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Protein

Probable palmitoyltransferase ZDHHC14

Gene

Zdhhc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei195S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

  • palmitoyltransferase activity Source: MGI
  • protein-cysteine S-palmitoyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC14 (EC:2.3.1.225)
Alternative name(s):
NEW1 domain-containing protein
Short name:
NEW1CP
Zinc finger DHHC domain-containing protein 14
Short name:
DHHC-14
Gene namesi
Name:Zdhhc14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2653229 Zdhhc14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128921 – 489Probable palmitoyltransferase ZDHHC14Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei456PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ8BQQ1
PeptideAtlasiQ8BQQ1
PRIDEiQ8BQQ1

PTM databases

iPTMnetiQ8BQQ1
PhosphoSitePlusiQ8BQQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000034265 Expressed in 267 organ(s), highest expression level in substantia nigra
CleanExiMM_ZDHHC14
GenevisibleiQ8BQQ1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086589

Structurei

3D structure databases

ProteinModelPortaliQ8BQQ1
SMRiQ8BQQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 215DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000242943
HOVERGENiHBG056239
InParanoidiQ8BQQ1
KOiK16675
OMAiHVGHQFL
OrthoDBiEOG091G0BOW
PhylomeDBiQ8BQQ1
TreeFamiTF312923

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BQQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPGGGGPMK DCEYSQISTH SSSPMESPHK KKKIAARRKW EVFPGRNKFF
60 70 80 90 100
CNGRIMMARQ TGVFYLTLIL ILVTSGLFFA FDCRYLAEKI TPAIPVVGGI
110 120 130 140 150
LFFFVMGTLL RTSFSDPGVL PRATPDEAAD LERQIDIANG TSSGGYRPPP
160 170 180 190 200
RTKEVVINGQ TVKLKYCFTC KIFRPPRASH CSLCDNCVEQ FDHHCPWVGN
210 220 230 240 250
CVGKRNYRFF YMFILSLSFL TVFIFAFVIT HVIHRSQQKG FLDALKDSPA
260 270 280 290 300
SVLEAVICFF SVWSIIGLSG FHTYLISSNQ TTNEDIKGSW SNKRGKENYN
310 320 330 340 350
PYSYGNIFTN CCVALCGPIS PSLIDRRGYV QPDTPQPAAP SNGITMYGAT
360 370 380 390 400
QSQSDMCDQD QCIQSTKFVL QAAATPLLQS EPSLTSEELH MPGKPGLGTP
410 420 430 440 450
CASLTLGQPT PPSSMPNLAT EATLSDIMPL KDEHGGHQFL TPDEAPSPPR
460 470 480
MLGAGSPLAH SRTMHMLGLA SQDSLHEDSV RGLVKLSSV
Length:489
Mass (Da):53,659
Last modified:March 1, 2003 - v1
Checksum:iEFF96E948FA45A03
GO
Isoform 2 (identifier: Q8BQQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Show »
Length:384
Mass (Da):41,897
Checksum:iF0A4E27B8C026B31
GO

Sequence cautioni

The sequence BAC38040 differs from that shown. Reason: Frameshift at position 7.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274Y → C in AAN47141 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0162721 – 105Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542387 mRNA Translation: AAN47141.1
AK046719 mRNA Translation: BAC32845.1
AK080845 mRNA Translation: BAC38040.1 Frameshift.
BC059814 mRNA Translation: AAH59814.1
CCDSiCCDS37422.1 [Q8BQQ1-1]
RefSeqiNP_666185.3, NM_146073.3 [Q8BQQ1-1]
UniGeneiMm.487663
Mm.491143

Genome annotation databases

EnsembliENSMUST00000089185; ENSMUSP00000086589; ENSMUSG00000034265 [Q8BQQ1-1]
GeneIDi224454
KEGGimmu:224454
UCSCiuc008aff.1 mouse [Q8BQQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542387 mRNA Translation: AAN47141.1
AK046719 mRNA Translation: BAC32845.1
AK080845 mRNA Translation: BAC38040.1 Frameshift.
BC059814 mRNA Translation: AAH59814.1
CCDSiCCDS37422.1 [Q8BQQ1-1]
RefSeqiNP_666185.3, NM_146073.3 [Q8BQQ1-1]
UniGeneiMm.487663
Mm.491143

3D structure databases

ProteinModelPortaliQ8BQQ1
SMRiQ8BQQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086589

PTM databases

iPTMnetiQ8BQQ1
PhosphoSitePlusiQ8BQQ1

Proteomic databases

PaxDbiQ8BQQ1
PeptideAtlasiQ8BQQ1
PRIDEiQ8BQQ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089185; ENSMUSP00000086589; ENSMUSG00000034265 [Q8BQQ1-1]
GeneIDi224454
KEGGimmu:224454
UCSCiuc008aff.1 mouse [Q8BQQ1-1]

Organism-specific databases

CTDi79683
MGIiMGI:2653229 Zdhhc14

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000242943
HOVERGENiHBG056239
InParanoidiQ8BQQ1
KOiK16675
OMAiHVGHQFL
OrthoDBiEOG091G0BOW
PhylomeDBiQ8BQQ1
TreeFamiTF312923

Miscellaneous databases

PROiPR:Q8BQQ1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034265 Expressed in 267 organ(s), highest expression level in substantia nigra
CleanExiMM_ZDHHC14
GenevisibleiQ8BQQ1 MM

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZDH14_MOUSE
AccessioniPrimary (citable) accession number: Q8BQQ1
Secondary accession number(s): Q8BNR2, Q8CFN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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