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Entry version 142 (13 Nov 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Sulfhydryl oxidase 1

Gene

Qsox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:26819240). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:26819240). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:26819240).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei73NucleophileBy similarity1
Active sitei76NucleophileBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei404FADCombined sources1 Publication1
Binding sitei411FADCombined sources1 Publication1
Binding sitei415FADCombined sources1 Publication1
Binding sitei454FADBy similarity1
Binding sitei458FADBy similarity1
Binding sitei503FADCombined sources1 Publication1
Binding sitei506FADCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi481 – 488FADCombined sources1 Publication8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.8.3.2 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.21 Publication)
Short name:
mSOx
Alternative name(s):
Quiescin Q6
Skin sulfhydryl oxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Qsox1
Synonyms:Qscn6, Sox
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1330818 Qsox1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei711 – 731HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi75H → A: Causes local perturbations of protein folding; when associated with T-122. 1 Publication1
Mutagenesisi122P → T: Causes local perturbations of protein folding; when associated with T-122. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024953433 – 748Sulfhydryl oxidase 1Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi73 ↔ 76Redox-activePROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi104 ↔ 113Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi396 ↔ 408PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi452 ↔ 455PROSITE-ProRule annotation
Disulfide bondi512 ↔ 515PROSITE-ProRule annotationCombined sources1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. O-glycosylated on Thr and Ser residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3297

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BND5

PeptideAtlas

More...
PeptideAtlasi
Q8BND5

PRoteomics IDEntifications database

More...
PRIDEi
Q8BND5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BND5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BND5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in skin (at protein level) (PubMed:12354420). Expressed in the seminal vesicles and skin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033684 Expressed in 241 organ(s), highest expression level in seminal vesicle

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BND5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035658

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1748
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BND5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 159ThioredoxinPROSITE-ProRule annotationAdd BLAST127
Domaini399 – 506ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST108

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1731 Eukaryota
ENOG410XVJT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159504

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BND5

KEGG Orthology (KO)

More...
KOi
K10758

Identification of Orthologs from Complete Genome Data

More...
OMAi
HNPQFVS

Database of Orthologous Groups

More...
OrthoDBi
498515at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BND5

TreeFam database of animal gene trees

More...
TreeFami
TF316749

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1960, 1 hit
1.20.120.310, 1 hit
3.40.30.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
IPR040986 QSOX_FAD-bd_dom
IPR042568 QSOX_FAD-bd_sf
IPR041269 QSOX_Trx1
IPR039798 Sulfhydryl_oxidase
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

The PANTHER Classification System

More...
PANTHERi
PTHR22897 PTHR22897, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04777 Evr1_Alr, 1 hit
PF18371 FAD_SOX, 1 hit
PF18108 QSOX_Trx1, 1 hit
PF00085 Thioredoxin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit
SSF69000 SSF69000, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51324 ERV_ALR, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8BND5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRCGRLSGP PSLLLLLLLL SPLLFSGPGA YAARLSVLYS SSDPLTLLDA
60 70 80 90 100
DSVRPTVLGS SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA
110 120 130 140 150
VLDCAEETNS AVCREFNIAG FPTVRFFQAF TKNGSGATLP GAGANVQTLR
160 170 180 190 200
MRLIDALESH RDTWPPACPP LEPAKLNDID GFFTRNKADY LALVFEREDS
210 220 230 240 250
YLGREVTLDL SQYHAVAVRR VLNTESDLVN KFGVTDFPSC YLLLRNGSVS
260 270 280 290 300
RVPVLVESRS FYTSYLRGLP GLTRDAPPTT ATPVTADKIA PTVWKFADRS
310 320 330 340 350
KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV
360 370 380 390 400
QNFLHSINDW LQKQQKKRIP YSFFKAALDS RKEDAVLTEK VNWVGCQGSE
410 420 430 440 450
PHFRGFPCSL WVLFHFLTVQ ANRYSEAHPQ EPADGQEVLQ AMRSYVQFFF
460 470 480 490 500
GCRDCADHFE QMAAASMHQV RSPSNAILWL WTSHNRVNAR LSGALSEDPH
510 520 530 540 550
FPKVQWPPRE LCSACHNELN GQVPLWDLGA TLNFLKAHFS PANIVIDSSA
560 570 580 590 600
SRHTGRRGSP EATPELVMDT LKLESRNSVL GHEQAASAES PGATALDVPA
610 620 630 640 650
EKPEASGPQE LYTGLRMGGA SPGQGPPERM EDHQRDMQEN APGQQHLSKR
660 670 680 690 700
DTEALFLPEV NHLQGPLELR RGGRSPKQLA PILEEEPEAL AIQGQGQWLQ
710 720 730 740
VLGGGISHLD ISLCVGLYSV SFMGLLAMYT YFRARLRTPK GHASYPTA
Length:748
Mass (Da):82,785
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0499F6B8DAB5A8D1
GO
Isoform 2 (identifier: Q8BND5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-661: VN → LL
     662-748: Missing.

Note: No experimental confirmation available.
Show »
Length:661
Mass (Da):73,297
Checksum:iAFC4B43576BEE56B
GO
Isoform 3 (identifier: Q8BND5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-568: VM → LL
     569-748: Missing.

