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UniProtKB - Q8BQ48 (CE295_MOUSE)

Entry version 106 (02 Dec 2020)
Sequence version 3 (18 Mar 2008)
Previous versions | rss
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Protein

Centrosomal protein of 295 kDa

Gene

Cep295

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 295 kDaCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep295By similarity
Synonyms:Kiaa1731By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2442521, Cep295

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003245961 – 2412Centrosomal protein of 295 kDaAdd BLAST2412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
Modified residuei634PhosphoserineBy similarity1
Modified residuei1573PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8BQ48

PRoteomics IDEntifications database

More...PRIDEi		Q8BQ48

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8BQ48

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8BQ48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000046111, Expressed in forelimb bud and 226 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via ALMS motif) with microtubules; this interaction is direct.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		235442, 6 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000123788

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8BQ48, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 540Necessary for centriole targeting and microtubule associationBy similarityAdd BLAST540
Regioni2367 – 2412ALMS motifAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili63 – 84Sequence analysisAdd BLAST22
Coiled coili114 – 134Sequence analysisAdd BLAST21
Coiled coili209 – 273Sequence analysisAdd BLAST65
Coiled coili489 – 535Sequence analysisAdd BLAST47
Coiled coili563 – 592Sequence analysisAdd BLAST30
Coiled coili811 – 841Sequence analysisAdd BLAST31
Coiled coili1300 – 1327Sequence analysisAdd BLAST28
Coiled coili1448 – 1493Sequence analysisAdd BLAST46

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal and the ALMS motif-containing C-terminal regions are essential for CEP295-mediated centriole elongation.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSZR, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001093_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8BQ48

Database of Orthologous Groups

More...OrthoDBi		97863at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8BQ48

