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Entry version 157 (08 May 2019)
Sequence version 2 (10 Oct 2003)
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Protein

Histone-lysine N-methyltransferase 2C

Gene

Kmt2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei4817S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4843ZincBy similarity1
Metal bindingi4891ZincBy similarity1
Metal bindingi4893ZincBy similarity1
Metal bindingi4898ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi34 – 46A.T hookAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri226 – 261C2HC pre-PHD-type 1; degeneratePROSITE-ProRule annotationAdd BLAST36
Zinc fingeri282 – 330PHD-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri340 – 390PHD-type 2PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri343 – 388RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri387 – 437PHD-type 3PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri463 – 519PHD-type 4PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri950 – 1003PHD-type 5PROSITE-ProRule annotationAdd BLAST54
Zinc fingeri1000 – 1050PHD-type 6PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1077 – 1132PHD-type 7PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri4391 – 4431C2HC pre-PHD-type 2PROSITE-ProRule annotationAdd BLAST41
Zinc fingeri4452 – 4499PHD-type 8PROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase 2C (EC:2.1.1.43)
Short name:
Lysine N-methyltransferase 2C
Alternative name(s):
Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kmt2c
Synonyms:Mll3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444959 Kmt2c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001248801 – 4903Histone-lysine N-methyltransferase 2CAdd BLAST4903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei751N6-acetyllysineBy similarity1
Modified residuei847PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1497N6-acetyllysineBy similarity1
Modified residuei1761N6-acetyllysineCombined sources1
Modified residuei1983PhosphoserineBy similarity1
Modified residuei2005N6-acetyllysineCombined sources1
Modified residuei2447Asymmetric dimethylarginineCombined sources1
Modified residuei2563Asymmetric dimethylarginineCombined sources1
Modified residuei2796N6-acetyllysineCombined sources1
Modified residuei2803N6-acetyllysineBy similarity1
Modified residuei2822PhosphoserineBy similarity1
Modified residuei2824PhosphotyrosineCombined sources1
Modified residuei2826N6-acetyllysineBy similarity1
Modified residuei2862N6-acetyllysineCombined sources1
Modified residuei3709N6-acetyllysineBy similarity1
Modified residuei4027PhosphoserineBy similarity1
Modified residuei4132Asymmetric dimethylarginineCombined sources1
Modified residuei4260PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BRH4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BRH4

PRoteomics IDEntifications database

More...
PRIDEi
Q8BRH4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BRH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BRH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adult, detected in testis, kidney, spleen and lung, weakly expressed in brain and absent in heart and liver. First detected throughout the embryo at 8 dpc when expression is strong in forebrain neuroepithelium and absent in heart. Expressed in the eye lens between 10 and 14.5 dpc. By 13 dpc, expressed strongly in spinal cord, hand/foot plates and gonads.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with histone H3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61282N

Protein interaction database and analysis system

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IntActi
Q8BRH4, 6 interactors

Molecular INTeraction database

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MINTi
Q8BRH4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000043874

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8BRH4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini435 – 488DHHCPROSITE-ProRule annotationAdd BLAST54
Domaini4537 – 4597FYR N-terminalPROSITE-ProRule annotationAdd BLAST61
Domaini4598 – 4683FYR C-terminalPROSITE-ProRule annotationAdd BLAST86
Domaini4763 – 4879SETPROSITE-ProRule annotationAdd BLAST117
Domaini4887 – 4903Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4840 – 4841S-adenosyl-L-methionine bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1330 – 1352Sequence analysisAdd BLAST23
Coiled coili1743 – 1790Sequence analysisAdd BLAST48
Coiled coili3047 – 3074Sequence analysisAdd BLAST28
Coiled coili3166 – 3193Sequence analysisAdd BLAST28
Coiled coili3224 – 3270Sequence analysisAdd BLAST47
Coiled coili3387 – 3432Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi384 – 487Cys-richAdd BLAST104
Compositional biasi970 – 1099Cys-richAdd BLAST130
Compositional biasi1519 – 1568Pro-richAdd BLAST50
Compositional biasi1708 – 1787Gln-richAdd BLAST80
Compositional biasi1831 – 2622Pro-richAdd BLAST792
Compositional biasi2682 – 2780Asp-richAdd BLAST99
Compositional biasi3022 – 3504Gln-richAdd BLAST483

