Smyd4

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	569	S-adenosyl-L-methioninePROSITE-ProRule annotation		1
Binding siteⁱ	591	S-adenosyl-L-methioninePROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	296 – 335	MYND-typePROSITE-ProRule annotationAdd BLAST		40

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
methyltransferase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Ligand	Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SET and MYND domain-containing protein 4 (EC:2.1.1.-)
Gene namesⁱ	Name:Smyd4 Synonyms:Kiaa1936
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2442796 Smyd4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000227785	1 – 799	SET and MYND domain-containing protein 4Add BLAST		799

Proteomic databases

PaxDbⁱ	Q8BTK5
PRIDEⁱ	Q8BTK5

PTM databases

iPTMnetⁱ	Q8BTK5
PhosphoSitePlusⁱ	Q8BTK5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000018809 Expressed in 169 organ(s), highest expression level in ureter smooth muscle
CleanExⁱ	MM_SMYD4
Genevisibleⁱ	Q8BTK5 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000047505

STRINGⁱ

10090.ENSMUSP00000047505

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BTK5
SMRⁱ	Q8BTK5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	233 – 570	SETPROSITE-ProRule annotationAdd BLAST		338

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	112 – 114	S-adenosyl-L-methionine bindingBy similarity		3
Regionⁱ	535 – 536	S-adenosyl-L-methionine bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	296 – 335	MYND-typePROSITE-ProRule annotationAdd BLAST		40

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2084 Eukaryota COG2940 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111079
HOVERGENⁱ	HBG082493
InParanoidⁱ	Q8BTK5
OMAⁱ	GQEILHC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BCB
TreeFamⁱ	TF106441

Family and domain databases

Gene3Dⁱ	1.25.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR001214 SET_dom IPR011990 TPR-like_helical_dom_sf IPR002893 Znf_MYND
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00856 SET, 1 hit PF01753 zf-MYND, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 2 hits
PROSITEⁱ	View protein in PROSITE PS50280 SET, 1 hit PS01360 ZF_MYND_1, 1 hit PS50865 ZF_MYND_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8BTK5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLPVDEWKS YLLKKWASLP KSVQDTISTA ETLSDIFLPS SSLLQPEDEM 
        60         70         80         90        100
FLKELSSSYS VEKDNDAPLF YREEGNRKFQ EKEYTDAAVL YSKGVSHSRP 
       110        120        130        140        150
NTEDISLCYA NRSAALFHLG QYEACLKDIV EAGMHGYPER LQPKMMVRKT 
       160        170        180        190        200
ECLVNLGRLQ EARQTISDLE SSLTAKPTLV LSSYQILQRN VQHLKIKIQE 
       210        220        230        240        250
KETLPEPIPA ALTNAFEDIA LGEENTQISG ASLSVSLCTH PLKGRHLVAT 
       260        270        280        290        300
KDILPGELLV KEDAFVSVLI PGEMPRPHHC LENKWDTRVT SGDLYCHRCL 
       310        320        330        340        350
KHTLATVPCG SCSYAKYCSQ ECMQQAWDLY HSTECSLGGL LLTLGVFCHV 
       360        370        380        390        400
ALRMTLLARF EDVDRVVRML CDEVGSTDTC LPESKNLVKA FDYTSQGESE 
       410        420        430        440        450
EKSKIGEPPI PGCNVNGKYG SNYNAIFSLL PHTEKHSPEH RFICAISVSA 
       460        470        480        490        500
LCRQLKADSV QAQTLKSPKL KAVTPGLCAD LTVWGAAMLR HMLQLQCNAQ 
       510        520        530        540        550
AITSICHTGS NESIITNSRQ IRLATGIFPV VSLLNHSCRP NTSVSFTGTV 
       560        570        580        590        600
ATVRAAQRIA KGQEILHCYG PHESRMGVAE RQQRLSSQYF FDCRCGACHA 
       610        620        630        640        650
ETLRAAAAPR WEAFCCKTCR ALMQGNDVLS CSNESCTNSV SRDQLVSRLQ 
       660        670        680        690        700
DLQQQVCMAQ KLLRTGKPEQ AIQQLLRCRE AAESFLSAEH TVLGEIEDGL 
       710        720        730        740        750
AQAHATLGNW LKSAAHVQKS LQVVETRHGP SSVEIGHELF KLAQVLFNGL 
       760        770        780        790 
AVPEALSAIW KAERILLVHC GPESEEVREL REMRSCLLDS SFVPVGPLV

Length:799

Mass (Da):88,538

Last modified:March 21, 2006 - v2

Checksum:ⁱ6C4CAA5AC7B5874A

GO

Isoform 2 (identifier: Q8BTK5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-133: Missing.