TreeFam database of animal gene trees

More...TreeFami		TF331536

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029560, CEP295

The PANTHER Classification System

More...PANTHERi		PTHR21553:SF25, PTHR21553:SF25, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BQ48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRKGMNTKL RLSPSEEAFI LKEDYERRRK LRLLQVREQE RGIAFQIREG 
        60         70         80         90        100
IKQRRSQQVS HLAEELRAKW EEAQSQKIQN LEKLYLASLR HMGDGHRQAK 
       110        120        130        140        150
ENEPDLDALS RRAAERKRKA EVRHKEALKV QKNQKEMLMK QKTRHIKARK 
       160        170        180        190        200
EAVLVEKQRS AKMARLPPPV PSPFENIDVN RIPSLKTNSS TYHHISTFVS 
       210        220        230        240        250
RQMGTKQPDA HLAAEEEARR VERLRKQAAQ ERVKQFERAH VRGSQAMKKI 
       260        270        280        290        300
HLAQNQERLM EELKQLQKED LARRRQTVAQ MPPQMLELPY RRSEMKEDRQ 
       310        320        330        340        350
RELEFAFEDM YNADRKVKGN LILHLKPEPL PTISDQLQDE ELDLSMEQEN 
       360        370        380        390        400
QVPLAAKIQQ IPSRILFKRL LNKIRSQKSL WTIKSVSEDE GEVTSSIIEI 
       410        420        430        440        450
ESKVPSVDSG AIITEERTAA SFEQEQVTDS DRLTIESGPL SSEDKPLYYK 
       460        470        480        490        500
AGTGREQAMA VSPPATAVAQ SSVLLHPQEE AVRIRMSLRR KQIMEIEEQK 
       510        520        530        540        550
QKQLELLEQI EQQKLRLETD CFRAQLEEQR KQADQPEVCC APMSHAMISD 
       560        570        580        590        600
EDSHRQMIRN YQHQLLQQNR LHKETVETAR KRLLEYQTVL KERSPSLSAS 
       610        620        630        640        650
ALVPDSVVSG PPQQSYKPAA ASDSWDPSQR LKLSPSKYQP VQPSQIPALE 
       660        670        680        690        700
QSHIQVPRHG HITQRQGKMA VSEMLGKQPV ESQERQWQFS QVETHQGDYE 
       710        720        730        740        750
FVLKDSHSLS RTLSYVRPQT LQDAREVSKP PRVIICQSLD SQQISSEDSE 
       760        770        780        790        800
NISSKPSEPS PFLPLVPERP FTSLPVKFHS GTIHKPFTTI NQSVISQMHD 
       810        820        830        840        850
QPLSSSETIT AQQGDLRFLQ EQLELQKKVL QARQEAREKL LLCTQKELGQ 
       860        870        880        890        900
QTGLPVFLPS PAGNIFSSLP SASAESGNFQ TSSTKSDATV SSDNMDRLWD 
       910        920        930        940        950
SSQPISSQQT HLEFLQEQSS VETDNLQARR EAQEVLFAHT QNTLEKIVRS 
       960        970        980        990       1000
EQAGSSLPHQ VAQQSFSSLT LADTQSKKIQ KQPLPANKKG LLPSQSEVSK 
      1010       1020       1030       1040       1050
AQDGSSGFLQ QTLPLQNTLK LLQEQLTRQR SMIPPRRDGQ ETLLLYKESC 
      1060       1070       1080       1090       1100
SEDSEAGPVE SLSSVVVQHA DASRAVSEVP KRLQDVYSSE EENRVLSSHL 
      1110       1120       1130       1140       1150
ITHGFPQHSL QRQEHFTPLQ EETHIQRLIL GARKNNEEFA PKQNELEKGL 
      1160       1170       1180       1190       1200
CSQQTDALSS PSQVTDWGTS RGSVSVRSDR TDPLRHFKIP AFRERLVRVS 
      1210       1220       1230       1240       1250
QHTFPLQDNL QEHQEWVDTE KESFQSSPLT PENPSSQQTG FSSFKASLRL 
      1260       1270       1280       1290       1300
PSCVSLPSAD SGITQHPLST ESDSKVKSSH LQIPELQHRL SKISQLIPPQ 
      1310       1320       1330       1340       1350
QDSLKALQEQ LATQREAIIH SRQEAHEETL REWKEKIFPE QVGPFSPLIP 
      1360       1370       1380       1390       1400
QHSLASFPVS DTERAQELCS TNSDTISSGY PEMLELPDRT LGLSHTALPQ 
      1410       1420       1430       1440       1450
QNNLTAHPEH LHAQTNFFHS TEKAQEGLVF PRPCQFEEMS AEHFIQPQHD 
      1460       1470       1480       1490       1500
DLKALQQQLD MQREAIRSGQ EMQEKMLLQR LNKLEQRISS KQISSSLFSS 
      1510       1520       1530       1540       1550
QVALPIANSD GTLQSFPTKS NETELLGSQD EYLSFSQPRL PLQNNMTEQL 
      1560       1570       1580       1590       1600
DLEKVFHKEL LLHKQKSQNK SESSEHSLPP LFLSKEIEHP FISLPFAESK 
      1610       1620       1630       1640       1650
SKSICELYLS DKKHAAPNDA VIPRLQDRLL SCSQPVLTQQ DNMSLQKQLN 
      1660       1670       1680       1690       1700
LQRETLHSRQ KAQEELLVQR QTSLQQQIQR HRETLKNFFN VSQARNPTDE 
      1710       1720       1730       1740       1750
NDLEMQKREQ LGGWFPHTQG LTWGDAGQGS ANGEQPRADV HAEHNGESLA 
      1760       1770       1780       1790       1800
KELSGRASKP PVSKVKCVLD LNQHELSTIQ EVESPASGRI SMPGKAEFYQ 
      1810       1820       1830       1840       1850
DRDPLRVSVS REQSFLESPL AHDPFGCHQP PAQENSKSHD DNAEAVKVKK 
      1860       1870       1880       1890       1900
SDVEDHAVLS HAVSKEEACT NLGPLGKPDD EAETQEISQE PLSSVTVSTG 
      1910       1920       1930       1940       1950
SFLSYEITDL SLTDPESFSE QTEHLEQEST NKQEETDPLS IAVPSVIYQQ 
      1960       1970       1980       1990       2000
QHSLGAHNSL LPMEEESTSD HTHVQQIMDN DVNEANLIPD KRDFQVPAVD 
      2010       2020       2030       2040       2050
LDFRELEHIF PHLHRQLFKP LEPHLDFDLS SPGTSQEDSD FYQSSESSSE 
      2060       2070       2080       2090       2100
KHVKALSTGT ICFPALTAKS HSPNPRLNQL DINLAHATTE GSEQSFQQLR 
      2110       2120       2130       2140       2150
PEFSSQESQH ADLPSIYSIE ARGPSQRMEN QNYSEMLQNK KKSLSLQPST 
      2160       2170       2180       2190       2200
EDLTPACSSS DTALFDQLHL QHSTPCASVS SECSVKLLES REEVLGFEEL 
      2210       2220       2230       2240       2250
SRRAVTMSQR LTEDENVVLP INPHVGRVEK EASVQGSNPL SIQNEKPIQN 
      2260       2270       2280       2290       2300
FIETDTTEAV GNVCQLAQAE HILKSCPFRS PIPIWETDTG YGIMEEPDLT 
      2310       2320       2330       2340       2350
LVSNSDISIT ETDLANLTLE DREDNEAQFF QAGVVLPTSS METSVCGAVS 
      2360       2370       2380       2390       2400
EPYVDQPTVA PSATSGSLQE AFMTRQTLTE RSYQRQREIW NKTRLPQTKV 
      2410 
SKEKLPTGCT GS
Length:2,412
Mass (Da):272,779
Last modified:March 18, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58D8E5F8DF469D7D
GO
Isoform 2 (identifier: Q8BQ48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2363-2412: ATSGSLQEAF...EKLPTGCTGS → GKPLISLRTLSTHVGMKATHNFSQIL

Show »
Length:2,388
Mass (Da):269,899
Checksum:iC08293948B87B6D4
GO
Isoform 3 (identifier: Q8BQ48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1995: Missing.

