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Protein

EGF-containing fibulin-like extracellular matrix protein 1

Gene

Efemp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-containing fibulin-like extracellular matrix protein 1
Alternative name(s):
Fibulin-3
Short name:
FIBL-3
Gene namesi
Name:Efemp1
Synonyms:Fbln3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1339998 Efemp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable and have no overt phenotype at birth. However, they exhibit reduced reproductivity and an early onset of aging-associated phenotypes including reduced lifespan, decreased body mass, lordokyphosis, reduced hair growth and generalized fat, muscle and organ atrophy. They also display multiple hernias associated with a reduction of elastic fibers in facia, the thin layer of connective tissue maintaining and protecting structures throughout the body. However, there is no apparent macular degeneration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000757218 – 493EGF-containing fibulin-like extracellular matrix protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi177 ↔ 190PROSITE-ProRule annotation
Disulfide bondi184 ↔ 199PROSITE-ProRule annotation
Disulfide bondi201 ↔ 212PROSITE-ProRule annotation
Disulfide bondi218 ↔ 228PROSITE-ProRule annotation
Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
Disulfide bondi239 ↔ 252PROSITE-ProRule annotation
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi258 ↔ 268PROSITE-ProRule annotation
Disulfide bondi264 ↔ 277PROSITE-ProRule annotation
Disulfide bondi279 ↔ 292PROSITE-ProRule annotation
Disulfide bondi298 ↔ 309PROSITE-ProRule annotation
Disulfide bondi305 ↔ 318PROSITE-ProRule annotation
Disulfide bondi320 ↔ 332PROSITE-ProRule annotation
Disulfide bondi338 ↔ 350PROSITE-ProRule annotation
Disulfide bondi344 ↔ 359PROSITE-ProRule annotation
Disulfide bondi365 ↔ 377PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BPB5
PaxDbiQ8BPB5
PeptideAtlasiQ8BPB5
PRIDEiQ8BPB5

PTM databases

iPTMnetiQ8BPB5
PhosphoSitePlusiQ8BPB5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020467 Expressed in 251 organ(s), highest expression level in ciliary body
ExpressionAtlasiQ8BPB5 baseline and differential
GenevisibleiQ8BPB5 MM

Interactioni

Subunit structurei

Interacts with ECM1. Interacts with TIMP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BPB5, 2 interactors
STRINGi10090.ENSMUSP00000020759

Structurei

3D structure databases

ProteinModelPortaliQ8BPB5
SMRiQ8BPB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 71EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Domaini173 – 213EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini214 – 253EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini254 – 293EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini294 – 333EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini334 – 378EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 493Mediates interaction with TIMP3By similarityAdd BLAST235

Sequence similaritiesi

Belongs to the fibulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD9V Eukaryota
ENOG410YCRW LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000234337
HOVERGENiHBG051560
InParanoidiQ8BPB5
KOiK18262
OMAiPCQDPYV
OrthoDBiEOG091G04QP
PhylomeDBiQ8BPB5
TreeFamiTF317514

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR032973 EFEMP1
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF2 PTHR44074:SF2, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BPB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQTLFLTML TLALVKSQYT EETITYTQCT DGYEWDPIRQ QCKDIDECDI
60 70 80 90 100
VPDACKGGMK CVNHYGGYLC LPKTAQIIVN NEHPQQETPA AEASSGATTG
110 120 130 140 150
TVAARSMATS GVVPGGGFMA SATAVAGPEV QTGRNNFVIR RNPADPQRIP
160 170 180 190 200
SNPSHRIQCA AGYEQSEHNV CQDIDECTSG THNCRTDQVC INLRGSFTCQ
210 220 230 240 250
CLPGYQKRGE QCVDIDECTV PPYCHQRCVN TPGSFYCQCS PGFQLAANNY
260 270 280 290 300
TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT
310 320 330 340 350
SSYLCQYQCV NEPGKFSCMC PQGYEVVRSR TCQDINECET TNECREDEMC
360 370 380 390 400
WNYHGGFRCY PRNPCQDHYV LTSENRCVCP VSNTMCRELP QSIVYKYMSI
410 420 430 440 450
RSDRSVPSDI FQIQATMIYA NTINTFRIKS GNENGEFYLR QTSPVSAMLV
460 470 480 490
LVKSLSGPRE YIVDLEMLTV SSIGTFRTSS VLRLTIIVGP FSF
Length:493
Mass (Da):54,953
Last modified:March 1, 2003 - v1
Checksum:i9CEDC7BF2FF9430F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZFS0F6ZFS0_MOUSE
EGF-containing fibulin-like extrace...
Efemp1
198Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251056 mRNA Translation: AAP79577.1
AY185605 mRNA Translation: AAO37642.1
AK077302 mRNA Translation: BAC36738.1
AL954346 Genomic DNA No translation available.
CCDSiCCDS48761.1
RefSeqiNP_666127.2, NM_146015.2
XP_006514723.1, XM_006514660.1
UniGeneiMm.44176

Genome annotation databases

EnsembliENSMUST00000020759; ENSMUSP00000020759; ENSMUSG00000020467
GeneIDi216616
KEGGimmu:216616
UCSCiuc007ign.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251056 mRNA Translation: AAP79577.1
AY185605 mRNA Translation: AAO37642.1
AK077302 mRNA Translation: BAC36738.1
AL954346 Genomic DNA No translation available.
CCDSiCCDS48761.1
RefSeqiNP_666127.2, NM_146015.2
XP_006514723.1, XM_006514660.1
UniGeneiMm.44176

3D structure databases

ProteinModelPortaliQ8BPB5
SMRiQ8BPB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BPB5, 2 interactors
STRINGi10090.ENSMUSP00000020759

PTM databases

iPTMnetiQ8BPB5
PhosphoSitePlusiQ8BPB5

Proteomic databases

MaxQBiQ8BPB5
PaxDbiQ8BPB5
PeptideAtlasiQ8BPB5
PRIDEiQ8BPB5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020759; ENSMUSP00000020759; ENSMUSG00000020467
GeneIDi216616
KEGGimmu:216616
UCSCiuc007ign.2 mouse

Organism-specific databases

CTDi2202
MGIiMGI:1339998 Efemp1

Phylogenomic databases

eggNOGiENOG410KD9V Eukaryota
ENOG410YCRW LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000234337
HOVERGENiHBG051560
InParanoidiQ8BPB5
KOiK18262
OMAiPCQDPYV
OrthoDBiEOG091G04QP
PhylomeDBiQ8BPB5
TreeFamiTF317514

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

PROiPR:Q8BPB5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020467 Expressed in 251 organ(s), highest expression level in ciliary body
ExpressionAtlasiQ8BPB5 baseline and differential
GenevisibleiQ8BPB5 MM

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR032973 EFEMP1
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF2 PTHR44074:SF2, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFBLN3_MOUSE
AccessioniPrimary (citable) accession number: Q8BPB5
Secondary accession number(s): Q6Y3N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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