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Protein

Coiled-coil domain-containing protein 151

Gene

Ccdc151

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.1 Publication

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 151
Gene namesi
Name:Ccdc151
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924859 Ccdc151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice have a spectrum of laterality defects, including complex congenital heart defects associated with heterotaxy, and airway epithelia show largely immotile cilia with loss of the outer dynein arms.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215271 – 593Coiled-coil domain-containing protein 151Add BLAST593

Proteomic databases

PaxDbiQ8BSN3
PRIDEiQ8BSN3

PTM databases

iPTMnetiQ8BSN3
PhosphoSitePlusiQ8BSN3

Expressioni

Developmental stagei

At E7.5 specifically expressed in the ventral node.1 Publication

Interactioni

Subunit structurei

Interacts with CCDC114.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110993

Structurei

3D structure databases

ProteinModelPortaliQ8BSN3
SMRiQ8BSN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili84 – 317Sequence analysisAdd BLAST234
Coiled coili378 – 449Sequence analysisAdd BLAST72

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZ0 Eukaryota
ENOG410ZD3T LUCA
HOGENOMiHOG000007822
HOVERGENiHBG062890
InParanoidiQ8BSN3
PhylomeDBiQ8BSN3
TreeFamiTF324955

Family and domain databases

InterProiView protein in InterPro
IPR033192 CCDC151
PANTHERiPTHR21694:SF24 PTHR21694:SF24, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BSN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSPLCWAAA TTTVTSPEQA PAPSSKAKGS KVHRSKSMGR AQAWPARHPK
60 70 80 90 100
SATSFHAMKS SVHAQVLELQ RKIQLLEGDR KAFYESSQWN MKKNQDTINQ
110 120 130 140 150
LQEETKALHV QLKDLLQGDS KVIQAIIQEW KSEKPFLKNR TCEQALEHLE
160 170 180 190 200
HQLREKMNQL NALRHQVILR QKRLEDLRLQ HSLRQLEMAE VQDSNMEAAK
210 220 230 240 250
TMRNLENRLE KARMKAEEAE HITNVYLQLK SYLQEESLNL ESRLDSMEAE
260 270 280 290 300
VMNTKHEVQE LKVVNQEAIN ARDIAKNQLQ YLEESAIRDR KKREHYITDC
310 320 330 340 350
KKRAEEKKLQ TERMERKTHR DHVLLQSEDT IQDHQRHREE ELRQRWSMYQ
360 370 380 390 400
MEVMFGKVKD ATGVAESHAV VRRFLAQDET FTQLENLKKD NELALAKLKE
410 420 430 440 450
EKQRLQRELE NLKYSGDATL VSQRRLHEEM QKTFKKEEQR HNDVHERLEH
460 470 480 490 500
TSRILQLVKD CLEHLANKLS HVKLDDTVLA GKKLDRDSED YAYNLLVVVQ
510 520 530 540 550
EKLLKLQDQL ESQDVPELLR HIADREFLAT LEGKLPLYNT RILLPVASVK
560 570 580 590
DKFFDEEESE DDDRDVVTRA AFKLRSQKLI EARSKKRNRL RRS
Length:593
Mass (Da):69,732
Last modified:March 1, 2003 - v1
Checksum:i665212AD9068BCE2
GO
Isoform 2 (identifier: Q8BSN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-166: QALEHLEHQLREKMNQLNALRHQ → VSPAITIPPFPPHWTFSFPELSL
     167-593: Missing.

Note: No experimental confirmation available.
Show »
Length:166
Mass (Da):18,675
Checksum:i32C1BED3A390D598
GO
Isoform 3 (identifier: Q8BSN3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: K → KQ

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):69,860
Checksum:iF675D6C6B6B90A12
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X951G3X951_MOUSE
Coiled-coil domain-containing prote...
Ccdc151 C330001K17Rik, mCG_142074
593Annotation score:
A0A0R4J1K3A0A0R4J1K3_MOUSE
Coiled-coil domain-containing prote...
Ccdc151
594Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47R → H in BAB32312 (PubMed:16141072).Curated1
Sequence conflicti47R → H in AAH57069 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031786144 – 166QALEH…ALRHQ → VSPAITIPPFPPHWTFSFPE LSL in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_031787167 – 593Missing in isoform 2. 1 PublicationAdd BLAST427
Alternative sequenceiVSP_031788317K → KQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021166 mRNA Translation: BAB32312.1
AK031175 mRNA Translation: BAC27290.1
BC057069 mRNA Translation: AAH57069.2
CCDSiCCDS22917.1 [Q8BSN3-1]
CCDS52740.1 [Q8BSN3-3]
RefSeqiNP_001157259.1, NM_001163787.1
NP_084215.2, NM_029939.3
XP_006510748.1, XM_006510685.2
UniGeneiMm.159953

Genome annotation databases

GeneIDi77609
KEGGimmu:77609
UCSCiuc009onh.1 mouse [Q8BSN3-2]
uc012gpk.1 mouse [Q8BSN3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021166 mRNA Translation: BAB32312.1
AK031175 mRNA Translation: BAC27290.1
BC057069 mRNA Translation: AAH57069.2
CCDSiCCDS22917.1 [Q8BSN3-1]
CCDS52740.1 [Q8BSN3-3]
RefSeqiNP_001157259.1, NM_001163787.1
NP_084215.2, NM_029939.3
XP_006510748.1, XM_006510685.2
UniGeneiMm.159953

3D structure databases

ProteinModelPortaliQ8BSN3
SMRiQ8BSN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110993

PTM databases

iPTMnetiQ8BSN3
PhosphoSitePlusiQ8BSN3

Proteomic databases

PaxDbiQ8BSN3
PRIDEiQ8BSN3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi77609
KEGGimmu:77609
UCSCiuc009onh.1 mouse [Q8BSN3-2]
uc012gpk.1 mouse [Q8BSN3-3]

Organism-specific databases

CTDi115948
MGIiMGI:1924859 Ccdc151

Phylogenomic databases

eggNOGiENOG410IFZ0 Eukaryota
ENOG410ZD3T LUCA
HOGENOMiHOG000007822
HOVERGENiHBG062890
InParanoidiQ8BSN3
PhylomeDBiQ8BSN3
TreeFamiTF324955

Miscellaneous databases

PROiPR:Q8BSN3
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR033192 CCDC151
PANTHERiPTHR21694:SF24 PTHR21694:SF24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC151_MOUSE
AccessioniPrimary (citable) accession number: Q8BSN3
Secondary accession number(s): Q6PGE8, Q9CWC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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