Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phostensin

Gene

Ppp1r18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May target protein phosphatase 1 to F-actin cytoskeleton.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phostensin
Alternative name(s):
Protein phosphatase 1 F-actin cytoskeleton-targeting subunit
Protein phosphatase 1 regulatory subunit 18
Gene namesi
Name:Ppp1r18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1923698 Ppp1r18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508091 – 594PhostensinAdd BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei174PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei198PhosphothreonineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei412PhosphoserineCombined sources1
Modified residuei437N6-acetyllysineCombined sources1
Modified residuei510PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BQ30
PaxDbiQ8BQ30
PeptideAtlasiQ8BQ30
PRIDEiQ8BQ30

PTM databases

iPTMnetiQ8BQ30
PhosphoSitePlusiQ8BQ30

Expressioni

Gene expression databases

BgeeiENSMUSG00000034595 Expressed in 263 organ(s), highest expression level in spleen
CleanExiMM_2310014H01RIK
ExpressionAtlasiQ8BQ30 baseline and differential
GenevisibleiQ8BQ30 MM

Interactioni

Subunit structurei

Interacts with Protein phosphatase 1 (PP1).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218132, 2 interactors
IntActiQ8BQ30, 3 interactors
STRINGi10090.ENSMUSP00000109445

Structurei

3D structure databases

ProteinModelPortaliQ8BQ30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 105Poly-Gln10

Phylogenomic databases

eggNOGiENOG410IJQY Eukaryota
ENOG410ZUB8 LUCA
GeneTreeiENSGT00530000064035
HOGENOMiHOG000088614
HOVERGENiHBG080180
InParanoidiQ8BQ30
KOiK17559
OMAiWTPRDTE
OrthoDBiEOG091G0B2C
PhylomeDBiQ8BQ30
TreeFamiTF337604

Family and domain databases

InterProiView protein in InterPro
IPR025903 Phostensin/Taperin_N_dom
IPR025907 Phostensin/Taperin_PP1-bd_dom
IPR026671 PPP1R18/Tprn
PANTHERiPTHR21685 PTHR21685, 1 hit
PfamiView protein in Pfam
PF13914 Phostensin, 1 hit
PF13916 Phostensin_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BQ30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAIPDWKLQ LLARRRQEEA AVRGREKAER DRLSQMPAWK RGILERRRAK
60 70 80 90 100
LGLPPGEGSP VPGNAEAGPP DPDESAVLLE AIGPVHQNRF IQQERQRQQQ
110 120 130 140 150
QQQQQRNEVL GDRKAGPLEV LERRSSPGNL RDQSPKGRES REERLSPRES
160 170 180 190 200
RDRRLVIGGA QESSSRSLRD WRQSPAEARD LSSRPAEAQK WRLSPGETPE
210 220 230 240 250
ESLRLAGSGD DSPKRKEVLE SILSPGEPGD QKASPTDVHK WNLDSREPQK
260 270 280 290 300
QSLIQLEATE WRLKSGEERK DYLEGCGREE EKLSSGIVPV TKEVQDITSS
310 320 330 340 350
EVETAEQRPT ESWKWTLNSG KARERTTWDI DTQTQKPDPP ASSEKHPGPS
360 370 380 390 400
GMEAEEEAEK EEAEAQSRPL RAQQNLCSGP SPLPPEHSGT EGSRQQEEEA
410 420 430 440 450
AEPRPPTPAP LSPPPSAPTA PQPSGDPLMS RLFYGVKPGP GVGAPRRSGH
460 470 480 490 500
TFTVNPRRCA PPASPAPPVN PATADAAGSG SGKKRYPTAE EILVLGGYLR
510 520 530 540 550
LSRSCLVKGS PERHHKQLKI SFSETALETT YQYPSESSVL EDLGPEPETP
560 570 580 590
IAPLATQPDE EEEEEEEEEE LLLQPGLQGG LRTKALIVDE SCRR
Length:594
Mass (Da):65,630
Last modified:March 1, 2003 - v1
Checksum:i6B7B10B39C5B44BA
GO
Isoform 2 (identifier: Q8BQ30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-594: DESCRR → GKRLRPGWRRAPPGVCGVVVL

Show »
Length:609
Mass (Da):67,139
Checksum:iFCCF8597C7C96CD6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRI9A0A087WRI9_MOUSE
Phostensin
Ppp1r18
166Annotation score:

