UniProtKB - Q8BTH7 (Q8BTH7_MOUSE)
Protein
Submitted name:
Uncharacterized protein
Gene
Isl1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:Isl1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:101791, Isl1 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 77 | LIM zinc-bindingInterPro annotationAdd BLAST | 63 | |
Domaini | 78 – 139 | LIM zinc-bindingInterPro annotationAdd BLAST | 62 | |
Domaini | 179 – 239 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 312 – 349 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 312 – 341 | PolarSequence analysisAdd BLAST | 30 |
Keywords - Domaini
HomeoboxUniRule annotationARBA annotation, LIM domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
OrthoDBi | 948890at2759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00132, LIM, 2 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q8BTH7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ
60 70 80 90 100
YLDESCTCLV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY
110 120 130 140 150
HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL
160 170 180 190 200
HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTWY
210 220 230 240 250
AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ
260 270 280 290 300
PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ
310 320 330 340
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090263 mRNA Translation: BAC41153.1 |
RefSeqi | NP_067434.3, NM_021459.4 |
Genome annotation databases
GeneIDi | 16392 |
KEGGi | mmu:16392 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090263 mRNA Translation: BAC41153.1 |
RefSeqi | NP_067434.3, NM_021459.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 16392 |
Genome annotation databases
GeneIDi | 16392 |
KEGGi | mmu:16392 |
Organism-specific databases
CTDi | 3670 |
MGIi | MGI:101791, Isl1 |
Phylogenomic databases
OrthoDBi | 948890at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16392, 0 hits in 52 CRISPR screens |
ChiTaRSi | Isl1, mouse |
SOURCEi | Search... |
Gene expression databases
Genevisiblei | Q8BTH7, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00132, LIM, 2 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8BTH7_MOUSE | |
Accessioni | Q8BTH7Primary (citable) accession number: Q8BTH7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |