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Protein

Zinc finger protein OZF

Gene

Znf146

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri44 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri128 – 150C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein OZF
Alternative name(s):
Only zinc finger protein
Zinc finger protein 146
Gene namesi
Name:Znf146
Synonyms:Ozf, Zfp146
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347092 Zfp146

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lacking Zfp146 in mammary gland display impaired mammary gland development. They cannot sustain full growth of their pups. This phenotype is associated with an impaired mammary gland development noticeable only after mid-gestation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472771 – 292Zinc finger protein OZFAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8BQN6
PaxDbiQ8BQN6
PeptideAtlasiQ8BQN6
PRIDEiQ8BQN6

PTM databases

iPTMnetiQ8BQN6
PhosphoSitePlusiQ8BQN6

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, lung, skeletal muscle and kidney, and at much lower level in spleen and testicle. Expressed in lactating mammary gland.2 Publications

Gene expression databases

BgeeiENSMUSG00000037029 Expressed in 168 organ(s), highest expression level in female gonad
CleanExiMM_ZFP146
GenevisibleiQ8BQN6 MM

Interactioni

Subunit structurei

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058588

Structurei

3D structure databases

ProteinModelPortaliQ8BQN6
SMRiQ8BQN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 292Interaction with TERF2IPBy similarityAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 38C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri44 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri72 – 94C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri100 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri128 – 150C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150959
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BQN6
OMAiHTEHEHF
OrthoDBiEOG091G02KC
PhylomeDBiQ8BQN6
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q8BQN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLSQQRIL SGGSPFACKV CGKLFSHKSN LTEHEHFHSR EKPFECNECG
60 70 80 90 100
KAFSQKQYVI KHQSTHSGEK LFECSDCGKA FSQKENLLTH QKIHTGEKPF
110 120 130 140 150
ECKDCGKAFI QKSNLIRHQR THTGEKPFIC KECGKTFSGK SNLTEHEKIH
160 170 180 190 200
IGEKPFKCNE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI
210 220 230 240 250
VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS
260 270 280 290
QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH
Length:292
Mass (Da):33,093
Last modified:November 8, 2005 - v2
Checksum:iA0F985ABBEE7CADD
GO

Sequence cautioni

The sequence BAC33129 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224763 mRNA Translation: CAB38320.1
AK047696 mRNA Translation: BAC33129.1 Different initiation.
BC127038 mRNA Translation: AAI27039.1
BC127039 mRNA Translation: AAI27040.1
CCDSiCCDS21079.1
RefSeqiNP_036110.1, NM_011980.3
XP_006540071.1, XM_006540008.2
XP_006540072.1, XM_006540009.2
UniGeneiMm.446516
Mm.456449

Genome annotation databases

EnsembliENSMUST00000062181; ENSMUSP00000058588; ENSMUSG00000037029
GeneIDi26465
KEGGimmu:26465
UCSCiuc009gdn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224763 mRNA Translation: CAB38320.1
AK047696 mRNA Translation: BAC33129.1 Different initiation.
BC127038 mRNA Translation: AAI27039.1
BC127039 mRNA Translation: AAI27040.1
CCDSiCCDS21079.1
RefSeqiNP_036110.1, NM_011980.3
XP_006540071.1, XM_006540008.2
XP_006540072.1, XM_006540009.2
UniGeneiMm.446516
Mm.456449

3D structure databases

ProteinModelPortaliQ8BQN6
SMRiQ8BQN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058588

PTM databases

iPTMnetiQ8BQN6
PhosphoSitePlusiQ8BQN6

Proteomic databases

MaxQBiQ8BQN6
PaxDbiQ8BQN6
PeptideAtlasiQ8BQN6
PRIDEiQ8BQN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062181; ENSMUSP00000058588; ENSMUSG00000037029
GeneIDi26465
KEGGimmu:26465
UCSCiuc009gdn.1 mouse

Organism-specific databases

CTDi26465
MGIiMGI:1347092 Zfp146

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150959
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BQN6
OMAiHTEHEHF
OrthoDBiEOG091G02KC
PhylomeDBiQ8BQN6
TreeFamiTF337055

Miscellaneous databases

PROiPR:Q8BQN6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037029 Expressed in 168 organ(s), highest expression level in female gonad
CleanExiMM_ZFP146
GenevisibleiQ8BQN6 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOZF_MOUSE
AccessioniPrimary (citable) accession number: Q8BQN6
Secondary accession number(s): A0JNX3, Q9Z0Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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