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Entry version 116 (11 Dec 2019)
Sequence version 2 (18 Mar 2008)
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Protein

Protocadherin Fat 3

Gene

Fat3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the interactions between neurites derived from specific subsets of neurons during development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 3
Alternative name(s):
FAT tumor suppressor homolog 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fat3
Synonyms:Gm1132, Gm510
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444314 Fat3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 4153ExtracellularSequence analysisAdd BLAST4122
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4154 – 4174HelicalSequence analysisAdd BLAST21
Topological domaini4175 – 4555CytoplasmicSequence analysisAdd BLAST381

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032463532 – 4555Protocadherin Fat 3Add BLAST4524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi879N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1944N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1993N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3618N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3741N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3798 ↔ 3809By similarity
Disulfide bondi3803 ↔ 3821By similarity
Disulfide bondi3823 ↔ 3831By similarity
Glycosylationi3926N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3984 ↔ 4017By similarity
Disulfide bondi4024 ↔ 4035By similarity
Disulfide bondi4029 ↔ 4045By similarity
Disulfide bondi4047 ↔ 4056By similarity
Disulfide bondi4063 ↔ 4074By similarity
Disulfide bondi4068 ↔ 4083By similarity
Disulfide bondi4085 ↔ 4094By similarity
Disulfide bondi4101 ↔ 4112By similarity
Disulfide bondi4106 ↔ 4121By similarity
Disulfide bondi4123 ↔ 4132By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4508Omega-N-methylarginineCombined sources1
Modified residuei4518Omega-N-methylarginineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8BNA6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8BNA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BNA6

PRoteomics IDEntifications database

More...
PRIDEi
Q8BNA6

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2655

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BNA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BNA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to the nervous system, mainly in brain. In brain, it is highly expressed in the olfactory bulb and retina. In the developing olfactory bulb, it localizes along the dendrites of these cells as well as in their axons to some extent. In retina, it cocentrates in the inner plexiform layer throughout development (at protein level).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8BNA6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000080808

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8BNA6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BNA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini158 – 262Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini263 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini376 – 471Cadherin 4PROSITE-ProRule annotationAdd BLAST96
Domaini472 – 577Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini578 – 680Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini726 – 830Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini831 – 935Cadherin 8PROSITE-ProRule annotationAdd BLAST105
Domaini936 – 1042Cadherin 9PROSITE-ProRule annotationAdd BLAST107
Domaini1043 – 1147Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1148 – 1253Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1254 – 1358Cadherin 12PROSITE-ProRule annotationAdd BLAST105
Domaini1362 – 1459Cadherin 13PROSITE-ProRule annotationAdd BLAST98
Domaini1460 – 1565Cadherin 14PROSITE-ProRule annotationAdd BLAST106
Domaini1566 – 1768Cadherin 15PROSITE-ProRule annotationAdd BLAST203
Domaini1769 – 1882Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1883 – 1985Cadherin 17PROSITE-ProRule annotationAdd BLAST103
Domaini1982 – 2083Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2084 – 2185Cadherin 19PROSITE-ProRule annotationAdd BLAST102
Domaini2186 – 2286Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2287 – 2393Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2394 – 2495Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2496 – 2599Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2600 – 2707Cadherin 24PROSITE-ProRule annotationAdd BLAST108
Domaini2708 – 2813Cadherin 25PROSITE-ProRule annotationAdd BLAST106
Domaini2814 – 2923Cadherin 26PROSITE-ProRule annotationAdd BLAST110
Domaini2924 – 3028Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3029 – 3130Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3131 – 3235Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3236 – 3340Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3341 – 3445Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3446 – 3550Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3551 – 3660Cadherin 33PROSITE-ProRule annotationAdd BLAST110
Domaini3794 – 3832EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini3834 – 4017Laminin G-likePROSITE-ProRule annotationAdd BLAST184
Domaini4020 – 4057EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini4059 – 4095EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini4097 – 4133EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4404 – 4466Pro-richAdd BLAST63

