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Protein

Protein kintoun

Gene

Dnaaf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kintounUniRule annotation
Alternative name(s):
Dynein assembly factor 2, axonemalUniRule annotation
Gene namesi
Name:Dnaaf2UniRule annotation
Synonyms:KtuUniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1923566 Dnaaf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899121 – 814Protein kintounAdd BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei444PhosphoserineBy similarity1
Modified residuei618PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BPI1
PRIDEiQ8BPI1

PTM databases

iPTMnetiQ8BPI1
PhosphoSitePlusiQ8BPI1

Expressioni

Tissue specificityi

Expressed in nearly all organs of adult, with higher expression in tissues known to have motile cilia and flagella, such as brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000020973 Expressed in 219 organ(s), highest expression level in testis
CleanExiMM_1110034A24RIK
GenevisibleiQ8BPI1 MM

Interactioni

Subunit structurei

Interacts with DNAI2 and HSPA1A (PubMed:19052621). Interacts with CFAP300. Interacts with DNAAF4. Interacts with PIH1D3 (By similarity).UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dnai2A2AC932EBI-15744709,EBI-15744757

Protein-protein interaction databases

DIPiDIP-59777N
IntActiQ8BPI1, 6 interactors
STRINGi10090.ENSMUSP00000021356

Structurei

3D structure databases

ProteinModelPortaliQ8BPI1
SMRiQ8BPI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIH1 family. Kintoun subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG4356 Eukaryota
ENOG410XQ8C LUCA
GeneTreeiENSGT00510000048466
HOGENOMiHOG000094570
HOVERGENiHBG108080
InParanoidiQ8BPI1
KOiK19751
OMAiTEPRCSV
OrthoDBiEOG091G0J98
TreeFamiTF336215

Family and domain databases

HAMAPiMF_03069 Kintoun, 1 hit
InterProiView protein in InterPro
IPR034727 Kintoun
IPR012981 PIH1_dom
PANTHERiPTHR22997 PTHR22997, 1 hit
PfamiView protein in Pfam
PF08190 PIH1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BPI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKAAASSAL EDLDLSREEV QRFTSAFQDP EFRRMFSEYA AEITDPENRR
60 70 80 90 100
RYEEEITALE RERGVDVRFV HPEPGHVLRT SLDGEHRCYV NVCSNSLVGV
110 120 130 140 150
PSSRPGPGRG GTAAGSHWSL PYSLAPGRQY AGRNGARYTV YDVVFHPEAL
160 170 180 190 200
ALARSHERFR EMLDATALEA VEQQFGVRLD RRNAKTLKIK YKGMPEAAVL
210 220 230 240 250
RTPLPGGVPA QPEGEPPGLF PDPPYPYRYP AAAAANTARS PASPAPEAVQ
260 270 280 290 300
RPEPTEPRCS VVQRHHVDLQ DYRCSRDAAP STVPHELVVT IELPLLRSVE
310 320 330 340 350
RAELEVKGKL LCLDSRNPDY RLRLSLPYPV DDGRGKAQYN KARRQLVVTL
360 370 380 390 400
PVALADARQE PPAATPEEPA EETGTDDVAR TSAGDFAAAR EESADGTGAD
410 420 430 440 450
HGEKSGVGAP DPGAAHAEGE LVPEPEQDFG GDSVAPLDLG KGTSPGDRSL
460 470 480 490 500
PYSAFPGGDT ESLCGDPGVQ TNEEQERTRH DTAGSAMGDP GTESIAPVCP
510 520 530 540 550
PLQCNQDEDS LTLLIQVPGI LPQTLHGHLS PVGYELCFST QDSGYSCTLQ
560 570 580 590 600
FAPENKLSTR EPETSVSLNN AVIVLAKSPE SHGLWREWYC GLNKESLEER
610 620 630 640 650
LFINEENVNG FLEEVLCSPL KQARSLAPPL IEVLQATDEQ VQIHAELQEC
660 670 680 690 700
SDPAGLQGKG KGVREGCPLS EAEAADQSAT SPAASDSAAA VEALKINTHG
710 720 730 740 750
SAVDLQHGCP EVPHVLSGKP LQPEAKMDPE FIRESSTTYS TEEKENIREP
760 770 780 790 800
VISKGEKING DHPSSLLNKT VVQNIPDFDT IKETNMQDGS VQIIRDHTTH
810
CAFSFQNPLL YDLD
Length:814
Mass (Da):88,327
Last modified:March 3, 2009 - v2
Checksum:i62F63A64B3BE73E3
GO
Isoform 2 (identifier: Q8BPI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-437: Missing.

