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UniProtKB - Q8BQC8 (RBAK_MOUSE)
Protein
RB-associated KRAB zinc finger protein
Gene
Rbak
Organism
Mus musculus (Mouse)
Status
Functioni
May repress E2F-dependent transcription. May promote AR-dependent transcription.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 258 – 280 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 286 – 308 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 314 – 336 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 342 – 364 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 370 – 392 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 398 – 420 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 426 – 448 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 454 – 476 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 508 – 530 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 536 – 558 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 564 – 586 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 592 – 614 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 620 – 642 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 648 – 670 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 676 – 698 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: RB-associated KRAB zinc finger proteinAlternative name(s): RB-associated KRAB repressor Zinc finger protein 769 |
Gene namesi | Name:Rbak Synonyms:Znf769 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927369, Rbak |
VEuPathDBi | HostDB:ENSMUSG00000061898 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316977 | 1 – 711 | RB-associated KRAB zinc finger proteinAdd BLAST | 711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 97 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 256 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 312 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 354 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 534 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q8BQC8 |
PaxDbi | Q8BQC8 |
PRIDEi | Q8BQC8 |
ProteomicsDBi | 255113 |
PTM databases
iPTMneti | Q8BQC8 |
PhosphoSitePlusi | Q8BQC8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000061898, Expressed in metanephric cortical collecting duct and 255 other tissues |
Genevisiblei | Q8BQC8, MM |
Interactioni
Subunit structurei
Interacts with AR (By similarity). May also interact with other nuclear hormone receptors such as NR3C1/GR (By similarity).
Interacts with RB1.
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 208328, 25 interactors |
STRINGi | 10090.ENSMUSP00000128731 |
Miscellaneous databases
RNActi | Q8BQC8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 170 – 257 | Required for interaction with RB1By similarityAdd BLAST | 88 | |
Regioni | 414 – 711 | Interaction with ARBy similarityAdd BLAST | 298 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 258 – 280 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 286 – 308 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 314 – 336 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 342 – 364 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 370 – 392 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 398 – 420 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 426 – 448 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 454 – 476 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 508 – 530 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 536 – 558 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 564 – 586 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 592 – 614 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 620 – 642 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 648 – 670 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 676 – 698 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154303 |
HOGENOMi | CLU_002678_0_12_1 |
InParanoidi | Q8BQC8 |
OMAi | ECGKMYH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BQC8 |
TreeFami | TF350803 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
i Sequence
Sequence statusi: Complete.
Q8BQC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRSKGPLSF KDVAVAFSQE EWQQLDPEER TTYRDVMLET YSNLVSVGYD
60 70 80 90 100
VTKPNMIIKL EQGEEPWTVE GDRHAQRHLE ISKVYDPREG IEEIGEKHLQ
110 120 130 140 150
CDDDPYCWRA EKGAAFDEAY TLETALISPS SGAHSCVSCG ETLESVSELI
160 170 180 190 200
SSDGSYALEK PSMCFECGKA YGESLEDFNQ DEGNSSQHDE NILQKVTILE
210 220 230 240 250
KPFAYECMEA LDSESVFMAR ERAYMGEKPY DWGDSGPDFI QMSDFSTYPR
260 270 280 290 300
SQMELKPFEC TQCGKSFCKK SKFIIHQRAH TGEKPYACSV CGKSFSQKGT
310 320 330 340 350
LTVHRRSHLE EKPYKCNECG KTFCQKLHLT QHQRTHSGEK PYECSECGKS
360 370 380 390 400
FCQKTHLTLH QRNHSGERPY PCNECGKSFS RKSALNDHQR THTGEKLYKC
410 420 430 440 450
NECGKSYYRK STLITHQRTH TGEKPYQCSE CGKFFSRVSY LTIHYRSHLE
460 470 480 490 500
EKPYECTECG KTFNLNSAFI RHWKVHAEER VQECGECGKP SPLQCAPDHT
510 520 530 540 550
GDLGEKRYEC NECGKTFLDS SAFHRHQSVP EGEKTYECNI CGKSFSDSSC
560 570 580 590 600
YTVHYRGHSE EKPFGCSECG KTFSHNSSLF RHQRVHTGEK PYECYECGKF
610 620 630 640 650
FSQKSYLTIH HRIHSGEKPY ECSKCGKVFS RMSNLTVHYR SHSGEKPYEC
660 670 680 690 700
NECGKVFSQK SYLTVHYRTH SGEKPYECNE CGKKFHHRSA FNSHQRIHKR
710
GTVNVLTVEK L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK051009 mRNA Translation: BAC34495.1 AF226870 mRNA Translation: AAF43390.1 |
CCDSi | CCDS19835.1 |
RefSeqi | NP_001038947.1, NM_001045482.2 NP_067301.1, NM_021326.3 XP_006504787.1, XM_006504724.3 |
Genome annotation databases
Ensembli | ENSMUST00000049861; ENSMUSP00000059273; ENSMUSG00000061898 ENSMUST00000165318; ENSMUSP00000128731; ENSMUSG00000061898 |
GeneIDi | 57782 |
KEGGi | mmu:57782 |
UCSCi | uc009ajp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK051009 mRNA Translation: BAC34495.1 AF226870 mRNA Translation: AAF43390.1 |
CCDSi | CCDS19835.1 |
RefSeqi | NP_001038947.1, NM_001045482.2 NP_067301.1, NM_021326.3 XP_006504787.1, XM_006504724.3 |
3D structure databases
SMRi | Q8BQC8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208328, 25 interactors |
STRINGi | 10090.ENSMUSP00000128731 |
PTM databases
iPTMneti | Q8BQC8 |
PhosphoSitePlusi | Q8BQC8 |
Proteomic databases
MaxQBi | Q8BQC8 |
PaxDbi | Q8BQC8 |
PRIDEi | Q8BQC8 |
ProteomicsDBi | 255113 |
Protocols and materials databases
Antibodypediai | 11262, 155 antibodies from 27 providers |
DNASUi | 57782 |
Genome annotation databases
Ensembli | ENSMUST00000049861; ENSMUSP00000059273; ENSMUSG00000061898 ENSMUST00000165318; ENSMUSP00000128731; ENSMUSG00000061898 |
GeneIDi | 57782 |
KEGGi | mmu:57782 |
UCSCi | uc009ajp.2, mouse |
Organism-specific databases
CTDi | 57786 |
MGIi | MGI:1927369, Rbak |
VEuPathDBi | HostDB:ENSMUSG00000061898 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154303 |
HOGENOMi | CLU_002678_0_12_1 |
InParanoidi | Q8BQC8 |
OMAi | ECGKMYH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8BQC8 |
TreeFami | TF350803 |
Miscellaneous databases
BioGRID-ORCSi | 57782, 1 hit in 64 CRISPR screens |
PROi | PR:Q8BQC8 |
RNActi | Q8BQC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000061898, Expressed in metanephric cortical collecting duct and 255 other tissues |
Genevisiblei | Q8BQC8, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RBAK_MOUSE | |
Accessioni | Q8BQC8Primary (citable) accession number: Q8BQC8 Secondary accession number(s): Q6PB38, Q9JKU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families