Show »
Length:2,332
Mass (Da):263,650
Checksum:i181E7A2C2BA61D0B
GO
Isoform 4 (identifier: Q8BQ48-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     655-1237: Missing.
     1341-1692: Missing.
     1916-1995: Missing.

Show »
Length:1,397
Mass (Da):157,945
Checksum:i22474DDBFBA35CF6
GO
Isoform 5 (identifier: Q8BQ48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2042-2042: Y → YQ
     2286-2287: ET → VS
     2288-2412: Missing.

Show »
Length:2,288
Mass (Da):259,156
Checksum:i4942174A7B8A8C0B
GO
Isoform 6 (identifier: Q8BQ48-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1916-1995: Missing.
     2286-2287: ET → VS
     2288-2412: Missing.

Show »
Length:2,207
Mass (Da):249,899
Checksum:i104D8153333945CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPW4E9QPW4_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
2,380Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BWD7F7BWD7_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
1,202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N9NPH8A0A1N9NPH8_MOUSE
Centrosomal protein of 295 kDa
Cep295
2,460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V9M5F6V9M5_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6URK1F6URK1_MOUSE
Centrosomal protein of 295 kDa
Cep295 5830418K08Rik
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1STC4A0A1L1STC4_MOUSE
Centrosomal protein of 295 kDa
Cep295
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI18969 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC27153 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD90195 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1344P → T in BAC27977 (PubMed:16141072).Curated1
Sequence conflicti1872L → M in BAC27977 (PubMed:16141072).Curated1
Sequence conflicti1924H → R in BAC27153 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032292655 – 1237Missing in isoform 4. 1 PublicationAdd BLAST583
Alternative sequenceiVSP_0322931341 – 1692Missing in isoform 4. 1 PublicationAdd BLAST352
Alternative sequenceiVSP_0322941916 – 1995Missing in isoform 3, isoform 4 and isoform 6. 3 PublicationsAdd BLAST80
Alternative sequenceiVSP_0322952042Y → YQ in isoform 5. 1 Publication1
Alternative sequenceiVSP_0322962286 – 2287ET → VS in isoform 5 and isoform 6. 1 Publication2
Alternative sequenceiVSP_0322972288 – 2412Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_0322982363 – 2412ATSGS…GCTGS → GKPLISLRTLSTHVGMKATH NFSQIL in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC154296 Genomic DNA No translation available.
AK030838 mRNA Translation: BAC27153.1 Different initiation.
AK032664 mRNA Translation: BAC27977.1
AK051561 mRNA Translation: BAC34674.2
AK134513 mRNA Translation: BAE22166.1
AK220270 mRNA Translation: BAD90195.1 Different initiation.
BC118968 mRNA Translation: AAI18969.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_795950.2, NM_176976.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		319675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:319675

UCSC genome browser

More...UCSCi		uc009ofv.2, mouse [Q8BQ48-4]
uc009ofw.3, mouse [Q8BQ48-1]
uc009ofy.2, mouse [Q8BQ48-6]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154296 Genomic DNA No translation available.
AK030838 mRNA Translation: BAC27153.1 Different initiation.
AK032664 mRNA Translation: BAC27977.1
AK051561 mRNA Translation: BAC34674.2
AK134513 mRNA Translation: BAE22166.1
AK220270 mRNA Translation: BAD90195.1 Different initiation.
BC118968 mRNA Translation: AAI18969.1 Different initiation.
RefSeqiNP_795950.2, NM_176976.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi235442, 6 interactors
STRINGi10090.ENSMUSP00000123788

PTM databases

iPTMnetiQ8BQ48
PhosphoSitePlusiQ8BQ48

Proteomic databases

PaxDbiQ8BQ48
PRIDEiQ8BQ48

Genome annotation databases

GeneIDi319675
KEGGimmu:319675
UCSCiuc009ofv.2, mouse [Q8BQ48-4]
uc009ofw.3, mouse [Q8BQ48-1]
uc009ofy.2, mouse [Q8BQ48-6]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		85459
MGIiMGI:2442521, Cep295

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502QSZR, Eukaryota
HOGENOMiCLU_001093_0_0_1
InParanoidiQ8BQ48
OrthoDBi97863at2759
PhylomeDBiQ8BQ48
TreeFamiTF331536

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		319675, 4 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cep295, mouse

Protein Ontology

More...PROi		PR:Q8BQ48
RNActiQ8BQ48, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000046111, Expressed in forelimb bud and 226 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR029560, CEP295
PANTHERiPTHR21553:SF25, PTHR21553:SF25, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE295_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BQ48
Secondary accession number(s): Q0VF60
, Q3UYP6, Q571B9, Q8CCJ2, Q8CDA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 2, 2020
This is version 106 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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