UniProtKB - Q8BNI4 (DERL2_MOUSE)
Derlin-2
Derl2
Functioni
GO - Molecular functioni
- misfolded protein binding Source: GO_Central
- ubiquitin-specific protease binding Source: GO_Central
GO - Biological processi
- endoplasmic reticulum unfolded protein response Source: UniProtKB
- negative regulation of retrograde protein transport, ER to cytosol Source: MGI
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- retrograde protein transport, ER to cytosol Source: MGI
- suckling behavior Source: MGI
- ubiquitin-dependent ERAD pathway Source: UniProtKB
Keywordsi
Biological process | Unfolded protein response |
Enzyme and pathway databases
Reactomei | R-MMU-382556, ABC-family proteins mediated transport R-MMU-5358346, Hedgehog ligand biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Derlin-21 PublicationAlternative name(s): Degradation in endoplasmic reticulum protein 2 Der1-like protein 21 Publication F-LANa1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2151483, Derl2 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- Hrd1p ubiquitin ligase ERAD-L complex Source: GO_Central
- integral component of endoplasmic reticulum membrane Source: UniProtKB
- signal recognition particle receptor complex Source: Ensembl
Endosome
- early endosome Source: MGI
- late endosome Source: MGI
Other locations
- signal recognition particle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 57 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 58 – 78 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 96 | LumenalSequence analysisAdd BLAST | 18 | |
Transmembranei | 97 – 117 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 150 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 151 – 171 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 172 | LumenalSequence analysis | 1 | |
Transmembranei | 173 – 193 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 239 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219046 | 1 – 239 | Derlin-2Add BLAST | 239 |
Proteomic databases
EPDi | Q8BNI4 |
PaxDbi | Q8BNI4 |
PeptideAtlasi | Q8BNI4 |
PRIDEi | Q8BNI4 |
PTM databases
iPTMneti | Q8BNI4 |
PhosphoSitePlusi | Q8BNI4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000018442, Expressed in cumulus cell and 304 other tissues |
ExpressionAtlasi | Q8BNI4, baseline and differential |
Genevisiblei | Q8BNI4, MM |
Interactioni
Subunit structurei
Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1 (By similarity).
Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes (PubMed:22016385). Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins (By similarity).
Interacts with OS9 (By similarity).
Interacts with SELENOK and SELENOS (PubMed:22016385).
Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (By similarity).
Interacts with CCDC47 (PubMed:25009997).
By similarity2 PublicationsGO - Molecular functioni
- misfolded protein binding Source: GO_Central
- ubiquitin-specific protease binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 228066, 2 interactors |
IntActi | Q8BNI4, 1 interactor |
STRINGi | 10090.ENSMUSP00000117052 |
Miscellaneous databases
RNActi | Q8BNI4, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0858, Eukaryota |
GeneTreei | ENSGT00530000063156 |
HOGENOMi | CLU_051898_5_2_1 |
InParanoidi | Q8BNI4 |
OMAi | IVVGHIW |
OrthoDBi | 1609512at2759 |
PhylomeDBi | Q8BNI4 |
TreeFami | TF314715 |
Family and domain databases
InterProi | View protein in InterPro IPR007599, DER1 |
Pfami | View protein in Pfam PF04511, DER1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK
60 70 80 90 100
HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM
110 120 130 140 150
