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Protein

RING finger protein 122

Gene

Rnf122

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May induce necrosis and apoptosis. May play a role in cell viability (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 122
Gene namesi
Name:Rnf122
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916117 Rnf122

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478531 – 155RING finger protein 122Add BLAST155

Proteomic databases

PaxDbiQ8BP31
PRIDEiQ8BP31

PTM databases

iPTMnetiQ8BP31
PhosphoSitePlusiQ8BP31

Expressioni

Gene expression databases

CleanExiMM_RNF122
ExpressionAtlasiQ8BP31 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040478

Structurei

3D structure databases

ProteinModelPortaliQ8BP31
SMRiQ8BP31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00710000106755
HOGENOMiHOG000004806
HOVERGENiHBG058899
InParanoidiQ8BP31
KOiK15699
OMAiQHTFHRK
PhylomeDBiQ8BP31

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8BP31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM
60 70 80 90 100
LSLIFCCYFI SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF
110 120 130 140 150
KGKDELGVLP CQHAFHRKCL VKWLEVRCVC PMCNKPIAGP TETSQSIGIL

LDELV
Length:155
Mass (Da):17,448
Last modified:March 1, 2003 - v1
Checksum:iF2AB6769825543A0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0G8A0A0R4J0G8_MOUSE
RING finger protein 122
Rnf122
154Annotation score:

Sequence cautioni

The sequence AAH50268 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91Missing in BAC39436 (PubMed:16141072).Curated1
Sequence conflicti91Missing in AAH38399 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077856 mRNA Translation: BAC37035.1
AK085376 mRNA Translation: BAC39436.1
AK171823 mRNA Translation: BAE42682.1
AK136206 mRNA Translation: BAE22874.1
BC038399 mRNA Translation: AAH38399.1
BC050268 mRNA Translation: AAH50268.1 Different initiation.
RefSeqiNP_780345.1, NM_175136.2
XP_006509253.1, XM_006509190.3
UniGeneiMm.29532
Mm.400167

Genome annotation databases

EnsembliENSMUST00000217278; ENSMUSP00000150893; ENSMUSG00000039328
GeneIDi68867
KEGGimmu:68867
UCSCiuc009ljd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077856 mRNA Translation: BAC37035.1
AK085376 mRNA Translation: BAC39436.1
AK171823 mRNA Translation: BAE42682.1
AK136206 mRNA Translation: BAE22874.1
BC038399 mRNA Translation: AAH38399.1
BC050268 mRNA Translation: AAH50268.1 Different initiation.
RefSeqiNP_780345.1, NM_175136.2
XP_006509253.1, XM_006509190.3
UniGeneiMm.29532
Mm.400167

3D structure databases

ProteinModelPortaliQ8BP31
SMRiQ8BP31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040478

PTM databases

iPTMnetiQ8BP31
PhosphoSitePlusiQ8BP31

Proteomic databases

PaxDbiQ8BP31
PRIDEiQ8BP31

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000217278; ENSMUSP00000150893; ENSMUSG00000039328
GeneIDi68867
KEGGimmu:68867
UCSCiuc009ljd.1 mouse

Organism-specific databases

CTDi79845
MGIiMGI:1916117 Rnf122

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00710000106755
HOGENOMiHOG000004806
HOVERGENiHBG058899
InParanoidiQ8BP31
KOiK15699
OMAiQHTFHRK
PhylomeDBiQ8BP31

Miscellaneous databases

PROiPR:Q8BP31
SOURCEiSearch...

Gene expression databases

CleanExiMM_RNF122
ExpressionAtlasiQ8BP31 baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN122_MOUSE
AccessioniPrimary (citable) accession number: Q8BP31
Secondary accession number(s): Q80VA7, Q8BGD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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