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154981

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046499

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BNA6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BNA6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 27 hits
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 32 hits
SM00181 EGF, 4 hits
SM00179 EGF_CA, 3 hits
SM00282 LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 19 hits
PS50268 CADHERIN_2, 32 hits
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8BNA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVTMGHCMG TKPPSCIILL LLKLFATVSQ GLPGTGPLGF HFTHSTYNAT
60 70 80 90 100
VYENSAARTY VNSQSRMGIT LIDLSWDIKY RIVSGDEEGF FKAEEVIIAD
110 120 130 140 150
FCFLRIRTKG GNSAILNREI QDNYLLIIKG SVRGEDLEAW TKVNIQVLDM
160 170 180 190 200
NDLRPLFSPT TYSVTIAEST PLRTSVAQVT ATDADIGSNG EFYYYFKNKV
210 220 230 240 250
DLFSVHPTSG VISLSGRLNY DEKNRYDLEI LAVDRGMKLY GNNGVSSTAK
260 270 280 290 300
LYVHIERINE HAPIIHVVSH TPFSLDKEPT YAVVTVDDLD EGANGEIESL
310 320 330 340 350
SIVDGDPLEQ FFLAKEGKWL NEYKVKERRQ VDWESFSYGY NLTIQAKDKG
360 370 380 390 400
SPQKFSELKT VHIANPRRDN TPVRFEKDVY EVSISEFSPP GVLVAIVKVS
410 420 430 440 450
PEPLDVEYKL LPGKDSDYFK INPRSGLIVT AQPLNTVKKE VYKLEVSDKE
460 470 480 490 500
GDAKAQVTIG IEDANDHTPE FQEALYETFV NESVRVGTNV LTVSASDKDK
510 520 530 540 550
GENGYITYSI ASLNLLPFAI NQFTGVISTT EELDFESSPE TYRFIVRASD
560 570 580 590 600
WGSPYRHESE VNVTIRVGNV NDNSPLFEKV ACQGVISYDF PVGGHITAIS
610 620 630 640 650
AIDIDELELV KYKIISGNEL GFFYLNPDSG VLQLKKSLMN SGIKNGNFAL
660 670 680 690 700
RITATDGENF ADPMAINISV LHGKVSSKSF SCRETRVAQK LAEKLLIKAK
710 720 730 740 750
ANGKLNLEDG FLDFYSINRQ GPHFDKSFPS DVAVKEDMLV GTNILKIKAY
760 770 780 790 800
DADSGFNGKV LFTISDGNTD SCFNIDMETG QLKVLMPMDR EHTDLYVLNI
810 820 830 840 850
TIYDLGKPQK SSWRLLTVNV EDANDNNPVF LQDSYSVSIL ESSSIGTEII
860 870 880 890 900
QVEARDKDLG SNGEVMYSVL TDTHQFIINS STGIVYIADQ LDRESKANYS
910 920 930 940 950
LKIEARDKAE SGQQLFSVVT LKIFLDDVND CSPAFIPSSY SVKVLEDLPV
960 970 980 990 1000
GTVIAWLETQ DPDLGLGGQV RYSLVNDYNG RFEVDKASGA IRLSKELDYE
1010 1020 1030 1040 1050
KQQFYNLTVR AKDKGRPVSL SSVSFVEVEV VDVNENLHTP YFPDFAVVGS
1060 1070 1080 1090 1100
VKENSRIGTS VLQVTAHDED SGRDGEIQYS IRDGSGLGRF NIDDESGVIT
1110 1120 1130 1140 1150
AADSLDRETT ASYWLTVYAT DRGVVPLYST IEVYIEVEDV NDNAPLTSEP
1160 1170 1180 1190 1200
IYYPVVMENS PKDVSVIQIQ AEDPDSGSNE KLTYRITSGN PQNFFAINIK
1210 1220 1230 1240 1250
TGLITTTSRK LDREQQAEHF LEVTVTDGGS SPKQSTIWVV VQVLDENDNR
1260 1270 1280 1290 1300
PQFPEKVYQI KLPERDRKKR GEPIYRAFAF DKDEGPNAEI SYSIVDGNDD
1310 1320 1330 1340 1350
