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Protein

Transmembrane protein 209

Gene

Tmem209

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 209
Gene namesi
Name:Tmem209
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919899 Tmem209

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316331 – 561Transmembrane protein 209Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei98PhosphoserineBy similarity1
Modified residuei201PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei278PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BRG8
PeptideAtlasiQ8BRG8
PRIDEiQ8BRG8

PTM databases

iPTMnetiQ8BRG8
PhosphoSitePlusiQ8BRG8

Expressioni

Gene expression databases

BgeeiENSMUSG00000029782 Expressed in 267 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ8BRG8 baseline and differential
GenevisibleiQ8BRG8 MM

Interactioni

Protein-protein interaction databases

BioGridi215490, 1 interactor
IntActiQ8BRG8, 2 interactors
STRINGi10090.ENSMUSP00000110813

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 201Ser-richAdd BLAST76

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4670 Eukaryota
ENOG410XQWI LUCA
GeneTreeiENSGT00390000013963
HOGENOMiHOG000154623
HOVERGENiHBG056529
InParanoidiQ8BRG8
OMAiSSFRWNG
OrthoDBiEOG091G047K
PhylomeDBiQ8BRG8
TreeFamiTF320043

Family and domain databases

InterProiView protein in InterPro
IPR019176 Cytochrome_B561-rel
PANTHERiPTHR21780 PTHR21780, 1 hit
PfamiView protein in Pfam
PF09786 CytochromB561_N, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BRG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQGDVSPNP SLIDRTIKMR KETETRKVVL AWGLLNVSMA GMIYTEMTGK
60 70 80 90 100
LISTYYNVTY WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG
110 120 130 140 150
QQALLGLKQA VVQTTPPRDL AATQISPSPP SPSIQGQSVL SYSPSRSPST
160 170 180 190 200
SPKFATSCMT GYSPQLQGLS SGGLGSYSPG VTYSPVSGYN KLASFSLSPS
210 220 230 240 250
SPYPTTVGPV ESSGLRARYR SPPTVYNSPT DKEDYMTDLR TLDTFLRSEE
260 270 280 290 300
EKQHRVKLGS PDSTSPSTSP TFWNYSRSVG DYAQTLKKFQ YQLACRSQAP
310 320 330 340 350
CANKDEADLI SKQAAEEVWA RVTMNRQLLD HMDSWTAKFR NWISETILVP
360 370 380 390 400
LVQEIESVST QMRRMGCPEL QIGEASVTSL KQAALVRAPL IPTLNAIVQY
410 420 430 440 450
LDLTPNQEYL FERIKELSQG GCMSSFRWNR GGDFKGRKWD TDLPTDSAII
460 470 480 490 500
MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV QTPNKPDVTN ENVFCIYQSA
510 520 530 540 550
VNPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES GMLGRVNLGL
560
SGVNILWIFG E
Length:561
Mass (Da):62,982
Last modified:March 1, 2003 - v1
Checksum:i0BE88792DD6BAE05
GO
Isoform 2 (identifier: Q8BRG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: Missing.

Show »
Length:560
Mass (Da):62,851
Checksum:i1E51896C09D39E05
GO
Isoform 3 (identifier: Q8BRG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-448: Missing.
     545-561: RVNLGLSGVNILWIFGE → N

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):49,202
Checksum:i7DF3FD82D30AED09
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGT2F8WGT2_MOUSE
Transmembrane protein 209
Tmem209
519Annotation score:
D3YZT2D3YZT2_MOUSE
Transmembrane protein 209
Tmem209
140Annotation score:
Q8C214Q8C214_MOUSE
Transmembrane protein 209
Tmem209
403Annotation score:
A0A0N4SVU6A0A0N4SVU6_MOUSE
Transmembrane protein 209
Tmem209
66Annotation score:

