Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat-containing protein 6

Gene

Armc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 6
Gene namesi
Name:Armc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1924063 Armc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426611 – 468Armadillo repeat-containing protein 6Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BNU0
PaxDbiQ8BNU0
PeptideAtlasiQ8BNU0
PRIDEiQ8BNU0

PTM databases

PhosphoSitePlusiQ8BNU0

Expressioni

Gene expression databases

BgeeiENSMUSG00000002343 Expressed in 246 organ(s), highest expression level in ear
CleanExiMM_ARMC6
ExpressionAtlasiQ8BNU0 baseline and differential
GenevisibleiQ8BNU0 MM

Interactioni

Protein-protein interaction databases

BioGridi218331, 1 interactor
IntActiQ8BNU0, 1 interactor
MINTiQ8BNU0
STRINGi10090.ENSMUSP00000019679

Structurei

3D structure databases

ProteinModelPortaliQ8BNU0
SMRiQ8BNU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati195 – 239ARM 1Add BLAST45
Repeati249 – 293ARM 2Add BLAST45
Repeati294 – 336ARM 3Add BLAST43
Repeati337 – 379ARM 4Add BLAST43

Sequence similaritiesi

Belongs to the ARMC6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4199 Eukaryota
ENOG410XR4D LUCA
GeneTreeiENSGT00390000002913
HOGENOMiHOG000290683
HOVERGENiHBG057500
InParanoidiQ8BNU0
OMAiWAIRNMV
OrthoDBiEOG091G0HWM
PhylomeDBiQ8BNU0
TreeFamiTF324526

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BNU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKRITQET FDAAVRENIE EFEMGTEEAI REAVEQFESQ GVDLSNIVKT
60 70 80 90 100
IPKVSLDGLQ EPTHSVLQAL NDLQESLTGS RLQEVSAHLV RFCDQCKQQK
110 120 130 140 150
ASRYLAAQKG AYPILLAAWQ LAATSNQGLL LQALNALAVL TDGQPDLLDA
160 170 180 190 200
QGLHLLVATL AQNAANTELT CCGIRCVRHV CLKHEQNRQD LVKAGVLPLL
210 220 230 240 250
TAAITQHGQH ADVVREACWA LRVMTFDDDI RVPFGHAHEH AKMIVQENKG
260 270 280 290 300
LKVLIEAARA FSDNPGVLSE LCSTLSRLAV RNEFCQEVID LGGLGILVTL
310 320 330 340 350
LADCNDHQDL VKQVLSALRA IAGNDDVKDA IVRAGGTESI VAAMTRHLAS
360 370 380 390 400
PQVCEQSCAA LCVLALRKPD NSRVIIEGGG ALAALQAMKA HPQEAGVQKQ
410 420 430 440 450
ACMLIRNLVS RSQVFSKPIL DLGAEELILQ ARAAHPDCED VAKAALRDLG
460
CRVELRELWT GKKGDLAL
Length:468
Mass (Da):50,683
Last modified:March 1, 2003 - v1
Checksum:i5FA79F94B2BDAF88
GO
Isoform 2 (identifier: Q8BNU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-271: AFSDNPGVLSEL → GRSSPGKRMVGG
     272-468: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,655
Checksum:iF5939223466437A4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3J0D3Z3J0_MOUSE
Armadillo repeat-containing protein...
Armc6
120Annotation score:

Sequence cautioni

The sequence BAC38256 differs from that shown. Reason: Frameshift at position 465.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277R → L in BAC33700 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019462260 – 271AFSDN…VLSEL → GRSSPGKRMVGG in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_019463272 – 468Missing in isoform 2. 1 PublicationAdd BLAST197

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010815 mRNA Translation: BAB27199.1
AK049351 mRNA Translation: BAC33700.1
AK080609 mRNA Translation: BAC37956.1
AK081550 mRNA Translation: BAC38256.1 Frameshift.
BC005754 mRNA Translation: AAH05754.1
BC030077 mRNA Translation: AAH30077.1
BC043070 mRNA Translation: AAH43070.1
BC055779 mRNA Translation: AAH55779.1
CCDSiCCDS40371.1 [Q8BNU0-1]
RefSeqiNP_598733.2, NM_133972.2 [Q8BNU0-1]
UniGeneiMm.383251

Genome annotation databases

EnsembliENSMUST00000019679; ENSMUSP00000019679; ENSMUSG00000002343 [Q8BNU0-1]
GeneIDi76813
KEGGimmu:76813
UCSCiuc009lzi.1 mouse [Q8BNU0-1]
uc009lzj.1 mouse [Q8BNU0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010815 mRNA Translation: BAB27199.1
AK049351 mRNA Translation: BAC33700.1
AK080609 mRNA Translation: BAC37956.1
AK081550 mRNA Translation: BAC38256.1 Frameshift.
BC005754 mRNA Translation: AAH05754.1
BC030077 mRNA Translation: AAH30077.1
BC043070 mRNA Translation: AAH43070.1
BC055779 mRNA Translation: AAH55779.1
CCDSiCCDS40371.1 [Q8BNU0-1]
RefSeqiNP_598733.2, NM_133972.2 [Q8BNU0-1]
UniGeneiMm.383251

3D structure databases

ProteinModelPortaliQ8BNU0
SMRiQ8BNU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218331, 1 interactor
IntActiQ8BNU0, 1 interactor
MINTiQ8BNU0
STRINGi10090.ENSMUSP00000019679

PTM databases

PhosphoSitePlusiQ8BNU0

Proteomic databases

EPDiQ8BNU0
PaxDbiQ8BNU0
PeptideAtlasiQ8BNU0
PRIDEiQ8BNU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019679; ENSMUSP00000019679; ENSMUSG00000002343 [Q8BNU0-1]
GeneIDi76813
KEGGimmu:76813
UCSCiuc009lzi.1 mouse [Q8BNU0-1]
uc009lzj.1 mouse [Q8BNU0-2]

Organism-specific databases

CTDi93436
MGIiMGI:1924063 Armc6

Phylogenomic databases

eggNOGiKOG4199 Eukaryota
ENOG410XR4D LUCA
GeneTreeiENSGT00390000002913
HOGENOMiHOG000290683
HOVERGENiHBG057500
InParanoidiQ8BNU0
OMAiWAIRNMV
OrthoDBiEOG091G0HWM
PhylomeDBiQ8BNU0
TreeFamiTF324526

Miscellaneous databases

PROiPR:Q8BNU0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002343 Expressed in 246 organ(s), highest expression level in ear
CleanExiMM_ARMC6
ExpressionAtlasiQ8BNU0 baseline and differential
GenevisibleiQ8BNU0 MM

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARMC6_MOUSE
AccessioniPrimary (citable) accession number: Q8BNU0
Secondary accession number(s): Q8C4P5
, Q8C7S1, Q8K2S7, Q99JQ2, Q9CWE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again