GKFFIDPKTG MVSSRKQFTA GSYDILTIKA VDNGRPQKSS TARLHIEWIK
1360 1370 1380 1390 1400
KPPPSPIPLT FDEPFYNFTV MESDKVTEIV GVVSVQPANT PLWFDIVGGN
1410 1420 1430 1440 1450
FDSSFDAEKG VGTIVIAKPL DAEQRSVYNM SVEVTDGTNI AVTQVFIKVL
1460 1470 1480 1490 1500
DNNDNGPEFS QPHYDVTISE DVLPDTEILQ IEATDRDEKH KLSYTIHSSI
1510 1520 1530 1540 1550
DAVSMRKFRM DPSTGVLYTA ERLDHEAQDK HILNIMVRDQ EFPYRRNLAR
1560 1570 1580 1590 1600
VIVNVEDAND HSPYFTNPLY EASVFESAAL GSVVLQVTAL DKDKGENAEL
1610 1620 1630 1640 1650
IYSIEAGNTG NTFKIEPVLG IITISKEPDM AAMGQFVLSV KVTDQGSPPM
1660 1670 1680 1690 1700
SATAIVRISI SMSDNSHPKF THKDYQAEVN ENVDIGTSVI LISAISQSTL
1710 1720 1730 1740 1750
IYEVKDGNIN GVFTINPYSG VITTRRALDY EHTSSYQLII QATNMAGMAS
1760 1770 1780 1790 1800
NATISVQIVD ENDNPPVFLF SQYSGSLSEA APINSIVRSL DNSPLVIRAT
1810 1820 1830 1840 1850
DADSNQNALL VYQIVESTAK KFFTVDSSTG AIRTIANLDH EAIAHFHFHV
1860 1870 1880 1890 1900
HVRDSGNPQL TAESPVEVNI EVTDVNDNPP VFTQAVFETV LLLPTYIGVE
1910 1920 1930 1940 1950
VLKVSATDPD SEVPPELTYS LMEGSVDNFL MDPNTGVLTI KNNNLSKDHY
1960 1970 1980 1990 2000
MLIVRVSDGK FYSTAMVTVM VKEAMDSGLH FTQSFYSTSI SENSTNITKV
2010 2020 2030 2040 2050
AIVNAVGNRL NEPLKYSILN PGNKFKIKST SGVIQTTGVP FDREEQELYE
2060 2070 2080 2090 2100
LVVEASRELD HLRVARVVVR VNIEDVNDNS PVFVGLPYYA AVQVDAEPGT
2110 2120 2130 2140 2150
LIYRVTAIDK DKGANGEVTY VLQDDYGHFE INPNSGNVIL REAFNSDLSN
2160 2170 2180 2190 2200
IDYGVTILAK DGGNPSLSTF VELPITIVNK AMPVFDKPFY TASINEDITM
2210 2220 2230 2240 2250
NTPILSINAT SPEGQGIIYL IIDGDPFQQF NIDFDTGVLK VISPLDYEVT
2260 2270 2280 2290 2300
SVYKLTVRAS DALTGARAEV TVDLLVDDIN DNPPVFDQPT YNTTLSESSL
2310 2320 2330 2340 2350
IGTPVLQLVS TDADSGNNKL VRYQIVQDTY NSTDYFHIDS SSGLILTARM
2360 2370 2380 2390 2400
LDHELVQHCT LKVTATDNGF PSLSSEVLVQ IYISDVNDNP PVFNQLIYES
2410 2420 2430 2440 2450
YVSELAPRGH FVTCVQASDA DSSDLDRLEY SILSGNDRAS FLMDSKSGVL
2460 2470 2480 2490 2500
TLSSHRKQRM EPLYSLNVSV SDGLFTSTAQ VHIRVLGANL YSPAFSQSTY
2510 2520 2530 2540 2550
VAEVRENAAS GTKVIHVRAT DGDPGTYGQV SYSIINDFAK DRFLIDSNGQ
2560 2570 2580 2590 2600
IITTERLDRE NPLEGDISIY LRALDGGGRT TFCTVRVIVV DENDNAPQFM
2610 2620 2630 2640 2650
TVEYRASVRA DVGRGHLVTQ VQALDPDDGA NSRITYSLYS EASVSVADLL
2660 2670 2680 2690 2700
EIDPDNGWMV TKGNFNQLRN TVLSFFVKAV DGGIPVRHSL IPVYIHVLPP
2710 2720 2730 2740 2750
ETFLPSFTQS QYSFTITEDT SIGSTVDTLR ILPNQSVRFS MVNGERPENN
2760 2770 2780 2790 2800
KEGVFIIEQE TGAIKLDKRL DHEVSPAFHF KVAATIPLDK VDIVFTVDVD
2810 2820 2830 2840 2850
VKVLDLNDNK PVFETSTYET IIMEGMPVGT KLAQVRAIDM DWGANGQVTY
2860 2870 2880 2890 2900
SLHSDSHLEK VIEAFNIDSN TGWISTLKDL DHETDPAFSF FVVASDLGEA
2910 2920 2930 2940 2950
