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Protein

La-related protein 6

Gene

Larp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 6
Alternative name(s):
Acheron
Short name:
Achn
La ribonucleoprotein domain family member 6
Gene namesi
Name:Larp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914807 Larp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002811422 – 492La-related protein 6Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BN59
PaxDbiQ8BN59
PRIDEiQ8BN59

PTM databases

iPTMnetiQ8BN59
PhosphoSitePlusiQ8BN59

Expressioni

Tissue specificityi

Expressed in numerous tissues. Highest expression in heart and brain, intermediate in kidney, skeletal muscle and testis, lowest expression in testis (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000034839 Expressed in 173 organ(s), highest expression level in pontine nuclear group
CleanExiMM_LARP6
GenevisibleiQ8BN59 MM

Interactioni

Subunit structurei

Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040309

Structurei

3D structure databases

ProteinModelPortaliQ8BN59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 177HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92
Domaini184 – 296RRMAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 193Nuclear export signalBy similarity8
Motifi296 – 302Nuclear localization signalBy similarity7

Domaini

The RRM domain mediates the association with collagen mRNAs stem-loops.By similarity

Phylogenomic databases

eggNOGiKOG1855 Eukaryota
ENOG4110VUA LUCA
GeneTreeiENSGT00830000128323
HOGENOMiHOG000010108
HOVERGENiHBG070244
InParanoidiQ8BN59
KOiK18733
OMAiHERGRAC
OrthoDBiEOG091G09LP
PhylomeDBiQ8BN59
TreeFamiTF326594

Family and domain databases

CDDicd12289 RRM_LARP6, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR034886 LARP6
IPR034880 LARP6_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024642 SUZ-C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22792:SF71 PTHR22792:SF71, 1 hit
PfamiView protein in Pfam
PF05383 La, 1 hit
PF12901 SUZ-C, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BN59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLGEQTLP GPETTVQIRV AIQEAEDLED LEEEDEGTSA RAAGDPARYL
60 70 80 90 100
SPGWGSASEE EPSRGHSSAT TSGGENDRED LEPEWRPPDE ELIRKLVDQI
110 120 130 140 150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH
160 170 180 190 200
ALKYSVTLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LHLSPKLWAL
210 220 230 240 250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY
260 270 280 290 300
SQVGTQECAI VEFEEVDAAI KAHEFMVTES QSKENMKAVL IGMKPPKKKP
310 320 330 340 350
LKDKNHDDEA TAGTHLSRSL NKRVEELQYM GDESSANSSS DPESNPTSPM
360 370 380 390 400
AGRRHAASNK LSPSGHQNIF LSPNASPCSS PWSSPLAQRK GVSRKSPLAE
410 420 430 440 450
EGRLNFSTSP EIFRKCMDYS SDSSITPSGS PWVRRRRQAE MGTQEKSPGA
460 470 480 490
SPLLSRRMQT ADGLPVGVLR LPRGPDNTRG FHGGHERGRA CV
Length:492
Mass (Da):54,873
Last modified:March 1, 2003 - v1
Checksum:iAA78A6BBCADDE231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → T in BAB30713 (PubMed:16141072).Curated1
Sequence conflicti107E → D in BAC30400 (PubMed:16141072).Curated1
Sequence conflicti314T → N in BAC31306 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017372 mRNA Translation: BAB30713.1
AK020966 mRNA Translation: BAB32263.1
AK039614 mRNA Translation: BAC30400.1
AK042616 mRNA Translation: BAC31306.1
AK087521 mRNA Translation: BAC39909.1
BC090615 mRNA Translation: AAH90615.1
CCDSiCCDS23258.1
RefSeqiNP_080511.2, NM_026235.4
UniGeneiMm.44546

Genome annotation databases

EnsembliENSMUST00000038407; ENSMUSP00000040309; ENSMUSG00000034839
GeneIDi67557
KEGGimmu:67557
UCSCiuc009pzh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017372 mRNA Translation: BAB30713.1
AK020966 mRNA Translation: BAB32263.1
AK039614 mRNA Translation: BAC30400.1
AK042616 mRNA Translation: BAC31306.1
AK087521 mRNA Translation: BAC39909.1
BC090615 mRNA Translation: AAH90615.1
CCDSiCCDS23258.1
RefSeqiNP_080511.2, NM_026235.4
UniGeneiMm.44546

3D structure databases

ProteinModelPortaliQ8BN59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040309

PTM databases

iPTMnetiQ8BN59
PhosphoSitePlusiQ8BN59

Proteomic databases

MaxQBiQ8BN59
PaxDbiQ8BN59
PRIDEiQ8BN59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038407; ENSMUSP00000040309; ENSMUSG00000034839
GeneIDi67557
KEGGimmu:67557
UCSCiuc009pzh.1 mouse

Organism-specific databases

CTDi55323
MGIiMGI:1914807 Larp6

Phylogenomic databases

eggNOGiKOG1855 Eukaryota
ENOG4110VUA LUCA
GeneTreeiENSGT00830000128323
HOGENOMiHOG000010108
HOVERGENiHBG070244
InParanoidiQ8BN59
KOiK18733
OMAiHERGRAC
OrthoDBiEOG091G09LP
PhylomeDBiQ8BN59
TreeFamiTF326594

Miscellaneous databases

PROiPR:Q8BN59
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034839 Expressed in 173 organ(s), highest expression level in pontine nuclear group
CleanExiMM_LARP6
GenevisibleiQ8BN59 MM

Family and domain databases

CDDicd12289 RRM_LARP6, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR034886 LARP6
IPR034880 LARP6_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024642 SUZ-C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22792:SF71 PTHR22792:SF71, 1 hit
PfamiView protein in Pfam
PF05383 La, 1 hit
PF12901 SUZ-C, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLARP6_MOUSE
AccessioniPrimary (citable) accession number: Q8BN59
Secondary accession number(s): Q8C9A3
, Q8CA51, Q9CTN3, Q9D3J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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