« Hide

        10         20         30         40         50
MHGYPERLQP KMMVRKTECL VNLGRLQEAR QTISDLESSL TAKPTLVLSS 
        60         70         80         90        100
YQILQRNVQH LKIKIQEKET LPEPIPAALT NAFEDIALGE ENTQISGASL 
       110        120        130        140        150
SVSLCTHPLK GRHLVATKDI LPGELLVKED AFVSVLIPGE MPRPHHCLEN 
       160        170        180        190        200
KWDTRVTSGD LYCHRCLKHT LATVPCGSCS YAKYCSQECM QQAWDLYHST 
       210        220        230        240        250
ECSLGGLLLT LGVFCHVALR MTLLARFEDV DRVVRMLCDE VGSTDTCLPE 
       260        270        280        290        300
SKNLVKAFDY TSQGESEEKS KIGEPPIPGC NVNGKYGSNY NAIFSLLPHT 
       310        320        330        340        350
EKHSPEHRFI CAISVSALCR QLKADSVQAQ TLKSPKLKAV TPGLCADLTV 
       360        370        380        390        400
WGAAMLRHML QLQCNAQAIT SICHTGSNES IITNSRQIRL ATGIFPVVSL 
       410        420        430        440        450
LNHSCRPNTS VSFTGTVATV RAAQRIAKGQ EILHCYGPHE SRMGVAERQQ 
       460        470        480        490        500
RLSSQYFFDC RCGACHAETL RAAAAPRWEA FCCKTCRALM QGNDVLSCSN 
       510        520        530        540        550
ESCTNSVSRD QLVSRLQDLQ QQVCMAQKLL RTGKPEQAIQ QLLRCREAAE 
       560        570        580        590        600
SFLSAEHTVL GEIEDGLAQA HATLGNWLKS AAHVQKSLQV VETRHGPSSV 
       610        620        630        640        650
EIGHELFKLA QVLFNGLAVP EALSAIWKAE RILLVHCGPE SEEVRELREM 
       660 
RSCLLDSSFV PVGPLV

Show »

Length:666

Mass (Da):73,475

Checksum:ⁱB0E543D471700937

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	363	V → D in BAC26933 (PubMed:16141072).Curated	1
Sequence conflictⁱ	374	V → I in BAC41013 (PubMed:16141072).Curated	1
Sequence conflictⁱ	751	A → P in BAC26933 (PubMed:16141072).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	65	N → Y in strain: Czech II. 1 Publication	1
Natural variantⁱ	208	I → V in strain: Czech II. 1 Publication	1
Natural variantⁱ	226	T → K in strain: Czech II. 1 Publication	1
Natural variantⁱ	397	G → E in strain: Czech II. 1 Publication	1
Natural variantⁱ	458	D → A in strain: Czech II. 1 Publication	1
Natural variantⁱ	486	A → T in strain: Czech II. 1 Publication	1
Natural variantⁱ	527	I → V in strain: Czech II. 1 Publication	1
Natural variantⁱ	553	V → I in strain: Czech II. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017580	1 – 133	Missing in isoform 2. 2 PublicationsAdd BLAST		133

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK030380 mRNA Translation: BAC26933.1 AK089959 mRNA Translation: BAC41013.1 AK154507 mRNA Translation: BAE32637.1 AL603834, AL591496 Genomic DNA Translation: CAI23978.1 AL591496, AL603834 Genomic DNA Translation: CAI35377.1 BC095952 mRNA Translation: AAH95952.1 BC130220 mRNA Translation: AAI30221.1 AK173306 mRNA Translation: BAD32584.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48848.1 [Q8BTK5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001096081.1, NM_001102611.1 [Q8BTK5-1] XP_006533600.1, XM_006533537.3 [Q8BTK5-2]
UniGeneⁱ	Mm.340377 Mm.445425

