UniProtKB - Q8BPP1 (MB212_MOUSE)
Protein
Protein mab-21-like 2
Gene
Mab21l2
Organism
Mus musculus (Mouse)
Status
Functioni
Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning.2 Publications
GO - Biological processi
- camera-type eye development Source: MGI
- embryonic body morphogenesis Source: MGI
- eye development Source: UniProtKB
- positive regulation of cell population proliferation Source: MGI
Keywordsi
Molecular function | Developmental protein |
Names & Taxonomyi
Protein namesi | Recommended name: Protein mab-21-like 2 |
Gene namesi | Name:Mab21l2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1346022, Mab21l2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312788 | 1 – 359 | Protein mab-21-like 2Add BLAST | 359 |
Proteomic databases
MaxQBi | Q8BPP1 |
PaxDbi | Q8BPP1 |
PRIDEi | Q8BPP1 |
ProteomicsDBi | 295702 |
PTM databases
iPTMneti | Q8BPP1 |
PhosphoSitePlusi | Q8BPP1 |
Expressioni
Tissue specificityi
Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain (PubMed:10556287). In embryos at 10.5 days post-coitum strongly expressed in the rostral and distal regions of the developing neural retina, with no expression immediately adjacent to the closing optic fissure. Expression is also observed in the dorsal and ventral aspects of the developing forelimb bud and in the developing pharyngeal arches, as well as in the midbrain (PubMed:24906020).2 Publications
Developmental stagei
Expressed in the developing dorsal midbrain, the posterior portion of the mesencephalon and the retinal primordium of the optic cup. At 10 dpc, expressed in the temporal and nasal aspect of the retina and throughout the length of the dorsal midbrain. At 10.5 dpc this retinal pattern of expression persists, and extraneural sites of expression include the branchial region, limb buds and intestine. Also highly expressed in the alar mesencephalon and the rhombencephalic basal plate from 10.5 dpc to 14.5 dpc, and in the posterior third of the tectum and the presumptive gut wall. Also strongly expressed in the hindbrain, optic vesicle, maxillary and mandible process, paraxial mesoderm, developing digits and the umbilical cord.5 Publications
Gene expression databases
Bgeei | ENSMUSG00000057777, Expressed in maxillary prominence and 194 other tissues |
Genevisiblei | Q8BPP1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076729 |
Miscellaneous databases
RNActi | Q8BPP1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the mab-21 family.Curated
Phylogenomic databases
eggNOGi | KOG3963, Eukaryota |
GeneTreei | ENSGT01020000230508 |
HOGENOMi | CLU_045315_0_0_1 |
InParanoidi | Q8BPP1 |
OMAi | YRRCPHY |
OrthoDBi | 101142at2759 |
PhylomeDBi | Q8BPP1 |
TreeFami | TF315012 |
Family and domain databases
InterProi | View protein in InterPro IPR024810, Mab-21_dom IPR020950, Mab21-l2 IPR000772, Ricin_B_lectin |
PANTHERi | PTHR10656:SF37, PTHR10656:SF37, 1 hit |
Pfami | View protein in Pfam PF03281, Mab-21, 1 hit |
SMARTi | View protein in SMART SM01265, Mab-21, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8BPP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIAAQAKLVY QLNKYYTERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP
60 70 80 90 100
RFISSLSEID ARYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL
110 120 130 140 150
KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK
160 170 180 190 200
MIADTSEVKL RIRERYVVQI TPAFKCTGIW PRSAAQWPMP HIPWPGPNRV
210 220 230 240 250
AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFGEAENR LLMGGCRNKC
260 270 280 290 300
LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDEACLGDRL
310 320 330 340 350
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL
TNPKSLDKL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 – 99 | AV → PC in AAD39141 (PubMed:10495284).Curated | 2 | |
Sequence conflicti | 98 – 99 | AV → PC in AAK49026 (PubMed:11857508).Curated | 2 | |
Sequence conflicti | 254 | L → Q in AAD40478 (PubMed:10556287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF149877 mRNA Translation: AAD40478.1 AF126427 mRNA Translation: AAD39141.1 AF223425 Genomic DNA Translation: AAK49026.1 AK053645 mRNA Translation: BAC35460.1 BC046628 mRNA Translation: AAH46628.1 |
CCDSi | CCDS17447.1 |
RefSeqi | NP_035969.2, NM_011839.3 |
Genome annotation databases
Ensembli | ENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777 |
GeneIDi | 23937 |
KEGGi | mmu:23937 |
UCSCi | uc008prj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF149877 mRNA Translation: AAD40478.1 AF126427 mRNA Translation: AAD39141.1 AF223425 Genomic DNA Translation: AAK49026.1 AK053645 mRNA Translation: BAC35460.1 BC046628 mRNA Translation: AAH46628.1 |
CCDSi | CCDS17447.1 |
RefSeqi | NP_035969.2, NM_011839.3 |
3D structure databases
SMRi | Q8BPP1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076729 |
PTM databases
iPTMneti | Q8BPP1 |
PhosphoSitePlusi | Q8BPP1 |
Proteomic databases
MaxQBi | Q8BPP1 |
PaxDbi | Q8BPP1 |
PRIDEi | Q8BPP1 |
ProteomicsDBi | 295702 |
Protocols and materials databases
Antibodypediai | 45517, 42 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777 |
GeneIDi | 23937 |
KEGGi | mmu:23937 |
UCSCi | uc008prj.1, mouse |
Organism-specific databases
CTDi | 10586 |
MGIi | MGI:1346022, Mab21l2 |
Phylogenomic databases
eggNOGi | KOG3963, Eukaryota |
GeneTreei | ENSGT01020000230508 |
HOGENOMi | CLU_045315_0_0_1 |
InParanoidi | Q8BPP1 |
OMAi | YRRCPHY |
OrthoDBi | 101142at2759 |
PhylomeDBi | Q8BPP1 |
TreeFami | TF315012 |
Miscellaneous databases
BioGRID-ORCSi | 23937, 0 hits in 53 CRISPR screens |
PROi | PR:Q8BPP1 |
RNActi | Q8BPP1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000057777, Expressed in maxillary prominence and 194 other tissues |
Genevisiblei | Q8BPP1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR024810, Mab-21_dom IPR020950, Mab21-l2 IPR000772, Ricin_B_lectin |
PANTHERi | PTHR10656:SF37, PTHR10656:SF37, 1 hit |
Pfami | View protein in Pfam PF03281, Mab-21, 1 hit |
SMARTi | View protein in SMART SM01265, Mab-21, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MB212_MOUSE | |
Accessioni | Q8BPP1Primary (citable) accession number: Q8BPP1 Secondary accession number(s): Q9R1B2, Q9WVF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families