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Protein

RAB6-interacting golgin

Gene

Gorab

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RAB6-interacting golgin
Alternative name(s):
N-terminal kinase-like-binding protein 1
Short name:
NTKL-BP1
Short name:
NTKL-binding protein 1
Short name:
mNTKL-BP1
SCY1-like 1-binding protein 1
Short name:
SCYL1-BP1
Short name:
SCYL1-binding protein 1
Gene namesi
Name:Gorab
Synonyms:Ntklbp1, Scyl1bp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138271 Gorab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524451 – 368RAB6-interacting golginAdd BLAST368

Proteomic databases

PaxDbiQ8BRM2
PeptideAtlasiQ8BRM2
PRIDEiQ8BRM2

PTM databases

iPTMnetiQ8BRM2
PhosphoSitePlusiQ8BRM2

Expressioni

Tissue specificityi

Expressed in small intestine, kidney, skeletal muscle, lung, spleen, brain and heart. High expression is observed in osteoblasts and skin; also expressed in osteoclasts albeit at lower levels.2 Publications

Gene expression databases

BgeeiENSMUSG00000040124 Expressed in 232 organ(s), highest expression level in manus
CleanExiMM_SCYL1BP1
ExpressionAtlasiQ8BRM2 baseline and differential
GenevisibleiQ8BRM2 MM

Interactioni

Subunit structurei

Interacts with RCHY1 (By similarity). Interacts with SCYL1 and RAB6A/RAB6.By similarity2 Publications

Protein-protein interaction databases

BioGridi221044, 1 interactor
STRINGi10090.ENSMUSP00000036253

Structurei

3D structure databases

ProteinModelPortaliQ8BRM2
SMRiQ8BRM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 368Necessary for interaction with RCHY1By similarityAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 310Sequence analysisAdd BLAST166

Sequence similaritiesi

Belongs to the GORAB family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJC7 Eukaryota
ENOG4111VTM LUCA
GeneTreeiENSGT00390000014886
HOGENOMiHOG000112758
InParanoidiQ8BRM2
KOiK19748
OMAiMKLKRIQ
OrthoDBiEOG091G0NTU
PhylomeDBiQ8BRM2
TreeFamiTF324839

Family and domain databases

InterProiView protein in InterPro
IPR007033 GORAB
PANTHERiPTHR21470 PTHR21470, 1 hit
PfamiView protein in Pfam
PF04949 Transcrip_act, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BRM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQDWAGFSE EELRRLKQNK DPFEPQRRIP VKKTRQQLQR EKALLEQSQK
60 70 80 90 100
LGLQDGSASL LPEQLLSAPK QRANSQKPRS PSPVAPSPLT PTSSSGDGKL
110 120 130 140 150
PGVGSQPQEP GLENSHHGHK SAEVRAPKPD CKVEKKKMEL QEKSRWEVLQ
160 170 180 190 200
QEQRLMEEKN KRKKALLAQA IAERSKKTQA ETIKLKRIQK ELQALDDMVS
210 220 230 240 250
ADIGILRNRI DQASLEYSYA RKRFDRAEAE YITAKLDLQR KTETKEQLTE
260 270 280 290 300
HLCTIIQQNE LRKAKKLEEL MQQLDVQADE EALQLEVEVE QLLREQEAEA
310 320 330 340 350
AKQMASVERL CPPDGESVSS ELAEENNEPQ KQAPSPETDK PGKCCSSSPH
360
RLDCPDPGAK NFSAAVAT
Length:368
Mass (Da):41,487
Last modified:March 1, 2003 - v1
Checksum:i5204B23BE1E0C196
GO
Isoform 2 (identifier: Q8BRM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Show »
Length:213
Mass (Da):24,078
Checksum:i3F50A0D2724C3378
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQS3A0A087WQS3_MOUSE
RAB6-interacting golgin
Gorab
161Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0209791 – 155Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039170 mRNA Translation: BAC30263.1
AK043953 mRNA Translation: BAC31712.1
AK165909 mRNA Translation: BAE38454.1
AK169151 mRNA Translation: BAE40930.1
BC119132 mRNA Translation: AAI19133.1
BC119134 mRNA Translation: AAI19135.1
CCDSiCCDS15429.1 [Q8BRM2-1]
RefSeqiNP_001300667.1, NM_001313738.1 [Q8BRM2-2]
NP_849214.2, NM_178883.6 [Q8BRM2-1]
UniGeneiMm.32901

Genome annotation databases

EnsembliENSMUST00000045138; ENSMUSP00000036253; ENSMUSG00000040124 [Q8BRM2-1]
GeneIDi98376
KEGGimmu:98376
UCSCiuc007dhl.1 mouse [Q8BRM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039170 mRNA Translation: BAC30263.1
AK043953 mRNA Translation: BAC31712.1
AK165909 mRNA Translation: BAE38454.1
AK169151 mRNA Translation: BAE40930.1
BC119132 mRNA Translation: AAI19133.1
BC119134 mRNA Translation: AAI19135.1
CCDSiCCDS15429.1 [Q8BRM2-1]
RefSeqiNP_001300667.1, NM_001313738.1 [Q8BRM2-2]
NP_849214.2, NM_178883.6 [Q8BRM2-1]
UniGeneiMm.32901

3D structure databases

ProteinModelPortaliQ8BRM2
SMRiQ8BRM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221044, 1 interactor
STRINGi10090.ENSMUSP00000036253

PTM databases

iPTMnetiQ8BRM2
PhosphoSitePlusiQ8BRM2

Proteomic databases

PaxDbiQ8BRM2
PeptideAtlasiQ8BRM2
PRIDEiQ8BRM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045138; ENSMUSP00000036253; ENSMUSG00000040124 [Q8BRM2-1]
GeneIDi98376
KEGGimmu:98376
UCSCiuc007dhl.1 mouse [Q8BRM2-1]

Organism-specific databases

CTDi92344
MGIiMGI:2138271 Gorab

Phylogenomic databases

eggNOGiENOG410IJC7 Eukaryota
ENOG4111VTM LUCA
GeneTreeiENSGT00390000014886
HOGENOMiHOG000112758
InParanoidiQ8BRM2
KOiK19748
OMAiMKLKRIQ
OrthoDBiEOG091G0NTU
PhylomeDBiQ8BRM2
TreeFamiTF324839

Miscellaneous databases

PROiPR:Q8BRM2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040124 Expressed in 232 organ(s), highest expression level in manus
CleanExiMM_SCYL1BP1
ExpressionAtlasiQ8BRM2 baseline and differential
GenevisibleiQ8BRM2 MM

Family and domain databases

InterProiView protein in InterPro
IPR007033 GORAB
PANTHERiPTHR21470 PTHR21470, 1 hit
PfamiView protein in Pfam
PF04949 Transcrip_act, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGORAB_MOUSE
AccessioniPrimary (citable) accession number: Q8BRM2
Secondary accession number(s): Q8CAA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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