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Protein

WD repeat-containing protein 35

Gene

Wdr35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 35
Gene namesi
Name:Wdr35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921932 Wdr35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513851 – 1181WD repeat-containing protein 35Add BLAST1181

Proteomic databases

PaxDbiQ8BND3
PeptideAtlasiQ8BND3
PRIDEiQ8BND3

PTM databases

iPTMnetiQ8BND3
PhosphoSitePlusiQ8BND3

Expressioni

Gene expression databases

BgeeiENSMUSG00000066643 Expressed in 221 organ(s), highest expression level in testis
CleanExiMM_WDR35
ExpressionAtlasiQ8BND3 baseline and differential
GenevisibleiQ8BND3 MM

Interactioni

Subunit structurei

Component of the IFT complex A (IFT-A). Interacts with IFT43 (By similarity).By similarity

Protein-protein interaction databases

BioGridi216937, 1 interactor
STRINGi10090.ENSMUSP00000082895

Structurei

3D structure databases

ProteinModelPortaliQ8BND3
SMRiQ8BND3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 51WD 1Add BLAST40
Repeati69 – 108WD 2Add BLAST40
Repeati113 – 152WD 3Add BLAST40
Repeati154 – 193WD 4Add BLAST40
Repeati502 – 539WD 5Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2041 Eukaryota
ENOG410XNSQ LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000255527
HOVERGENiHBG079343
InParanoidiQ8BND3
KOiK19674
OMAiQYYVQGR
OrthoDBiEOG091G014X
TreeFamiTF314076

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR017233 WDR35
PANTHERiPTHR16517:SF1 PTHR16517:SF1, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PIRSFiPIRSF037536 WD_repeat_p35, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BND3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFFYLSKKIA VPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LRLETQTDDS
60 70 80 90 100
KLRGLAAPSN LSMNQNLEGH SGAVQVVTWN EQYQKLTTSD QNGLIIVWML
110 120 130 140 150
YKGSWYEEMI NNRNKSVVRS MSWNADGQKI CIVYEDGAVI VGSVDGNRIW
160 170 180 190 200
GKDLKGIQLC HVTWSADSKI LLFGMANGEI HIYDNQGNFI MKMKLNCLVN
210 220 230 240 250
VTGAISIAGI HWYHGTEGYV EPDCPCLAIC FDNGRCQIMR HENDQNPVLI
260 270 280 290 300
DTGMYVVGIQ WNHIGSVLAV AGSQKVVTQD KDINIVQFYT PFGEHLGTLK
310 320 330 340 350
VPGKQMCSLS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR
360 370 380 390 400
PDRPEYCVVF WDTKNSEKYV KYVKSLISIT TCGDFCILAT KADENHPQEE
410 420 430 440 450
NEMETFGATF VLVLCNSIGT PLDPKYIDLV PLFVAMTKTH VIAASKEAFY
460 470 480 490 500
TWQYRVAKKL TALEINQITR SRKEGRERIY HVDDVPSGSV DGVFDYSKAI
510 520 530 540 550
QGTRDPICAI TASDKTLIVG RESGVIQRYS FPNVALIQKY SLDCRACQLS
560 570 580 590 600
LNCNSSRLAI IDIAGVLTFF DLDTRVTDST GQQVVGELLK LERKDVWDMK
610 620 630 640 650
WAKDNPDLFA MMEKTRMYVF RNLDPEEPIQ TSGYICNFED LEIKSVLLDE
660 670 680 690 700
ILKDPEHPSK DYIMNFEIRS LRDSRALIEK VGIEDASQFI EDNPHPRLWR
710 720 730 740 750
LLAEAALQKL DLYTAQQAFV RCKDYQGIKF VKLLGNLQSE SMKQAEVIAY
760 770 780 790 800
FGRFEDAERM YQDMDRRDLA IGLRMKLGDW FRVLQLLKTG SGDADDSLLE
810 820 830 840 850
QANNAIGEYF ADRQKWQNAV QYYVKGRNQE RLAECYYMLE DYEGLETLAN
860 870 880 890 900
SLPENHKLLP EIAQMFVRVG MCEQAVSAFL KCNQPKAAVD TCVHLNQWNK
910 920 930 940 950
AVELAKSHSM KEIGSLLARY ASHLLEKNKT LDAIELYRKA SYFFDAAKLM
960 970 980 990 1000
YKIADEEAKK RTKPLRVKKL YVLSALLIEQ YHEQMKNAQR GKVKGKNSEA
1010 1020 1030 1040 1050
TSALAGLLEE EVLSTTSRFT DNAWRGAEAY HFFILAQRQL YEGYVDTALK
1060 1070 1080 1090 1100
TALHLRDYED IIPSVEIYSL LALCACASRA FGTCSKAFIK LESLETLSAE
1110 1120 1130 1140 1150
QKQQYEDLAL EIFTKHTPKD NRKSELNSLL EGGEGKLPTC IATGSPIIEY
1160 1170 1180
QFWVCKVCKH YVLAQEISNY NFCPLCHSSV E
Length:1,181
Mass (Da):133,991
Last modified:July 27, 2011 - v3
Checksum:iF69BA836E9CA65CE
GO
Isoform 2 (identifier: Q8BND3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-409: Missing.

Show »
Length:1,170
Mass (Da):132,752
Checksum:iC74FFD8594961B2E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYD5E0CYD5_MOUSE
WD repeat-containing protein 35
Wdr35
186Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti634Y → H in AAH56925 (PubMed:15489334).Curated1
Sequence conflicti828N → D in BAC39081 (PubMed:16141072).Curated1
Sequence conflicti915S → Y in BAC26663 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009733399 – 409Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029896 mRNA Translation: BAC26663.1
AK083971 mRNA Translation: BAC39081.1
AC110376 Genomic DNA No translation available.
BC056925 mRNA Translation: AAH56925.1
CCDSiCCDS25807.1 [Q8BND3-1]
CCDS49027.1 [Q8BND3-2]
RefSeqiNP_001152999.1, NM_001159527.1 [Q8BND3-2]
NP_766058.3, NM_172470.3 [Q8BND3-1]
UniGeneiMm.87389

Genome annotation databases

EnsembliENSMUST00000085745; ENSMUSP00000082895; ENSMUSG00000066643 [Q8BND3-1]
ENSMUST00000111113; ENSMUSP00000106742; ENSMUSG00000066643 [Q8BND3-2]
GeneIDi74682
KEGGimmu:74682
UCSCiuc007naj.2 mouse [Q8BND3-1]
uc007nak.2 mouse [Q8BND3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029896 mRNA Translation: BAC26663.1
AK083971 mRNA Translation: BAC39081.1
AC110376 Genomic DNA No translation available.
BC056925 mRNA Translation: AAH56925.1
CCDSiCCDS25807.1 [Q8BND3-1]
CCDS49027.1 [Q8BND3-2]
RefSeqiNP_001152999.1, NM_001159527.1 [Q8BND3-2]
NP_766058.3, NM_172470.3 [Q8BND3-1]
UniGeneiMm.87389

3D structure databases

ProteinModelPortaliQ8BND3
SMRiQ8BND3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216937, 1 interactor
STRINGi10090.ENSMUSP00000082895

PTM databases

iPTMnetiQ8BND3
PhosphoSitePlusiQ8BND3

Proteomic databases

PaxDbiQ8BND3
PeptideAtlasiQ8BND3
PRIDEiQ8BND3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085745; ENSMUSP00000082895; ENSMUSG00000066643 [Q8BND3-1]
ENSMUST00000111113; ENSMUSP00000106742; ENSMUSG00000066643 [Q8BND3-2]
GeneIDi74682
KEGGimmu:74682
UCSCiuc007naj.2 mouse [Q8BND3-1]
uc007nak.2 mouse [Q8BND3-2]

Organism-specific databases

CTDi57539
MGIiMGI:1921932 Wdr35

Phylogenomic databases

eggNOGiKOG2041 Eukaryota
ENOG410XNSQ LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000255527
HOVERGENiHBG079343
InParanoidiQ8BND3
KOiK19674
OMAiQYYVQGR
OrthoDBiEOG091G014X
TreeFamiTF314076

Enzyme and pathway databases

ReactomeiR-MMU-5610787 Hedgehog 'off' state
R-MMU-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSiWdr35 mouse
PROiPR:Q8BND3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066643 Expressed in 221 organ(s), highest expression level in testis
CleanExiMM_WDR35
ExpressionAtlasiQ8BND3 baseline and differential
GenevisibleiQ8BND3 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR017233 WDR35
PANTHERiPTHR16517:SF1 PTHR16517:SF1, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PIRSFiPIRSF037536 WD_repeat_p35, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR35_MOUSE
AccessioniPrimary (citable) accession number: Q8BND3
Secondary accession number(s): E9QLW3, Q8CDL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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