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Protein

FAST kinase domain-containing protein 3, mitochondrial

Gene

Fastkd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
FAST kinase domain-containing protein 3, mitochondrial
Gene namesi
Name:Fastkd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1916827 Fastkd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000284716? – 661FAST kinase domain-containing protein 3, mitochondrial
Transit peptidei1 – ?MitochondrionCurated

Proteomic databases

PaxDbiQ8BSN9
PeptideAtlasiQ8BSN9
PRIDEiQ8BSN9

PTM databases

iPTMnetiQ8BSN9
PhosphoSitePlusiQ8BSN9

Expressioni

Tissue specificityi

Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue with highest expression in testis and smooth muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000021532 Expressed in 209 organ(s), highest expression level in embryo
CleanExiMM_FASTKD3
ExpressionAtlasiQ8BSN9 baseline and differential
GenevisibleiQ8BSN9 MM

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini592 – 650RAPPROSITE-ProRule annotationAdd BLAST59

Domaini

RAP domain is required for FASTKD3 function in mRNA stability and translation.By similarity

Sequence similaritiesi

Belongs to the FAST kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IQQ6 Eukaryota
ENOG4111H0K LUCA
GeneTreeiENSGT00530000063266
HOGENOMiHOG000054193
HOVERGENiHBG088296
InParanoidiQ8BSN9
OMAiQSEKFSP
OrthoDBiEOG091G0WV6
PhylomeDBiQ8BSN9
TreeFamiTF324885

Family and domain databases

InterProiView protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP
PfamiView protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit
SMARTiView protein in SMART
SM00952 RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286 RAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BSN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFITLRRAF CHKSILWIPG AVVALKIHPA SHAPKAVTDR LSVCFCSLQP
60 70 80 90 100
ELFRVRFHHA YCKNFHSEKG NDFHPVGEPW SSQAQEWNQP GQSLQNEDEE
110 120 130 140 150
MLFRRLSYFT SFEEVLSFIS ALDTLPVPLA MAALLRICEI GRRDGEQRLP
160 170 180 190 200
EGVLENRAFQ ALCLRCERDP SHLTNAGLVT ALQSLLTLLP ADPQSSLMLS
210 220 230 240 250
LVAECQRRLQ RGNLEVHHLC VLGESLAMLQ GASCETLKLV VRQLQSKSVE
260 270 280 290 300
TFAPEEITSV YRILQVCPEE VDKHQMFLNT LNNFSISVVP YLSPKSISHV
310 320 330 340 350
LTALVALDQT HALPLLIKLG KYVVRYIPRF TNEELRKVLE AFVYFGHSDR
360 370 380 390 400
FFTEALEQHV SALCFSLDPA VASSVMGYCS RKRILSKPIF DVVSEIVVCQ
410 420 430 440 450
WDRLSPSQIA ELIEPFGKLN YVPPNAPALF RKVENVLCAR LHHFPPKMLL
460 470 480 490 500
RLLHSCALIE RHPVNFMSKL FSPFFLQRLQ GKESYLDRLS LAQLTQLFLT
510 520 530 540 550
SVLECPFYKG PKLLPKYQVK SFLTPCCSLE TPLDLHLYKS VVIGLIDLLG
560 570 580 590 600
SRLYFASKVL TPYYYTIDVE VKLDEDGFVL PCTVDEDIHK RVALCIDGPQ
610 620 630 640 650
RFCLDSKHLL GKEATKQRHL RLLGYQVVQL PYHELELLTS RLELVDYLQR
660
KLFSQSSAVH W
Length:661
Mass (Da):75,317
Last modified:April 17, 2007 - v2
Checksum:i67A53D7BFD52AB74
GO
Isoform 2 (identifier: Q8BSN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     568-571: DVEV → ASAL
     572-661: Missing.

