Mab21l2

Functionⁱ

Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning.2 Publications

GO - Biological processⁱ

camera-type eye development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15385160
embryonic body morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15385160
eye development Source: UniProtKB
positive regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15385160

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein

Molecular function

Developmental protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein mab-21-like 2
Gene namesⁱ	Name:Mab21l2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1346022 Mab21l2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000312788	1 – 359	Protein mab-21-like 2Add BLAST		359

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8BPP1
PaxDbⁱ	Q8BPP1
PRIDEⁱ	Q8BPP1

PTM databases

iPTMnetⁱ	Q8BPP1
PhosphoSitePlusⁱ	Q8BPP1

Expressionⁱ

Tissue specificityⁱ

Expressed in the adult cerebellum and eye, with lower levels in the adult forebrain (PubMed:10556287). In embryos at 10.5 days post-coitum strongly expressed in the rostral and distal regions of the developing neural retina, with no expression immediately adjacent to the closing optic fissure. Expression is also observed in the dorsal and ventral aspects of the developing forelimb bud and in the developing pharyngeal arches, as well as in the midbrain (PubMed:24906020).2 Publications

Developmental stageⁱ

Expressed in the developing dorsal midbrain, the posterior portion of the mesencephalon and the retinal primordium of the optic cup. At E10, expressed in the temporal and nasal aspect of the retina and throughout the length of the dorsal midbrain. At E10.5 this retinal pattern of expression persists, and extraneural sites of expression include the branchial region, limb buds and intestine. Also highly expressed in the alar mesencephalon and the rhombencephalic basal plate from E10.5 to E14.5, and in the posterior third of the tectum and the presumptive gut wall. Also strongly expressed in the hindbrain, optic vesicle, maxillary and mandible process, paraxial mesoderm, developing digits and the umbilical cord.5 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000057777 Expressed in 176 organ(s), highest expression level in maxillary prominence
CleanExⁱ	MM_MAB21L2
Genevisibleⁱ	Q8BPP1 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000076729

STRINGⁱ

10090.ENSMUSP00000076729

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BPP1
SMRⁱ	Q8BPP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3963 Eukaryota ENOG410XNRJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046791
HOGENOMⁱ	HOG000007337
HOVERGENⁱ	HBG053080
InParanoidⁱ	Q8BPP1
OMAⁱ	NLLLYEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0939
PhylomeDBⁱ	Q8BPP1
TreeFamⁱ	TF315012

Family and domain databases

InterProⁱ	View protein in InterPro IPR024810 Mab-21_dom IPR020950 Mab21/Mab21-l2 IPR000772 Ricin_B_lectin
PANTHERⁱ	PTHR10656:SF37 PTHR10656:SF37, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03281 Mab-21, 1 hit
SMARTⁱ	View protein in SMART SM01265 Mab-21, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8BPP1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIAAQAKLVY QLNKYYTERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP 
        60         70         80         90        100
RFISSLSEID ARYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL 
       110        120        130        140        150
KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK 
       160        170        180        190        200
MIADTSEVKL RIRERYVVQI TPAFKCTGIW PRSAAQWPMP HIPWPGPNRV 
       210        220        230        240        250
AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFGEAENR LLMGGCRNKC 
       260        270        280        290        300
LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDEACLGDRL 
       310        320        330        340        350
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL 

TNPKSLDKL

Length:359

Mass (Da):40,907

Last modified:March 1, 2003 - v1

Checksum:ⁱ24B7A0CF0E78A1AA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	98 – 99	AV → PC in AAD39141 (PubMed:10495284).Curated	2
Sequence conflictⁱ	98 – 99	AV → PC in AAK49026 (PubMed:11857508).Curated	2
Sequence conflictⁱ	254	L → Q in AAD40478 (PubMed:10556287).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF149877 mRNA Translation: AAD40478.1 AF126427 mRNA Translation: AAD39141.1 AF223425 Genomic DNA Translation: AAK49026.1 AK053645 mRNA Translation: BAC35460.1 BC046628 mRNA Translation: AAH46628.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17447.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035969.2, NM_011839.3
UniGeneⁱ	Mm.389466

