Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sin3 histone deacetylase corepressor complex component SDS3

Gene

Suds3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: MGI
  • histone deacetylase binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Sin3 histone deacetylase corepressor complex component SDS3
Alternative name(s):
Suppressor of defective silencing 3 protein homolog
Gene namesi
Name:Suds3
Synonyms:Sds3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919204 Suds3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000976532 – 328Sin3 histone deacetylase corepressor complex component SDS3Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei228PhosphoserineBy similarity1
Modified residuei234PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei244PhosphothreonineBy similarity1

Post-translational modificationi

Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BR65
MaxQBiQ8BR65
PaxDbiQ8BR65
PeptideAtlasiQ8BR65
PRIDEiQ8BR65

PTM databases

iPTMnetiQ8BR65
PhosphoSitePlusiQ8BR65

Expressioni

Tissue specificityi

Expressed in all newborn tissues tested, including brain, kidney and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000066900 Expressed in 291 organ(s), highest expression level in testis
ExpressionAtlasiQ8BR65 baseline and differential
GenevisibleiQ8BR65 MM

Interactioni

Subunit structurei

Interacts with HCFC1 (By similarity). Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct (By similarity). Interacts with FOXK2 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215053, 9 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CPX-3444 SIN3B histone deacetylase complex
CORUMiQ8BR65
IntActiQ8BR65, 3 interactors
MINTiQ8BR65
STRINGi10090.ENSMUSP00000130535

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8BR65
SMRiQ8BR65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 170Mediates interaction with USP17L2By similarityAdd BLAST169
Regioni188 – 226Sin3 interaction domain (SID)Add BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 171Sequence analysisAdd BLAST106

Domaini

The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.By similarity

Sequence similaritiesi

Belongs to the SDS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144281
HOGENOMiHOG000007054
HOVERGENiHBG108465
InParanoidiQ8BR65
KOiK19201
PhylomeDBiQ8BR65
TreeFamiTF323740

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BR65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAGLLAPA PAPAAAPAAP EYYPEDEEEL ESAEDDERSC RGRESDEDTE
60 70 80 90 100
DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK
110 120 130 140 150
KLDQQYRERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL
160 170 180 190 200
IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR
210 220 230 240 250
KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA
260 270 280 290 300
QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR
310 320
KTSDSTKMRI YVGQLQRGLF VIRRRSAA
Length:328
Mass (Da):38,107
Last modified:March 1, 2003 - v1
Checksum:i05C22EA578C318E8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J243A0A0R4J243_MOUSE
Sin3 histone deacetylase corepresso...
Suds3
332Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142K → N in BAC31608 (PubMed:16141072).Curated1
Sequence conflicti186R → W in AAM22676 (PubMed:11909966).Curated1
Sequence conflicti326 – 328SAA → KFLTYRD in AAH62176 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469109 mRNA Translation: AAM22676.1
AK043652 mRNA Translation: BAC31608.1
AK045475 mRNA Translation: BAC32387.1
AK138947 mRNA Translation: BAE23831.1
AK150633 mRNA Translation: BAE29722.1
BC055764 mRNA Translation: AAH55764.2
BC062176 mRNA Translation: AAH62176.1
CCDSiCCDS39232.1
RefSeqiNP_001116138.1, NM_001122666.2
NP_848737.3, NM_178622.5
UniGeneiMm.34456

Genome annotation databases

EnsembliENSMUST00000086471; ENSMUSP00000083662; ENSMUSG00000066900
GeneIDi71954
KEGGimmu:71954
UCSCiuc008zff.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469109 mRNA Translation: AAM22676.1
AK043652 mRNA Translation: BAC31608.1
AK045475 mRNA Translation: BAC32387.1
AK138947 mRNA Translation: BAE23831.1
AK150633 mRNA Translation: BAE29722.1
BC055764 mRNA Translation: AAH55764.2
BC062176 mRNA Translation: AAH62176.1
CCDSiCCDS39232.1
RefSeqiNP_001116138.1, NM_001122666.2
NP_848737.3, NM_178622.5
UniGeneiMm.34456

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N2HNMR-A205-228[»]
4ZQAX-ray1.65A90-172[»]
ProteinModelPortaliQ8BR65
SMRiQ8BR65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215053, 9 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CPX-3444 SIN3B histone deacetylase complex
CORUMiQ8BR65
IntActiQ8BR65, 3 interactors
MINTiQ8BR65
STRINGi10090.ENSMUSP00000130535

PTM databases

iPTMnetiQ8BR65
PhosphoSitePlusiQ8BR65

Proteomic databases

EPDiQ8BR65
MaxQBiQ8BR65
PaxDbiQ8BR65
PeptideAtlasiQ8BR65
PRIDEiQ8BR65

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086471; ENSMUSP00000083662; ENSMUSG00000066900
GeneIDi71954
KEGGimmu:71954
UCSCiuc008zff.3 mouse

Organism-specific databases

CTDi64426
MGIiMGI:1919204 Suds3

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144281
HOGENOMiHOG000007054
HOVERGENiHBG108465
InParanoidiQ8BR65
KOiK19201
PhylomeDBiQ8BR65
TreeFamiTF323740

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

PROiPR:Q8BR65
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066900 Expressed in 291 organ(s), highest expression level in testis
ExpressionAtlasiQ8BR65 baseline and differential
GenevisibleiQ8BR65 MM

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDS3_MOUSE
AccessioniPrimary (citable) accession number: Q8BR65
Secondary accession number(s): Q3UC92
, Q6P6K1, Q7TNT0, Q8BRR7, Q8K5B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again