Show »
Length:568
Mass (Da):63,336
Checksum:i761F44799536DBBB
GO
Isoform 4 (identifier: Q8BND5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-154: FFQAFTKNGSGATLPGAGANVQTLRMRLI → VCEGGATVEWFWPSTQSSVPHFPGTFLGC
     155-748: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:154
Mass (Da):16,624
Checksum:iF13FDA0BC3335587
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti637M → I in BAE41429 (PubMed:16141072).Curated1
Sequence conflicti656F → L in BAE41429 (PubMed:16141072).Curated1
Isoform 4 (identifier: Q8BND5-4)
Sequence conflicti127C → Y in BAE37202 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020491126 – 154FFQAF…RMRLI → VCEGGATVEWFWPSTQSSVP HFPGTFLGC in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_020492155 – 748Missing in isoform 4. 1 PublicationAdd BLAST594
Alternative sequenceiVSP_020493567 – 568VM → LL in isoform 3. 3 Publications2
Alternative sequenceiVSP_020494569 – 748Missing in isoform 3. 3 PublicationsAdd BLAST180
Alternative sequenceiVSP_020495660 – 661VN → LL in isoform 2. 1 Publication2
Alternative sequenceiVSP_020496662 – 748Missing in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB044284 mRNA Translation: BAB21936.1
AK004880 mRNA Translation: BAB23638.1
AK083938 mRNA Translation: BAC39073.1
AK149465 mRNA Translation: BAE28897.1
AK163119 mRNA Translation: BAE37202.1
AK166839 mRNA Translation: BAE39061.1
AK169877 mRNA Translation: BAE41429.1
AK169920 mRNA Translation: BAE41459.1
AK170449 mRNA Translation: BAE41807.1
BC034131 mRNA Translation: AAH34131.1
BC076590 mRNA Translation: AAH76590.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS15386.1 [Q8BND5-1]
CCDS78713.1 [Q8BND5-3]

NCBI Reference Sequences

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RefSeqi
NP_001020116.1, NM_001024945.1 [Q8BND5-1]
NP_075757.1, NM_023268.2 [Q8BND5-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000035325; ENSMUSP00000035658; ENSMUSG00000033684 [Q8BND5-1]
ENSMUST00000111764; ENSMUSP00000107394; ENSMUSG00000033684 [Q8BND5-2]
ENSMUST00000194632; ENSMUSP00000142301; ENSMUSG00000033684 [Q8BND5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
104009

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:104009

UCSC genome browser

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UCSCi
uc007dbo.1 mouse [Q8BND5-3]
uc007dbp.1 mouse [Q8BND5-1]
uc007dbq.1 mouse [Q8BND5-4]
uc011wtx.1 mouse [Q8BND5-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044284 mRNA Translation: BAB21936.1
AK004880 mRNA Translation: BAB23638.1
AK083938 mRNA Translation: BAC39073.1
AK149465 mRNA Translation: BAE28897.1
AK163119 mRNA Translation: BAE37202.1
AK166839 mRNA Translation: BAE39061.1
AK169877 mRNA Translation: BAE41429.1
AK169920 mRNA Translation: BAE41459.1
AK170449 mRNA Translation: BAE41807.1
BC034131 mRNA Translation: AAH34131.1
BC076590 mRNA Translation: AAH76590.1
CCDSiCCDS15386.1 [Q8BND5-1]
CCDS78713.1 [Q8BND5-3]
RefSeqiNP_001020116.1, NM_001024945.1 [Q8BND5-1]
NP_075757.1, NM_023268.2 [Q8BND5-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T58X-ray2.40A/B/C/D36-550[»]
3T59X-ray2.80A/B/C/D36-550[»]
5D8IX-ray2.05A/B36-275[»]
5D93X-ray2.20A/D36-275[»]
5D96X-ray2.30A/D36-275[»]
6HF1X-ray1.94A/D37-274[»]
SMRiQ8BND5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035658

PTM databases

iPTMnetiQ8BND5
PhosphoSitePlusiQ8BND5

Proteomic databases

CPTACinon-CPTAC-3297
PaxDbiQ8BND5
PeptideAtlasiQ8BND5
PRIDEiQ8BND5

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q8BND5

Genome annotation databases

EnsembliENSMUST00000035325; ENSMUSP00000035658; ENSMUSG00000033684 [Q8BND5-1]
ENSMUST00000111764; ENSMUSP00000107394; ENSMUSG00000033684 [Q8BND5-2]
ENSMUST00000194632; ENSMUSP00000142301; ENSMUSG00000033684 [Q8BND5-3]
GeneIDi104009
KEGGimmu:104009
UCSCiuc007dbo.1 mouse [Q8BND5-3]
uc007dbp.1 mouse [Q8BND5-1]
uc007dbq.1 mouse [Q8BND5-4]
uc011wtx.1 mouse [Q8BND5-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5768
MGIiMGI:1330818 Qsox1

Phylogenomic databases

eggNOGiKOG1731 Eukaryota
ENOG410XVJT LUCA
GeneTreeiENSGT00940000159504
InParanoidiQ8BND5
KOiK10758
OMAiHNPQFVS
OrthoDBi498515at2759
PhylomeDBiQ8BND5
TreeFamiTF316749

Enzyme and pathway databases

BRENDAi1.8.3.2 3474
ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Qsox1 mouse

Protein Ontology

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PROi
PR:Q8BND5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033684 Expressed in 241 organ(s), highest expression level in seminal vesicle
GenevisibleiQ8BND5 MM

Family and domain databases

Gene3Di1.20.120.1960, 1 hit
1.20.120.310, 1 hit
3.40.30.10, 2 hits
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
IPR040986 QSOX_FAD-bd_dom
IPR042568 QSOX_FAD-bd_sf
IPR041269 QSOX_Trx1
IPR039798 Sulfhydryl_oxidase
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PANTHERiPTHR22897 PTHR22897, 1 hit
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
PF18371 FAD_SOX, 1 hit
PF18108 QSOX_Trx1, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQSOX1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BND5
Secondary accession number(s): Q3TDY9
, Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: November 13, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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