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Protein

Rab11 family-interacting protein 4

Gene

Rab11fip4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development, in a Rab11-independent manner.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi62 – 73PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • endocytic recycling Source: GO_Central
  • neural retina development Source: MGI
  • positive regulation of G1 to G0 transition Source: MGI
  • regulation of cytokinesis Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Transport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 4
Short name:
FIP4-Rab11
Short name:
Rab11-FIP4
Short name:
mRab11-FIP4A
Gene namesi
Name:Rab11fip4
Synonyms:Kiaa1821
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442920 Rab11fip4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738811 – 635Rab11 family-interacting protein 4Add BLAST635

Proteomic databases

MaxQBiQ8BQP8
PaxDbiQ8BQP8
PRIDEiQ8BQP8

PTM databases

iPTMnetiQ8BQP8
PhosphoSitePlusiQ8BQP8

Expressioni

Tissue specificityi

Strongly expressed in the developing retina. Expressed predominantly in neural tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000017639 Expressed in 250 organ(s), highest expression level in brain
CleanExiMM_RAB11FIP4
ExpressionAtlasiQ8BQP8 baseline and differential
GenevisibleiQ8BQP8 MM

Interactioni

Subunit structurei

Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5 (By similarity). Interacts with ECPAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017783

Structurei

3D structure databases

ProteinModelPortaliQ8BQP8
SMRiQ8BQP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 84EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini572 – 634FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 635Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerizationBy similarityAdd BLAST554

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili279 – 615Sequence analysisAdd BLAST337

Domaini

The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0982 Eukaryota
ENOG4111K32 LUCA
GeneTreeiENSGT00440000033742
HOGENOMiHOG000063670
HOVERGENiHBG054059
InParanoidiQ8BQP8
KOiK12485
OMAiKDQETMA
OrthoDBiEOG091G0421
PhylomeDBiQ8BQP8
TreeFamiTF327221

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR037245 FIP-RBD_C_sf
IPR019018 Rab-bd_FIP-RBD
PfamiView protein in Pfam
PF09457 RBD-FIP, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS51511 FIP_RBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BQP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGAGWAGA PAALLRSVRR LREVFEVCGR DPDGFLRVER VAALGLRFGQ
60 70 80 90 100
GEEVEKLVKC LDPNDLGRIN FKDFCRGVFA MKGCEELLKD VLSVESAGTL
110 120 130 140 150
PCSPDIPDCV EQGSDFSGST DGEQLPREPD FFQEDEEEAM TLALPEGPQE
160 170 180 190 200
LDMDSPMESS QGPEGSVKGC GEEKEPELGG LFLPEDKCLV LTPSVTTSDL
210 220 230 240 250
STHSTASLIS NEEQFEDYGE GDDVDCAPSS PCPDDETRTN VYSDLGSSVS
260 270 280 290 300
SSAGQTPRKM RHAYNSELLD VYCSQCCKKI NLLNDLEARL KNLKANSPNR
310 320 330 340 350
KISSTAFGRQ LMHNSNFSSS NGSTEDLFRD SIDSCDNDIT EKVSFLEKKV
360 370 380 390 400
TELENDSLTS GGLKSKLKQE NMQLVHRVHE LEEMVKDQET TAEQALEEEA
410 420 430 440 450
RRHREVYCKL EREKSTELEL LNTRVQQLEE ENTDLRTTVA RLKSQTEKLD
460 470 480 490 500
EERQRMSDRL EDTSLRLKDE MDLYKRMMDK LRQNRLEFQK EREATQELIE
510 520 530 540 550
DLRRELEHLQ MYKLDCERPG RGRSSSGLGE FNARAREVEL EHEVKRLKQE
560 570 580 590 600
NHKLRDQNDD LNGQILSLSL YEAKNLFATQ TKAQSLAAEI DTASRDELME
610 620 630
ALKEQEEINF RLRQYMDKII LAILDHNPSI LEIKH
Length:635
Mass (Da):71,901
Last modified:March 1, 2003 - v1
Checksum:i85F3C779A2963AAD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YI06F6YI06_MOUSE
Rab11 family-interacting protein 4
Rab11fip4
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368 – 377KQENMQLVHR → WGTVAPGSAE in BAC65841 (PubMed:12693553).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046734 mRNA Translation: BAC32850.1
AL591174 Genomic DNA No translation available.
AK122559 mRNA Translation: BAC65841.1
CCDSiCCDS25123.1
RefSeqiNP_780752.1, NM_175543.3
UniGeneiMm.130656
Mm.491175

Genome annotation databases

EnsembliENSMUST00000017783; ENSMUSP00000017783; ENSMUSG00000017639
GeneIDi268451
KEGGimmu:268451
UCSCiuc007kku.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046734 mRNA Translation: BAC32850.1
AL591174 Genomic DNA No translation available.
AK122559 mRNA Translation: BAC65841.1
CCDSiCCDS25123.1
RefSeqiNP_780752.1, NM_175543.3
UniGeneiMm.130656
Mm.491175

3D structure databases

ProteinModelPortaliQ8BQP8
SMRiQ8BQP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017783

Chemistry databases

ChEMBLiCHEMBL2176809

PTM databases

iPTMnetiQ8BQP8
PhosphoSitePlusiQ8BQP8

Proteomic databases

MaxQBiQ8BQP8
PaxDbiQ8BQP8
PRIDEiQ8BQP8

Protocols and materials databases

DNASUi268451
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017783; ENSMUSP00000017783; ENSMUSG00000017639
GeneIDi268451
KEGGimmu:268451
UCSCiuc007kku.1 mouse

Organism-specific databases

CTDi84440
MGIiMGI:2442920 Rab11fip4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0982 Eukaryota
ENOG4111K32 LUCA
GeneTreeiENSGT00440000033742
HOGENOMiHOG000063670
HOVERGENiHBG054059
InParanoidiQ8BQP8
KOiK12485
OMAiKDQETMA
OrthoDBiEOG091G0421
PhylomeDBiQ8BQP8
TreeFamiTF327221

Miscellaneous databases

ChiTaRSiRab11fip4 mouse
PROiPR:Q8BQP8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017639 Expressed in 250 organ(s), highest expression level in brain
CleanExiMM_RAB11FIP4
ExpressionAtlasiQ8BQP8 baseline and differential
GenevisibleiQ8BQP8 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR037245 FIP-RBD_C_sf
IPR019018 Rab-bd_FIP-RBD
PfamiView protein in Pfam
PF09457 RBD-FIP, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS51511 FIP_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFIP4_MOUSE
AccessioniPrimary (citable) accession number: Q8BQP8
Secondary accession number(s): Q80T87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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