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri226 – 261C2HC pre-PHD-type 1; degeneratePROSITE-ProRule annotationAdd BLAST36
Zinc fingeri282 – 330PHD-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri340 – 390PHD-type 2PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri343 – 388RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri387 – 437PHD-type 3PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri463 – 519PHD-type 4PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri950 – 1003PHD-type 5PROSITE-ProRule annotationAdd BLAST54
Zinc fingeri1000 – 1050PHD-type 6PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1077 – 1132PHD-type 7PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri4391 – 4431C2HC pre-PHD-type 2PROSITE-ProRule annotationAdd BLAST41
Zinc fingeri4452 – 4499PHD-type 8PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4443 Eukaryota
COG2940 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113602

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BRH4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BRH4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15696 ePHD1_KMT2C, 1 hit
cd15697 ePHD2_KMT2C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit
3.30.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR000637 HMGI/Y_DNA-bd_CS
IPR037877 KMT2C
IPR041967 KMT2C_ePHD1
IPR041968 KMT2C_ePHD2
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR45888:SF1 PTHR45888:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00398 HMG, 1 hit
SM00249 PHD, 8 hits
SM00508 PostSET, 1 hit
SM00184 RING, 4 hits
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095 SSF47095, 1 hit
SSF57903 SSF57903, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50216 DHHC, 1 hit
PS51805 EPHD, 2 hits
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS00354 HMGI_Y, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 5 hits
PS50016 ZF_PHD_2, 6 hits
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BRH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR
60 70 80 90 100
ARKKPRSRGK STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS
110 120 130 140 150
SKQPVSALQR SVSEESANSL VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL
160 170 180 190 200
KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC EKIQNYAPRK QRGQRKERPP
210 220 230 240 250
QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA LFDSTGTCWA
260 270 280 290 300
HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK
310 320 330 340 350
CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG
360 370 380 390 400
DLLDQFFCTT CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS
410 420 430 440 450
KMLVCDTCDK GYHTFCLQPV MKSVPTNGWK CKNCRICIEC GTRSSTQWHH
460 470 480 490 500
NCLICDTCYQ QQDNLCPFCG KCYHPELQKD MLHCNMCKRW VHLECDKPTD
510 520 530 540 550
QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD YASGMEIEGT
560 570 580 590 600
EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI
610 620 630 640 650
TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN
660 670 680 690 700
IEVLPHQTIV PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER
710 720 730 740 750
SLSCKEPLLT ERVQEEMEQK ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD
760 770 780 790 800
KYVELPAEEE STFSSATDLN KADVSSSSTL CSDLPSCDML HGYPPAFNSA
810 820 830 840 850
AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW SNHNTVSPPS
860 870 880 890 900
WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR
910 920 930 940 950
GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ
960 970 980 990 1000
DMCVVCGSFG QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC
1010 1020 1030 1040 1050
TVCEACGKAT DPGRLLLCDD CDISYHTYCL DPPLQTVPKG GWKCKWCVWC
1060 1070 1080 1090 1100
RHCGATSAGL RCEWQNNYTQ CAPCASLSSC PVCCRNYREE DLILQCRQCD
1110 1120 1130 1140 1150
RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS SDCCDSSLVA
1160 1170 1180 1190 1200
QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK
1210 1220 1230 1240 1250
IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG
1260 1270 1280 1290 1300
DDETKGIEGT DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS
1310 1320 1330 1340 1350
SGSISEQLPS RDDGWREQLP DTLVDEPVSV AENTDKIKKR YRKRKNKLEE
1360 1370 1380 1390 1400
TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS EDAAQLSFKT GFLDPSSDPL
1410 1420 1430 1440 1450
LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD LAKSVDHSDI
1460 1470 1480 1490 1500
GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK
1510 1520 1530 1540 1550
IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL
1560 1570 1580 1590 1600
MNGLIGPSPH LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP
1610 1620 1630 1640 1650
NSSWAPTTPS MEGENDTLSN AQRSTLKWEK EEALGEMATV APVLYTNINF
1660 1670 1680 1690 1700
PNLKEEFPDW TTRVKQIAKL WRKASSQERA PYVQKARDNR AALRINKVQM
1710 1720 1730 1740 1750
SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW KFRQQMRQKS
1760 1770 1780 1790 1800
KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS
1810 1820 1830 1840 1850
GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP
1860 1870 1880 1890 1900
PPSTPSRIPV QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT
1910 1920 1930 1940 1950
PRPPPGGHSF PRRNSVTPVE NCVPLSSVPR PIHMNETSAT RPSPARDLCA
1960 1970 1980 1990 2000
SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL PRSPVISEQS TKGPLTTGTS
2010 2020 2030 2040 2050
DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP LHPPPSQDPY
2060 2070 2080 2090 2100
GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE
2110 2120 2130 2140 2150
SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD
2160 2170 2180 2190 2200
PYSQPPGTPR PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL
2210 2220 2230 2240 2250
GPPRPGISVP YSQPPAVPRP RTSEGFTRPS SARPALMPNQ DPFLQAAQNR
2260 2270 2280 2290 2300
VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF THASSSAVRD PYDQPPVTPR
2310 2320 2330 2340 2350
PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ QFSSVSQLPG
2360 2370 2380 2390 2400
PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG
2410 2420 2430 2440 2450
PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV
2460 2470 2480 2490 2500
FPKDQRGPYP PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS
2510 2520 2530 2540 2550
GIPPHIRRPM SMEMPRPSNN PPLNNPVGLP QHFPPQGLPV QQHNILGQAF
2560 2570 2580 2590 2600
IELRHRAPDG RSRLPFAASP SSVIESPSHP RHGNFLPRPD FPGPRHTDPI
2610 2620 2630 2640 2650
RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP LNHPLSGEFS
2660 2670 2680 2690 2700
EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE
2710 2720 2730 2740 2750
VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA
2760 2770 2780 2790 2800
YTDPELDLGD KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL
2810 2820 2830 2840 2850
EDKDLPQRKS SVSSEIKTEA LSPYSKEEIQ SEIKNHDDSR GDADTACSQA
2860 2870 2880 2890 2900
ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE NAGPVVSAIQ GSTPLPARDV
2910 2920 2930 2940 2950
MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS PSTHGSSLPP
2960 2970 2980 2990 3000
TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG
3010 3020 3030 3040 3050
TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD
3060 3070 3080 3090 3100
LLDQERQEQQ QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI
3110 3120 3130 3140 3150
NKVMAQNSLG MPPMVMSRFP FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH
3160 3170 3180 3190 3200
QISRPNPPNF GPGFVNDSQR KQYEEWLQET QQLLQMQQKY LEEQIGAHRK
3210 3220 3230 3240 3250
SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ LEQIRKQQKE
3260 3270 3280 3290 3300
HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF
3310 3320 3330 3340 3350
PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP
3360 3370 3380 3390 3400
IAQLSLKTCT PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL
3410 3420 3430 3440 3450
REQQERQRVQ LMQEVDRQRA LQQRMEMEQH CLMGAELANR TPVSQMPFYG
3460 3470 3480 3490 3500
SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ QNVQQGSVNS PPNQTFMQTN
3510 3520 3530 3540 3550
EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ QSPLRPPFTP
3560 3570 3580 3590 3600
ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK
3610 3620 3630 3640 3650
RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ
3660 3670 3680 3690 3700
RQQEPVEPVP VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD
3710 3720 3730 3740 3750
KPSVETPNKT EEIKLEKAET QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC
3760 3770 3780 3790 3800
PSHPVGTPTT KGDTGNELLK HLLKNKKASS LLTQKPEGTL SSDESSTKDG
3810 3820 3830 3840 3850
KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK KQRSKRTQRT
3860 3870 3880 3890 3900
GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT
3910 3920 3930 3940 3950
PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL
3960 3970 3980 3990 4000
LARAIAQGPK TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP
4010 4020 4030 4040 4050
ESVVGVEVNK YPDLSLVKEE PPEPVPSPII PILPSISGKN SESRRNDIKT
4060 4070 4080 4090 4100
EPGTLFFTSP FGSSPNGPRS GLISVAITLH PTAAENISSV VAAFSDLLHV
4110 4120 4130 4140 4150
RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP PPGSANPPRL
4160 4170 4180 4190 4200
ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG
4210 4220 4230 4240 4250
SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN
4260 4270 4280 4290 4300
KESLPSLPQS PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS
4310 4320 4330 4340 4350
FPPAFEAAKV ESKPDELKVT VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK
4360 4370 4380 4390 4400
KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT CLKPDPVPKD CRKCCFCHEE
4410 4420 4430 4440 4450
GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI NVELALRRGL
4460 4470 4480 4490 4500
QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP
4510 4520 4530 4540 4550
KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI
4560 4570 4580 4590 4600
GQLLPQQMQA FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR
4610 4620 4630 4640 4650
PVFVIRIVEQ GHEDLVLSDS SPKDVWDKIL EPVACVRKKS EMLQLFPAYL
4660 4670 4680 4690 4700
KGEDLFGLTV SAVARIAESL PGVEACENYT FRYGRNPLME LPLAVNPTGC
4710 4720 4730 4740 4750
ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA PYSKQFVHSK
4760 4770 4780 4790 4800
SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE
4810 4820 4830 4840 4850
VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE
4860 4870 4880 4890 4900
VVTFERGHKI IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK

WMN
Length:4,903
Mass (Da):540,187
Last modified:October 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B896490B081BA6C
GO
Isoform 2 (identifier: Q8BRH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-878: Missing.
     1414-1448: Missing.
     1791-3080: Missing.
     3814-3884: Missing.
     4714-4717: Missing.

