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Protein

Sec1 family domain-containing protein 1

Gene

Scfd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sec1 family domain-containing protein 1
Alternative name(s):
Syntaxin-binding protein 1-like 2
Gene namesi
Name:Scfd1
Synonyms:Stxbp1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1924233 Scfd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062881 – 639Sec1 family domain-containing protein 1Add BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei300PhosphoserineCombined sources1
Modified residuei525PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BRF7
PaxDbiQ8BRF7
PeptideAtlasiQ8BRF7
PRIDEiQ8BRF7

PTM databases

iPTMnetiQ8BRF7
PhosphoSitePlusiQ8BRF7

Expressioni

Gene expression databases

BgeeiENSMUSG00000020952 Expressed in 273 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SCFD1
ExpressionAtlasiQ8BRF7 baseline and differential
GenevisibleiQ8BRF7 MM

Interactioni

Subunit structurei

Interacts with STX17. Interacts with STX5A. Interacts with the COG complex via COG4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218443, 1 interactor
IntActiQ8BRF7, 3 interactors
MINTiQ8BRF7
STRINGi10090.ENSMUSP00000021335

Structurei

3D structure databases

ProteinModelPortaliQ8BRF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1301 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00550000074845
HOGENOMiHOG000199564
HOVERGENiHBG061536
InParanoidiQ8BRF7
KOiK19998
OMAiIWKVLVF
OrthoDBiEOG091G04JV
PhylomeDBiQ8BRF7
TreeFamiTF105740

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BRF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGSKMAATA SIRERQTVAL KRMLNFNVPH VKNSTGEPVW KVLIYDRFGQ
60 70 80 90 100
DIISPLLSVK ELRDMGITLH LLLHSDRDPI PDVPAVYFVM PTEENIDRLC
110 120 130 140 150
QDLRNQLYES YYLNFISAIS RSKLEDIANA ALAASAVTQV AKVFDQYLNF
160 170 180 190 200
ITLEDDMFVL CNQNKELVSY RAINRPDITD TEMETVMDTI VDSLFCFFVT
210 220 230 240 250
LGAVPIIRCS RGTAAEMVAV KLDKKLRENL RDARNSLFTG DPLGTGQFSF
260 270 280 290 300
QRPLLVLVDR NIDLATPLHH TWTYQALVHD VLDFHLNRVN LEESTGVENS
310 320 330 340 350
PAGARPKRKN KKSYDLTPVD KFWQKHKGSP FPEVAESVQQ ELESYRAQED
360 370 380 390 400
EVKRLKSIMG LEGEDEGAIS MLSDNTAKLT SAVSSLPELL EKKRLIDLHT
410 420 430 440 450
NVATAVLEHI KARKLDVYFE YEEKIMSKTT LDKSLLDVIS DPDAGTPEDK
460 470 480 490 500
MRLFLIYYIS AQQAPSEVDL EQYKKALTDA GCNLSPLQYI KQWKAFAKMA
510 520 530 540 550
STPASYGNTT TKPMGLLSRV MNTGSQFVME GVKNLVLKQQ NLPVTRILDN
560 570 580 590 600
LMEMKSNPET DDYRYFDPKM LRSNDSSVPR NKSPFQEAIV FVVGGGNYIE
610 620 630
YQNLVDYIKA KQGKHILYGC SEIFNATQFI KQLSQLGQK
Length:639
Mass (Da):72,323
Last modified:March 1, 2003 - v1
Checksum:iD7058563F8549322
GO
Isoform 2 (identifier: Q8BRF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-390: SLPELL → ALMSVH
     391-639: Missing.

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):43,998
Checksum:i21391FF3AC49A6D6
GO
Isoform 3 (identifier: Q8BRF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-597: VPRNKSPFQEAIVFVVGGGN → FLYKTEEPPASQEGGPGIPS
     598-639: Missing.

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):67,407
Checksum:iF6733FFE4C697028
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6R7A0A1W2P6R7_MOUSE
Sec1 family domain-containing prote...
Scfd1
159Annotation score:

Sequence cautioni

The sequence AAH27793 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328G → E in BAB29141 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011310385 – 390SLPELL → ALMSVH in isoform 2. 1 Publication6
Alternative sequenceiVSP_011311391 – 639Missing in isoform 2. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_011312578 – 597VPRNK…VGGGN → FLYKTEEPPASQEGGPGIPS in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_011313598 – 639Missing in isoform 3. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014070 mRNA Translation: BAB29141.1
AK041028 mRNA Translation: BAC30788.1
AK044943 mRNA Translation: BAC32152.1
BC027793 mRNA Translation: AAH27793.1 Different initiation.
CCDSiCCDS36439.1 [Q8BRF7-1]
RefSeqiNP_001293107.1, NM_001306178.1 [Q8BRF7-2]
NP_084101.1, NM_029825.3 [Q8BRF7-1]
UniGeneiMm.216511

Genome annotation databases

EnsembliENSMUST00000021335; ENSMUSP00000021335; ENSMUSG00000020952 [Q8BRF7-1]
ENSMUST00000219434; ENSMUSP00000151347; ENSMUSG00000020952 [Q8BRF7-2]
GeneIDi76983
KEGGimmu:76983
UCSCiuc007nmo.1 mouse [Q8BRF7-2]
uc007nmq.1 mouse [Q8BRF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014070 mRNA Translation: BAB29141.1
AK041028 mRNA Translation: BAC30788.1
AK044943 mRNA Translation: BAC32152.1
BC027793 mRNA Translation: AAH27793.1 Different initiation.
CCDSiCCDS36439.1 [Q8BRF7-1]
RefSeqiNP_001293107.1, NM_001306178.1 [Q8BRF7-2]
NP_084101.1, NM_029825.3 [Q8BRF7-1]
UniGeneiMm.216511

3D structure databases

ProteinModelPortaliQ8BRF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218443, 1 interactor
IntActiQ8BRF7, 3 interactors
MINTiQ8BRF7
STRINGi10090.ENSMUSP00000021335

PTM databases

iPTMnetiQ8BRF7
PhosphoSitePlusiQ8BRF7

Proteomic databases

EPDiQ8BRF7
PaxDbiQ8BRF7
PeptideAtlasiQ8BRF7
PRIDEiQ8BRF7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021335; ENSMUSP00000021335; ENSMUSG00000020952 [Q8BRF7-1]
ENSMUST00000219434; ENSMUSP00000151347; ENSMUSG00000020952 [Q8BRF7-2]
GeneIDi76983
KEGGimmu:76983
UCSCiuc007nmo.1 mouse [Q8BRF7-2]
uc007nmq.1 mouse [Q8BRF7-1]

Organism-specific databases

CTDi23256
MGIiMGI:1924233 Scfd1

Phylogenomic databases

eggNOGiKOG1301 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00550000074845
HOGENOMiHOG000199564
HOVERGENiHBG061536
InParanoidiQ8BRF7
KOiK19998
OMAiIWKVLVF
OrthoDBiEOG091G04JV
PhylomeDBiQ8BRF7
TreeFamiTF105740

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport

Miscellaneous databases

PROiPR:Q8BRF7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020952 Expressed in 273 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SCFD1
ExpressionAtlasiQ8BRF7 baseline and differential
GenevisibleiQ8BRF7 MM

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCFD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BRF7
Secondary accession number(s): Q8BRZ2, Q8K179, Q9CXR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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