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Protein

Zinc finger protein 436

Gene

Znf436

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri120 – 142C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri148 – 170C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 436
Alternative name(s):
Zinc finger protein 46
Short name:
Zfp-46
Zinc finger protein MLZ-4
Gene namesi
Name:Znf436
Synonyms:Kiaa1710, Mlz-4, Zfp46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99192 Zfp46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475851 – 452Zinc finger protein 436Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BPP0
PRIDEiQ8BPP0

PTM databases

iPTMnetiQ8BPP0
PhosphoSitePlusiQ8BPP0

Expressioni

Tissue specificityi

Lens, liver, heart, kidney, spleen and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000051351 Expressed in 282 organ(s), highest expression level in telencephalon
ExpressionAtlasiQ8BPP0 baseline and differential
GenevisibleiQ8BPP0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070216

Structurei

3D structure databases

ProteinModelPortaliQ8BPP0
SMRiQ8BPP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 100KRABPROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri120 – 142C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri148 – 170C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150882
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BPP0
KOiK09228
OMAiERPVGNT
OrthoDBiEOG091G02KC
PhylomeDBiQ8BPP0
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8BPP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMYLTREEW RPLDPTQRDL YRDVMQENYG NVVSLDFEIR SENEANPKQE
60 70 80 90 100
FSDDVEFATM SEEPLENAEK NPGSEEAFES GDQAERPWGD LTAEEWVSYP
110 120 130 140 150
LQQVTDLLVH KEAHAGIRYH ICSQCGKAFS QISDLNRHQK THTGDRPYKC
160 170 180 190 200
YECGKGFSRS SHLIQHQRTH TGERPYDCNE CGKSFGRSSH LIQHQTIHTG
210 220 230 240 250
EKPHKCTECG KSFCRLSHLI QHQRTHSGEK PYECEECGKS FSRSSHLAQH
260 270 280 290 300
QRTHTGEKPY ECHECGRGFS ERSDLIKHYR VHTGERPYKC DECGKNFSQN
310 320 330 340 350
SDLVRHRRAH TGEKPYHCNE CGENFSRISH LVQHQRTHTG EKPYECTACG
360 370 380 390 400
KSFSRSSHLI THQKIHTGEK PYECNECWRS FGERSDLIKH QRTHTGEKPY
410 420 430 440 450
ECVQCGKGFT QSSNLITHQR VHTGEKPYEC TECDKSFSRS SALIKHKRVH

TD
Length:452
Mass (Da):52,363
Last modified:March 1, 2003 - v1
Checksum:i46614D72AF7EB1AC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AW49A2AW49_MOUSE
Zinc finger protein 46
Zfp46
157Annotation score:
A2AW48A2AW48_MOUSE
Zinc finger protein 46
Zfp46
130Annotation score:
A2AW47A2AW47_MOUSE
Zinc finger protein 46
Zfp46
76Annotation score:

Sequence cautioni

The sequence AAA39949 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32518 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3M → I in BAC34503 (PubMed:16141072).Curated1
Sequence conflicti210 – 217GKSFCRLS → AKASAASP in AAA39949 (PubMed:8444344).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173240 mRNA Translation: BAD32518.1 Different initiation.
AK051031 mRNA Translation: BAC34503.1
AK053652 mRNA Translation: BAC35464.1
AK136405 mRNA Translation: BAE22966.1
AK148255 mRNA Translation: BAE28441.1
M98502 mRNA Translation: AAA39949.1 Different initiation.
CCDSiCCDS18804.1
PIRiJN0533
RefSeqiNP_033583.2, NM_009557.3
XP_006538794.1, XM_006538731.1
XP_006538795.1, XM_006538732.1
UniGeneiMm.1504

Genome annotation databases

EnsembliENSMUST00000069195; ENSMUSP00000070216; ENSMUSG00000051351
GeneIDi22704
KEGGimmu:22704
UCSCiuc008vhw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173240 mRNA Translation: BAD32518.1 Different initiation.
AK051031 mRNA Translation: BAC34503.1
AK053652 mRNA Translation: BAC35464.1
AK136405 mRNA Translation: BAE22966.1
AK148255 mRNA Translation: BAE28441.1
M98502 mRNA Translation: AAA39949.1 Different initiation.
CCDSiCCDS18804.1
PIRiJN0533
RefSeqiNP_033583.2, NM_009557.3
XP_006538794.1, XM_006538731.1
XP_006538795.1, XM_006538732.1
UniGeneiMm.1504

3D structure databases

ProteinModelPortaliQ8BPP0
SMRiQ8BPP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070216

PTM databases

iPTMnetiQ8BPP0
PhosphoSitePlusiQ8BPP0

Proteomic databases

PaxDbiQ8BPP0
PRIDEiQ8BPP0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069195; ENSMUSP00000070216; ENSMUSG00000051351
GeneIDi22704
KEGGimmu:22704
UCSCiuc008vhw.1 mouse

Organism-specific databases

CTDi22704
MGIiMGI:99192 Zfp46
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150882
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8BPP0
KOiK09228
OMAiERPVGNT
OrthoDBiEOG091G02KC
PhylomeDBiQ8BPP0
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q8BPP0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051351 Expressed in 282 organ(s), highest expression level in telencephalon
ExpressionAtlasiQ8BPP0 baseline and differential
GenevisibleiQ8BPP0 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN436_MOUSE
AccessioniPrimary (citable) accession number: Q8BPP0
Secondary accession number(s): Q03309, Q69ZC6, Q8BQC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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