UniProtKB - Q8BPX9 (S15A3_MOUSE)
Protein
Solute carrier family 15 member 3
Gene
Slc15a3
Organism
Mus musculus (Mouse)
Status
Functioni
Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:24695226). Also able to transport carnosine (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:24695226).By similarity1 Publication
Catalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
- H+(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) = H+(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- dipeptide transmembrane transporter activity Source: UniProtKB
- peptidoglycan transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- dipeptide import across plasma membrane Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- peptidoglycan transport Source: UniProtKB
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Immunity, Innate immunity, Peptide transport, Protein transport, Symport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-427975, Proton/oligopeptide cotransporters |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 15 member 3CuratedAlternative name(s): Peptide transporter 3By similarity Peptide/histidine transporter 2By similarity cAMP-inducible gene 1 protein1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929691, Slc15a3 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Lysosome
- Lysosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endosome
- endosome membrane Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 102 – 122 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 367 – 387 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 462 – 481 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 494 – 514 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 538 – 558 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endosome, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295913 | 1 – 578 | Solute carrier family 15 member 3Add BLAST | 578 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 223 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 353 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 436 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q8BPX9 |
PaxDbi | Q8BPX9 |
PeptideAtlasi | Q8BPX9 |
PRIDEi | Q8BPX9 |
PTM databases
GlyGeni | Q8BPX9, 3 sites |
iPTMneti | Q8BPX9 |
PhosphoSitePlusi | Q8BPX9 |
SwissPalmi | Q8BPX9 |
Expressioni
Tissue specificityi
Expressed highly in bone marrow derived macrophages, and weakly in spleen and lung (PubMed:11004510). Expressed in plasmacytoid dendritic cells (pDCs) in response to toll-like receptors (TLR) stimulation (PubMed:24695226).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000024737, Expressed in granulocyte and 110 other tissues |
Genevisiblei | Q8BPX9, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 211140, 3 interactors |
IntActi | Q8BPX9, 1 interactor |
MINTi | Q8BPX9 |
STRINGi | 10090.ENSMUSP00000025646 |
Miscellaneous databases
RNActi | Q8BPX9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000161889 |
HOGENOMi | CLU_009313_6_1_1 |
InParanoidi | Q8BPX9 |
OMAi | LQNCCPR |
OrthoDBi | 365203at2759 |
PhylomeDBi | Q8BPX9 |
TreeFami | TF330897 |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR000109, POT_fam IPR018456, PTR2_symporter_CS |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS01023, PTR2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8BPX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAPRAEEQP SRSGERQPLV ARGPRGPRRW RRTAAAAVLL VQMLERAAFF
60 70 80 90 100
GVTSNLVLYL NSLNFNWDGQ QASRATLLFL GASYLLAPVG GWLADVYLGR
110 120 130 140 150
FLTISLSLLL YLAASGLLLT TITNDGRRSF CGEMPELPLE PACPSSSCQG
160 170 180 190 200
SWSSPYCATT LYLVLLLLAL AASSVRSTLT SFGADQVMDL GRDATRRFFN
210 220 230 240 250
WFYWSINLGA ILSLLVVAFI EQNISFLWGY SIIVGLVGLA FFIFLFATPV
260 270 280 290 300
FITKPPTGSQ VSSMLKLAFQ NCCPCRRSSS RDSESAHLLP DQRSNQPGPS
310 320 330 340 350
PQEDMANFQV LVKILPVMVT LVPYWMVYFQ MQSTYVLQGL HLHIPNIFRT
360 370 380 390 400
NPNISLLLRS DSSNYRIPEA WLLLANVAVI LILIPVKDHL IDPLLLRCKL
410 420 430 440 450
LPSSLQKMAL GMFFGFTSII VAGVLEKERL QYIAANQTVP QLIGKDLYYA
460 470 480 490 500
APLSIWWQIP QYLLIGVSEI FASIPGLEFA YSEAPRSMQG AIMGIFFCLS
510 520 530 540 550
GVGSLLGSGL VALLSFPGGW MYCPKDFGNI NNCQMDRYFF LLAGIEAVTA
560 570
VLFLWIAGRY ERTRQDPASQ RSSSRVRG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 277 | R → K in AAD24570 (PubMed:11004510).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF121080 mRNA Translation: AAD24570.1 AK051941 mRNA Translation: BAC34816.1 BC051940 mRNA Translation: AAH51940.1 |
CCDSi | CCDS29588.1 |
RefSeqi | NP_075531.2, NM_023044.2 |
Genome annotation databases
Ensembli | ENSMUST00000025646; ENSMUSP00000025646; ENSMUSG00000024737 |
GeneIDi | 65221 |
KEGGi | mmu:65221 |
UCSCi | uc008gra.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF121080 mRNA Translation: AAD24570.1 AK051941 mRNA Translation: BAC34816.1 BC051940 mRNA Translation: AAH51940.1 |
CCDSi | CCDS29588.1 |
RefSeqi | NP_075531.2, NM_023044.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 211140, 3 interactors |
IntActi | Q8BPX9, 1 interactor |
MINTi | Q8BPX9 |
STRINGi | 10090.ENSMUSP00000025646 |
PTM databases
GlyGeni | Q8BPX9, 3 sites |
iPTMneti | Q8BPX9 |
PhosphoSitePlusi | Q8BPX9 |
SwissPalmi | Q8BPX9 |
Proteomic databases
MaxQBi | Q8BPX9 |
PaxDbi | Q8BPX9 |
PeptideAtlasi | Q8BPX9 |
PRIDEi | Q8BPX9 |
Protocols and materials databases
Antibodypediai | 50766, 98 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025646; ENSMUSP00000025646; ENSMUSG00000024737 |
GeneIDi | 65221 |
KEGGi | mmu:65221 |
UCSCi | uc008gra.2, mouse |
Organism-specific databases
CTDi | 51296 |
MGIi | MGI:1929691, Slc15a3 |
Phylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000161889 |
HOGENOMi | CLU_009313_6_1_1 |
InParanoidi | Q8BPX9 |
OMAi | LQNCCPR |
OrthoDBi | 365203at2759 |
PhylomeDBi | Q8BPX9 |
TreeFami | TF330897 |
Enzyme and pathway databases
Reactomei | R-MMU-427975, Proton/oligopeptide cotransporters |
Miscellaneous databases
BioGRID-ORCSi | 65221, 2 hits in 17 CRISPR screens |
PROi | PR:Q8BPX9 |
RNActi | Q8BPX9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024737, Expressed in granulocyte and 110 other tissues |
Genevisiblei | Q8BPX9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR000109, POT_fam IPR018456, PTR2_symporter_CS |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS01023, PTR2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S15A3_MOUSE | |
Accessioni | Q8BPX9Primary (citable) accession number: Q8BPX9 Secondary accession number(s): Q9WU80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families