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Protein

Protein FAM69C

Gene

Fam69c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM69C
Gene namesi
Name:Fam69c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3041188 Fam69c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 410LumenalSequence analysisAdd BLAST370

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002867081 – 410Protein FAM69CAdd BLAST410

Post-translational modificationi

Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8BQT2
PRIDEiQ8BQT2

Expressioni

Tissue specificityi

Mainly expressed in the brain and eye, some expression in kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000047992 Expressed in 27 organ(s), highest expression level in vestibular labyrinth
CleanExiMM_B230399E16RIK
ExpressionAtlasiQ8BQT2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ8BQT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 19May mediate ER retention2

Sequence similaritiesi

Belongs to the FAM69 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH7Q Eukaryota
ENOG410ZZZ5 LUCA
GeneTreeiENSGT00390000006452
HOGENOMiHOG000111953
HOVERGENiHBG094879
InParanoidiQ8BQT2
OMAiWHGQVAS
OrthoDBiEOG091G06T4
PhylomeDBiQ8BQT2
TreeFamiTF313319

Family and domain databases

InterProiView protein in InterPro
IPR022049 FAM69_kinase_dom
IPR029244 FAM69_N
PfamiView protein in Pfam
PF12260 PIP49_C, 1 hit
PF14875 PIP49_N, 1 hit
SMARTiView protein in SMART
SM01299 PIP49_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BQT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARAAGERGR AARCGRWRRG ALLAFAAWTA GWVLAAALLL RAHPSVLSER
60 70 80 90 100
CTDEKSRRIL AALCQDYRRG WLTGALCEDL CVGGELLYQR CLYYERGKKV
110 120 130 140 150
LQAQWRGRTV VLKSKREAFS SFPPLTLLEE EAGAGAPGIP EAELLLMVAG
160 170 180 190 200
EVKNTLGLEL PNNSIAPLWP ARQGPGWRQQ LASAWSLLQQ EEYVYFSLLP
210 220 230 240 250
DLSRHILPVL GSCGHFYAVE YLAAGSPHHK ALFPLDDAGQ AQAISHIALS
260 270 280 290 300
FLDMVSHFDS DFSHRLHLCD VKPENFAIKR DFTVVAIDVD MAFFEPKMRE
310 320 330 340 350
ILEQNCTGDE DCNFFDCFSK CDLRVHKCGA QRVNSNLQVI CDKIFRHWFS
360 370 380 390 400
STHRSPAVSL QLRLQLQQAV QECAQHGGSS GNSWTASSSV FWKLRWLLQA
410
TLKELQEAEK
Length:410
Mass (Da):45,976
Last modified:May 18, 2010 - v2
Checksum:i306CBDAFDF165D44
GO
Isoform 2 (identifier: Q8BQT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Show »
Length:264
Mass (Da):29,833
Checksum:i2868834A09FBE3ED
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXZ4E0CXZ4_MOUSE
Protein FAM69C
Fam69c
56Annotation score:

Sequence cautioni

The sequence AAI19041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI19043 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0390891 – 146Missing in isoform 2. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046504 mRNA Translation: BAC32758.1
AC142448 Genomic DNA No translation available.
BC119040 mRNA Translation: AAI19041.1 Different initiation.
BC119042 mRNA Translation: AAI19043.1 Different initiation.
CCDSiCCDS29384.1 [Q8BQT2-2]
RefSeqiNP_776131.1, NM_173770.4 [Q8BQT2-2]
XP_006526534.1, XM_006526471.3 [Q8BQT2-1]
XP_006526538.1, XM_006526475.2 [Q8BQT2-2]
XP_017173394.1, XM_017317905.1 [Q8BQT2-2]
XP_017173395.1, XM_017317906.1 [Q8BQT2-2]
UniGeneiMm.472378

Genome annotation databases

EnsembliENSMUST00000052501; ENSMUSP00000057697; ENSMUSG00000047992 [Q8BQT2-2]
GeneIDi240479
KEGGimmu:240479
UCSCiuc008fuv.1 mouse [Q8BQT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046504 mRNA Translation: BAC32758.1
AC142448 Genomic DNA No translation available.
BC119040 mRNA Translation: AAI19041.1 Different initiation.
BC119042 mRNA Translation: AAI19043.1 Different initiation.
CCDSiCCDS29384.1 [Q8BQT2-2]
RefSeqiNP_776131.1, NM_173770.4 [Q8BQT2-2]
XP_006526534.1, XM_006526471.3 [Q8BQT2-1]
XP_006526538.1, XM_006526475.2 [Q8BQT2-2]
XP_017173394.1, XM_017317905.1 [Q8BQT2-2]
XP_017173395.1, XM_017317906.1 [Q8BQT2-2]
UniGeneiMm.472378

3D structure databases

ProteinModelPortaliQ8BQT2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ8BQT2
PRIDEiQ8BQT2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052501; ENSMUSP00000057697; ENSMUSG00000047992 [Q8BQT2-2]
GeneIDi240479
KEGGimmu:240479
UCSCiuc008fuv.1 mouse [Q8BQT2-1]

Organism-specific databases

CTDi125704
MGIiMGI:3041188 Fam69c

Phylogenomic databases

eggNOGiENOG410IH7Q Eukaryota
ENOG410ZZZ5 LUCA
GeneTreeiENSGT00390000006452
HOGENOMiHOG000111953
HOVERGENiHBG094879
InParanoidiQ8BQT2
OMAiWHGQVAS
OrthoDBiEOG091G06T4
PhylomeDBiQ8BQT2
TreeFamiTF313319

Miscellaneous databases

ChiTaRSiFam69c mouse
PROiPR:Q8BQT2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047992 Expressed in 27 organ(s), highest expression level in vestibular labyrinth
CleanExiMM_B230399E16RIK
ExpressionAtlasiQ8BQT2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR022049 FAM69_kinase_dom
IPR029244 FAM69_N
PfamiView protein in Pfam
PF12260 PIP49_C, 1 hit
PF14875 PIP49_N, 1 hit
SMARTiView protein in SMART
SM01299 PIP49_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA69C_MOUSE
AccessioniPrimary (citable) accession number: Q8BQT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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