Genome annotation databases

Ensemblⁱ	ENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777
GeneIDⁱ	23937
KEGGⁱ	mmu:23937
UCSC genome browser More...UCSCⁱ	uc008prj.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BPP1	Protein mab-21-like 2		Bengalese finch		438	UniRef100_Q8BPP1
Uncharacterized protein (Fragment)		AILME		359
Protein mab-21-like 2-like protein		CAMFR		359
protein mab-21-like 2		BALAS		359
Uncharacterized protein		MUSPF		359
+55

Protein	Similar proteins		Species	Score	Length	Source
Q8BPP1	Protein mab-21-like 2		HUMAN		359	UniRef90_Q9Y586
Protein mab-21-like 2		XENTR		359
Protein mab-21-like 2		DANRE		359
Putative nucleotidyltransferase MAB21L1		XENLA		359
MAB21L2 isoform 1		PANTR		359
+215

Protein	Similar proteins		Species	Score	Length	Source
Q8BPP1	Putative nucleotidyltransferase MAB21L1	)	HUMAN		359	UniRef50_Q13394
Putative nucleotidyltransferase MAB21L1		BOVIN		359
Putative nucleotidyltransferase MAB21L1		CHICK		359
Putative nucleotidyltransferase MAB21L1		MOUSE		359
Putative nucleotidyltransferase MAB21L1		XENTR		359
+514

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF149877 mRNA Translation: AAD40478.1 AF126427 mRNA Translation: AAD39141.1 AF223425 Genomic DNA Translation: AAK49026.1 AK053645 mRNA Translation: BAC35460.1 BC046628 mRNA Translation: AAH46628.1
CCDSⁱ	CCDS17447.1
RefSeqⁱ	NP_035969.2, NM_011839.3
UniGeneⁱ	Mm.389466

3D structure databases

ProteinModelPortalⁱ	Q8BPP1
SMRⁱ	Q8BPP1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000076729

STRINGⁱ

10090.ENSMUSP00000076729

PTM databases

iPTMnetⁱ	Q8BPP1
PhosphoSitePlusⁱ	Q8BPP1

Proteomic databases

MaxQBⁱ	Q8BPP1
PaxDbⁱ	Q8BPP1
PRIDEⁱ	Q8BPP1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000077524; ENSMUSP00000076729; ENSMUSG00000057777
GeneIDⁱ	23937
KEGGⁱ	mmu:23937
UCSCⁱ	uc008prj.1 mouse

Organism-specific databases

CTDⁱ	10586
MGIⁱ	MGI:1346022 Mab21l2

Phylogenomic databases

eggNOGⁱ	KOG3963 Eukaryota ENOG410XNRJ LUCA
GeneTreeⁱ	ENSGT00510000046791
HOGENOMⁱ	HOG000007337
HOVERGENⁱ	HBG053080
InParanoidⁱ	Q8BPP1
OMAⁱ	NLLLYEC
OrthoDBⁱ	EOG091G0939
PhylomeDBⁱ	Q8BPP1
TreeFamⁱ	TF315012

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8BPP1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000057777 Expressed in 176 organ(s), highest expression level in maxillary prominence
CleanExⁱ	MM_MAB21L2
Genevisibleⁱ	Q8BPP1 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR024810 Mab-21_dom IPR020950 Mab21/Mab21-l2 IPR000772 Ricin_B_lectin
PANTHERⁱ	PTHR10656:SF37 PTHR10656:SF37, 1 hit
Pfamⁱ	View protein in Pfam PF03281 Mab-21, 1 hit
SMARTⁱ	View protein in SMART SM01265 Mab-21, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MB212_MOUSE
Accessionⁱ	Q8BPP1Primary (citable) accession number: Q8BPP1 Secondary accession number(s): Q9R1B2, Q9WVF2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q8BPP1 (MB212_MOUSE)

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Protein mab-21-like 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