UniProtKB - Q8BN59 (LARP6_MOUSE)
Protein
La-related protein 6
Gene
Larp6
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).By similarity
GO - Molecular functioni
- mRNA 5'-UTR binding Source: UniProtKB
- myosin binding Source: MGI
- RNA stem-loop binding Source: MGI
- sequence-specific mRNA binding Source: UniProtKB
GO - Biological processi
- positive regulation of collagen biosynthetic process Source: MGI
- positive regulation of mRNA binding Source: UniProtKB
- positive regulation of translation Source: MGI
- RNA processing Source: InterPro
Keywordsi
Molecular function | RNA-binding |
Biological process | Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 6Alternative name(s): Acheron Short name: Achn La ribonucleoprotein domain family member 6 |
Gene namesi | Name:Larp6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914807, Larp6 |
Subcellular locationi
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
- polysome Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000281142 | 2 – 492 | La-related protein 6Add BLAST | 491 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | Q8BN59 |
PaxDbi | Q8BN59 |
PRIDEi | Q8BN59 |
ProteomicsDBi | 265043 |
PTM databases
iPTMneti | Q8BN59 |
PhosphoSitePlusi | Q8BN59 |
Expressioni
Tissue specificityi
Expressed in numerous tissues. Highest expression in heart and brain, intermediate in kidney, skeletal muscle and testis, lowest expression in testis (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000034839, Expressed in primary visual cortex and 196 other tissues |
Genevisiblei | Q8BN59, MM |
Interactioni
Subunit structurei
Interacts (via the HTH domain) with VIM/vimentin.
Interacts (via C-terminus) with non-muscle myosin MYH10.
Interacts (via C-terminus) with DHX9 (By similarity).
By similarityGO - Molecular functioni
- myosin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 212276, 1 interactor |
STRINGi | 10090.ENSMUSP00000040309 |
Miscellaneous databases
RNActi | Q8BN59, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 86 – 177 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 184 – 296 | RRMAdd BLAST | 113 | |
Domaini | 427 – 485 | SUZ-CPROSITE-ProRule annotationAdd BLAST | 59 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 186 – 193 | Nuclear export signalBy similarity | 8 | |
Motifi | 296 – 302 | Nuclear localization signalBy similarity | 7 |
Domaini
The RRM domain mediates the association with collagen mRNAs stem-loops.By similarity
Phylogenomic databases
eggNOGi | KOG1855, Eukaryota |
GeneTreei | ENSGT00940000159103 |
HOGENOMi | CLU_015330_1_0_1 |
InParanoidi | Q8BN59 |
OMAi | PHSHKSP |
OrthoDBi | 1179659at2759 |
PhylomeDBi | Q8BN59 |
TreeFami | TF326594 |
Family and domain databases
CDDi | cd12289, RRM_LARP6, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR034886, LARP6 IPR034880, LARP6_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR024642, SUZ-C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR22792:SF71, PTHR22792:SF71, 1 hit |
Pfami | View protein in Pfam PF05383, La, 1 hit PF12901, SUZ-C, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS51938, SUZ_C, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8BN59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQLGEQTLP GPETTVQIRV AIQEAEDLED LEEEDEGTSA RAAGDPARYL
60 70 80 90 100
SPGWGSASEE EPSRGHSSAT TSGGENDRED LEPEWRPPDE ELIRKLVDQI
110 120 130 140 150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH
160 170 180 190 200
ALKYSVTLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LHLSPKLWAL
210 220 230 240 250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY
260 270 280 290 300
SQVGTQECAI VEFEEVDAAI KAHEFMVTES QSKENMKAVL IGMKPPKKKP
310 320 330 340 350
LKDKNHDDEA TAGTHLSRSL NKRVEELQYM GDESSANSSS DPESNPTSPM
360 370 380 390 400
AGRRHAASNK LSPSGHQNIF LSPNASPCSS PWSSPLAQRK GVSRKSPLAE
410 420 430 440 450
EGRLNFSTSP EIFRKCMDYS SDSSITPSGS PWVRRRRQAE MGTQEKSPGA
460 470 480 490
SPLLSRRMQT ADGLPVGVLR LPRGPDNTRG FHGGHERGRA CV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | S → T in BAB30713 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 107 | E → D in BAC30400 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 314 | T → N in BAC31306 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017372 mRNA Translation: BAB30713.1 AK020966 mRNA Translation: BAB32263.1 AK039614 mRNA Translation: BAC30400.1 AK042616 mRNA Translation: BAC31306.1 AK087521 mRNA Translation: BAC39909.1 BC090615 mRNA Translation: AAH90615.1 |
CCDSi | CCDS23258.1 |
RefSeqi | NP_080511.2, NM_026235.4 |
Genome annotation databases
Ensembli | ENSMUST00000038407; ENSMUSP00000040309; ENSMUSG00000034839 |
GeneIDi | 67557 |
KEGGi | mmu:67557 |
UCSCi | uc009pzh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK017372 mRNA Translation: BAB30713.1 AK020966 mRNA Translation: BAB32263.1 AK039614 mRNA Translation: BAC30400.1 AK042616 mRNA Translation: BAC31306.1 AK087521 mRNA Translation: BAC39909.1 BC090615 mRNA Translation: AAH90615.1 |
CCDSi | CCDS23258.1 |
RefSeqi | NP_080511.2, NM_026235.4 |
3D structure databases
SMRi | Q8BN59 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212276, 1 interactor |
STRINGi | 10090.ENSMUSP00000040309 |
PTM databases
iPTMneti | Q8BN59 |
PhosphoSitePlusi | Q8BN59 |
Proteomic databases
MaxQBi | Q8BN59 |
PaxDbi | Q8BN59 |
PRIDEi | Q8BN59 |
ProteomicsDBi | 265043 |
Protocols and materials databases
Antibodypediai | 14073, 126 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000038407; ENSMUSP00000040309; ENSMUSG00000034839 |
GeneIDi | 67557 |
KEGGi | mmu:67557 |
UCSCi | uc009pzh.1, mouse |
Organism-specific databases
CTDi | 55323 |
MGIi | MGI:1914807, Larp6 |
Phylogenomic databases
eggNOGi | KOG1855, Eukaryota |
GeneTreei | ENSGT00940000159103 |
HOGENOMi | CLU_015330_1_0_1 |
InParanoidi | Q8BN59 |
OMAi | PHSHKSP |
OrthoDBi | 1179659at2759 |
PhylomeDBi | Q8BN59 |
TreeFami | TF326594 |
Miscellaneous databases
BioGRID-ORCSi | 67557, 1 hit in 52 CRISPR screens |
PROi | PR:Q8BN59 |
RNActi | Q8BN59, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034839, Expressed in primary visual cortex and 196 other tissues |
Genevisiblei | Q8BN59, MM |
Family and domain databases
CDDi | cd12289, RRM_LARP6, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR034886, LARP6 IPR034880, LARP6_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR024642, SUZ-C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR22792:SF71, PTHR22792:SF71, 1 hit |
Pfami | View protein in Pfam PF05383, La, 1 hit PF12901, SUZ-C, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS51938, SUZ_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP6_MOUSE | |
Accessioni | Q8BN59Primary (citable) accession number: Q8BN59 Secondary accession number(s): Q8C9A3 Q9D3J0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot