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Entry version 101 (16 Oct 2019)
Sequence version 3 (18 Mar 2008)
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Protein

Centrosomal protein of 295 kDa

Gene

Cep295

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 295 kDaCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep295By similarity
Synonyms:Kiaa1731By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442521 Cep295

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003245961 – 2412Centrosomal protein of 295 kDaAdd BLAST2412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
Modified residuei634PhosphoserineBy similarity1
Modified residuei1573PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BQ48

PRoteomics IDEntifications database

More...
PRIDEi
Q8BQ48

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BQ48

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BQ48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046111 Expressed in 205 organ(s), highest expression level in embryonic stem cell

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via ALMS motif) with microtubules; this interaction is direct.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
235442, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000123788

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 540Necessary for centriole targeting and microtubule associationBy similarityAdd BLAST540
Regioni2367 – 2412ALMS motifAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili63 – 84Sequence analysisAdd BLAST22
Coiled coili114 – 134Sequence analysisAdd BLAST21
Coiled coili209 – 273Sequence analysisAdd BLAST65
Coiled coili489 – 535Sequence analysisAdd BLAST47
Coiled coili563 – 592Sequence analysisAdd BLAST30
Coiled coili811 – 841Sequence analysisAdd BLAST31
Coiled coili1300 – 1327Sequence analysisAdd BLAST28
Coiled coili1448 – 1493Sequence analysisAdd BLAST46

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal and the ALMS motif-containing C-terminal regions are essential for CEP295-mediated centriole elongation.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK6S Eukaryota
ENOG41124ZG LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000185824

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BQ48

Database of Orthologous Groups

More...
OrthoDBi
97863at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BQ48

TreeFam database of animal gene trees

More...
TreeFami
TF331536

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029560 CEP295

The PANTHER Classification System

More...
PANTHERi
PTHR21553:SF25 PTHR21553:SF25, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BQ48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRKGMNTKL RLSPSEEAFI LKEDYERRRK LRLLQVREQE RGIAFQIREG
60 70 80 90 100
IKQRRSQQVS HLAEELRAKW EEAQSQKIQN LEKLYLASLR HMGDGHRQAK
110 120 130 140 150
ENEPDLDALS RRAAERKRKA EVRHKEALKV QKNQKEMLMK QKTRHIKARK
160 170 180 190 200
EAVLVEKQRS AKMARLPPPV PSPFENIDVN RIPSLKTNSS TYHHISTFVS
210 220 230 240 250
RQMGTKQPDA HLAAEEEARR VERLRKQAAQ ERVKQFERAH VRGSQAMKKI
260 270 280 290 300
HLAQNQERLM EELKQLQKED LARRRQTVAQ MPPQMLELPY RRSEMKEDRQ
310 320 330 340 350
RELEFAFEDM YNADRKVKGN LILHLKPEPL PTISDQLQDE ELDLSMEQEN
360 370 380 390 400
QVPLAAKIQQ IPSRILFKRL LNKIRSQKSL WTIKSVSEDE GEVTSSIIEI
410 420 430 440 450
ESKVPSVDSG AIITEERTAA SFEQEQVTDS DRLTIESGPL SSEDKPLYYK
460 470 480 490 500
AGTGREQAMA VSPPATAVAQ SSVLLHPQEE AVRIRMSLRR KQIMEIEEQK
510 520 530 540 550
QKQLELLEQI EQQKLRLETD CFRAQLEEQR KQADQPEVCC APMSHAMISD
560 570 580 590 600
EDSHRQMIRN YQHQLLQQNR LHKETVETAR KRLLEYQTVL KERSPSLSAS
610 620 630 640 650
ALVPDSVVSG PPQQSYKPAA ASDSWDPSQR LKLSPSKYQP VQPSQIPALE
660 670 680 690 700
QSHIQVPRHG HITQRQGKMA VSEMLGKQPV ESQERQWQFS QVETHQGDYE
710 720 730 740 750
FVLKDSHSLS RTLSYVRPQT LQDAREVSKP PRVIICQSLD SQQISSEDSE
760 770 780 790 800
NISSKPSEPS PFLPLVPERP FTSLPVKFHS GTIHKPFTTI NQSVISQMHD
810 820 830 840 850
QPLSSSETIT AQQGDLRFLQ EQLELQKKVL QARQEAREKL LLCTQKELGQ
860 870 880 890 900
QTGLPVFLPS PAGNIFSSLP SASAESGNFQ TSSTKSDATV SSDNMDRLWD
910 920 930 940 950
SSQPISSQQT HLEFLQEQSS VETDNLQARR EAQEVLFAHT QNTLEKIVRS
960 970 980 990 1000
EQAGSSLPHQ VAQQSFSSLT LADTQSKKIQ KQPLPANKKG LLPSQSEVSK
1010 1020 1030 1040 1050
AQDGSSGFLQ QTLPLQNTLK LLQEQLTRQR SMIPPRRDGQ ETLLLYKESC
1060 1070 1080 1090 1100
SEDSEAGPVE SLSSVVVQHA DASRAVSEVP KRLQDVYSSE EENRVLSSHL
1110 1120 1130 1140 1150
ITHGFPQHSL QRQEHFTPLQ EETHIQRLIL GARKNNEEFA PKQNELEKGL
1160 1170 1180 1190 1200
CSQQTDALSS PSQVTDWGTS RGSVSVRSDR TDPLRHFKIP AFRERLVRVS
1210 1220 1230 1240 1250
QHTFPLQDNL QEHQEWVDTE KESFQSSPLT PENPSSQQTG FSSFKASLRL
1260 1270 1280 1290 1300
PSCVSLPSAD SGITQHPLST ESDSKVKSSH LQIPELQHRL SKISQLIPPQ
1310 1320 1330 1340 1350
QDSLKALQEQ LATQREAIIH SRQEAHEETL REWKEKIFPE QVGPFSPLIP
1360 1370 1380 1390 1400
QHSLASFPVS DTERAQELCS TNSDTISSGY PEMLELPDRT LGLSHTALPQ
1410 1420 1430 1440 1450
QNNLTAHPEH LHAQTNFFHS TEKAQEGLVF PRPCQFEEMS AEHFIQPQHD
1460 1470 1480 1490 1500
DLKALQQQLD MQREAIRSGQ EMQEKMLLQR LNKLEQRISS KQISSSLFSS
1510 1520 1530 1540 1550
QVALPIANSD GTLQSFPTKS NETELLGSQD EYLSFSQPRL PLQNNMTEQL
1560 1570 1580 1590 1600
DLEKVFHKEL LLHKQKSQNK SESSEHSLPP LFLSKEIEHP FISLPFAESK
1610 1620 1630 1640 1650
SKSICELYLS DKKHAAPNDA VIPRLQDRLL SCSQPVLTQQ DNMSLQKQLN
1660 1670 1680 1690 1700
LQRETLHSRQ KAQEELLVQR QTSLQQQIQR HRETLKNFFN VSQARNPTDE
1710 1720 1730 1740 1750
NDLEMQKREQ LGGWFPHTQG LTWGDAGQGS ANGEQPRADV HAEHNGESLA
1760 1770 1780 1790 1800
KELSGRASKP PVSKVKCVLD LNQHELSTIQ EVESPASGRI SMPGKAEFYQ
1810 1820 1830 1840 1850
DRDPLRVSVS REQSFLESPL AHDPFGCHQP PAQENSKSHD DNAEAVKVKK
1860 1870 1880 1890 1900
SDVEDHAVLS HAVSKEEACT NLGPLGKPDD EAETQEISQE PLSSVTVSTG
1910 1920 1930 1940 1950
SFLSYEITDL SLTDPESFSE QTEHLEQEST NKQEETDPLS IAVPSVIYQQ
1960 1970 1980 1990 2000
QHSLGAHNSL LPMEEESTSD HTHVQQIMDN DVNEANLIPD KRDFQVPAVD
2010 2020 2030 2040 2050
LDFRELEHIF PHLHRQLFKP LEPHLDFDLS SPGTSQEDSD FYQSSESSSE
2060 2070 2080 2090 2100
KHVKALSTGT ICFPALTAKS HSPNPRLNQL DINLAHATTE GSEQSFQQLR
2110 2120 2130 2140 2150
PEFSSQESQH ADLPSIYSIE ARGPSQRMEN QNYSEMLQNK KKSLSLQPST
2160 2170 2180 2190 2200
EDLTPACSSS DTALFDQLHL QHSTPCASVS SECSVKLLES REEVLGFEEL
2210 2220 2230 2240 2250
SRRAVTMSQR LTEDENVVLP INPHVGRVEK EASVQGSNPL SIQNEKPIQN
2260 2270 2280 2290 2300
FIETDTTEAV GNVCQLAQAE HILKSCPFRS PIPIWETDTG YGIMEEPDLT
2310 2320 2330 2340 2350
LVSNSDISIT ETDLANLTLE DREDNEAQFF QAGVVLPTSS METSVCGAVS
2360 2370 2380 2390 2400
EPYVDQPTVA PSATSGSLQE AFMTRQTLTE RSYQRQREIW NKTRLPQTKV
2410
SKEKLPTGCT GS
Length:2,412
Mass (Da):272,779
Last modified:March 18, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58D8E5F8DF469D7D
GO
Isoform 2 (identifier: Q8BQ48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2363-2412: ATSGSLQEAF...EKLPTGCTGS → GKPLISLRTLSTHVGMKATHNFSQIL

Note: No experimental confirmation available.
Show »
Length:2,388
Mass (Da):269,899
Checksum:iC08293948B87B6D4
GO
Isoform 3 (identifier: Q8BQ48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1995: Missing.

Note: No experimental confirmation available.
Show »
Length:2,332
Mass (Da):263,650
Checksum:i181E7A2C2BA61D0B
GO
Isoform 4 (identifier: Q8BQ48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-1237: Missing.
     1341-1692: Missing.
     1916-1995: Missing.

Note: No experimental confirmation available.
Show »
Length:1,397
Mass (Da):157,945
Checksum:i22474DDBFBA35CF6
GO
Isoform 5 (identifier: Q8BQ48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2042-2042: Y → YQ
     2286-2287: ET → VS
     2288-2412: Missing.

Note: No experimental confirmation available.
Show »
Length:2,288
Mass (Da):259,156
Checksum:i4942174A7B8A8C0B
GO
Isoform 6 (identifier: Q8BQ48-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1995: Missing.
     2286-2287: ET → VS
     2288-2412: Missing.

Note: No experimental confirmation available.
Show »
Length:2,207
Mass (Da):249,899
Checksum:i104D8153333945CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPW4E9QPW4_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
2,380Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BWD7F7BWD7_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
1,202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N9NPH8A0A1N9NPH8_MOUSE
Centrosomal protein of 295 kDa
Cep295
2,460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V9M5F6V9M5_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6URK1F6URK1_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1STC4A0A1L1STC4_MOUSE
Centrosomal protein of 295 kDa
Cep295
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI18969 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC27153 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD90195 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1344P → T in BAC27977 (PubMed:16141072).Curated1
Sequence conflicti1872L → M in BAC27977 (PubMed:16141072).Curated1
Sequence conflicti1924H → R in BAC27153 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032292655 – 1237Missing in isoform 4. 1 PublicationAdd BLAST583
Alternative sequenceiVSP_0322931341 – 1692Missing in isoform 4. 1 PublicationAdd BLAST352
Alternative sequenceiVSP_0322941916 – 1995Missing in isoform 3, isoform 4 and isoform 6. 3 PublicationsAdd BLAST80
Alternative sequenceiVSP_0322952042Y → YQ in isoform 5. 1 Publication1
Alternative sequenceiVSP_0322962286 – 2287ET → VS in isoform 5 and isoform 6. 1 Publication2
Alternative sequenceiVSP_0322972288 – 2412Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_0322982363 – 2412ATSGS…GCTGS → GKPLISLRTLSTHVGMKATH NFSQIL in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC154296 Genomic DNA No translation available.
AK030838 mRNA Translation: BAC27153.1 Different initiation.
AK032664 mRNA Translation: BAC27977.1
AK051561 mRNA Translation: BAC34674.2
AK134513 mRNA Translation: BAE22166.1
AK220270 mRNA Translation: BAD90195.1 Different initiation.
BC118968 mRNA Translation: AAI18969.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_795950.2, NM_176976.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
319675

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:319675

UCSC genome browser

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UCSCi
uc009ofv.2 mouse [Q8BQ48-4]
uc009ofw.3 mouse [Q8BQ48-1]
uc009ofy.2 mouse [Q8BQ48-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154296 Genomic DNA No translation available.
AK030838 mRNA Translation: BAC27153.1 Different initiation.
AK032664 mRNA Translation: BAC27977.1
AK051561 mRNA Translation: BAC34674.2
AK134513 mRNA Translation: BAE22166.1
AK220270 mRNA Translation: BAD90195.1 Different initiation.
BC118968 mRNA Translation: AAI18969.1 Different initiation.
RefSeqiNP_795950.2, NM_176976.4

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi235442, 1 interactor
STRINGi10090.ENSMUSP00000123788

PTM databases

iPTMnetiQ8BQ48
PhosphoSitePlusiQ8BQ48

Proteomic databases

PaxDbiQ8BQ48
PRIDEiQ8BQ48

Genome annotation databases

GeneIDi319675
KEGGimmu:319675
UCSCiuc009ofv.2 mouse [Q8BQ48-4]
uc009ofw.3 mouse [Q8BQ48-1]
uc009ofy.2 mouse [Q8BQ48-6]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85459
MGIiMGI:2442521 Cep295

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410IK6S Eukaryota
ENOG41124ZG LUCA
HOGENOMiHOG000185824
InParanoidiQ8BQ48
OrthoDBi97863at2759
PhylomeDBiQ8BQ48
TreeFamiTF331536

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cep295 mouse

Protein Ontology

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PROi
PR:Q8BQ48

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046111 Expressed in 205 organ(s), highest expression level in embryonic stem cell

Family and domain databases

InterProiView protein in InterPro
IPR029560 CEP295
PANTHERiPTHR21553:SF25 PTHR21553:SF25, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE295_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BQ48
Secondary accession number(s): Q0VF60
, Q3UYP6, Q571B9, Q8CCJ2, Q8CDA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 16, 2019
This is version 101 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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