Sequence cautioni

The sequence AAH25573 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278R → I in AAH25573 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014260589 – 594DESCRR → GKRLRPGWRRAPPGVCGVVV L in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009340 mRNA Translation: BAC25252.1
AK051656 mRNA Translation: BAC34706.1
AK149943 mRNA Translation: BAE29185.1
CR974451 Genomic DNA No translation available.
BC025573 mRNA Translation: AAH25573.1 Different initiation.
CCDSiCCDS50094.1 [Q8BQ30-1]
RefSeqiNP_001140182.1, NM_001146710.1 [Q8BQ30-1]
NP_001140183.1, NM_001146711.1 [Q8BQ30-1]
NP_780451.1, NM_175242.1 [Q8BQ30-1]
XP_006525155.2, XM_006525092.3 [Q8BQ30-2]
UniGeneiMm.359982
Mm.421125

Genome annotation databases

EnsembliENSMUST00000113814; ENSMUSP00000109445; ENSMUSG00000034595 [Q8BQ30-1]
ENSMUST00000122899; ENSMUSP00000120343; ENSMUSG00000034595 [Q8BQ30-1]
ENSMUST00000127442; ENSMUSP00000115753; ENSMUSG00000034595 [Q8BQ30-2]
ENSMUST00000144382; ENSMUSP00000116100; ENSMUSG00000034595 [Q8BQ30-1]
ENSMUST00000187690; ENSMUSP00000141094; ENSMUSG00000034595 [Q8BQ30-1]
GeneIDi76448
KEGGimmu:76448
UCSCiuc008cit.2 mouse [Q8BQ30-2]
uc008ciu.2 mouse [Q8BQ30-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009340 mRNA Translation: BAC25252.1
AK051656 mRNA Translation: BAC34706.1
AK149943 mRNA Translation: BAE29185.1
CR974451 Genomic DNA No translation available.
BC025573 mRNA Translation: AAH25573.1 Different initiation.
CCDSiCCDS50094.1 [Q8BQ30-1]
RefSeqiNP_001140182.1, NM_001146710.1 [Q8BQ30-1]
NP_001140183.1, NM_001146711.1 [Q8BQ30-1]
NP_780451.1, NM_175242.1 [Q8BQ30-1]
XP_006525155.2, XM_006525092.3 [Q8BQ30-2]
UniGeneiMm.359982
Mm.421125

3D structure databases

ProteinModelPortaliQ8BQ30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218132, 2 interactors
IntActiQ8BQ30, 3 interactors
STRINGi10090.ENSMUSP00000109445

PTM databases

iPTMnetiQ8BQ30
PhosphoSitePlusiQ8BQ30

Proteomic databases

EPDiQ8BQ30
PaxDbiQ8BQ30
PeptideAtlasiQ8BQ30
PRIDEiQ8BQ30

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113814; ENSMUSP00000109445; ENSMUSG00000034595 [Q8BQ30-1]
ENSMUST00000122899; ENSMUSP00000120343; ENSMUSG00000034595 [Q8BQ30-1]
ENSMUST00000127442; ENSMUSP00000115753; ENSMUSG00000034595 [Q8BQ30-2]
ENSMUST00000144382; ENSMUSP00000116100; ENSMUSG00000034595 [Q8BQ30-1]
ENSMUST00000187690; ENSMUSP00000141094; ENSMUSG00000034595 [Q8BQ30-1]
GeneIDi76448
KEGGimmu:76448
UCSCiuc008cit.2 mouse [Q8BQ30-2]
uc008ciu.2 mouse [Q8BQ30-1]

Organism-specific databases

CTDi170954
MGIiMGI:1923698 Ppp1r18

Phylogenomic databases

eggNOGiENOG410IJQY Eukaryota
ENOG410ZUB8 LUCA
GeneTreeiENSGT00530000064035
HOGENOMiHOG000088614
HOVERGENiHBG080180
InParanoidiQ8BQ30
KOiK17559
OMAiWTPRDTE
OrthoDBiEOG091G0B2C
PhylomeDBiQ8BQ30
TreeFamiTF337604

Miscellaneous databases

PROiPR:Q8BQ30
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034595 Expressed in 263 organ(s), highest expression level in spleen
CleanExiMM_2310014H01RIK
ExpressionAtlasiQ8BQ30 baseline and differential
GenevisibleiQ8BQ30 MM

Family and domain databases

InterProiView protein in InterPro
IPR025903 Phostensin/Taperin_N_dom
IPR025907 Phostensin/Taperin_PP1-bd_dom
IPR026671 PPP1R18/Tprn
PANTHERiPTHR21685 PTHR21685, 1 hit
PfamiView protein in Pfam
PF13914 Phostensin, 1 hit
PF13916 Phostensin_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR18_MOUSE
AccessioniPrimary (citable) accession number: Q8BQ30
Secondary accession number(s): B8JJ63
, B8JJ64, Q3UDS6, Q8CEY9, Q8R3D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again