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Protein

Gap junction delta-4 protein

Gene

Gjd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

  • cell communication Source: InterPro
  • regulation of satellite cell activation involved in skeletal muscle regeneration Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-4 protein
Alternative name(s):
Connexin-39
Short name:
Cx39
Gene namesi
Name:Gjd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444990 Gjd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 128CytoplasmicSequence analysisAdd BLAST31
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 173ExtracellularSequence analysisAdd BLAST24
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 364CytoplasmicSequence analysisAdd BLAST170

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130111 – 364Gap junction delta-4 proteinAdd BLAST364

Proteomic databases

PaxDbiQ8BSD4
PRIDEiQ8BSD4

PTM databases

PhosphoSitePlusiQ8BSD4

Expressioni

Gene expression databases

BgeeiENSMUSG00000036855 Expressed in 16 organ(s), highest expression level in cumulus cell
CleanExiMM_GJD4
GenevisibleiQ8BSD4 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035472

Structurei

3D structure databases

ProteinModelPortaliQ8BSD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEKW Eukaryota
ENOG4111ING LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000112113
HOVERGENiHBG062544
InParanoidiQ8BSD4
KOiK07630
OMAiLRTTQWV
OrthoDBiEOG091G0GK6
PhylomeDBiQ8BSD4
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 2 hits
PfamiView protein in Pfam
PF00029 Connexin, 2 hits
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BSD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLNLLGFL IITLNCNVTI MGMIWLIVEV LLRMLVVVLA GSPIYEDEQE
60 70 80 90 100
RFICNTLQPG CANVCYDLFS PVSPLRFWLV QSLALLLPSV VFGTYTLHRG
110 120 130 140 150
AKLAAVGGAC RPQVPDLSTA YLVHLLLRML LEAGLAFLHY FLFGFSVPAR
160 170 180 190 200
VSCSHVPCSG AVDCYVSRPT EKSLLILFFW AVSALSFLLS LADLLWILPR
210 220 230 240 250
RKTLRTTQWV NGEARPVCEV PAPPPCLLQN PQGYLSQGQV DQEDRQEEQV
260 270 280 290 300
VPEFPCMWTA GQSDNSNVGQ ACVSGLLEHS DQDASEATSS AGDRLTVAHT
310 320 330 340 350
AHELRFHRET SLDLGGKNTQ ADELSLATQS HLARHSSASK PQAPCRLTTS
360
GSAPHLRTKK SEWV
Length:364
Mass (Da):40,042
Last modified:March 1, 2003 - v1
Checksum:iFA58BCCFB1E6B758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198L → P in BAC35240 (PubMed:16141072).Curated1
Sequence conflicti222A → T in BAC35240 (PubMed:16141072).Curated1
Sequence conflicti345C → G in CAC93844 (PubMed:12108537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414562 mRNA Translation: CAC93844.1
AK034663 mRNA Translation: BAC28788.1
AK053016 mRNA Translation: BAC35240.1
BC137984 mRNA Translation: AAI37985.1
CCDSiCCDS29049.1
RefSeqiNP_694726.2, NM_153086.5
UniGeneiMm.119273

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855
GeneIDi225152
KEGGimmu:225152
UCSCiuc008eah.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414562 mRNA Translation: CAC93844.1
AK034663 mRNA Translation: BAC28788.1
AK053016 mRNA Translation: BAC35240.1
BC137984 mRNA Translation: AAI37985.1
CCDSiCCDS29049.1
RefSeqiNP_694726.2, NM_153086.5
UniGeneiMm.119273

3D structure databases

ProteinModelPortaliQ8BSD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035472

PTM databases

PhosphoSitePlusiQ8BSD4

Proteomic databases

PaxDbiQ8BSD4
PRIDEiQ8BSD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855
GeneIDi225152
KEGGimmu:225152
UCSCiuc008eah.1 mouse

Organism-specific databases

CTDi219770
MGIiMGI:2444990 Gjd4

Phylogenomic databases

eggNOGiENOG410IEKW Eukaryota
ENOG4111ING LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000112113
HOVERGENiHBG062544
InParanoidiQ8BSD4
KOiK07630
OMAiLRTTQWV
OrthoDBiEOG091G0GK6
PhylomeDBiQ8BSD4
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Miscellaneous databases

PROiPR:Q8BSD4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036855 Expressed in 16 organ(s), highest expression level in cumulus cell
CleanExiMM_GJD4
GenevisibleiQ8BSD4 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 2 hits
PfamiView protein in Pfam
PF00029 Connexin, 2 hits
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BSD4
Secondary accession number(s): B2RQL7, Q8C6W6, Q91YD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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