Show »
Length:3,463
Mass (Da):383,966
Checksum:iD14871D89FC23DAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WI37F8WI37_MOUSE
Histone-lysine N-methyltransferase
Kmt2c Mll3
4,904Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UY45G3UY45_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2c Mll3
1,748Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZC8G3UZC8_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2c Mll3
1,716Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWZ3G3UWZ3_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2c Mll3
1,524Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWI5G3UWI5_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2c Mll3
813Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN11291 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28 – 36SPAAADKRP → RSFVCGCGA in AAN11291 (PubMed:16459028).Curated9
Sequence conflicti276V → A in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti433 – 440NCRICIEC → VSDFLICF in BAC32109 (PubMed:16141072).Curated8
Sequence conflicti533E → G in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti577D → DA in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti675S → C in BAC35712 (PubMed:16141072).Curated1
Sequence conflicti720K → E in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti763F → L in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti791H → Y in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti1324 – 1325VD → LH in AAN11291 (PubMed:16459028).Curated2
Sequence conflicti1737E → V in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti1776Q → R in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti3236M → MM in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti3423 – 3424QR → P in AAN11291 (PubMed:16459028).Curated2
Sequence conflicti3657E → G in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti3668A → V in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti4283C → Y in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti4306E → D in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti4520Q → R in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti4531V → G in AAN11291 (PubMed:16459028).Curated1
Sequence conflicti4649Y → H in AAN11291 (PubMed:16459028).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020568839 – 878Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0205691414 – 1448Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0205701791 – 3080Missing in isoform 2. 1 PublicationAdd BLAST1290
Alternative sequenceiVSP_0205713814 – 3884Missing in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0205724714 – 4717Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY138582 mRNA Translation: AAN11291.1 Different initiation.
AC116469 Genomic DNA No translation available.
AC127319 Genomic DNA No translation available.
AC134910 Genomic DNA No translation available.
AK044828 mRNA Translation: BAC32109.1
AK054270 mRNA Translation: BAC35712.2
AK077567 mRNA Translation: BAC36867.1
AY036886 mRNA Translation: AAK70213.1
AY036887 mRNA Translation: AAK70214.1

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138582 mRNA Translation: AAN11291.1 Different initiation.
AC116469 Genomic DNA No translation available.
AC127319 Genomic DNA No translation available.
AC134910 Genomic DNA No translation available.
AK044828 mRNA Translation: BAC32109.1
AK054270 mRNA Translation: BAC35712.2
AK077567 mRNA Translation: BAC36867.1
AY036886 mRNA Translation: AAK70213.1
AY036887 mRNA Translation: AAK70214.1

3D structure databases

SMRiQ8BRH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61282N
IntActiQ8BRH4, 6 interactors
MINTiQ8BRH4
STRINGi10090.ENSMUSP00000043874

PTM databases

iPTMnetiQ8BRH4
PhosphoSitePlusiQ8BRH4

Proteomic databases

jPOSTiQ8BRH4
PaxDbiQ8BRH4
PRIDEiQ8BRH4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2444959 Kmt2c

Phylogenomic databases

eggNOGiKOG4443 Eukaryota
COG2940 LUCA
HOGENOMiHOG000113602
InParanoidiQ8BRH4
PhylomeDBiQ8BRH4

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kmt2c mouse

Protein Ontology

More...
PROi
PR:Q8BRH4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd15696 ePHD1_KMT2C, 1 hit
cd15697 ePHD2_KMT2C, 1 hit
Gene3Di1.10.30.10, 1 hit
3.30.40.10, 7 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR000637 HMGI/Y_DNA-bd_CS
IPR037877 KMT2C
IPR041967 KMT2C_ePHD1
IPR041968 KMT2C_ePHD2
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45888:SF1 PTHR45888:SF1, 1 hit
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00398 HMG, 1 hit
SM00249 PHD, 8 hits
SM00508 PostSET, 1 hit
SM00184 RING, 4 hits
SM00317 SET, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
SSF57903 SSF57903, 6 hits
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
PS51805 EPHD, 2 hits
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS00354 HMGI_Y, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 5 hits
PS50016 ZF_PHD_2, 6 hits
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKMT2C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BRH4
Secondary accession number(s): Q5YLV9
, Q8BK12, Q8C6M3, Q923H5, Q923H6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: May 8, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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