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Protein

Integral membrane protein GPR180

Gene

Gpr180

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR180
Gene namesi
Name:Gpr180
ORF Names:MNCb-3029
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1930949 Gpr180

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023966324 – 441Integral membrane protein GPR180Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BPS4
PaxDbiQ8BPS4
PeptideAtlasiQ8BPS4
PRIDEiQ8BPS4

PTM databases

iPTMnetiQ8BPS4
PhosphoSitePlusiQ8BPS4

Expressioni

Gene expression databases

BgeeiENSMUSG00000022131 Expressed in 268 organ(s), highest expression level in iris
CleanExiMM_GPR180
GenevisibleiQ8BPS4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022728

Structurei

3D structure databases

ProteinModelPortaliQ8BPS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4290 Eukaryota
ENOG410XRGS LUCA
GeneTreeiENSGT00730000111205
HOGENOMiHOG000013021
HOVERGENiHBG056171
InParanoidiQ8BPS4
OMAiCHPGLAC
OrthoDBiEOG091G0LC1
PhylomeDBiQ8BPS4
TreeFamiTF314975

Family and domain databases

InterProiView protein in InterPro
IPR019336 Intimal_thickness-rel_rcpt
PfamiView protein in Pfam
PF10192 GpcrRhopsn4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BPS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGLRLLAVA LTCSCWWPQG GQGKTLRGSF SSAAARDAQG QSIGHFEFHG
60 70 80 90 100
DHALLCVRIN NVAVAVGKEA KLYLFQAQEW LKLLESSPGY SCSERLARAQ
110 120 130 140 150
LTVTVTQTEH NLTVSQLPAP QTWRVFYADK FTCRDDSESP QGEEIPFEMV
160 170 180 190 200
LLNPDAEGNP LDHFSARESG LHEFFFLLVL VYFVTACIYA QSLWQAMKKG
210 220 230 240 250
GPMHTILKVL TTALLLQAAS ALANYIHLSR YSRDGLGVPL IGSLAEVFDI
260 270 280 290 300
ASQIQMLYLL LSLCMGWTIV RMKKSQSRPL QWDSTPASTG IAVFIVITQS
310 320 330 340 350
ILLLWEQFED TSHHSAHSHR SLAGLLLIVL RICLALSLGC GLYQVITVER
360 370 380 390 400
SALKREFYIT FAKGCILWFL CQPALACIAV AFNDYQRDKL ITVGVILCQA
410 420 430 440
VAMVILYRLF LSHSLYWEVS SLSSVTLPLT ISSAHRGRPH F
Length:441
Mass (Da):48,975
Last modified:March 1, 2003 - v1
Checksum:i4FEFB71F60063ED9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti420S → P in BAA95030 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041545 mRNA Translation: BAA95030.1
AK053422 mRNA Translation: BAC35382.1
AK169908 mRNA Translation: BAE41450.1
BC069981 mRNA Translation: AAH69981.1
CCDSiCCDS27333.1
RefSeqiNP_067409.2, NM_021434.5
UniGeneiMm.275411

Genome annotation databases

EnsembliENSMUST00000022728; ENSMUSP00000022728; ENSMUSG00000022131
GeneIDi58245
KEGGimmu:58245
UCSCiuc007uyq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041545 mRNA Translation: BAA95030.1
AK053422 mRNA Translation: BAC35382.1
AK169908 mRNA Translation: BAE41450.1
BC069981 mRNA Translation: AAH69981.1
CCDSiCCDS27333.1
RefSeqiNP_067409.2, NM_021434.5
UniGeneiMm.275411

3D structure databases

ProteinModelPortaliQ8BPS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022728

PTM databases

iPTMnetiQ8BPS4
PhosphoSitePlusiQ8BPS4

Proteomic databases

MaxQBiQ8BPS4
PaxDbiQ8BPS4
PeptideAtlasiQ8BPS4
PRIDEiQ8BPS4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022728; ENSMUSP00000022728; ENSMUSG00000022131
GeneIDi58245
KEGGimmu:58245
UCSCiuc007uyq.2 mouse

Organism-specific databases

CTDi160897
MGIiMGI:1930949 Gpr180

Phylogenomic databases

eggNOGiKOG4290 Eukaryota
ENOG410XRGS LUCA
GeneTreeiENSGT00730000111205
HOGENOMiHOG000013021
HOVERGENiHBG056171
InParanoidiQ8BPS4
OMAiCHPGLAC
OrthoDBiEOG091G0LC1
PhylomeDBiQ8BPS4
TreeFamiTF314975

Miscellaneous databases

ChiTaRSiGpr180 mouse
PROiPR:Q8BPS4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022131 Expressed in 268 organ(s), highest expression level in iris
CleanExiMM_GPR180
GenevisibleiQ8BPS4 MM

Family and domain databases

InterProiView protein in InterPro
IPR019336 Intimal_thickness-rel_rcpt
PfamiView protein in Pfam
PF10192 GpcrRhopsn4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP180_MOUSE
AccessioniPrimary (citable) accession number: Q8BPS4
Secondary accession number(s): Q9JJG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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