Sequence cautioni

The sequence BAC41016 differs from that shown. Reason: Frameshift at position 553.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39M → I in BAC37329 (PubMed:16141072).Curated1
Sequence conflicti68L → V in BAC37329 (PubMed:16141072).Curated1
Sequence conflicti407Q → R in BAC37329 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0332841Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_033285342 – 448Missing in isoform 3. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_033286545 – 561RVNLG…WIFGE → N in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029366 mRNA Translation: BAC26420.1
AK044877 mRNA Translation: BAC32126.1
AK078544 mRNA Translation: BAC37329.1
AK089962 mRNA Translation: BAC41016.1 Frameshift.
BC057109 mRNA Translation: AAH57109.1
BC052187 mRNA Translation: AAH52187.1
CCDSiCCDS19972.1 [Q8BRG8-1]
CCDS80511.1 [Q8BRG8-2]
RefSeqiNP_001298022.1, NM_001311093.1 [Q8BRG8-2]
NP_848740.3, NM_178625.4 [Q8BRG8-1]
XP_006505233.2, XM_006505170.3 [Q8BRG8-2]
UniGeneiMm.45418

Genome annotation databases

EnsembliENSMUST00000064330; ENSMUSP00000067667; ENSMUSG00000029782 [Q8BRG8-3]
ENSMUST00000115157; ENSMUSP00000110810; ENSMUSG00000029782 [Q8BRG8-2]
ENSMUST00000115160; ENSMUSP00000110813; ENSMUSG00000029782 [Q8BRG8-1]
ENSMUST00000138823; ENSMUSP00000138292; ENSMUSG00000029782 [Q8BRG8-1]
GeneIDi72649
KEGGimmu:72649
UCSCiuc009bfi.1 mouse [Q8BRG8-3]
uc009bfj.1 mouse [Q8BRG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029366 mRNA Translation: BAC26420.1
AK044877 mRNA Translation: BAC32126.1
AK078544 mRNA Translation: BAC37329.1
AK089962 mRNA Translation: BAC41016.1 Frameshift.
BC057109 mRNA Translation: AAH57109.1
BC052187 mRNA Translation: AAH52187.1
CCDSiCCDS19972.1 [Q8BRG8-1]
CCDS80511.1 [Q8BRG8-2]
RefSeqiNP_001298022.1, NM_001311093.1 [Q8BRG8-2]
NP_848740.3, NM_178625.4 [Q8BRG8-1]
XP_006505233.2, XM_006505170.3 [Q8BRG8-2]
UniGeneiMm.45418

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215490, 1 interactor
IntActiQ8BRG8, 2 interactors
STRINGi10090.ENSMUSP00000110813

PTM databases

iPTMnetiQ8BRG8
PhosphoSitePlusiQ8BRG8

Proteomic databases

PaxDbiQ8BRG8
PeptideAtlasiQ8BRG8
PRIDEiQ8BRG8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064330; ENSMUSP00000067667; ENSMUSG00000029782 [Q8BRG8-3]
ENSMUST00000115157; ENSMUSP00000110810; ENSMUSG00000029782 [Q8BRG8-2]
ENSMUST00000115160; ENSMUSP00000110813; ENSMUSG00000029782 [Q8BRG8-1]
ENSMUST00000138823; ENSMUSP00000138292; ENSMUSG00000029782 [Q8BRG8-1]
GeneIDi72649
KEGGimmu:72649
UCSCiuc009bfi.1 mouse [Q8BRG8-3]
uc009bfj.1 mouse [Q8BRG8-1]

Organism-specific databases

CTDi84928
MGIiMGI:1919899 Tmem209

Phylogenomic databases

eggNOGiKOG4670 Eukaryota
ENOG410XQWI LUCA
GeneTreeiENSGT00390000013963
HOGENOMiHOG000154623
HOVERGENiHBG056529
InParanoidiQ8BRG8
OMAiSSFRWNG
OrthoDBiEOG091G047K
PhylomeDBiQ8BRG8
TreeFamiTF320043

Miscellaneous databases

PROiPR:Q8BRG8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029782 Expressed in 267 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ8BRG8 baseline and differential
GenevisibleiQ8BRG8 MM

Family and domain databases

InterProiView protein in InterPro
IPR019176 Cytochrome_B561-rel
PANTHERiPTHR21780 PTHR21780, 1 hit
PfamiView protein in Pfam
PF09786 CytochromB561_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM209_MOUSE
AccessioniPrimary (citable) accession number: Q8BRG8
Secondary accession number(s): Q80WQ3
, Q8BP02, Q8C202, Q8CDY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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