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Protein

MOB kinase activator 1B

Gene

Mob1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79ZincBy similarity1
Metal bindingi84ZincBy similarity1
Metal bindingi161ZincBy similarity1
Metal bindingi166ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 1B
Alternative name(s):
Mob1 homolog 1A
Mps one binder kinase activator-like 1A
Gene namesi
Name:Mob1b
Synonyms:Mobkl1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915723 Mob1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001935652 – 216MOB kinase activator 1BAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei12Phosphothreonine; by STK4/MST1By similarity1
Modified residuei35Phosphothreonine; by STK4/MST1By similarity1

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BPB0
PaxDbiQ8BPB0
PRIDEiQ8BPB0

PTM databases

iPTMnetiQ8BPB0
PhosphoSitePlusiQ8BPB0

Expressioni

Gene expression databases

BgeeiENSMUSG00000006262 Expressed in 286 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ8BPB0 baseline and differential

Interactioni

Subunit structurei

Binds STK38L. Interacts with LATS1 and LATS2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006424

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8BPB0
SMRiQ8BPB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG0440 Eukaryota
ENOG410XSUJ LUCA
GeneTreeiENSGT00550000074456
HOGENOMiHOG000164685
HOVERGENiHBG052489
InParanoidiQ8BPB0
KOiK06685
OMAiDFFNHLN
PhylomeDBiQ8BPB0
TreeFamiTF300789

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BPB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG
60 70 80 90 100
EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LTSKDR
Length:216
Mass (Da):25,091
Last modified:January 23, 2007 - v3
Checksum:i29EBA287B0CDAF90
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UDM0Q3UDM0_MOUSE
MOB kinase activator 1B
Mob1b Mobkl1a
221Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077320 mRNA Translation: BAC36748.1
CCDSiCCDS39139.1
RefSeqiNP_081011.1, NM_026735.2
UniGeneiMm.35764
Mm.392493
Mm.486660

Genome annotation databases

EnsembliENSMUST00000006424; ENSMUSP00000006424; ENSMUSG00000006262
GeneIDi68473
KEGGimmu:68473
UCSCiuc008yae.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077320 mRNA Translation: BAC36748.1
CCDSiCCDS39139.1
RefSeqiNP_081011.1, NM_026735.2
UniGeneiMm.35764
Mm.392493
Mm.486660

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B5VX-ray2.19A/B/C/D/E/F1-216[»]
5B5WX-ray2.96A33-216[»]
5B6BX-ray3.54A/B/D/F/H/K/M/O1-216[»]
ProteinModelPortaliQ8BPB0
SMRiQ8BPB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006424

PTM databases

iPTMnetiQ8BPB0
PhosphoSitePlusiQ8BPB0

Proteomic databases

MaxQBiQ8BPB0
PaxDbiQ8BPB0
PRIDEiQ8BPB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006424; ENSMUSP00000006424; ENSMUSG00000006262
GeneIDi68473
KEGGimmu:68473
UCSCiuc008yae.1 mouse

Organism-specific databases

CTDi92597
MGIiMGI:1915723 Mob1b

Phylogenomic databases

eggNOGiKOG0440 Eukaryota
ENOG410XSUJ LUCA
GeneTreeiENSGT00550000074456
HOGENOMiHOG000164685
HOVERGENiHBG052489
InParanoidiQ8BPB0
KOiK06685
OMAiDFFNHLN
PhylomeDBiQ8BPB0
TreeFamiTF300789

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Miscellaneous databases

ChiTaRSiMob1b mouse
PROiPR:Q8BPB0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006262 Expressed in 286 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ8BPB0 baseline and differential

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOB1B_MOUSE
AccessioniPrimary (citable) accession number: Q8BPB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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