Derl2

Functionⁱ

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.By similarity

GO - Biological processⁱ

endoplasmic reticulum unfolded protein response Source: UniProtKB
negative regulation of retrograde protein transport, ER to cytosol Source: MGI
positive regulation of cell growth Source: UniProtKB
positive regulation of cell proliferation Source: UniProtKB
retrograde protein transport, ER to cytosol
Source: MGI
Inferred from mutant phenotypeⁱ
- 21220515
suckling behavior
Source: MGI
Inferred from mutant phenotypeⁱ
- 21220515
ubiquitin-dependent ERAD pathway Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Unfolded protein response

Biological process

Unfolded protein response

Enzyme and pathway databases

Reactomeⁱ	R-MMU-382556 ABC-family proteins mediated transport R-MMU-5358346 Hedgehog ligand biogenesis R-MMU-901032 ER Quality Control Compartment (ERQC)

Reactomeⁱ

R-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-901032 ER Quality Control Compartment (ERQC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Derlin-21 Publication Alternative name(s): Degradation in endoplasmic reticulum protein 2 Der1-like protein 21 Publication F-LANa1 Publication
Gene namesⁱ	Name:Derl2Imported Synonyms:Der2, Flana1 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2151483 Derl2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 57	CytoplasmicSequence analysisAdd BLAST	57
Transmembraneⁱ	58 – 78	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	79 – 96	LumenalSequence analysisAdd BLAST	18
Transmembraneⁱ	97 – 117	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	118 – 150	CytoplasmicSequence analysisAdd BLAST	33
Transmembraneⁱ	151 – 171	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	172	LumenalSequence analysis	1
Transmembraneⁱ	173 – 193	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	194 – 239	CytoplasmicSequence analysisAdd BLAST	46

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219046	1 – 239	Derlin-2Add BLAST		239

Proteomic databases

EPDⁱ	Q8BNI4
PaxDbⁱ	Q8BNI4
PeptideAtlas More...PeptideAtlasⁱ	Q8BNI4
PRIDEⁱ	Q8BNI4

PTM databases

iPTMnetⁱ	Q8BNI4
PhosphoSitePlusⁱ	Q8BNI4

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with lowest levels in brain and heart.2 Publications

Inductionⁱ

Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000018442 Expressed in 289 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_DERL2
ExpressionAtlasⁱ	Q8BNI4 baseline and differential
Genevisibleⁱ	Q8BNI4 MM

Interactionⁱ

Subunit structureⁱ

Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1 (By similarity). Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes (PubMed:22016385). Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins (By similarity). Interacts with OS9 (By similarity). Interacts with SELENOK and SELENOS (PubMed:22016385). Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	228066, 2 interactors
IntActⁱ	Q8BNI4, 1 interactor
STRINGⁱ	10090.ENSMUSP00000117052

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8BNI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the derlin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0858 Eukaryota COG5291 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063156
HOGENOMⁱ	HOG000200948
HOVERGENⁱ	HBG051338
InParanoidⁱ	Q8BNI4
KEGG Orthology (KO) More...KOⁱ	K13989
OMAⁱ	WWRRLFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IPJ
PhylomeDBⁱ	Q8BNI4
TreeFamⁱ	TF314715

Family and domain databases

InterProⁱ	View protein in InterPro IPR007599 DER1
PANTHERⁱ	PTHR11009 PTHR11009, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04511 DER1, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8BNI4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK 
        60         70         80         90        100
HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM 
       110        120        130        140        150
FLFGGFLMTL FGLFVSLVFL GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ 
       160        170        180        190        200
APFLPWVLMG FSLLLGNSII VDLLGIAVGH IYFFLEDIFP NQPGGIRILK 
       210        220        230 
TPSILRTIFD TPDEDPNYNP LPEERPGGFA WGEGQRLGG

Length:239

Mass (Da):27,640

Last modified:July 19, 2004 - v2

Checksum:ⁱD702B14B47516A8C

GO

Isoform 2 (identifier: Q8BNI4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
233-239: EGQRLGG → WNKTDLD

« Hide

        10         20         30         40         50
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK 
        60         70         80         90        100
HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM 
       110        120        130        140        150
FLFGGFLMTL FGLFVSLVFL GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ 
       160        170        180        190        200
APFLPWVLMG FSLLLGNSII VDLLGIAVGH IYFFLEDIFP NQPGGIRILK 
       210        220        230 
TPSILRTIFD TPDEDPNYNP LPEERPGGFA WGWNKTDLD

Note: No experimental confirmation available.

Show »

Length:239

Mass (Da):27,815

Checksum:ⁱD5DDECCEF2BD42EC

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3U957	Q3U957_MOUSE	Derlin Derlin	Derl2	165	Annotation score:
J3QMF4	J3QMF4_MOUSE	Derlin-2 Derlin-2	Derl2	83	Annotation score:
J3QMQ7	J3QMQ7_MOUSE	Derlin-2 Derlin-2	Derl2	46	Annotation score:
J3KMR6	J3KMR6_MOUSE	Derlin-2 Derlin-2	Derl2	65	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	228	G → A in AAL14868 (PubMed:11500051).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011085	233 – 239	EGQRLGG → WNKTDLD in isoform 2. 1 Publication		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF208064 mRNA Translation: AAL14868.1 AK048627 mRNA Translation: BAC33399.1 AK077659 mRNA Translation: BAC36934.1 AK082564 mRNA Translation: BAC38533.1 AK083632 mRNA Translation: BAC38974.1 BC005682 mRNA Translation: AAH05682.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24972.1 [Q8BNI4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001278075.1, NM_001291146.1 NP_001278076.1, NM_001291147.1 NP_001278077.1, NM_001291148.1 NP_291040.1, NM_033562.4 [Q8BNI4-1]
UniGeneⁱ	Mm.28131 Mm.446351

Genome annotation databases

Ensemblⁱ	ENSMUST00000108523; ENSMUSP00000104163; ENSMUSG00000018442 [Q8BNI4-2] ENSMUST00000143850; ENSMUSP00000117052; ENSMUSG00000018442 [Q8BNI4-1]
GeneIDⁱ	116891
KEGGⁱ	mmu:116891
UCSC genome browser More...UCSCⁱ	uc007jxi.2 mouse [Q8BNI4-2] uc007jxj.2 mouse [Q8BNI4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8BNI4	Derlin		RAT		239	UniRef100_Q8BNI4
Derlin		MESAU		239
Derlin		NEOLE		239
Derlin		MOUSE		165
Derlin		CRIGR		113
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8BNI4	Derlin		RAT		239	UniRef90_Q8BNI4
Derlin		MESAU		239
Derlin		NEOLE		239
Derlin		MOUSE		165
Derlin		CRIGR		113
+90

Protein	Similar proteins		Species	Score	Length	Source
Q8BNI4	Derlin		RAT		239	UniRef50_Q8BNI4
Derlin		MESAU		239
Derlin		NEOLE		239
Derlin		MOUSE		165
Derlin		CRIGR		113
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF208064 mRNA Translation: AAL14868.1 AK048627 mRNA Translation: BAC33399.1 AK077659 mRNA Translation: BAC36934.1 AK082564 mRNA Translation: BAC38533.1 AK083632 mRNA Translation: BAC38974.1 BC005682 mRNA Translation: AAH05682.1
CCDSⁱ	CCDS24972.1 [Q8BNI4-1]
RefSeqⁱ	NP_001278075.1, NM_001291146.1 NP_001278076.1, NM_001291147.1 NP_001278077.1, NM_001291148.1 NP_291040.1, NM_033562.4 [Q8BNI4-1]
UniGeneⁱ	Mm.28131 Mm.446351

3D structure databases

ProteinModelPortalⁱ	Q8BNI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	228066, 2 interactors
IntActⁱ	Q8BNI4, 1 interactor
STRINGⁱ	10090.ENSMUSP00000117052

PTM databases

iPTMnetⁱ	Q8BNI4
PhosphoSitePlusⁱ	Q8BNI4

Proteomic databases

EPDⁱ	Q8BNI4
PaxDbⁱ	Q8BNI4
PeptideAtlasⁱ	Q8BNI4
PRIDEⁱ	Q8BNI4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000108523; ENSMUSP00000104163; ENSMUSG00000018442 [Q8BNI4-2] ENSMUST00000143850; ENSMUSP00000117052; ENSMUSG00000018442 [Q8BNI4-1]
GeneIDⁱ	116891
KEGGⁱ	mmu:116891
UCSCⁱ	uc007jxi.2 mouse [Q8BNI4-2] uc007jxj.2 mouse [Q8BNI4-1]

Organism-specific databases

CTDⁱ	51009
MGIⁱ	MGI:2151483 Derl2

Phylogenomic databases

eggNOGⁱ	KOG0858 Eukaryota COG5291 LUCA
GeneTreeⁱ	ENSGT00530000063156
HOGENOMⁱ	HOG000200948
HOVERGENⁱ	HBG051338
InParanoidⁱ	Q8BNI4
KOⁱ	K13989
OMAⁱ	WWRRLFE
OrthoDBⁱ	EOG091G0IPJ
PhylomeDBⁱ	Q8BNI4
TreeFamⁱ	TF314715

Enzyme and pathway databases

Reactomeⁱ	R-MMU-382556 ABC-family proteins mediated transport R-MMU-5358346 Hedgehog ligand biogenesis R-MMU-901032 ER Quality Control Compartment (ERQC)

Reactomeⁱ

R-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

ChiTaRSⁱ	Derl2 mouse
Protein Ontology More...PROⁱ	PR:Q8BNI4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000018442 Expressed in 289 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_DERL2
ExpressionAtlasⁱ	Q8BNI4 baseline and differential
Genevisibleⁱ	Q8BNI4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR007599 DER1
PANTHERⁱ	PTHR11009 PTHR11009, 1 hit
Pfamⁱ	View protein in Pfam PF04511 DER1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DERL2_MOUSE
Accessionⁱ	Q8BNI4Primary (citable) accession number: Q8BNI4 Secondary accession number(s): Q920I5, Q99J12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	July 19, 2004
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8BNI4 (DERL2_MOUSE)

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Derlin-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Endosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