Genome annotation databases

Ensemblⁱ	ENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809 [Q8BTK5-1]
GeneIDⁱ	319822
KEGGⁱ	mmu:319822
UCSC genome browser More...UCSCⁱ	uc007kdm.1 mouse [Q8BTK5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8BTK5	Isoform 2 of SET and MYND domain-containing protein 4		MOUSE		666	UniRef90_Q8BTK5
UPI000A310701		MUSPA		687
UPI0003D72AE9		MOUSE		747
UPI0003D72B6C		MOUSE		731

Protein	Similar proteins		Species	Score	Length	Source
Q8BTK5	SET and MYND domain-containing protein 4		HUMAN		804	UniRef50_Q8BTK5
SET and MYND domain-containing protein 4		PONAB		804
Isoform 2 of SET and MYND domain-containing protein 4		MOUSE		666
SET and MYND domain-containing protein 4		Patagioenas fasciata monilis		798
SET and MYND domain containing 4 (Fragment)		COLLI		705
+367

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK030380 mRNA Translation: BAC26933.1 AK089959 mRNA Translation: BAC41013.1 AK154507 mRNA Translation: BAE32637.1 AL603834, AL591496 Genomic DNA Translation: CAI23978.1 AL591496, AL603834 Genomic DNA Translation: CAI35377.1 BC095952 mRNA Translation: AAH95952.1 BC130220 mRNA Translation: AAI30221.1 AK173306 mRNA Translation: BAD32584.1
CCDSⁱ	CCDS48848.1 [Q8BTK5-1]
RefSeqⁱ	NP_001096081.1, NM_001102611.1 [Q8BTK5-1] XP_006533600.1, XM_006533537.3 [Q8BTK5-2]
UniGeneⁱ	Mm.340377 Mm.445425

3D structure databases

ProteinModelPortalⁱ	Q8BTK5
SMRⁱ	Q8BTK5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000047505

STRINGⁱ

10090.ENSMUSP00000047505

PTM databases

iPTMnetⁱ	Q8BTK5
PhosphoSitePlusⁱ	Q8BTK5

Proteomic databases

PaxDbⁱ	Q8BTK5
PRIDEⁱ	Q8BTK5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000044530; ENSMUSP00000047505; ENSMUSG00000018809 [Q8BTK5-1]
GeneIDⁱ	319822
KEGGⁱ	mmu:319822
UCSCⁱ	uc007kdm.1 mouse [Q8BTK5-1]

Organism-specific databases

CTDⁱ	114826
MGIⁱ	MGI:2442796 Smyd4
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2084 Eukaryota COG2940 LUCA
GeneTreeⁱ	ENSGT00730000111079
HOVERGENⁱ	HBG082493
InParanoidⁱ	Q8BTK5
OMAⁱ	GQEILHC
OrthoDBⁱ	EOG091G0BCB
TreeFamⁱ	TF106441

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BTK5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000018809 Expressed in 169 organ(s), highest expression level in ureter smooth muscle
CleanExⁱ	MM_SMYD4
Genevisibleⁱ	Q8BTK5 MM

Family and domain databases

Gene3Dⁱ	1.25.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR001214 SET_dom IPR011990 TPR-like_helical_dom_sf IPR002893 Znf_MYND
Pfamⁱ	View protein in Pfam PF00856 SET, 1 hit PF01753 zf-MYND, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 2 hits
PROSITEⁱ	View protein in PROSITE PS50280 SET, 1 hit PS01360 ZF_MYND_1, 1 hit PS50865 ZF_MYND_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMYD4_MOUSE
Accessionⁱ	Q8BTK5Primary (citable) accession number: Q8BTK5 Secondary accession number(s): A2BDD0 , Q3U3Z8, Q501N5, Q5SWN4, Q69Z60, Q8BMP3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	March 21, 2006
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8BTK5 (SMYD4_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

SET and MYND domain-containing protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