UniProtKB - Q8BSL0 (Q8BSL0_MOUSE)
Protein
Submitted name:
Zinc finger with KRAB and SCAN domains 8
Gene
Zkscan8
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger with KRAB and SCAN domains 8Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913815, Zkscan8 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000063894, Expressed in retina and 260 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 134 | SCAN boxInterPro annotationAdd BLAST | 83 | |
Domaini | 230 – 326 | KRABInterPro annotationAdd BLAST | 97 | |
Domaini | 332 – 359 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 360 – 387 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 388 – 415 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 416 – 443 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 444 – 471 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 472 – 499 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 500 – 527 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 528 – 555 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 556 – 583 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 162 – 216 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 163 – 178 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 194 – 216 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161576 |
HOGENOMi | CLU_002678_49_8_1 |
OMAi | AARCNGD |
OrthoDBi | 1318335at2759 |
TreeFami | TF338146 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8BSL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATEPRKPSS APSPPDQAPE EDLVIVKIEE DHGWDEESGV HENNTPGQEL
60 70 80 90 100
FRLRFRQLCY QETLGPREAL IQLRAFCHQW LRPDLNSKEQ ILELLVLEQF
110 120 130 140 150
LTILPGELQA LVKEHQLQNG EEVVTLLEDL ERQINVLGRP VSTHTHGHRV
160 170 180 190 200
LWDEVIPSKS ASEPPSIHVQ SLATVPKSPV PQKPQDRGKR PDFTYNAMSS
210 220 230 240 250
SQKPTPSQKG SSGDQEVTAR LLTAGFQTLE RIEDMAVSLI REEWLLDPSQ
260 270 280 290 300
KDLNRDNRPE KYRNMFSLDG ETRSENKELF PKQGISPGIQ PHGEATAKCN
310 320 330 340 350
GDVIVGLAHG ETQDLLGKLE RHQGNPTQER RHKCDECGKS FAQNSGLVRH
360 370 380 390 400
WRIHTGEKPY QCTVCGKAFS YRSALLSHQD IHNKVKRYHC KECGKAFSQN
410 420 430 440 450
TGLILHQRIH TGEKPYQCNQ CGKAFSQSAG LILHQRIHSG ERPYECNECG
460 470 480 490 500
KAFSHSSHLI GHQRIHTGEK PYECDECGKT FRRSSHLIGH QRSHTGEKPY
510 520 530 540 550
KCNECGRAFS QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH
560 570 580
TGEKPYQCSE CRKAFIQRSS LIRHQRIHSA EKPQSTGV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z716 | D3Z716_MOUSE | Zinc finger with KRAB and SCAN doma... | Zkscan8 Zfp192 | 253 | Annotation score: | ||
A0A286YCX3 | A0A286YCX3_MOUSE | Zinc finger with KRAB and SCAN doma... | Zkscan8 | 516 | Annotation score: | ||
Q78WV9 | Q78WV9_MOUSE | Zinc finger with KRAB and SCAN doma... | Zkscan8 Zfp192 | 148 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL589742 Genomic DNA No translation available. AK032718 mRNA Translation: BAC27997.1 AK134299 mRNA Translation: BAE22090.1 |
RefSeqi | NP_631880.2, NM_139141.4 |
Genome annotation databases
Ensembli | ENSMUST00000045228; ENSMUSP00000040248; ENSMUSG00000063894 |
GeneIDi | 93681 |
UCSCi | uc007pqr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL589742 Genomic DNA No translation available. AK032718 mRNA Translation: BAC27997.1 AK134299 mRNA Translation: BAE22090.1 |
RefSeqi | NP_631880.2, NM_139141.4 |
3D structure databases
SMRi | Q8BSL0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040248 |
Proteomic databases
PRIDEi | Q8BSL0 |
Protocols and materials databases
Antibodypediai | 830, 175 antibodies |
DNASUi | 93681 |
Genome annotation databases
Ensembli | ENSMUST00000045228; ENSMUSP00000040248; ENSMUSG00000063894 |
GeneIDi | 93681 |
UCSCi | uc007pqr.2, mouse |
Organism-specific databases
CTDi | 7745 |
MGIi | MGI:1913815, Zkscan8 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161576 |
HOGENOMi | CLU_002678_49_8_1 |
OMAi | AARCNGD |
OrthoDBi | 1318335at2759 |
TreeFami | TF338146 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 93681, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063894, Expressed in retina and 260 other tissues |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8BSL0_MOUSE | |
Accessioni | Q8BSL0Primary (citable) accession number: Q8BSL0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |