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Protein

Small G protein signaling modulator 1

Gene

Sgsm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • activation of GTPase activity Source: GO_Central
  • intracellular protein transport Source: GO_Central
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Small G protein signaling modulator 1
Alternative name(s):
RUN and TBC1 domain-containing protein 2
Gene namesi
Name:Sgsm1
Synonyms:Rutbc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107320 Sgsm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi256L → A: Abolishes interaction with RAB9A. 1 Publication1
Mutagenesisi260K → A: Abolishes interaction with RAB9A. 1 Publication1
Mutagenesisi261N → A: Abolishes interaction with RAB9A. 1 Publication1
Mutagenesisi262N → A: Mildly impaired interaction with RAB9A. 1 Publication1
Mutagenesisi277Y → A: Abolishes interaction with RAB9A. 1 Publication1
Mutagenesisi294N → A: Abolishes interaction with RAB9A. 1 Publication1
Mutagenesisi297M → A: Abolishes interaction with RAB9A. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848341 – 1093Small G protein signaling modulator 1Add BLAST1093

Proteomic databases

PaxDbiQ8BPQ7
PeptideAtlasiQ8BPQ7
PRIDEiQ8BPQ7

PTM databases

iPTMnetiQ8BPQ7
PhosphoSitePlusiQ8BPQ7

Expressioni

Tissue specificityi

Expressed only in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000042216 Expressed in 175 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_SGSM1
ExpressionAtlasiQ8BPQ7 baseline and differential
GenevisibleiQ8BPQ7 MM

Interactioni

Subunit structurei

Interacts with RAB9A (GTP-bound form) and RAB9B (PubMed:25220469). Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61070N
IntActiQ8BPQ7, 2 interactors
STRINGi10090.ENSMUSP00000046544

Structurei

Secondary structure

11093
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8BPQ7
SMRiQ8BPQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 190RUNPROSITE-ProRule annotationAdd BLAST155
Domaini562 – 1026Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST465

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 297Important for interaction with RAB9A and RAB9B1 PublicationAdd BLAST42
Regioni301 – 350Required for interaction with RAP family membersBy similarityAdd BLAST50

Sequence similaritiesi

Belongs to the RUTBC family.Curated

Phylogenomic databases

eggNOGiKOG1648 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00550000074386
HOGENOMiHOG000007057
HOVERGENiHBG108483
InParanoidiQ8BPQ7
KOiK21847
OMAiGGIQHEI
PhylomeDBiQ8BPQ7

Family and domain databases

CDDicd15784 PH_RUTBC, 1 hit
InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR037745 SGSM1/2
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BPQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASVPAEAET RQRLLRTVKK EVKQIMEEAV TRKFVHEDSS HIISFCAAVE
60 70 80 90 100
ACVLHGLRRR AAGFLRSNKI AALFMKVGKG FPPAEELSRK VQELEQLIES
110 120 130 140 150
ARNQIQGLQE NVRKLPKLPN LSPLAIKHLW IRTALFGRVL DKIVHYLVEN
160 170 180 190 200
SSKYYEKEAL LMDPVDGPIL ASLLVGPCAL EYTKMKTADH FWTDPSADEL
210 220 230 240 250
VQRHRIHSSH LRQDSPTKRP ALCIQKRHSS GSMDDRPSIS ARDYVESLHQ
260 270 280 290 300
DSRATLLYGK NNVLVQPRDD MEAVPGYLSL HQTADVMTLK WTPNQLMNGS
310 320 330 340 350
VGDLDYEKSV YWDYAVTIRL EEIVYLHCHQ QVDSGGTVVL VSQDGIQRPP
360 370 380 390 400
FRFPKGGHLL QFLSCLENGL LPHGQLDPPL WSQRGKGKVF PKLRKRSPQG
410 420 430 440 450
SSESTSSDKE DDEATDYVFR IIYPGTQSEF VPQDLMDVSM NNLPPLWQPS
460 470 480 490 500
PRKSSCSSCS QSGSADGGST NGCNHERAPL KLLCDNMKYQ ILSRAFYGWL
510 520 530 540 550
AYCRHLSTVR THLSALVNHM IVSPDLPCDA GQGLTASIWE KYIQDSTTYP
560 570 580 590 600
EQELLRLIYY GGVQPEIRRA VWPFLLGHYQ FGMTEMERKE VDEQIHACYA
610 620 630 640 650
QTMSEWLGCE AIVRQRERES HAAALAKCSS GASLDSHLHR MLHRDSTISN
660 670 680 690 700
ESSQSCSSGR QNLRLQSDSS SSTQVFESVD EVEQTEAEGR SEEKHPKIPN
710 720 730 740 750
GNPANGTCSP DSGHPSSHNF SSGLSEHSEP SLSTEDSVLD AQRSLPAVFR
760 770 780 790 800
PGDSSVEDGQ SSEATTSRDE APREELAVQD SLESDLLANE SLEEFMSIPG
810 820 830 840 850
SLDVALPEKD GAVMDGWPGE ADKPSRADSE DNLSEEPEME SLFPALASLA
860 870 880 890 900
VTSSANNEAS PVSSSGVTYS PELLDLYTVN LHRIEKDVQR CDRSYWYFTA
910 920 930 940 950
ANLEKLRNIM CSYIWQHIEI GYVQGMCDLL APLLVILDDE ALAFSCFTEL
960 970 980 990 1000
MKRMNQNFPH GGAMDTHFAN MRSLIQILDS ELFELMHQNG DYTHFYFCYR
1010 1020 1030 1040 1050
WFLLDFKREL VYDDVFSVWE TIWAAKHVSS AHYVLFIALA LVEVYRDIIL
1060 1070 1080 1090
ENNMDFTDII KFFNEMAERH NAKQILQLAR DLVHKVQILI ENK
Length:1,093
Mass (Da):123,196
Last modified:April 17, 2007 - v2
Checksum:i947E0CDB3220A6FA
GO
Isoform 2 (identifier: Q8BPQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.
     288-308: TLKWTPNQLMNGSVGDLDYEK → MLGQVGLGDLWLPTVSLTSPS