FLFGGFLMTL FGLFVSLVFL GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ
160 170 180 190 200
APFLPWVLMG FSLLLGNSII VDLLGIAVGH IYFFLEDIFP NQPGGIRILK
210 220 230
TPSILRTIFD TPDEDPNYNP LPEERPGGFA WGEGQRLGG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U957 | Q3U957_MOUSE | Derlin | Derl2 | 165 | Annotation score: | ||
J3QMF4 | J3QMF4_MOUSE | Derlin-2 | Derl2 | 83 | Annotation score: | ||
J3QMQ7 | J3QMQ7_MOUSE | Derlin-2 | Derl2 | 46 | Annotation score: | ||
J3KMR6 | J3KMR6_MOUSE | Derlin-2 | Derl2 | 65 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 228 | G → A in AAL14868 (PubMed:11500051).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011085 | 233 – 239 | EGQRLGG → WNKTDLD in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF208064 mRNA Translation: AAL14868.1 AK048627 mRNA Translation: BAC33399.1 AK077659 mRNA Translation: BAC36934.1 AK082564 mRNA Translation: BAC38533.1 AK083632 mRNA Translation: BAC38974.1 BC005682 mRNA Translation: AAH05682.1 |
CCDSi | CCDS24972.1 [Q8BNI4-1] |
RefSeqi | NP_001278075.1, NM_001291146.1 NP_001278076.1, NM_001291147.1 NP_001278077.1, NM_001291148.1 NP_291040.1, NM_033562.4 [Q8BNI4-1] |
Genome annotation databases
Ensembli | ENSMUST00000108523; ENSMUSP00000104163; ENSMUSG00000018442 [Q8BNI4-2] ENSMUST00000143850; ENSMUSP00000117052; ENSMUSG00000018442 [Q8BNI4-1] |
GeneIDi | 116891 |
KEGGi | mmu:116891 |
UCSCi | uc007jxi.2, mouse [Q8BNI4-2] uc007jxj.2, mouse [Q8BNI4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF208064 mRNA Translation: AAL14868.1 AK048627 mRNA Translation: BAC33399.1 AK077659 mRNA Translation: BAC36934.1 AK082564 mRNA Translation: BAC38533.1 AK083632 mRNA Translation: BAC38974.1 BC005682 mRNA Translation: AAH05682.1 |
CCDSi | CCDS24972.1 [Q8BNI4-1] |
RefSeqi | NP_001278075.1, NM_001291146.1 NP_001278076.1, NM_001291147.1 NP_001278077.1, NM_001291148.1 NP_291040.1, NM_033562.4 [Q8BNI4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 228066, 2 interactors |
IntActi | Q8BNI4, 1 interactor |
STRINGi | 10090.ENSMUSP00000117052 |
PTM databases
iPTMneti | Q8BNI4 |
PhosphoSitePlusi | Q8BNI4 |
Proteomic databases
EPDi | Q8BNI4 |
PaxDbi | Q8BNI4 |
PeptideAtlasi | Q8BNI4 |
PRIDEi | Q8BNI4 |
Protocols and materials databases
Antibodypediai | 23707, 138 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000108523; ENSMUSP00000104163; ENSMUSG00000018442 [Q8BNI4-2] ENSMUST00000143850; ENSMUSP00000117052; ENSMUSG00000018442 [Q8BNI4-1] |
GeneIDi | 116891 |
KEGGi | mmu:116891 |
UCSCi | uc007jxi.2, mouse [Q8BNI4-2] uc007jxj.2, mouse [Q8BNI4-1] |
Organism-specific databases
CTDi | 51009 |
MGIi | MGI:2151483, Derl2 |
Phylogenomic databases
eggNOGi | KOG0858, Eukaryota |
GeneTreei | ENSGT00530000063156 |
HOGENOMi | CLU_051898_5_2_1 |
InParanoidi | Q8BNI4 |
OMAi | IVVGHIW |
OrthoDBi | 1609512at2759 |
PhylomeDBi | Q8BNI4 |
TreeFami | TF314715 |
Enzyme and pathway databases
Reactomei | R-MMU-382556, ABC-family proteins mediated transport R-MMU-5358346, Hedgehog ligand biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 116891, 5 hits in 18 CRISPR screens |
ChiTaRSi | Derl2, mouse |
PROi | PR:Q8BNI4 |
RNActi | Q8BNI4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018442, Expressed in cumulus cell and 304 other tissues |
ExpressionAtlasi | Q8BNI4, baseline and differential |
Genevisiblei | Q8BNI4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007599, DER1 |
Pfami | View protein in Pfam PF04511, DER1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DERL2_MOUSE | |
Accessioni | Q8BNI4Primary (citable) accession number: Q8BNI4 Secondary accession number(s): Q920I5, Q99J12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families