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Protein

IQ calmodulin-binding motif-containing protein 1

Gene

Iqcb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calmodulin binding Source: HGNC
  • enzyme binding Source: MGI

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • maintenance of animal organ identity Source: HGNC
  • photoreceptor cell maintenance Source: HGNC

Keywordsi

Molecular functionCalmodulin-binding
Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
IQ calmodulin-binding motif-containing protein 1
Gene namesi
Name:Iqcb1
Synonyms:Kiaa0036
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443764 Iqcb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842261 – 598IQ calmodulin-binding motif-containing protein 1Add BLAST598

Proteomic databases

PaxDbiQ8BP00
PeptideAtlasiQ8BP00
PRIDEiQ8BP00

PTM databases

iPTMnetiQ8BP00
PhosphoSitePlusiQ8BP00

Expressioni

Tissue specificityi

Localized to the outer segment and connecting cilia of photoreceptor cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000022837 Expressed in 224 organ(s), highest expression level in brain
CleanExiMM_IQCB1
GenevisibleiQ8BP00 MM

Interactioni

Subunit structurei

Interacts with calmodulin (PubMed:15723066). Interacts with CEP290/NPHP6; IQCB1/NPHP5 and CEP290/NPHP6; are proposed to form a functional NPHP5-6 module localized to the centrosome. Interacts with ATXN10. Interacts with NPHP1, INVS, NPHP4 and RPGRIP1L; these interactions likely require additional interactors (PubMed:21565611). Associates with the BBSome complex; interacts with BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9 (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi235913, 163 interactors
CORUMiQ8BP00
IntActiQ8BP00, 134 interactors
STRINGi10090.ENSMUSP00000023535

Structurei

3D structure databases

ProteinModelPortaliQ8BP00
SMRiQ8BP00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 317IQ 1PROSITE-ProRule annotationAdd BLAST24
Domaini318 – 338IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini387 – 416IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini417 – 437IQ 4PROSITE-ProRule annotationAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 157Interaction with BBS1, BBS8 and BBS9By similarityAdd BLAST157
Regioni287 – 598Interaction with CEP290, BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9By similarityAdd BLAST312
Regioni530 – 598Interaction with BBS1, BBS2, BBS4, BBS7, BBS8 and BBS9By similarityAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili336 – 362Sequence analysisAdd BLAST27

Domaini

The IQ domains mediate the interaction with calmodulin.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00390000002188
HOGENOMiHOG000113095
HOVERGENiHBG052142
InParanoidiQ8BP00
KOiK16774
OMAiLSQDCSR
OrthoDBiEOG091G06IO
PhylomeDBiQ8BP00
TreeFamiTF351884

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000048 IQ_motif_EF-hand-BS
IPR028765 IQCB1
IPR027417 P-loop_NTPase
PANTHERiPTHR15673 PTHR15673, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 2 hits
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BP00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPAGTDPRI LSLAAEVAKS PEQNVPVILL KLKEIINNTP LGSSELKKVK
60 70 80 90 100
QDIYCYDLIQ YCLLVLSQDS SRIQGGWSTI SQLTQILSHC CVGLEPGEDG
110 120 130 140 150
EEFYKELLPS AAENFLILGR RLQTCFINAT KGEEQDKLLH FFQIVTDSLF
160 170 180 190 200
WLLGGHVQLI QNVLQSDHFL HLLQTDNVQI GASVMTLLQN ILQINSGNLL
210 220 230 240 250
KIEGKALHSI LDEILFKLLS TPSPVIRSTA TKLLLVLAES HQEILILLRL
260 270 280 290 300
SACYKGLRSL LNKQETLTEF SRELRQLVDL LTPKIHQEVE EQKLHKAACL
310 320 330 340 350
IQAYWKGFQT RKRLKKLPSA VIALQRSFRS KRTKMMLELN RQKEEEDLRL
360 370 380 390 400
KLQLQRQRAM RLSRESRLNM LEIIHPGQVE KYNREMEEKS ALTIQKHWRG
410 420 430 440 450
YRERKNFRQQ RPSLTEYKAA VTLQRAVLKF LAKCRKKKKL FASWHGLQEL
460 470 480 490 500
TDARRVELKQ QVDDYVKRHP CSQMSEAASR ELHAQAQERL QHYFMGRAIE
510 520 530 540 550
ERAQQHREAL MAQISTNIEQ LMKAPSLKEA EGKEPEQFLS RSRPVAAKAK
560 570 580 590
QAHLTTLKHI QAPWWKKLGE EPGDEVDVPK DELSIDLGML FIGGTKPP
Length:598
Mass (Da):68,734
Last modified:May 10, 2004 - v2
Checksum:i87FBCB9B68899997
GO
Isoform 2 (identifier: Q8BP00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     523-598: KAPSLKEAEG...MLFIGGTKPP → SMLYLHPCFI...ITNFKEVIIF