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):84,605
Checksum:iCA6EA380AF386A6F
GO

Sequence cautioni

The sequence AAH58344 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB28455 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC35879 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE32466 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE43032 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463L → Q in BAB28455 (PubMed:16141072).Curated1
Sequence conflicti753S → T in BAE32466 (PubMed:16141072).Curated1
Sequence conflicti791V → E in BAB28455 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036538400 – 437Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB455811 mRNA Translation: BAG75151.1
BC055807 mRNA Translation: AAH55807.1
BC058344 mRNA Translation: AAH58344.1 Different initiation.
BC062898 mRNA Translation: AAH62898.1
AK012767 mRNA Translation: BAB28455.1 Different initiation.
AK075648 mRNA Translation: BAC35879.1 Different initiation.
AK154254 mRNA Translation: BAE32466.1 Different initiation.
AK172494 mRNA Translation: BAE43032.1 Different initiation.
CCDSiCCDS25948.1 [Q8BPI1-1]
RefSeqiNP_081545.3, NM_027269.4 [Q8BPI1-1]
UniGeneiMm.107180

Genome annotation databases

EnsembliENSMUST00000021356; ENSMUSP00000021356; ENSMUSG00000020973 [Q8BPI1-1]
GeneIDi109065
KEGGimmu:109065
UCSCiuc007nrt.1 mouse [Q8BPI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB455811 mRNA Translation: BAG75151.1
BC055807 mRNA Translation: AAH55807.1
BC058344 mRNA Translation: AAH58344.1 Different initiation.
BC062898 mRNA Translation: AAH62898.1
AK012767 mRNA Translation: BAB28455.1 Different initiation.
AK075648 mRNA Translation: BAC35879.1 Different initiation.
AK154254 mRNA Translation: BAE32466.1 Different initiation.
AK172494 mRNA Translation: BAE43032.1 Different initiation.
CCDSiCCDS25948.1 [Q8BPI1-1]
RefSeqiNP_081545.3, NM_027269.4 [Q8BPI1-1]
UniGeneiMm.107180

3D structure databases

ProteinModelPortaliQ8BPI1
SMRiQ8BPI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59777N
IntActiQ8BPI1, 6 interactors
STRINGi10090.ENSMUSP00000021356

PTM databases

iPTMnetiQ8BPI1
PhosphoSitePlusiQ8BPI1

Proteomic databases

PaxDbiQ8BPI1
PRIDEiQ8BPI1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021356; ENSMUSP00000021356; ENSMUSG00000020973 [Q8BPI1-1]
GeneIDi109065
KEGGimmu:109065
UCSCiuc007nrt.1 mouse [Q8BPI1-1]

Organism-specific databases

CTDi55172
MGIiMGI:1923566 Dnaaf2

Phylogenomic databases

eggNOGiKOG4356 Eukaryota
ENOG410XQ8C LUCA
GeneTreeiENSGT00510000048466
HOGENOMiHOG000094570
HOVERGENiHBG108080
InParanoidiQ8BPI1
KOiK19751
OMAiTEPRCSV
OrthoDBiEOG091G0J98
TreeFamiTF336215

Miscellaneous databases

PROiPR:Q8BPI1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020973 Expressed in 219 organ(s), highest expression level in testis
CleanExiMM_1110034A24RIK
GenevisibleiQ8BPI1 MM

Family and domain databases

HAMAPiMF_03069 Kintoun, 1 hit
InterProiView protein in InterPro
IPR034727 Kintoun
IPR012981 PIH1_dom
PANTHERiPTHR22997 PTHR22997, 1 hit
PfamiView protein in Pfam
PF08190 PIH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKTU_MOUSE
AccessioniPrimary (citable) accession number: Q8BPI1
Secondary accession number(s): Q3T9I8
, Q3U4G5, Q6P5G9, Q9CZC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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