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Protein

Four-jointed box protein 1

Gene

Fjx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an inhibitor of dendrite extension and branching.1 Publication

Miscellaneous

Knockout mice for this gene exhibited an increase in dendrite extension and branching of pyramidal neurons in the CA1 region of the hippocampus.

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • retina layer formation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Four-jointed box protein 1
Short name:
Four-jointed protein x1
Alternative name(s):
Four-jointed protein homolog
Gene namesi
Name:Fjx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1341907 Fjx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000033304629 – 450Four-jointed box protein 1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication
Undergoes proteolytic cleavage.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BQB4
PaxDbiQ8BQB4
PRIDEiQ8BQB4

PTM databases

PhosphoSitePlusiQ8BQB4

Expressioni

Tissue specificityi

Expressed in brain, kidney and lung. In the telencephalon, expressed in the piriform cortex, hippocampus and olfactory bulb. In the diencephalon, expressed in the dorsal thalamus. Expressed in Purkinje cells of the cerebellum and in numerous medullary nuclei.3 Publications

Developmental stagei

Expressed in embryo at 8.5 dpc onward. In the neural plate, expressed in the presumptive forebrain and midbrain and in rhombomere at 4 and 8.5 dpc. Expressed in the limb buds and in the ectoderm of the first branchial arches at 9.5 dpc. In the brain, expressed in the dorsal mesencephalon (tectum) and prosencephalon (presumptive isocortex) at 9.5, 10.5 and 11.5 dpc. In the cortex, expressed in dorsolateral patch of the neuroepithelium at 10.5 dpc. Expressed in the ectoderm of the branchial arch and the oral ectoderm at 10.5 dpc. In the limbs, expressed in the apical ectodermal ridge at 11.5 dpc. Expressed in the telecephalon, ventricles, diencephalon and medulla oblongata at 12.5 dpc. Expressed in the neural tube, cochlear ganglion and olfactory bulb at 14.5 dpc. In the kidney, lung and intestine, expressed in epithelial cells at 14.5 dpc.3 Publications

Inductioni

Up-regulated by Notch.1 Publication

Gene expression databases

BgeeiENSMUSG00000075012 Expressed in 225 organ(s), highest expression level in lumbar subsegment of spinal cord
GenevisibleiQ8BQB4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097270

Structurei

3D structure databases

ProteinModelPortaliQ8BQB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 67Pro-richAdd BLAST37

Sequence similaritiesi

Belongs to the FJX1/FJ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHNI Eukaryota
ENOG410XSE2 LUCA
GeneTreeiENSGT00390000016768
HOGENOMiHOG000112598
HOVERGENiHBG098046
InParanoidiQ8BQB4
KOiK16674
OMAiMERDTNN
OrthoDBiEOG091G0L1D
PhylomeDBiQ8BQB4
TreeFamiTF324767

Family and domain databases

InterProiView protein in InterPro
IPR024868 FJX1/FJ
PANTHERiPTHR13147 PTHR13147, 1 hit
PRINTSiPR02072 4JOINTEDBOX1

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BQB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRKMRGAAA AAGLWLLALS SLLTLWGGLL PPRTELPASR PPEDRLPPHP
60 70 80 90 100
IQSGGPAPEP RFPLPPPLVW DARGGSLKTF RALLTLAAGA DNPPRRHQDD
110 120 130 140 150
RGRHEPSGLS WPEERRAVHG GVFWSRGLEE QVPRGFSEAQ AAAWLEVARG
160 170 180 190 200
ARVVALDRGG CGRSSNRLAR FADGTRACVR YGINPEQIQG EALSYYLARL
210 220 230 240 250
LGLQRHVPPL ALARVEARGA QWVQVQEELR TAHWTEGSVV SLTRWLPNLT
260 270 280 290 300
DVVVPEPWRS EDGRLRPLRD AGGELTNLSQ AELVDLVQWT DLILFDYLTA
310 320 330 340 350
NFDRLVSNLF SLQWDPRVMH RATSNLHRGP GGALVFLDNE AGLVHGYRVA
360 370 380 390 400
GMWDKYNEPL LQSVCVFRER TARRVLELHR GQDAAARLLR LYSRHEPRFP
410 420 430 440 450
ELAELSEPHA QLLQRRLDFL AKHILHCKAK YGRRPGDLIT LRGREGLGYE
Length:450
Mass (Da):50,396
Last modified:March 1, 2003 - v1
Checksum:i4DC00C72457ECE87
GO

Sequence cautioni

The sequence CAA08764 differs from that shown. Reason: Frameshift at position 437.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109L → C in CAA08764 (PubMed:10072791).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009634 Genomic DNA Translation: CAA08764.1 Frameshift.
AK051097 mRNA Translation: BAC34524.1
AL691444 Genomic DNA Translation: CAM17929.1
BC051990 mRNA Translation: AAH51990.1
CCDSiCCDS16467.1
RefSeqiNP_034348.2, NM_010218.2
UniGeneiMm.29730

Genome annotation databases

EnsembliENSMUST00000099678; ENSMUSP00000097270; ENSMUSG00000075012
GeneIDi14221
KEGGimmu:14221
UCSCiuc008lhw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009634 Genomic DNA Translation: CAA08764.1 Frameshift.
AK051097 mRNA Translation: BAC34524.1
AL691444 Genomic DNA Translation: CAM17929.1
BC051990 mRNA Translation: AAH51990.1
CCDSiCCDS16467.1
RefSeqiNP_034348.2, NM_010218.2
UniGeneiMm.29730

3D structure databases

ProteinModelPortaliQ8BQB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097270

PTM databases

PhosphoSitePlusiQ8BQB4

Proteomic databases

MaxQBiQ8BQB4
PaxDbiQ8BQB4
PRIDEiQ8BQB4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099678; ENSMUSP00000097270; ENSMUSG00000075012
GeneIDi14221
KEGGimmu:14221
UCSCiuc008lhw.1 mouse

Organism-specific databases

CTDi24147
MGIiMGI:1341907 Fjx1

Phylogenomic databases

eggNOGiENOG410IHNI Eukaryota
ENOG410XSE2 LUCA
GeneTreeiENSGT00390000016768
HOGENOMiHOG000112598
HOVERGENiHBG098046
InParanoidiQ8BQB4
KOiK16674
OMAiMERDTNN
OrthoDBiEOG091G0L1D
PhylomeDBiQ8BQB4
TreeFamiTF324767

Miscellaneous databases

PROiPR:Q8BQB4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075012 Expressed in 225 organ(s), highest expression level in lumbar subsegment of spinal cord
GenevisibleiQ8BQB4 MM

Family and domain databases

InterProiView protein in InterPro
IPR024868 FJX1/FJ
PANTHERiPTHR13147 PTHR13147, 1 hit
PRINTSiPR02072 4JOINTEDBOX1
ProtoNetiSearch...

Entry informationi

Entry nameiFJX1_MOUSE
AccessioniPrimary (citable) accession number: Q8BQB4
Secondary accession number(s): Q9Z1M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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