Show »
Length:571
Mass (Da):64,734
Checksum:iA4D78F00111FE713
GO
Isoform 3 (identifier: Q8BSN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     510-661: GPKLLPKYQV...LFSQSSAVHW → VRTETRVV

Note: No experimental confirmation available.
Show »
Length:517
Mass (Da):58,769
Checksum:i34016FE23DD10991
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJ24A0A1Y7VJ24_MOUSE
FAST kinase domain-containing prote...
Fastkd3
101Annotation score:
A0A1Y7VJT5A0A1Y7VJT5_MOUSE
FAST kinase domain-containing prote...
Fastkd3
80Annotation score:
A0A1Y7VM85A0A1Y7VM85_MOUSE
FAST kinase domain-containing prote...
Fastkd3
135Annotation score:
A0A1Y7VLJ1A0A1Y7VLJ1_MOUSE
FAST kinase domain-containing prote...
Fastkd3
83Annotation score:
A0A1Y7VLF1A0A1Y7VLF1_MOUSE
FAST kinase domain-containing prote...
Fastkd3
77Annotation score:

Sequence cautioni

The sequence BAC27277 differs from that shown. Reason: Frameshift at position 599.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34P → Q in AAH42506 (PubMed:15489334).Curated1
Sequence conflicti108Y → V in AAH42506 (PubMed:15489334).Curated1
Sequence conflicti175N → S in AAH42506 (PubMed:15489334).Curated1
Sequence conflicti258T → A in AAH42506 (PubMed:15489334).Curated1
Sequence conflicti266V → A in AAH42506 (PubMed:15489334).Curated1
Sequence conflicti276M → T in AAH42506 (PubMed:15489334).Curated1
Sequence conflicti533L → M in AAH42506 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024624510 – 661GPKLL…SAVHW → VRTETRVV in isoform 3. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_024625568 – 571DVEV → ASAL in isoform 2. 2 Publications4
Alternative sequenceiVSP_024626572 – 661Missing in isoform 2. 2 PublicationsAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031142 mRNA Translation: BAC27277.1 Frameshift.
AK033189 mRNA Translation: BAC28191.1
AK036778 mRNA Translation: BAC29573.1
BC042506 mRNA Translation: AAH42506.1
BC060688 mRNA Translation: AAH60688.1
CCDSiCCDS36719.1 [Q8BSN9-1]
RefSeqiNP_001317352.1, NM_001330423.1 [Q8BSN9-1]
NP_081399.3, NM_027123.5 [Q8BSN9-1]
UniGeneiMm.23670

Genome annotation databases

EnsembliENSMUST00000051784; ENSMUSP00000061737; ENSMUSG00000021532 [Q8BSN9-1]
ENSMUST00000223319; ENSMUSP00000152635; ENSMUSG00000021532 [Q8BSN9-2]
GeneIDi69577
KEGGimmu:69577
UCSCiuc007rca.1 mouse [Q8BSN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031142 mRNA Translation: BAC27277.1 Frameshift.
AK033189 mRNA Translation: BAC28191.1
AK036778 mRNA Translation: BAC29573.1
BC042506 mRNA Translation: AAH42506.1
BC060688 mRNA Translation: AAH60688.1
CCDSiCCDS36719.1 [Q8BSN9-1]
RefSeqiNP_001317352.1, NM_001330423.1 [Q8BSN9-1]
NP_081399.3, NM_027123.5 [Q8BSN9-1]
UniGeneiMm.23670

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BSN9
PhosphoSitePlusiQ8BSN9

Proteomic databases

PaxDbiQ8BSN9
PeptideAtlasiQ8BSN9
PRIDEiQ8BSN9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051784; ENSMUSP00000061737; ENSMUSG00000021532 [Q8BSN9-1]
ENSMUST00000223319; ENSMUSP00000152635; ENSMUSG00000021532 [Q8BSN9-2]
GeneIDi69577
KEGGimmu:69577
UCSCiuc007rca.1 mouse [Q8BSN9-1]

Organism-specific databases

CTDi79072
MGIiMGI:1916827 Fastkd3

Phylogenomic databases

eggNOGiENOG410IQQ6 Eukaryota
ENOG4111H0K LUCA
GeneTreeiENSGT00530000063266
HOGENOMiHOG000054193
HOVERGENiHBG088296
InParanoidiQ8BSN9
OMAiQSEKFSP
OrthoDBiEOG091G0WV6
PhylomeDBiQ8BSN9
TreeFamiTF324885

Miscellaneous databases

PROiPR:Q8BSN9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021532 Expressed in 209 organ(s), highest expression level in embryo
CleanExiMM_FASTKD3
ExpressionAtlasiQ8BSN9 baseline and differential
GenevisibleiQ8BSN9 MM

Family and domain databases

InterProiView protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP
PfamiView protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit
SMARTiView protein in SMART
SM00952 RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286 RAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAKD3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSN9
Secondary accession number(s): Q5XKD3
, Q6P9N4, Q8CB52, Q8CCG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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