Note: No experimental confirmation available.
Show »
Length:806
Mass (Da):90,498
Checksum:i70B7E2A118BB6A4A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RQR5B2RQR5_MOUSE
Small G protein signaling modulator...
Sgsm1
1,093Annotation score:
D3Z7V4D3Z7V4_MOUSE
Small G protein-signaling modulator...
Sgsm1
677Annotation score:
D3YUT7D3YUT7_MOUSE
Small G protein-signaling modulator...
Sgsm1
706Annotation score:
D3Z7V5D3Z7V5_MOUSE
Small G protein-signaling modulator...
Sgsm1
257Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321E → V in BAE39683 (PubMed:16141072).Curated1
Sequence conflicti550P → T in BAC35428 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246691 – 287Missing in isoform 2. 1 PublicationAdd BLAST287
Alternative sequenceiVSP_024670288 – 308TLKWT…LDYEK → MLGQVGLGDLWLPTVSLTSP S in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053555 mRNA Translation: BAC35428.1
AK167632 mRNA Translation: BAE39683.1
CCDSiCCDS39218.1 [Q8BPQ7-1]
CCDS84935.1 [Q8BPQ7-2]
RefSeqiNP_001156437.1, NM_001162965.1
NP_001296457.1, NM_001309528.1 [Q8BPQ7-2]
NP_766306.2, NM_172718.3
UniGeneiMm.200203

Genome annotation databases

EnsembliENSMUST00000057209; ENSMUSP00000084106; ENSMUSG00000042216 [Q8BPQ7-2]
GeneIDi52850
KEGGimmu:52850
UCSCiuc008yuc.2 mouse [Q8BPQ7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053555 mRNA Translation: BAC35428.1
AK167632 mRNA Translation: BAE39683.1
CCDSiCCDS39218.1 [Q8BPQ7-1]
CCDS84935.1 [Q8BPQ7-2]
RefSeqiNP_001156437.1, NM_001162965.1
NP_001296457.1, NM_001309528.1 [Q8BPQ7-2]
NP_766306.2, NM_172718.3
UniGeneiMm.200203

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QXAX-ray2.30B254-425[»]
ProteinModelPortaliQ8BPQ7
SMRiQ8BPQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61070N
IntActiQ8BPQ7, 2 interactors
STRINGi10090.ENSMUSP00000046544

PTM databases

iPTMnetiQ8BPQ7
PhosphoSitePlusiQ8BPQ7

Proteomic databases

PaxDbiQ8BPQ7
PeptideAtlasiQ8BPQ7
PRIDEiQ8BPQ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057209; ENSMUSP00000084106; ENSMUSG00000042216 [Q8BPQ7-2]
GeneIDi52850
KEGGimmu:52850
UCSCiuc008yuc.2 mouse [Q8BPQ7-2]

Organism-specific databases

CTDi129049
MGIiMGI:107320 Sgsm1

Phylogenomic databases

eggNOGiKOG1648 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00550000074386
HOGENOMiHOG000007057
HOVERGENiHBG108483
InParanoidiQ8BPQ7
KOiK21847
OMAiGGIQHEI
PhylomeDBiQ8BPQ7

Miscellaneous databases

PROiPR:Q8BPQ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042216 Expressed in 175 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_SGSM1
ExpressionAtlasiQ8BPQ7 baseline and differential
GenevisibleiQ8BPQ7 MM

Family and domain databases

CDDicd15784 PH_RUTBC, 1 hit
InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR037745 SGSM1/2
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGSM1_MOUSE
AccessioniPrimary (citable) accession number: Q8BPQ7
Secondary accession number(s): Q3TJ12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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