Q8BTK5-1]
GeneIDi319822
KEGGimmu:319822
UCSCiuc007kdm.1 mouse [Q8BTK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030380 mRNA Translation: BAC26933.1
AK089959 mRNA Translation: BAC41013.1
AK154507 mRNA Translation: BAE32637.1
AL603834, AL591496 Genomic DNA Translation: CAI23978.1
AL591496, AL603834 Genomic DNA Translation: CAI35377.1
BC095952 mRNA Translation: AAH95952.1
BC130220 mRNA Translation: AAI30221.1
AK173306 mRNA Translation: BAD32584.1
CCDSiCCDS48848.1 [Q8BTK5-1]
RefSeqiNP_001096081.1, NM_001102611.1 [Q8BTK5-1]
XP_006533600.1, XM_006533537.3 [Q8BTK5-2]
UniGeneiMm.340377
Mm.445425

3D structure databases

ProteinModelPortaliQ8BTK5
SMRiQ8BTK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047505

PTM databases

iPTMnetiQ8BTK5
PhosphoSitePlusiQ8BTK5

Proteomic databases

PaxDbiQ8BTK5
PRIDEiQ8BTK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809 [Q8BTK5-1]
GeneIDi319822
KEGGimmu:319822
UCSCiuc007kdm.1 mouse [Q8BTK5-1]

Organism-specific databases

CTDi114826
MGIiMGI:2442796 Smyd4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00730000111079
HOVERGENiHBG082493
InParanoidiQ8BTK5
OMAiGQEILHC
OrthoDBiEOG091G0BCB
TreeFamiTF106441

Miscellaneous databases

PROiPR:Q8BTK5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018809 Expressed in 169 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_SMYD4
GenevisibleiQ8BTK5 MM

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR001214 SET_dom
IPR011990 TPR-like_helical_dom_sf
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMYD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BTK5
Secondary accession number(s): A2BDD0
, Q3U3Z8, Q501N5, Q5SWN4, Q69Z60, Q8BMP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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