FSLSSMALVS VKVTDINDNA PVFAHEVYRG NVKESDPPGE VVAVLSTLDK
2960 2970 2980 2990 3000
DTSNINRQVS YHITGGNPRG QFALGMVQSE WKVYVKRPLD REEQDIYFLN
3010 3020 3030 3040 3050
ITASDGLFVT QAMVEVTVSD VNDNSPVCDQ VAYSASLPED IPSNKIILKV
3060 3070 3080 3090 3100
SAKDADIGSN GDIRYSLYGS GNNEFFLDPE SGELKTLAVL DRERVPVYNL
3110 3120 3130 3140 3150
IARATDGGGR FCSSSVLLLL EDVNDNPPVF SSNHYTACVY ENTATKALLT
3160 3170 3180 3190 3200
RVQAMDPDVG INRKVVYSLE DSASGVFSID SSSGVIVLEQ PLDREQQSSY
3210 3220 3230 3240 3250
NISVRATDQS PGQSLSSLAS VTITVLDIND NPPVFERRDY LVTVPEDTSL
3260 3270 3280 3290 3300
GTQVLSVFAT SKDIGTNAEI TYLIRSGNEQ GKFSINPKTG GISVLEALDY
3310 3320 3330 3340 3350
ETCRRFYLVV EAKDGGTPAL STAATVSIDL TDVNDNPPRF SQDVYSAVIS
3360 3370 3380 3390 3400
EDALEGDSVI LLIAEDVDSK PNGQIRFSIV GGDRDNEFAV DPILGLVKVK
3410 3420 3430 3440 3450
KKLDRERVSG YSLLIQAVDS GIPAMSSTTT VNIDISDVND NSPVFTPANY
3460 3470 3480 3490 3500
TAVIQENKPV GTSILQLVVT DRDSFHNGPP FSFSILSGNE DEEFMLDSHG
3510 3520 3530 3540 3550
ILRSAVVFRH MESPEYLLCI QAKDSGKPQQ VSHTYIRVRV IEESTHKPTA
3560 3570 3580 3590 3600
IPLEIFIVTM EDDFPGGVIG KIHATDQDMY DVLTFALKSE QKSLFKVNSH
3610 3620 3630 3640 3650
DGKIIALGGL DSGKYVLNVS VSDGRFQVPI DVVVHVEQLV HEMLQNTVTI
3660 3670 3680 3690 3700
RFEDVSPEDF VGLHMHGFRR ILRNAVLTQK QDSLRIISIQ PVVGTNQLDM
3710 3720 3730 3740 3750
LFAVEMHSSE FYKPAYLIQK LSNARRHLEN VMHIAAILEK NCSGLDCQEQ
3760 3770 3780 3790 3800
HCEQGLSLDS HALMTYSTAR ISFVCPRFYR NVRCTCNGGV CPGSNDPCVE
3810 3820 3830 3840 3850
KPCPEDMQCV GYEASRRPFL CQCPPGKLGE CSGHTSLSFA GNSYIKYRLS
3860 3870 3880 3890 3900
ENSKEEDFKL ALRLRTLQSN GIIMYTRANP CMILKIVEGK LWFQLDCGSG
3910 3920 3930 3940 3950
PGILGISSRA VNDGSWHSVF LELNRNFTSL ALDDSYVERR RAPLYFQTLS
3960 3970 3980 3990 4000
TDSAIFFGAL VQADNVRSLT DTRVTQVLGG FQGCLDSVVL NHYELPLQNK
4010 4020 4030 4040 4050
RSSFAEVVGL TELKLGCVLY PDACQRSPCL HGGSCSSLPS GGYQCSCLSQ
4060 4070 4080 4090 4100
FTGTNCESEI TACFPNPCRN GGSCDPIGNT FVCSCKAGLT GVTCEDDVDE
4110 4120 4130 4140 4150
CEREECENGG SCVNLFGSFF CNCTPGYVGQ YCGLRPVVVP NIQAGHSYVG
4160 4170 4180 4190 4200
KEELIGIAVV LFVIFTLIVL FIVFRKKVFR KNYSRNNITL VQDPATAALL
4210 4220 4230 4240 4250
HKSNGIPFRS LRAGDGRNVY QEVGPPQVPV RPMAYTPCFQ SDSRSNLDKG
4260 4270 4280 4290 4300
LDVLGGEPQE MSTFHPESPR ILTARRGVVV CSVAPNLPAV SPCRSDCDSI
4310 4320 4330 4340 4350
RKNGWDTGSE NKGTEDTGEV TCFTNSNKGS NSEVQSLSSF QSDSGDDNAY
4360 4370 4380 4390 4400
HWDTSDWMPG ARLSDIEEMP NYESQDGGAA HQGSTRELES DYYLGGYDID
4410 4420 4430 4440 4450
SEYPPPHEEE FLSRDQLPPP LPEDFPDQYE ALPPSQPTSL TSTMSPDCRR
4460 4470 4480 4490 4500
RPRFHPSQYL PPHPLPGETD LGGPSSSCDF STFAVNMNQG TEVMAPTDSV
4510 4520 4530 4540 4550
SLSLHNSRGT SSSEMSARCG FDDSEVAMSD YESAGELSLT NLHIPFVETQ

QQTQV
Length:4,555
Mass (Da):502,011
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E23122CCAC98DDD
GO
Isoform 2 (identifier: Q8BNA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1538-1591: RDQEFPYRRN...SVVLQVTALD → GPDLGFCSPG...YFNEEVTVLR
     1592-4555: Missing.

Show »
Length:1,591
Mass (Da):177,314
Checksum:i535E9D0C786B814E
GO
Isoform 3 (identifier: Q8BNA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3806: Missing.
     4043-4121: YQCSCLSQFT...CVNLFGSFFC → ECTSVQARGG...RGEGTWGNLN
     4122-4555: Missing.

Show »
Length:315
Mass (Da):34,397
Checksum:i857E070E91363B1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK16E9QK16_MOUSE
Protocadherin Fat 3
Fat3
4,551Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SU86A0A1L1SU86_MOUSE
Protocadherin Fat 3
Fat3
404Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0323291 – 3806Missing in isoform 3. 1 PublicationAdd BLAST3806
Alternative sequenceiVSP_0323301538 – 1591RDQEF…VTALD → GPDLGFCSPGRTVNQPRHIP QEARAFKFYRPSFCTARLHA VLPLYFNEEVTVLR in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0323311592 – 4555Missing in isoform 2. 1 PublicationAdd BLAST2964
Alternative sequenceiVSP_0323324043 – 4121YQCSC…GSFFC → ECTSVQARGGSAPEVCPLHS QPLPPSPGPSQKGWSFGYNF TSAFMGWRSGPAMVGRELRG RGLWSTLEKRGEGTWGNLN in isoform 3. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_0323334122 – 4555Missing in isoform 3. 1 PublicationAdd BLAST434

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC154406 Genomic DNA No translation available.
AC154741 Genomic DNA No translation available.
AC161370 Genomic DNA No translation available.
AC161421 Genomic DNA No translation available.
AC162903 Genomic DNA No translation available.
BC117744 mRNA Translation: AAI17745.1
AK084245 mRNA Translation: BAC39147.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40539.1 [Q8BNA6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000217308; ENSMUSP00000148968; ENSMUSG00000074505 [Q8BNA6-1]

UCSC genome browser

More...
UCSCi
uc009ogj.1 mouse [Q8BNA6-1]
uc009ogk.1 mouse [Q8BNA6-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154406 Genomic DNA No translation available.
AC154741 Genomic DNA No translation available.
AC161370 Genomic DNA No translation available.
AC161421 Genomic DNA No translation available.
AC162903 Genomic DNA No translation available.
BC117744 mRNA Translation: AAI17745.1
AK084245 mRNA Translation: BAC39147.1
CCDSiCCDS40539.1 [Q8BNA6-1]

3D structure databases

SMRiQ8BNA6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8BNA6, 1 interactor
STRINGi10090.ENSMUSP00000080808

PTM databases

GlyConnecti2655
iPTMnetiQ8BNA6
PhosphoSitePlusiQ8BNA6

Proteomic databases

EPDiQ8BNA6
jPOSTiQ8BNA6
PaxDbiQ8BNA6
PRIDEiQ8BNA6

Genome annotation databases

EnsembliENSMUST00000217308; ENSMUSP00000148968; ENSMUSG00000074505 [Q8BNA6-1]
UCSCiuc009ogj.1 mouse [Q8BNA6-1]
uc009ogk.1 mouse [Q8BNA6-3]

Organism-specific databases

MGIiMGI:2444314 Fat3

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000154981
HOGENOMiHOG000046499
InParanoidiQ8BNA6
PhylomeDBiQ8BNA6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fat3 mouse

Protein Ontology

More...
PROi
PR:Q8BNA6
RNActiQ8BNA6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 27 hits
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 32 hits
SM00181 EGF, 4 hits
SM00179 EGF_CA, 3 hits
SM00282 LamG, 1 hit
SUPFAMiSSF49313 SSF49313, 34 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 19 hits
PS50268 CADHERIN_2, 32 hits
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BNA6
Secondary accession number(s): Q08ED4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 11, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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