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):69,070
Checksum:iE360B9345680D54E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → P in BAC37333 (PubMed:16141072).Curated1
Sequence conflicti9R → G in BAC37333 (PubMed:16141072).Curated1
Sequence conflicti19K → R in BAC37333 (PubMed:16141072).Curated1
Sequence conflicti32L → V in BAC37333 (PubMed:16141072).Curated1
Sequence conflicti352L → W in BAC37333 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010246523 – 598KAPSL…GTKPP → SMLYLHPCFINGIPLARDVA SKLFRRKVPQVVFIQVLGKS YIIPVFNSIPSVCACYKFKY FSFIKITNFKEVIIF in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078554 mRNA Translation: BAC37333.1
AK165220 mRNA Translation: BAE38084.1
BC029084 mRNA Translation: AAH29084.1
CCDSiCCDS28157.1 [Q8BP00-1]
RefSeqiNP_796102.2, NM_177128.4 [Q8BP00-1]
XP_006522310.1, XM_006522247.3 [Q8BP00-1]
XP_006522311.1, XM_006522248.2 [Q8BP00-1]
XP_006522312.1, XM_006522249.3 [Q8BP00-1]
UniGeneiMm.222934

Genome annotation databases

EnsembliENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837 [Q8BP00-1]
ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837 [Q8BP00-2]
GeneIDi320299
KEGGimmu:320299
UCSCiuc007zda.1 mouse [Q8BP00-2]
uc007zdb.2 mouse [Q8BP00-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078554 mRNA Translation: BAC37333.1
AK165220 mRNA Translation: BAE38084.1
BC029084 mRNA Translation: AAH29084.1
CCDSiCCDS28157.1 [Q8BP00-1]
RefSeqiNP_796102.2, NM_177128.4 [Q8BP00-1]
XP_006522310.1, XM_006522247.3 [Q8BP00-1]
XP_006522311.1, XM_006522248.2 [Q8BP00-1]
XP_006522312.1, XM_006522249.3 [Q8BP00-1]
UniGeneiMm.222934

3D structure databases

ProteinModelPortaliQ8BP00
SMRiQ8BP00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi235913, 163 interactors
CORUMiQ8BP00
IntActiQ8BP00, 134 interactors
STRINGi10090.ENSMUSP00000023535

PTM databases

iPTMnetiQ8BP00
PhosphoSitePlusiQ8BP00

Proteomic databases

PaxDbiQ8BP00
PeptideAtlasiQ8BP00
PRIDEiQ8BP00

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023535; ENSMUSP00000023535; ENSMUSG00000022837 [Q8BP00-1]
ENSMUST00000114819; ENSMUSP00000110467; ENSMUSG00000022837 [Q8BP00-2]
GeneIDi320299
KEGGimmu:320299
UCSCiuc007zda.1 mouse [Q8BP00-2]
uc007zdb.2 mouse [Q8BP00-1]

Organism-specific databases

CTDi9657
MGIiMGI:2443764 Iqcb1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00390000002188
HOGENOMiHOG000113095
HOVERGENiHBG052142
InParanoidiQ8BP00
KOiK16774
OMAiLSQDCSR
OrthoDBiEOG091G06IO
PhylomeDBiQ8BP00
TreeFamiTF351884

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

PROiPR:Q8BP00
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022837 Expressed in 224 organ(s), highest expression level in brain
CleanExiMM_IQCB1
GenevisibleiQ8BP00 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000048 IQ_motif_EF-hand-BS
IPR028765 IQCB1
IPR027417 P-loop_NTPase
PANTHERiPTHR15673 PTHR15673, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 2 hits
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIQCB1_MOUSE
AccessioniPrimary (citable) accession number: Q8BP00
Secondary accession number(s): Q3TNK4, Q8K306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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