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Entry version 128 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Kelch repeat and BTB domain-containing protein 11

Gene

Kbtbd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kbtbd11
Synonyms:Kiaa0711
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922151 Kbtbd11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190911 – 633Kelch repeat and BTB domain-containing protein 11Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei70PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei113PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BNW9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8BNW9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8BNW9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BNW9

PeptideAtlas

More...
PeptideAtlasi
Q8BNW9

PRoteomics IDEntifications database

More...
PRIDEi
Q8BNW9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BNW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BNW9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8BNW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055675 Expressed in 243 organ(s), highest expression level in mesenteric lymph node

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BNW9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
217065, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8BNW9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068321

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BNW9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 206BTBPROSITE-ProRule annotationAdd BLAST61
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati317 – 365Kelch 1Add BLAST49
Repeati366 – 418Kelch 2Add BLAST53
Repeati419 – 463Kelch 3Add BLAST45
Repeati465 – 506Kelch 4Add BLAST42

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1072 Eukaryota
ENOG4110X8D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161983

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246990

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BNW9

KEGG Orthology (KO)

More...
KOi
K10476

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEDINTK

Database of Orthologous Groups

More...
OrthoDBi
594274at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328485

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF01344 Kelch_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00612 Kelch, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8BNW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSVAPFVL YSGTEPRTPG EDSLPLPAEE EGAASTAQTP CSLSASLCFS
60 70 80 90 100
SGDDSPPQSR ASAAEGSEAS PPSLRSDLRV VETQWDVSSA ASPESPEECA
110 120 130 140 150
RPEEPASPED PPSRHEHARP VELESLDELG EPVPVPPGVG SVHGEPDLVI
160 170 180 190 200
EVAGRRLRAH KAVLAARSDY FRARASRDVL RVQGVSFTAL RLLLADAYSG
210 220 230 240 250
RMAGVRPDNV AEVVAGARRL QLPGAAQRAT EAMAPQLSLD NCYEVLSAGK
260 270 280 290 300
RQRLTELRDA AYRFMSDHYL EVLREPAVFG RLSGAERDLL LRRRLCTGRA
310 320 330 340 350
CLLAAALGTT GERSGSRPQS PSGDAESRGD AAVYCYQAEA GEWRELTRLP
360 370 380 390 400
EGAPARGCGL CVLFNYLFLA GGVAPAGPDG RARPSDQVYC YNPVTDSWST
410 420 430 440 450
VRPLRQARSQ VQLLALDGHL YAVGGECLLS VERYDPRADR WTAVAPLPRG
460 470 480 490 500
AFAVAHEAAT CNGEIYVSGG SLFYRLLKYD PRRDEWQECP CSSSRERSAD
510 520 530 540 550
MVALDGFLYR FDLCGSRGEA QAAVGSGGGV SVFRYHCLAK QWSQCAVHLR
560 570 580 590 600
PPGAPAGLQP FRCVALDGTI YCVSRAGTWR FVPSQDTEAG SDMGPGGSFE
610 620 630
PEPLGSPLDV RGVLFPFVLN LPEKPDRGEQ GAV
Length:633
Mass (Da):67,946
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D37E3C68C98EC73
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98007 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173A → S in BAC37803 (PubMed:16141072).Curated1
Sequence conflicti369L → V in BAC98007 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129197 mRNA Translation: BAC98007.1 Different initiation.
AK080001 mRNA Translation: BAC37803.1
BC080858 mRNA Translation: AAH80858.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52493.1

NCBI Reference Sequences

More...
RefSeqi
NP_083392.1, NM_029116.2
XP_006508978.1, XM_006508915.1
XP_006508979.1, XM_006508916.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000069399; ENSMUSP00000068321; ENSMUSG00000055675
ENSMUST00000183471; ENSMUSP00000139292; ENSMUSG00000055675

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74901

UCSC genome browser

More...
UCSCi
uc009kzk.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129197 mRNA Translation: BAC98007.1 Different initiation.
AK080001 mRNA Translation: BAC37803.1
BC080858 mRNA Translation: AAH80858.1
CCDSiCCDS52493.1
RefSeqiNP_083392.1, NM_029116.2
XP_006508978.1, XM_006508915.1
XP_006508979.1, XM_006508916.2

3D structure databases

SMRiQ8BNW9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi217065, 1 interactor
IntActiQ8BNW9, 2 interactors
STRINGi10090.ENSMUSP00000068321

PTM databases

iPTMnetiQ8BNW9
PhosphoSitePlusiQ8BNW9
SwissPalmiQ8BNW9

Proteomic databases

EPDiQ8BNW9
jPOSTiQ8BNW9
MaxQBiQ8BNW9
PaxDbiQ8BNW9
PeptideAtlasiQ8BNW9
PRIDEiQ8BNW9

Genome annotation databases

EnsembliENSMUST00000069399; ENSMUSP00000068321; ENSMUSG00000055675
ENSMUST00000183471; ENSMUSP00000139292; ENSMUSG00000055675
GeneIDi74901
KEGGimmu:74901
UCSCiuc009kzk.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9920
MGIiMGI:1922151 Kbtbd11

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00940000161983
HOGENOMiHOG000246990
InParanoidiQ8BNW9
KOiK10476
OMAiPEDINTK
OrthoDBi594274at2759
TreeFamiTF328485

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kbtbd11 mouse

Protein Ontology

More...
PROi
PR:Q8BNW9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000055675 Expressed in 243 organ(s), highest expression level in mesenteric lymph node
GenevisibleiQ8BNW9 MM

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF01344 Kelch_1, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00612 Kelch, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKBTBB_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BNW9
Secondary accession number(s): A3KME3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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