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Protein

Cilia- and flagella-associated protein 91

Gene

Maats1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). May play a role in spermatogenesis (PubMed:12223483).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 91By similarity
Short name:
CFAP91Curated
Alternative name(s):
AMY-1-associating protein expressed in testis 1 homolog
Short name:
AAT-1
MYCBP/AMY-1-associated testis-expressed protein 1
Protein MAATS1Curated
Gene namesi
Name:Maats1Imported
Synonyms:Aat1, Cfap91Curated, Spata26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443598 Maats1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644191 – 783Cilia- and flagella-associated protein 91Add BLAST783

Post-translational modificationi

Phosphorylated by PKA.By similarity

Proteomic databases

MaxQBiQ8BRC6
PaxDbiQ8BRC6
PRIDEiQ8BRC6

PTM databases

iPTMnetiQ8BRC6
PhosphoSitePlusiQ8BRC6

Expressioni

Tissue specificityi

Expressed in the testis, in cells involved in spermatogenesis.1 Publication

Developmental stagei

Expression begins in 1 week old mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000022805 Expressed in 69 organ(s), highest expression level in testis
CleanExiMM_4932425I24RIK
GenevisibleiQ8BRC6 MM

Interactioni

Subunit structurei

Part of a complex containing MYCBP, AKAP1 and PRKAR2B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023501

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG6N Eukaryota
ENOG410XQ2Y LUCA
GeneTreeiENSGT00390000003024
HOGENOMiHOG000185870
InParanoidiQ8BRC6
OMAiCLPDFVT
OrthoDBiEOG091G02QA
TreeFamiTF328648

Family and domain databases

InterProiView protein in InterPro
IPR026720 CFAP91
IPR032840 CFAP91_dom
PANTHERiPTHR22455 PTHR22455, 1 hit
PfamiView protein in Pfam
PF14738 PaaSYMP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BRC6-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQTVTIQEP RPNDQRIPYQ CREVRRAKGG FANRTYDYLY DPLFIVSSER
60 70 80 90 100
DHAQANIQAT LIRSRLKKVP NFRSMFSNLF HHPRYSMYWS KTDPVPLHVT
110 120 130 140 150
REWRGQEAKH KEVLRLQAAM DTSFQMPKEK DEDPDVSGKN RYKFFDRPFL
160 170 180 190 200
PFLQQMPLNV VLSPVKTQPL LLTPESSKYA IIPTKSTVAT QTDYRDADVQ
210 220 230 240 250
TDPYSPEYVV CQDTIPELLT LANLTWGRGL PAGQAEVEII ERAREKRAWE
260 270 280 290 300
ATLPPLNDSV QAEKRRKMMN AMERKEWAFR EGEIEKLQEL RLEVLKQLLK
310 320 330 340 350
RREEDQNELN MRHLNDQWYK LQEAKEAKVA QIRHKHVSDI RKLMGKGKNI
360 370 380 390 400
EGKLQRRDII SDYSNFASQV YGPLSRLGRF PDNNSEDFVV RNHYLNTYEG
410 420 430 440 450
LVELESSLPD FVTQPRIKPP KPQIITTKAG FLKRTARMDY ELAEVHKALV
460 470 480 490 500
DKKNKGLEGT KSLRFLQKNP ISQARLPTPS LEMTSYEEGE IEMAVIYLQK
510 520 530 540 550
LLRGRVVQNM MFEGKEKRLE LILELRTSHA LQEDDKLVKK AEKQVTLALQ
560 570 580 590 600
RQRNLHEDKL SVIENHLGDL EGRVLADMFD FLSKELVRLQ EERRIHAFAM
610 620 630 640 650
LAERQRRMRE AEESGRRQVE QKRLQQEDMI FKEVIKVHQS TVTSYLEDII
660 670 680 690 700
LNTEERTAEE QARKEIEKIA EEINNIAYEM ENRRTYLQSE EIVAELVYSF
710 720 730 740 750
LIPEVQKDFV KEKVRNAQRK HILAAHEIIH SNTETMLEEQ VYKELQSEDF
760 770 780
ELEEEAESLD SEVPTVSVSK TSTIKPTQDE GEG
Note: No experimental confirmation available.
Length:783
Mass (Da):91,623
Last modified:March 6, 2013 - v3
Checksum:i12237970B7041685
GO
Isoform 2 (identifier: Q8BRC6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     339-345: DIRKLMG → EAEEMAQ
     346-783: Missing.

Show »
Length:345
Mass (Da):40,598
Checksum:i216993D183D22766
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238E → K in BAC32231 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045751339 – 345DIRKLMG → EAEEMAQ in isoform 2. 1 Publication7
Alternative sequenceiVSP_045752346 – 783Missing in isoform 2. 1 PublicationAdd BLAST438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045121 mRNA Translation: BAC32231.1
AC154809 Genomic DNA No translation available.
CCDSiCCDS37341.1 [Q8BRC6-2]
RefSeqiNP_001074494.1, NM_001081025.1 [Q8BRC6-2]
UniGeneiMm.294342

Genome annotation databases

EnsembliENSMUST00000023501; ENSMUSP00000023501; ENSMUSG00000022805 [Q8BRC6-2]
ENSMUST00000114740; ENSMUSP00000110388; ENSMUSG00000022805 [Q8BRC6-1]
GeneIDi320214
KEGGimmu:320214
UCSCiuc007zer.1 mouse [Q8BRC6-2]
uc007zes.1 mouse [Q8BRC6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045121 mRNA Translation: BAC32231.1
AC154809 Genomic DNA No translation available.
CCDSiCCDS37341.1 [Q8BRC6-2]
RefSeqiNP_001074494.1, NM_001081025.1 [Q8BRC6-2]
UniGeneiMm.294342

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023501

PTM databases

iPTMnetiQ8BRC6
PhosphoSitePlusiQ8BRC6

Proteomic databases

MaxQBiQ8BRC6
PaxDbiQ8BRC6
PRIDEiQ8BRC6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023501; ENSMUSP00000023501; ENSMUSG00000022805 [Q8BRC6-2]
ENSMUST00000114740; ENSMUSP00000110388; ENSMUSG00000022805 [Q8BRC6-1]
GeneIDi320214
KEGGimmu:320214
UCSCiuc007zer.1 mouse [Q8BRC6-2]
uc007zes.1 mouse [Q8BRC6-1]

Organism-specific databases

CTDi89876
MGIiMGI:2443598 Maats1

Phylogenomic databases

eggNOGiENOG410IG6N Eukaryota
ENOG410XQ2Y LUCA
GeneTreeiENSGT00390000003024
HOGENOMiHOG000185870
InParanoidiQ8BRC6
OMAiCLPDFVT
OrthoDBiEOG091G02QA
TreeFamiTF328648

Miscellaneous databases

PROiPR:Q8BRC6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022805 Expressed in 69 organ(s), highest expression level in testis
CleanExiMM_4932425I24RIK
GenevisibleiQ8BRC6 MM

Family and domain databases

InterProiView protein in InterPro
IPR026720 CFAP91
IPR032840 CFAP91_dom
PANTHERiPTHR22455 PTHR22455, 1 hit
PfamiView protein in Pfam
PF14738 PaaSYMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFA91_MOUSE
AccessioniPrimary (citable) accession number: Q8BRC6
Secondary accession number(s): E9PZ32, E9QND1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 6, 2013
Last modified: November 7, 2018
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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