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Protein

Protein mab-21-like 2

Gene

Mab21l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning.2 Publications

GO - Biological processi

  • camera-type eye development Source: MGI
  • embryonic body morphogenesis Source: MGI
  • eye development Source: UniProtKB
  • positive regulation of cell proliferation Source: MGI

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mab-21-like 2
Gene namesi
Name:Mab21l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1346022 Mab21l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127881 – 359Protein mab-21-like 2Add BLAST359

Proteomic databases

MaxQBiQ8BPP1
PaxDbiQ8BPP1
PRIDEiQ8BPP1

PTM databases

iPTMnetiQ8BPP1
PhosphoSitePlusiQ8BPP1

Expressioni

Tissue specificityi

Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain (PubMed:10556287). In embryos at 10.5 days post-coitum strongly expressed in the rostral and distal regions of the developing neural retina, with no expression immediately adjacent to the closing optic fissure. Expression is also observed in the dorsal and ventral aspects of the developing forelimb bud and in the developing pharyngeal arches, as well as in the midbrain (PubMed:24906020).2 Publications

Developmental stagei

Expressed in the developing dorsal midbrain, the posterior portion of the mesencephalon and the retinal primordium of the optic cup. At E10, expressed in the temporal and nasal aspect of the retina and throughout the length of the dorsal midbrain. At E10.5 this retinal pattern of expression persists, and extraneural sites of expression include the branchial region, limb buds and intestine. Also highly expressed in the alar mesencephalon and the rhombencephalic basal plate from E10.5 to E14.5, and in the posterior third of the tectum and the presumptive gut wall. Also strongly expressed in the hindbrain, optic vesicle, maxillary and mandible process, paraxial mesoderm, developing digits and the umbilical cord.5 Publications

Gene expression databases

BgeeiENSMUSG00000057777 Expressed in 176 organ(s), highest expression level in maxillary prominence
CleanExiMM_MAB21L2
GenevisibleiQ8BPP1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076729

Structurei

3D structure databases

ProteinModelPortaliQ8BPP1
SMRiQ8BPP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGiKOG3963 Eukaryota
ENOG410XNRJ LUCA
GeneTreeiENSGT00510000046791
HOGENOMiHOG000007337
HOVERGENiHBG053080
InParanoidiQ8BPP1
OMAiNLLLYEC
OrthoDBiEOG091G0939
PhylomeDBiQ8BPP1
TreeFamiTF315012

Family and domain databases

InterProiView protein in InterPro
IPR024810 Mab-21_dom
IPR020950 Mab21/Mab21-l2
IPR000772 Ricin_B_lectin
PANTHERiPTHR10656:SF37 PTHR10656:SF37, 1 hit
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BPP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIAAQAKLVY QLNKYYTERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP
60 70 80 90 100
RFISSLSEID ARYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL
110 120 130 140 150
KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK
160 170 180 190 200
MIADTSEVKL RIRERYVVQI TPAFKCTGIW PRSAAQWPMP HIPWPGPNRV
210 220 230 240 250
AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFGEAENR LLMGGCRNKC
260 270 280 290 300
LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDEACLGDRL
310 320 330 340 350
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL

TNPKSLDKL
Length:359
Mass (Da):40,907
Last modified:March 1, 2003 - v1
Checksum:i24B7A0CF0E78A1AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98 – 99AV → PC in AAD39141 (PubMed:10495284).Curated2
Sequence conflicti98 – 99AV → PC in AAK49026 (PubMed:11857508).Curated2
Sequence conflicti254L → Q in AAD40478 (PubMed:10556287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149877 mRNA Translation: AAD40478.1
AF126427 mRNA Translation: AAD39141.1
AF223425 Genomic DNA Translation: AAK49026.1
AK053645 mRNA Translation: BAC35460.1
BC046628 mRNA Translation: AAH46628.1
CCDSiCCDS17447.1
RefSeqiNP_035969.2, NM_011839.3
UniGeneiMm.389466

Genome annotation databases

EnsembliENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777
GeneIDi23937
KEGGimmu:23937
UCSCiuc008prj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149877 mRNA Translation: AAD40478.1
AF126427 mRNA Translation: AAD39141.1
AF223425 Genomic DNA Translation: AAK49026.1
AK053645 mRNA Translation: BAC35460.1
BC046628 mRNA Translation: AAH46628.1
CCDSiCCDS17447.1
RefSeqiNP_035969.2, NM_011839.3
UniGeneiMm.389466

3D structure databases

ProteinModelPortaliQ8BPP1
SMRiQ8BPP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076729

PTM databases

iPTMnetiQ8BPP1
PhosphoSitePlusiQ8BPP1

Proteomic databases

MaxQBiQ8BPP1
PaxDbiQ8BPP1
PRIDEiQ8BPP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777
GeneIDi23937
KEGGimmu:23937
UCSCiuc008prj.1 mouse

Organism-specific databases

CTDi10586
MGIiMGI:1346022 Mab21l2

Phylogenomic databases

eggNOGiKOG3963 Eukaryota
ENOG410XNRJ LUCA
GeneTreeiENSGT00510000046791
HOGENOMiHOG000007337
HOVERGENiHBG053080
InParanoidiQ8BPP1
OMAiNLLLYEC
OrthoDBiEOG091G0939
PhylomeDBiQ8BPP1
TreeFamiTF315012

Miscellaneous databases

PROiPR:Q8BPP1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057777 Expressed in 176 organ(s), highest expression level in maxillary prominence
CleanExiMM_MAB21L2
GenevisibleiQ8BPP1 MM

Family and domain databases

InterProiView protein in InterPro
IPR024810 Mab-21_dom
IPR020950 Mab21/Mab21-l2
IPR000772 Ricin_B_lectin
PANTHERiPTHR10656:SF37 PTHR10656:SF37, 1 hit
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMB212_MOUSE
AccessioniPrimary (citable) accession number: Q8BPP1
Secondary accession number(s): Q9R1B2, Q9WVF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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